BDgene

SNP Report

Basic Info
Name rs3800373 dbSNP Ensembl
Location chr6:35574699 - 35574699(1)
Variant Alleles C/A
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.32528
Functional Annotation 3_prime_UTR_variant.
Consequence to Transcript 3_prime_UTR_variant(ENST00000357266, ENST00000536438, ENST00000539068)
No. of Studies 3 (Positive: 1; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? YES

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Willour, V. L.,2009 A/C FBAT: Additive model: major allele P-value = 0.060, minor al...... FBAT: Additive model: major allele P-value = 0.060, minor allele P-value = 0.060; Dominant model: major allele P-value = 0.010, minor allele P-value = 0.452; Genotypic association: TDT P-value = 0.03 More... It showed a significant overtransmission under the dominant ...... It showed a significant overtransmission under the dominant model and a significant association in TDT result. More... Positive
Szczepankiewicz A., 2014 A/C P-value=0.891 P-value=0.891 Our main finding is no association with bipolar disorder. Our main finding is no association with bipolar disorder. Negative
Gawlik, M., 2006 T/G allelic P-value = 0.23, genotypic P-value = 0.87 allelic P-value = 0.23, genotypic P-value = 0.87 Allele and genotype frequencies of rs3800373 were not signif...... Allele and genotype frequencies of rs3800373 were not significantly different between cases and controls. More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
FKBP5 FK506 binding protein 5 6p21.31 5(1/4/0)

SNPs in LD with rs3800373 (count: 6) View in gBrowse (chr6:35574699..35690550 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 6)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Szczepankiewicz A., 2014 P-value=0.083 association analysis for single polymorphisms within FKBP5 gene Negative