BD & SZ & MDD shared genes

Total unqiue gene count: 183

Note: The shared genes from cross-disorder studies that investigated the three diseases (BD, SZ and MDD) in one study simultaneously were considered from cross-disorder studies, other overlapped genes between BD-SZ shared genes and BD-MDD shared genes (including both from cross-disorder study and intersection analysis) were all considered from candidate gene intersection analysis.

From cross-disorder studies (count: 78)
Approved Symbol Approved Name Location No. of Studies for BD (Positive/Negative/Trend) Overlap with SZ Overlap with MDD Help
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 44(18/26/0) YES YES
BDNF brain-derived neurotrophic factor 11p14.1 37(24/12/1) YES YES
COMT catechol-O-methyltransferase 22q11.21 28(14/14/0) YES YES
DRD2 dopamine receptor D2 11q22-q23 28(8/20/0) YES YES
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0) YES YES
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1) YES YES
MAOA monoamine oxidase A Xp11.4-p11.3 21(10/11/0) YES YES
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0) YES YES
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 17(13/3/1) YES YES
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1p36.3 16(10/6/0) YES YES
TPH1 tryptophan hydroxylase 1 11p15.3-p14 14(5/9/0) YES YES
DRD4 dopamine receptor D4 11p15.5 13(1/12/0) YES YES
CLOCK clock circadian regulator 4q12 12(5/7/0) YES YES
PER2 period circadian clock 2 2q37.3 7(1/6/0) YES YES
PER3 period circadian clock 3 1p36.23 7(3/4/0) YES YES
ARNTL aryl hydrocarbon receptor nuclear translocator-like 11p15 7(5/2/0) YES YES
SYNE1 spectrin repeat containing, nuclear envelope 1 6q25.2 6(3/2/1) YES YES
NR1D1 nuclear receptor subfamily 1, group D, member 1 17q11.2 6(2/4/0) YES YES
TENM4 teneurin transmembrane protein 4 11q13 6(4/2/0) YES YES
DGKH diacylglycerol kinase, eta 13q13.3 6(3/3/0) YES YES
NPAS2 neuronal PAS domain protein 2 2q11.2 5(3/2/0) YES YES
CSNK1E casein kinase 1, epsilon 22q13.1 5(1/3/1) YES YES
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 5(0/5/0) YES YES
ACE angiotensin I converting enzyme 17q23.3 5(2/3/0) YES YES
CRY2 cryptochrome circadian clock 2 11p11.2 5(3/2/0) YES YES
PER1 period circadian clock 1 17p13.1 5(2/3/0) YES YES
CSNK1D casein kinase 1, delta 17q25 4(2/2/0) YES YES
RORB RAR-related orphan receptor B 9q22 4(3/1/0) YES YES
BHLHE41 basic helix-loop-helix family, member e41 12p12.1 3(2/1/0) YES YES
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 3(2/1/0) YES YES
TIMELESS timeless circadian clock 12q13.3 3(0/3/0) YES YES
GPR50 G protein-coupled receptor 50 Xq28 3(2/1/0) YES YES
EGR3 early growth response 3 8p23-p21 3(2/1/0) YES YES
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 12p12.2-p11.2 3(1/2/0) YES YES
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3p21.1 3(3/0/0) YES YES
SP8 Sp8 transcription factor 7p21.2 3(2/0/1) YES YES
TIPIN TIMELESS interacting protein 15q22.31 2(0/2/0) YES YES
CSNK2A1 casein kinase 2, alpha 1 polypeptide 20p13 2(0/2/0) YES YES
AANAT aralkylamine N-acetyltransferase 17q25.1 2(0/2/0) YES YES
FOXP2 forkhead box P2 7q31 2(0/2/0) YES YES
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 7p12.3 2(2/0/0) YES YES
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 2(1/1/0) YES YES
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 12p13 2(1/1/0) YES YES
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0) YES YES
MYO18B myosin XVIIIB 22q12.1 2(0/2/0) YES YES
NPAS3 neuronal PAS domain protein 3 14q13.1 2(1/1/0) YES YES
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2q33 2(1/1/0) YES YES
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 22q12.3 2(1/1/0) YES YES
NFIL3 nuclear factor, interleukin 3 regulated 9q22 2(0/2/0) YES YES
FGFR2 fibroblast growth factor receptor 2 10q25.3-q26 2(1/1/0) YES YES
DRD5 dopamine receptor D5 4p16.1 2(0/2/0) YES YES
NT5C2 5'-nucleotidase, cytosolic II 10q24.32 2(2/0/0) YES YES
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 17p13.3 1(0/1/0) YES YES
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2p21 1(0/1/0) YES YES
IFT88 intraflagellar transport 88 13q12.1 1(0/1/0) YES YES
BCL9 B-cell CLL/lymphoma 9 1q21 1(1/0/0) YES YES
TXNL1 thioredoxin-like 1 18q21.31 1(0/0/1) YES YES
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 1(0/1/0) YES YES
CCDC102B coiled-coil domain containing 102B 18q22.1 1(0/1/0) YES YES
FAM20B family with sequence similarity 20, member B 1q25.2 1(0/1/0) YES YES
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 6p21 1(1/0/0) YES YES
AS3MT arsenite methyltransferase 10q24.33 1(1/0/0) YES YES
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 22q11.2 1(1/0/0) YES YES
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 7q36.1 1(0/0/1) YES YES
CTNND2 catenin (cadherin-associated protein), delta 2 5p15.2 1(0/1/0) YES YES
ANXA1 annexin A1 9q21.13 1(0/0/1) YES YES
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 21q11 1(0/1/0) YES YES
CCDC68 coiled-coil domain containing 68 18q21 1(1/0/0) YES YES
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 20p12.1 1(0/1/0) YES YES
ADM adrenomedullin 11p15.4 1(1/0/0) YES YES
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 15q13.3 1(0/1/0) YES YES
FZD3 frizzled class receptor 3 8p21 1(0/1/0) YES YES
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 7q33 1(0/1/0) YES YES
ANO2 anoctamin 2, calcium activated chloride channel 12p13.3 1(0/1/0) YES YES
RBMS3 RNA binding motif, single stranded interacting protein 3 3p24-p23 1(0/1/0) YES YES
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 10q26.3 1(0/0/1) YES YES
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 4p15.3 1(1/0/0) YES YES
OPTN optineurin 10p14 1(0/0/1) YES YES

From candidate gene intersection analysis (count: 105)
Approved Symbol Approved Name Location No. of Studies for BD (Positive/Negative/Trend) Overlap with SZ Overlap with MDD Help
DRD3 dopamine receptor D3 3q13.3 19(4/15/0) YES YES
DISC1 disrupted in schizophrenia 1 1q42.1 18(10/7/1) YES YES
TH tyrosine hydroxylase 11p15.5 16(4/12/0) YES YES
NRG1 neuregulin 1 8p12 15(10/5/0) YES YES
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0) YES YES
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0) YES YES
DRD1 dopamine receptor D1 5q34-q35 11(6/5/0) YES YES
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 12q24 9(2/7/0) YES YES
GSK3B glycogen synthase kinase 3 beta 3q13.3 8(0/8/0) YES YES
DTNBP1 dystrobrevin binding protein 1 6p22.3 8(4/3/1) YES YES
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 8(2/5/1) YES YES
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p13.1 8(4/4/0) YES YES
WFS1 Wolfram syndrome 1 (wolframin) 4p16.1 7(1/6/0) YES YES
GRM3 glutamate receptor, metabotropic 3 7q21.1-q21.2 7(3/4/0) YES YES
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1q21.3 7(1/6/0) YES YES
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 7(4/3/0) YES YES
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 15q12 6(6/0/0) YES YES
RGS4 regulator of G-protein signaling 4 1q23.3 6(3/2/1) YES YES
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 22q13.33 5(1/4/0) YES YES
TAAR6 trace amine associated receptor 6 6q23.1 5(4/1/0) YES YES
PDLIM5 PDZ and LIM domain 5 4q22 5(4/1/0) YES YES
PBRM1 polybromo 1 3p21 5(4/0/1) YES YES
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0) YES YES
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 7p12.1 5(2/3/0) YES YES
FKBP5 FK506 binding protein 5 6p21.31 5(1/4/0) YES YES
DUSP6 dual specificity phosphatase 6 12q22-q23 5(3/2/0) YES YES
TSNAX translin-associated factor X 1q42.2 4(3/1/0) YES YES
TNF tumor necrosis factor 6p21.3 4(2/2/0) YES YES
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) YES YES
MAOB monoamine oxidase B Xp11.4-p11.3 4(2/2/0) YES YES
TSPO translocator protein (18kDa) 22q13.3 3(1/2/0) YES YES
PDE4B phosphodiesterase 4B, cAMP-specific 1p31 3(1/2/0) YES YES
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 3(1/2/0) YES YES
DBP D site of albumin promoter (albumin D-box) binding protein 19q13.33 3(0/3/0) YES YES
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q11.2-q13 3(2/1/0) YES YES
CCL2 chemokine (C-C motif) ligand 2 17q11.2-q21.1 3(1/2/0) YES YES
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 18p11 3(1/2/0) YES YES
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 3(1/1/1) YES YES
XBP1 X-box binding protein 1 22q12.1 3(2/1/0) YES YES
NCAM1 neural cell adhesion molecule 1 11q23.2 3(2/1/0) YES YES
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 3(1/2/0) YES YES
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 3p21.1 2(2/0/0) YES YES
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 5q34 2(1/1/0) YES YES
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 2(0/2/0) YES YES
SOD2 superoxide dismutase 2, mitochondrial 6q25 2(1/1/0) YES YES
SLCO3A1 solute carrier organic anion transporter family, member 3A1 15q26 2(1/1/0) YES YES
HSPA1A heat shock 70kDa protein 1A 6p21.3 2(2/0/0) YES YES
IFNG interferon, gamma 12q14 2(2/0/0) YES YES
CCK cholecystokinin 3p22.1 2(0/1/1) YES YES
KCTD12 potassium channel tetramerization domain containing 12 13q21 2(0/1/1) YES YES
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 15q24-q25 2(2/0/0) YES YES
GRIA1 glutamate receptor, ionotropic, AMPA 1 5q33 2(2/0/0) YES YES
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 16q12.2 2(0/2/0) YES YES
S100B S100 calcium binding protein B 21q22.3 2(1/1/0) YES YES
NOS3 nitric oxide synthase 3 (endothelial cell) 7q36 2(1/1/0) YES YES
FAAH fatty acid amide hydrolase 1p35-p34 2(0/2/0) YES YES
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2q31 2(1/1/0) YES YES
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 2(1/1/0) YES YES
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 11q23.1 2(1/1/0) YES YES
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 2(2/0/0) YES YES
INPP1 inositol polyphosphate-1-phosphatase 2q32 1(0/1/0) YES YES
NQO1 NAD(P)H dehydrogenase, quinone 1 16q12-q22 1(0/1/0) YES YES
RGMA repulsive guidance molecule family member a 15q26.1 1(1/0/0) YES YES
GRM2 glutamate receptor, metabotropic 2 3p21.2 1(0/1/0) YES YES
SYN2 synapsin II 3p25.2 1(0/1/0) YES YES
GRIK3 glutamate receptor, ionotropic, kainate 3 1p34.3 1(1/0/0) YES YES
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(1/0/0) YES YES
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 1(1/0/0) YES YES
CCKBR cholecystokinin B receptor 11p15.4 1(1/0/0) YES YES
PAWR PRKC, apoptosis, WT1, regulator 12q21.2 1(0/1/0) YES YES
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1p36.3-p34.3 1(0/1/0) YES YES
INS insulin 11p15.5 1(0/1/0) YES YES
GRIA3 glutamate receptor, ionotropic, AMPA 3 Xq25 1(0/1/0) YES YES
GNAS GNAS complex locus 20q13.2-q13.3 1(0/1/0) YES YES
KLK8 kallikrein-related peptidase 8 19q13 1(1/0/0) YES YES
EGR1 early growth response 1 5q23-q31 1(0/1/0) YES YES
APOE apolipoprotein E 19q13.31 1(1/0/0) YES YES
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 7q21.12 1(1/0/0) YES YES
GDNF glial cell derived neurotrophic factor 5p13.1-p12 1(1/0/0) YES YES
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 10p13-p11.2 1(0/1/0) YES YES
IL6 interleukin 6 7p21-p15 1(0/1/0) YES YES
VIPR2 vasoactive intestinal peptide receptor 2 7q36.3 1(1/0/0) YES YES
IL10 interleukin 10 1q31-q32 1(0/1/0) YES YES
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 11p15.5-p14 1(0/1/0) YES YES
ESR1 estrogen receptor 1 6q24-q27 1(0/1/0) YES YES
SST somatostatin 3q28 1(0/1/0) YES YES
USP46 ubiquitin specific peptidase 46 4q12 1(0/1/0) YES YES
MBP myelin basic protein 18q23 1(1/0/0) YES YES
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 1(1/0/0) YES YES
ADRA2A adrenoceptor alpha 2A 10q25.2 1(0/1/0) YES YES
PENK proenkephalin 8q23-q24 1(0/1/0) YES YES
GFAP glial fibrillary acidic protein 17q21 1(1/0/0) YES YES
OXTR oxytocin receptor 3p25 1(0/1/0) YES YES
GLT8D1 glycosyltransferase 8 domain containing 1 3p21.1 1(1/0/0) YES YES
QKI QKI, KH domain containing, RNA binding 6q26 1(0/1/0) YES YES
SIRT1 sirtuin 1 10q21 1(0/1/0) YES YES
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 1(1/0/0) YES YES
IL1B interleukin 1, beta 2q14 1(1/0/0) YES YES
PCNT pericentrin 21q22.3 1(0/1/0) YES YES
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 11p13-p12 1(1/0/0) YES YES
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 6p22.3 1(0/1/0) YES YES
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 5q34 1(1/0/0) YES YES
SLIT3 slit homolog 3 (Drosophila) 5q35 1(1/0/0) YES YES
APOD apolipoprotein D 3q29 1(0/1/0) YES YES
MED12 mediator complex subunit 12 Xq13 1(0/1/0) YES YES