SNP Report

Basic Info

Name	rs1049353 dbSNP Ensembl
Location	chr6:88143916 - 88143916(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.129393
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; synonymous_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000362094); downstream_gene_variant(ENST00000551417); synonymous_variant(ENST00000369499, ENST00000369501, ENST00000428600, ENST00000468898, ENST00000549890)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Pisanu, C., 2013	A/G		logistic regression, P-value=0.385, OR=0.89 logistic regression, P-value=0.385, OR=0.89	None of the SNPs of CNR1 showed nominal association with BD ...... None of the SNPs of CNR1 showed nominal association with BD or lithium response. More...	Negative
Monteleone, P.,2010	G/A		Pearson's X² test: BD patients as a whole group(X...... Pearson's X² test: BD patients as a whole group(X²= 0.926; df = 2, P-value = 0.6 for genotypes; X²= 1.05; df = 1, P-value = 0.3 for alleles) or in type I BD subjects (X²= 0.225; df = 2, P-value = 0.8 for genotypes; X²= 0.016 df = 1, P-value = 0.9 for alleles) and in type II BD individuals(X²= 2.514; df = 2, P-value = 0.2 for genotypes; X²= 3.075 df = 1, P-value = 0.08 for alleles). More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CNR1	cannabinoid receptor 1 (brain)	6q14-q15	5(0/5/0)

SNPs in LD with rs1049353 (count: 1) View in gBrowse (chr6:88142032..88143916 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs4707436		3_prime_UTR_variant; downstream_gene_variant	0.946[CEU]; 0.931[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Monteleone, P.,2010	Pearson's X² test: X²= 10.321; df = 2, P-value = 0.005 for genotypes; X²= 12.469;df = 1, P-value = 0.0004 for alleles	Significant association was found.	Positive