GO Report

Basic Info

ID	GO:0016021
Name	integral component of membrane
Type	cellular component
No. of Genes in BDgene	219
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
GO: 0016021: integral to membrane	PBA paper	Askland, K.,2009	NIMH	Fisher's exact test	Results given for gene sets with P < 0.01 from the NIMH PBA-CC data

GO related genes in BDgene (count: 219)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
TMEM217	transmembrane protein 217	6p21.31-p21.2	1(0/0/1)	IEA
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	15q13.3	4(2/2/0)	NAS[8145738]
SLC18A1	solute carrier family 18 (vesicular monoamine transporter), member 1	8p21.3	3(2/1/0)	IEA
CSMD3	CUB and Sushi multiple domains 3	8q23.3	1(0/1/0)	IEA
NOTCH3	notch 3	19p13.2-p13.1	1(0/1/0)	IEA
DNAJC16	DnaJ (Hsp40) homolog, subfamily C, member 16	1p36.1	1(0/1/0)	IEA
GPR124	adhesion G protein-coupled receptor A2	8p11.22	0	IEA
TAOK2	TAO kinase 2	16p11.2	1(0/1/0)	IEA
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	9q34	3(1/2/0)	IEA
SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 5	11p15.1	1(0/1/0)	IEA
HEPACAM2	HEPACAM family member 2	7q21.3	1(0/0/1)	IEA
FGFR2	fibroblast growth factor receptor 2	10q25.3-q26	2(1/1/0)	NAS[1697263]
EVC	Ellis van Creveld syndrome	4p16	1(0/0/1)	IEA
SYNE1	spectrin repeat containing, nuclear envelope 1	6q25.2	6(3/2/1)	IDA[11792814]
OPA1	optic atrophy 1 (autosomal dominant)	3q29	1(0/1/0)	IEA
PRLR	prolactin receptor	5p14-p13	1(1/0/0)	IEA
OR2Y1	olfactory receptor, family 2, subfamily Y, member 1	5q35	1(0/0/1)	IEA
GGTA1P	glycoprotein, alpha-galactosyltransferase 1 pseudogene	9q33.2	1(1/0/0)	IEA
DPP10	dipeptidyl-peptidase 10 (non-functional)	2q14.1	3(2/1/0)	IEA
PTPRT	protein tyrosine phosphatase, receptor type, T	20q12-q13	2(0/1/1)	NAS[9602027]
ABCC12	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	16q12.1	1(0/1/0)	IEA
DIO2	deiodinase, iodothyronine, type II	14q24.2-q24.3	1(1/0/0)	IEA
KCND2	potassium channel, voltage gated Shal related subfamily D, member 2	7q31	1(1/0/0)	IBA
ABHD2	abhydrolase domain containing 2	15q26.1	2(0/1/1)	IEA
LRRC15	leucine rich repeat containing 15	3q29	1(0/1/0)	IEA
MALL	mal, T-cell differentiation protein-like	2q13	1(0/1/0)	IEA
NAALAD2	N-acetylated alpha-linked acidic dipeptidase 2	11q14.3-q21	1(0/1/0)	NAS[10085079]
LMBR1L	limb development membrane protein 1-like	12q13.12	1(0/0/1)	IEA
CDH7	cadherin 7, type 2	18q22.1	1(0/0/1)	IEA
THSD7A	thrombospondin, type I, domain containing 7A	7p21.3	1(1/0/0)	IEA
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)	IEA
ASTN2	astrotactin 2	9q33	1(1/0/0)	IEA
ZDHHC8	zinc finger, DHHC-type containing 8	22q11.21	1(0/1/0)	IEA
SLC39A3	solute carrier family 39 (zinc transporter), member 3	19p13.3	1(0/1/0)	IEA
SLCO3A1	solute carrier organic anion transporter family, member 3A1	15q26	2(1/1/0)	IEA
ATP6V0A2	ATPase, H+ transporting, lysosomal V0 subunit a2	12q24.31	1(0/1/0)	IEA
BET1	Bet1 golgi vesicular membrane trafficking protein	7q21.1-q22	1(1/0/0)	IEA
TMEM108	transmembrane protein 108	3q22.1	1(1/0/0)	IEA
MPPE1	metallophosphoesterase 1	18p11.21	2(2/0/0)	IEA
CLDN16	claudin 16	3q28	1(0/1/0)	IEA
SEL1L2	sel-1 suppressor of lin-12-like 2 (C. elegans)	20p12.1	1(0/1/0)	IEA
TYR	tyrosinase	11q14.3	1(0/1/0)	IEA
ALG10B	ALG10B, alpha-1,2-glucosyltransferase	12q12	1(0/1/0)	IEA
GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	9q31.1	1(0/1/0)	NAS[11880201]
MFSD11	major facilitator superfamily domain containing 11	17q25.1	1(0/1/0)	IEA
VAMP7	vesicle-associated membrane protein 7	Xq28 and Yq12	2(0/2/0)	IEA
TAAR1	trace amine associated receptor 1	6q23.1	1(0/1/0)	IC[15718104]
EGFR	epidermal growth factor receptor	7p12	1(0/0/1)	IEA
PCDH15	protocadherin-related 15	10q21.1	4(2/1/1)	IEA
ATP13A4	ATPase type 13A4	3q29	1(0/1/0)	IEA
SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	2p15-p13	1(0/1/0)	NAS[8101838]
ZDHHC13	zinc finger, DHHC-type containing 13	11p15.1	1(0/0/1)	IEA
DIO3	deiodinase, iodothyronine, type III	14q32	1(0/1/0)	IEA
ACE	angiotensin I converting enzyme	17q23.3	5(2/3/0)	IEA
RNF144B	ring finger protein 144B	6p22.3	1(1/0/0)	IEA
TPST2	tyrosylprotein sulfotransferase 2	22q12.1	2(1/0/1)	IEA
PILRA	paired immunoglobin-like type 2 receptor alpha	7q22.1	1(0/0/1)	IEA
GALNT13	polypeptide N-acetylgalactosaminyltransferase 13	2q24.1	1(0/1/0)	IEA
B3GALT5	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	21q22.3	1(0/0/1)	IEA
COX10	COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor	17p12	1(1/0/0)	IEA
ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	19q13.2	3(2/1/0)	NAS[15260953]
EXTL1	exostosin-like glycosyltransferase 1	1p36.1	1(1/0/0)	IEA
IL15RA	interleukin 15 receptor, alpha	10p15.1	1(1/0/0)	IEA
SCN8A	sodium channel, voltage gated, type VIII alpha subunit	12q13.1	1(1/0/0)	TAS[9828131]
THSD7B	thrombospondin, type I, domain containing 7B	2q22.1	1(1/0/0)	IEA
GPR78	G protein-coupled receptor 78	4p16.1	2(2/0/0)	IEA
UPK3B	uroplakin 3B	7q11.2	1(0/0/1)	IEA
TAS1R3	taste receptor, type 1, member 3	1p36	1(0/0/1)	IC[11917125]
LINGO2	leucine rich repeat and Ig domain containing 2	9p21.2	1(0/0/1)	IEA
FZD2	frizzled class receptor 2	17q21.1	1(0/1/0)	IBA
FAR2	fatty acyl CoA reductase 2	12p11.23	1(0/1/0)	IEA
SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	5p15.31	1(1/0/0)	IEA
PCSK5	proprotein convertase subtilisin/kexin type 5	9q21.13	1(1/0/0)	IEA
CHRNA3	cholinergic receptor, nicotinic, alpha 3 (neuronal)	15q24	3(1/2/0)	NAS[8906617]
LHFPL3	lipoma HMGIC fusion partner-like 3	7q22.2	1(0/1/0)	IEA
MUC16	mucin 16, cell surface associated	19p13.2	1(0/0/1)	IEA
FAAH	fatty acid amide hydrolase	1p35-p34	2(0/2/0)	IEA
MAOB	monoamine oxidase B	Xp11.4-p11.3	4(2/2/0)	IEA
SEZ6L	seizure related 6 homolog (mouse)-like	22q12.1	1(1/0/0)	IEA
CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	15q24	2(1/1/0)	NAS[8906617]
KCNQ2	potassium channel, voltage gated KQT-like subfamily Q, member 2	20q13.33	1(1/0/0)	IBA
SLC30A8	solute carrier family 30 (zinc transporter), member 8	8q24.11	1(1/0/0)	IEA
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	18p11.2	1(1/0/0)	IEA
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	7q21.12	1(1/0/0)	IBA
PTPRE	protein tyrosine phosphatase, receptor type, E	10q26	1(1/0/0)	IEA
ADCY2	adenylate cyclase 2 (brain)	5p15.3	2(1/1/0)	IEA
SLC6A3	solute carrier family 6 (neurotransmitter transporter), member 3	5p15.3	11(5/6/0)	TAS[8628395]
SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	5p15.2	1(1/0/0)	IEA
ASTN1	astrotactin 1	1q25.2	1(1/0/0)	IEA
SLC25A21	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	14q13.3	1(0/0/1)	IEA
FAM20B	family with sequence similarity 20, member B	1q25.2	1(0/1/0)	IEA
TM4SF19	transmembrane 4 L six family member 19	3q29	1(0/1/0)	IBA
SLC22A23	solute carrier family 22, member 23	6p25.2	1(1/0/0)	IEA
MAOA	monoamine oxidase A	Xp11.4-p11.3	21(10/11/0)	IEA
SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	5p15.3	1(1/0/0)	IEA
ERBB4	erb-b2 receptor tyrosine kinase 4	2q33.3-q34	2(1/1/0)	IEA
PTPRO	protein tyrosine phosphatase, receptor type, O	12p13-p12	1(0/1/0)	TAS[10498613]
ITPRIPL2	inositol 1,4,5-trisphosphate receptor interacting protein-like 2	16p12.3	1(0/0/1)	IEA
VAMP3	vesicle-associated membrane protein 3	1p36.23	1(0/1/0)	IEA
GLT8D1	glycosyltransferase 8 domain containing 1	3p21.1	1(1/0/0)	IEA
ADAM18	ADAM metallopeptidase domain 18	8p11.22	1(0/0/1)	IEA
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	4(2/2/0)	IDA[23863939]
LAMP3	lysosomal-associated membrane protein 3	3q26.3-q27	1(1/0/0)	IEA
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11p13-p12	1(1/0/0)	IEA
ZAN	zonadhesin (gene/pseudogene)	7q22.1	1(0/0/1)	IEA
ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	1p13	1(1/0/0)	ISS
TMEM151B	transmembrane protein 151B	6p21.1	1(1/0/0)	IEA
TBXAS1	thromboxane A synthase 1 (platelet)	7q34-q35	1(0/1/0)	IEA
SORCS2	sortilin-related VPS10 domain containing receptor 2	4p16.1	5(3/2/0)	IEA
SLC22A16	solute carrier family 22 (organic cation/carnitine transporter), member 16	6q21	1(1/0/0)	IDA[12089149]
ATRNL1	attractin-like 1	10q26	1(0/1/0)	IEA
ADAM12	ADAM metallopeptidase domain 12	10q26	1(1/0/0)	IEA
NCAM1	neural cell adhesion molecule 1	11q23.2	3(2/1/0)	IEA
HS3ST4	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	16p11.2	1(1/0/0)	IEA
FMO5	flavin containing monooxygenase 5	1q21.1	1(1/0/0)	IEA
ZDHHC19	zinc finger, DHHC-type containing 19	3q29	1(0/1/0)	IEA
MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	2q12	1(0/0/1)	IEA
B3GALT1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	2q24.3	1(1/0/0)	NAS[9582303]
CERS3	ceramide synthase 3	15q26.3	1(0/0/1)	IEA
ESR1	estrogen receptor 1	6q24-q27	1(0/1/0)	IEA
FER1L6	fer-1-like family member 6	8q24.13	1(0/1/0)	IEA
PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	12q24.31	1(0/1/0)	NAS[10022914]
DPP6	dipeptidyl-peptidase 6	7q36.2	2(1/1/0)	IDA[18364354]
GLRA1	glycine receptor, alpha 1	5q33.1	1(1/0/0)	NAS[15952785]
ALG9	ALG9, alpha-1,2-mannosyltransferase	11q23	1(0/1/0)	IEA
OR3A1	olfactory receptor, family 3, subfamily A, member 1	17p13.3	1(0/0/1)	IBA
SYNGR1	synaptogyrin 1	22q13	3(2/1/0)	IEA; NAS[9760194]
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	20(17/3/0)	IDA[8392192]
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	3p22.2	2(1/1/0)	IEA
TMEM132E	transmembrane protein 132E	17q12	1(0/0/1)	IEA
NRXN2	neurexin 2	11q13	1(1/0/0)	IEA
CHRNB3	cholinergic receptor, nicotinic, beta 3 (neuronal)	8p11.21	3(1/2/0)	NAS[8906617]
SERINC1	serine incorporator 1	6q22.32	1(1/0/0)	IEA
SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)	2p23.1	1(0/1/0)	IEA
FLVCR2	feline leukemia virus subgroup C cellular receptor family, member 2	14q24.3	1(1/0/0)	IEA
HS6ST2	heparan sulfate 6-O-sulfotransferase 2	Xq26.2	1(0/0/1)	IEA
CHL1	cell adhesion molecule L1-like	3p26	1(1/0/0)	IEA
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	4q13	1(0/0/1)	IEA
CDHR3	cadherin-related family member 3	7q22.2	1(0/1/0)	IEA
SEC63	SEC63 homolog (S. cerevisiae)	6q21	1(1/0/0)	IEA
GRM7	glutamate receptor, metabotropic 7	3p26-p25	3(2/1/0)	IDA[12746871]
HCAR2	hydroxycarboxylic acid receptor 2	12q24.31	1(0/1/0)	IEA
POMGNT2	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)	3p22.1	1(0/0/1)	IEA
PVRIG	poliovirus receptor related immunoglobulin domain containing	7q22.1	1(0/0/1)	IEA
MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	22q13.33	5(1/4/0)	IDA[17628813]
EDAR	ectodysplasin A receptor	2q13	1(0/1/0)	NAS[10431241]
SPTLC1	serine palmitoyltransferase, long chain base subunit 1	9q22.31	1(0/1/0)	IEA
STX12	syntaxin 12	1p35.3	1(0/1/0)	IBA
CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	20q13.33	1(1/0/0)	NAS[8906617]
CMKLR1	chemokine-like receptor 1	12q23.3	1(0/1/0)	NAS[9603476]
OR4X2	olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene)	11p11.2	1(0/0/1)	IBA
NMUR2	neuromedin U receptor 2	5q33.1	1(0/1/0)	IDA[10899166]
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	1q21.3	1(1/0/0)	NAS[8906617]
LMAN2L	lectin, mannose-binding 2-like	2q11.1	2(2/0/0)	TAS[12609988]
XKR4	XK, Kell blood group complex subunit-related family, member 4	8q12.1	1(0/1/0)	IEA
TSPAN8	tetraspanin 8	12q14.1-q21.1	2(1/0/1)	IEA
DPY19L1	dpy-19-like 1 (C. elegans)	7p14.3-p14.2	1(0/0/1)	IEA
PRSS55	protease, serine, 55	8p23.1	1(0/1/0)	IEA
SYPL1	synaptophysin-like 1	7q22.2	1(1/0/0)	TAS[1730063]
HLA-B	major histocompatibility complex, class I, B	6p21.3	2(0/1/1)	IEA
KCNN3	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3	1q21.3	7(1/6/0)	IEA
PLD5	phospholipase D family, member 5	1q43	1(0/1/0)	IEA
DPCR1	diffuse panbronchiolitis critical region 1	6p21.32	1(0/0/1)	IEA
GLDN	gliomedin	15q15.3	1(1/0/0)	IEA
PROKR2	prokineticin receptor 2	20p12.3	1(1/0/0)	IEA
CSMD1	CUB and Sushi multiple domains 1	8p23.2	4(2/1/1)	IEA
DCC	DCC netrin 1 receptor	18q21.1	2(1/1/0)	IEA
COMT	catechol-O-methyltransferase	22q11.21	28(14/14/0)	IEA
DPY19L3	dpy-19-like 3 (C. elegans)	19q13.11	1(0/0/1)	IEA
JAM3	junctional adhesion molecule 3	11q25	2(1/1/0)	IEA
MCHR2	melanin-concentrating hormone receptor 2	6q16	1(1/0/0)	IEA
NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	4q26	1(1/0/0)	IEA
EDA2R	ectodysplasin A2 receptor	Xq11.1	1(0/0/1)	IC[12270937]
AGTR1	angiotensin II receptor, type 1	3q24	1(1/0/0)	NAS[8135787]
LEPR	leptin receptor	1p31	1(1/0/0)	IEA
SMCO1	single-pass membrane protein with coiled-coil domains 1	3q29	1(0/1/0)	IEA
FGFRL1	fibroblast growth factor receptor-like 1	4p16	1(0/0/1)	IEA
CHRFAM7A	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion	15q13.2	1(0/1/0)	IEA
KHDC1	KH homology domain containing 1	6q13	1(0/1/0)	IEA
CADM2	cell adhesion molecule 2	3p12.2	1(0/1/0)	IEA
DST	dystonin	6p12.1	1(0/0/1)	IEA
CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	2q11.2	1(1/0/0)	IEA
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	8p21	3(0/3/0)	NAS[8906617]
OR1B1	olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene)	9q33.2	1(0/1/0)	IBA
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	4p16.1	1(0/0/1)	NAS[10860667]
SDK1	sidekick cell adhesion molecule 1	7p22.3	1(1/0/0)	IEA
ARV1	ARV1 homolog (S. cerevisiae)	1q42.2	1(0/0/1)	IEA
EVA1A	eva-1 homolog A (C. elegans)	2p12	1(1/0/0)	IEA
FZD3	frizzled class receptor 3	8p21	1(0/1/0)	IBA
FRMD3	FERM domain containing 3	9q21.33	1(0/1/0)	IEA
NRXN1	neurexin 1	2p16.3	1(1/0/0)	IEA
CNTNAP5	contactin associated protein-like 5	2q14.1	2(0/2/0)	IEA
LRP8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	1p32.3	1(1/0/0)	IC[11152697]
PLA2R1	phospholipase A2 receptor 1, 180kDa	2q23-q24	1(1/0/0)	IEA
NRXN3	neurexin 3	14q31	2(2/0/0)	IEA
SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	15q13	1(1/0/0)	NAS[10187864]
TAAR6	trace amine associated receptor 6	6q23.1	5(4/1/0)	IC[15718104]
MARCH1	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	4q32.2	1(0/1/0)	IEA
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	3p12.3	1(0/1/0)	IEA
KCNQ3	potassium channel, voltage gated KQT-like subfamily Q, member 3	8q24	4(3/0/1)	IBA
NALCN	sodium leak channel, non selective	13q32.3	2(0/2/0)	IEA
ANO3	anoctamin 3	11p14.2	1(1/0/0)	IEA
TSPO	translocator protein (18kDa)	22q13.3	3(1/2/0)	IEA
CDH15	cadherin 15, type 1, M-cadherin (myotubule)	16q24.3	1(1/0/0)	IEA
SLC5A12	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	11p14.2	1(1/0/0)	IEA
XBP1	X-box binding protein 1	22q12.1	3(2/1/0)	IEA
SGCZ	sarcoglycan, zeta	8p22	1(0/0/1)	IEA
IMMP2L	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	7q31	1(1/0/0)	IEA
TAAR8	trace amine associated receptor 8	6q23.2	1(0/1/0)	IC[15718104]
POPDC3	popeye domain containing 3	6q21	1(1/0/0)	NAS[10882522]
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	2p21	1(0/1/0)	IEA
VRK2	vaccinia related kinase 2	2p16.1	1(0/1/0)	IEA
TMEM222	transmembrane protein 222	1p36.11	1(0/0/1)	IEA
XXYLT1	xyloside xylosyltransferase 1	3q29	2(0/2/0)	IEA
MPC2	mitochondrial pyruvate carrier 2	1q24	1(0/1/0)	IEA
VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1	7q11.21	1(1/0/0)	IEA
BVES	blood vessel epicardial substance	6q21	1(1/0/0)	IDA[16188940]; NAS[10441744]
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	13q12-q13	2(0/2/0)	IEA
CD276	CD276 molecule	15q23-q24	1(0/1/0)	NAS[15188059]