SNP Report

Basic Info

Name	rs3800373 dbSNP Ensembl
Location	chr6:35574699 - 35574699(1)
Variant Alleles	C/A
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.32528
Functional Annotation	3_prime_UTR_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000357266, ENST00000536438, ENST00000539068)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Willour, V. L.,2009	A/C	FBAT: Additive model: major allele P-value = 0.060, minor al...... FBAT: Additive model: major allele P-value = 0.060, minor allele P-value = 0.060; Dominant model: major allele P-value = 0.010, minor allele P-value = 0.452; Genotypic association: TDT P-value = 0.03 More...	It showed a significant overtransmission under the dominant ...... It showed a significant overtransmission under the dominant model and a significant association in TDT result. More...	Positive
Szczepankiewicz A., 2014	A/C	P-value=0.891 P-value=0.891	Our main finding is no association with bipolar disorder. Our main finding is no association with bipolar disorder.	Negative
Gawlik, M., 2006	T/G	allelic P-value = 0.23, genotypic P-value = 0.87 allelic P-value = 0.23, genotypic P-value = 0.87	Allele and genotype frequencies of rs3800373 were not signif...... Allele and genotype frequencies of rs3800373 were not significantly different between cases and controls. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
FKBP5	FK506 binding protein 5	6p21.31	5(1/4/0)

SNPs in LD with rs3800373 (count: 6) View in gBrowse (chr6:35574699..35690550 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs9368878	intron_variant	0.945[CEU]; 0.828[TSI]
rs7751598	intron_variant	0.945[CEU]; 0.855[TSI]
rs9380526	intron_variant; upstream_gene_variant	0.804[CEU]
rs9368881	intron_variant; upstream_gene_variant	0.804[CEU]
rs3798347	intron_variant	0.945[CEU]
rs2395634	intron_variant	0.945[CEU]; 0.855[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Szczepankiewicz A., 2014	P-value=0.083	association analysis for single polymorphisms within FKBP5 gene	Negative