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BD & SZ & MDD shared genes
Total unqiue gene count: 183
Note: The shared genes from cross-disorder studies that investigated the three diseases (BD, SZ and MDD) in one study simultaneously were considered from cross-disorder studies, other overlapped genes between BD-SZ shared genes and BD-MDD shared genes (including both from cross-disorder study and intersection analysis) were all considered from candidate gene intersection analysis.
From cross-disorder studies (count: 78)
| Approved Symbol | Approved Name | Location | No. of Studies for BD (Positive/Negative/Trend) | Overlap with SZ | Overlap with MDD |  |
|---|---|---|---|---|---|---|
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4 | 17q11.2 | 44(18/26/0) | YES | YES | |
| BDNF | brain-derived neurotrophic factor | 11p14.1 | 37(24/12/1) | YES | YES | |
| COMT | catechol-O-methyltransferase | 22q11.21 | 28(14/14/0) | YES | YES | |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 28(8/20/0) | YES | YES | |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | 13q14-q21 | 22(7/15/0) | YES | YES | |
| DAOA | D-amino acid oxidase activator | 13q33.2 | 21(13/7/1) | YES | YES | |
| MAOA | monoamine oxidase A | Xp11.4-p11.3 | 21(10/11/0) | YES | YES | |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 20(17/3/0) | YES | YES | |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 10q21 | 17(13/3/1) | YES | YES | |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 1p36.3 | 16(10/6/0) | YES | YES | |
| TPH1 | tryptophan hydroxylase 1 | 11p15.3-p14 | 14(5/9/0) | YES | YES | |
| DRD4 | dopamine receptor D4 | 11p15.5 | 13(1/12/0) | YES | YES | |
| CLOCK | clock circadian regulator | 4q12 | 12(5/7/0) | YES | YES | |
| PER2 | period circadian clock 2 | 2q37.3 | 7(1/6/0) | YES | YES | |
| PER3 | period circadian clock 3 | 1p36.23 | 7(3/4/0) | YES | YES | |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | 11p15 | 7(5/2/0) | YES | YES | |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 6q25.2 | 6(3/2/1) | YES | YES | |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 17q11.2 | 6(2/4/0) | YES | YES | |
| TENM4 | teneurin transmembrane protein 4 | 11q13 | 6(4/2/0) | YES | YES | |
| DGKH | diacylglycerol kinase, eta | 13q13.3 | 6(3/3/0) | YES | YES | |
| NPAS2 | neuronal PAS domain protein 2 | 2q11.2 | 5(3/2/0) | YES | YES | |
| CSNK1E | casein kinase 1, epsilon | 22q13.1 | 5(1/3/1) | YES | YES | |
| CNR1 | cannabinoid receptor 1 (brain) | 6q14-q15 | 5(0/5/0) | YES | YES | |
| ACE | angiotensin I converting enzyme | 17q23.3 | 5(2/3/0) | YES | YES | |
| CRY2 | cryptochrome circadian clock 2 | 11p11.2 | 5(3/2/0) | YES | YES | |
| PER1 | period circadian clock 1 | 17p13.1 | 5(2/3/0) | YES | YES | |
| CSNK1D | casein kinase 1, delta | 17q25 | 4(2/2/0) | YES | YES | |
| RORB | RAR-related orphan receptor B | 9q22 | 4(3/1/0) | YES | YES | |
| BHLHE41 | basic helix-loop-helix family, member e41 | 12p12.1 | 3(2/1/0) | YES | YES | |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 10p12 | 3(2/1/0) | YES | YES | |
| TIMELESS | timeless circadian clock | 12q13.3 | 3(0/3/0) | YES | YES | |
| GPR50 | G protein-coupled receptor 50 | Xq28 | 3(2/1/0) | YES | YES | |
| EGR3 | early growth response 3 | 8p23-p21 | 3(2/1/0) | YES | YES | |
| ARNTL2 | aryl hydrocarbon receptor nuclear translocator-like 2 | 12p12.2-p11.2 | 3(1/2/0) | YES | YES | |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 | 3p21.1 | 3(3/0/0) | YES | YES | |
| SP8 | Sp8 transcription factor | 7p21.2 | 3(2/0/1) | YES | YES | |
| TIPIN | TIMELESS interacting protein | 15q22.31 | 2(0/2/0) | YES | YES | |
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide | 20p13 | 2(0/2/0) | YES | YES | |
| AANAT | aralkylamine N-acetyltransferase | 17q25.1 | 2(0/2/0) | YES | YES | |
| FOXP2 | forkhead box P2 | 7q31 | 2(0/2/0) | YES | YES | |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 7p12.3 | 2(2/0/0) | YES | YES | |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | 5q31-q33 | 2(1/1/0) | YES | YES | |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | 12p13 | 2(1/1/0) | YES | YES | |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 2q33.3-q34 | 2(1/1/0) | YES | YES | |
| MYO18B | myosin XVIIIB | 22q12.1 | 2(0/2/0) | YES | YES | |
| NPAS3 | neuronal PAS domain protein 3 | 14q13.1 | 2(1/1/0) | YES | YES | |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 2q33 | 2(1/1/0) | YES | YES | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 22q12.3 | 2(1/1/0) | YES | YES | |
| NFIL3 | nuclear factor, interleukin 3 regulated | 9q22 | 2(0/2/0) | YES | YES | |
| FGFR2 | fibroblast growth factor receptor 2 | 10q25.3-q26 | 2(1/1/0) | YES | YES | |
| DRD5 | dopamine receptor D5 | 4p16.1 | 2(0/2/0) | YES | YES | |
| NT5C2 | 5'-nucleotidase, cytosolic II | 10q24.32 | 2(2/0/0) | YES | YES | |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 17p13.3 | 1(0/1/0) | YES | YES | |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 2p21 | 1(0/1/0) | YES | YES | |
| IFT88 | intraflagellar transport 88 | 13q12.1 | 1(0/1/0) | YES | YES | |
| BCL9 | B-cell CLL/lymphoma 9 | 1q21 | 1(1/0/0) | YES | YES | |
| TXNL1 | thioredoxin-like 1 | 18q21.31 | 1(0/0/1) | YES | YES | |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 2q22-q23 | 1(0/1/0) | YES | YES | |
| CCDC102B | coiled-coil domain containing 102B | 18q22.1 | 1(0/1/0) | YES | YES | |
| FAM20B | family with sequence similarity 20, member B | 1q25.2 | 1(0/1/0) | YES | YES | |
| MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 | 6p21 | 1(1/0/0) | YES | YES | |
| AS3MT | arsenite methyltransferase | 10q24.33 | 1(1/0/0) | YES | YES | |
| GNB1L | guanine nucleotide binding protein (G protein), beta polypeptide 1-like | 22q11.2 | 1(1/0/0) | YES | YES | |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | 7q36.1 | 1(0/0/1) | YES | YES | |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 5p15.2 | 1(0/1/0) | YES | YES | |
| ANXA1 | annexin A1 | 9q21.13 | 1(0/0/1) | YES | YES | |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 21q11 | 1(0/1/0) | YES | YES | |
| CCDC68 | coiled-coil domain containing 68 | 18q21 | 1(1/0/0) | YES | YES | |
| SEL1L2 | sel-1 suppressor of lin-12-like 2 (C. elegans) | 20p12.1 | 1(0/1/0) | YES | YES | |
| ADM | adrenomedullin | 11p15.4 | 1(1/0/0) | YES | YES | |
| EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 | 15q13.3 | 1(0/1/0) | YES | YES | |
| FZD3 | frizzled class receptor 3 | 8p21 | 1(0/1/0) | YES | YES | |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 7q33 | 1(0/1/0) | YES | YES | |
| ANO2 | anoctamin 2, calcium activated chloride channel | 12p13.3 | 1(0/1/0) | YES | YES | |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 3p24-p23 | 1(0/1/0) | YES | YES | |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 10q26.3 | 1(0/0/1) | YES | YES | |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 4p15.3 | 1(1/0/0) | YES | YES | |
| OPTN | optineurin | 10p14 | 1(0/0/1) | YES | YES |
From candidate gene intersection analysis (count: 105)
| Approved Symbol | Approved Name | Location | No. of Studies for BD (Positive/Negative/Trend) | Overlap with SZ | Overlap with MDD | |
|---|---|---|---|---|---|---|
| DRD3 | dopamine receptor D3 | 3q13.3 | 19(4/15/0) | YES | YES | |
| DISC1 | disrupted in schizophrenia 1 | 1q42.1 | 18(10/7/1) | YES | YES | |
| TH | tyrosine hydroxylase | 11p15.5 | 16(4/12/0) | YES | YES | |
| NRG1 | neuregulin 1 | 8p12 | 15(10/5/0) | YES | YES | |
| TPH2 | tryptophan hydroxylase 2 | 12q15 | 13(10/3/0) | YES | YES | |
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter), member 3 | 5p15.3 | 11(5/6/0) | YES | YES | |
| DRD1 | dopamine receptor D1 | 5q34-q35 | 11(6/5/0) | YES | YES | |
| P2RX7 | purinergic receptor P2X, ligand gated ion channel, 7 | 12q24 | 9(2/7/0) | YES | YES | |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 8(0/8/0) | YES | YES | |
| DTNBP1 | dystrobrevin binding protein 1 | 6p22.3 | 8(4/3/1) | YES | YES | |
| NOS1 | nitric oxide synthase 1 (neuronal) | 12q24.22 | 8(2/5/1) | YES | YES | |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 12p13.1 | 8(4/4/0) | YES | YES | |
| WFS1 | Wolfram syndrome 1 (wolframin) | 4p16.1 | 7(1/6/0) | YES | YES | |
| GRM3 | glutamate receptor, metabotropic 3 | 7q21.1-q21.2 | 7(3/4/0) | YES | YES | |
| KCNN3 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 | 1q21.3 | 7(1/6/0) | YES | YES | |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Xq23 | 7(4/3/0) | YES | YES | |
| GABRA5 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 15q12 | 6(6/0/0) | YES | YES | |
| RGS4 | regulator of G-protein signaling 4 | 1q23.3 | 6(3/2/1) | YES | YES | |
| MLC1 | megalencephalic leukoencephalopathy with subcortical cysts 1 | 22q13.33 | 5(1/4/0) | YES | YES | |
| TAAR6 | trace amine associated receptor 6 | 6q23.1 | 5(4/1/0) | YES | YES | |
| PDLIM5 | PDZ and LIM domain 5 | 4q22 | 5(4/1/0) | YES | YES | |
| PBRM1 | polybromo 1 | 3p21 | 5(4/0/1) | YES | YES | |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5q31-q32 | 5(2/3/0) | YES | YES | |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 7p12.1 | 5(2/3/0) | YES | YES | |
| FKBP5 | FK506 binding protein 5 | 6p21.31 | 5(1/4/0) | YES | YES | |
| DUSP6 | dual specificity phosphatase 6 | 12q22-q23 | 5(3/2/0) | YES | YES | |
| TSNAX | translin-associated factor X | 1q42.2 | 4(3/1/0) | YES | YES | |
| TNF | tumor necrosis factor | 6p21.3 | 4(2/2/0) | YES | YES | |
| CHRNA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 15q13.3 | 4(2/2/0) | YES | YES | |
| MAOB | monoamine oxidase B | Xp11.4-p11.3 | 4(2/2/0) | YES | YES | |
| TSPO | translocator protein (18kDa) | 22q13.3 | 3(1/2/0) | YES | YES | |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 1p31 | 3(1/2/0) | YES | YES | |
| HTR6 | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | 1p36-p35 | 3(1/2/0) | YES | YES | |
| DBP | D site of albumin promoter (albumin D-box) binding protein | 19q13.33 | 3(0/3/0) | YES | YES | |
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 5q11.2-q13 | 3(2/1/0) | YES | YES | |
| CCL2 | chemokine (C-C motif) ligand 2 | 17q11.2-q21.1 | 3(1/2/0) | YES | YES | |
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) | 18p11 | 3(1/2/0) | YES | YES | |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 9q22.1 | 3(1/1/1) | YES | YES | |
| XBP1 | X-box binding protein 1 | 22q12.1 | 3(2/1/0) | YES | YES | |
| NCAM1 | neural cell adhesion molecule 1 | 11q23.2 | 3(2/1/0) | YES | YES | |
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | 9q34 | 3(1/2/0) | YES | YES | |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 3p21.1 | 2(2/0/0) | YES | YES | |
| GABRA1 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 5q34 | 2(1/1/0) | YES | YES | |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | 18p11.22-p11.21 | 2(0/2/0) | YES | YES | |
| SOD2 | superoxide dismutase 2, mitochondrial | 6q25 | 2(1/1/0) | YES | YES | |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 15q26 | 2(1/1/0) | YES | YES | |
| HSPA1A | heat shock 70kDa protein 1A | 6p21.3 | 2(2/0/0) | YES | YES | |
| IFNG | interferon, gamma | 12q14 | 2(2/0/0) | YES | YES | |
| CCK | cholecystokinin | 3p22.1 | 2(0/1/1) | YES | YES | |
| KCTD12 | potassium channel tetramerization domain containing 12 | 13q21 | 2(0/1/1) | YES | YES | |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 | 15q24-q25 | 2(2/0/0) | YES | YES | |
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | 5q33 | 2(2/0/0) | YES | YES | |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter), member 2 | 16q12.2 | 2(0/2/0) | YES | YES | |
| S100B | S100 calcium binding protein B | 21q22.3 | 2(1/1/0) | YES | YES | |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 7q36 | 2(1/1/0) | YES | YES | |
| FAAH | fatty acid amide hydrolase | 1p35-p34 | 2(0/2/0) | YES | YES | |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 2q31 | 2(1/1/0) | YES | YES | |
| HTR5A | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled | 7q36.1 | 2(1/1/0) | YES | YES | |
| HTR3B | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic | 11q23.1 | 2(1/1/0) | YES | YES | |
| SNAP25 | synaptosomal-associated protein, 25kDa | 20p12-p11.2 | 2(2/0/0) | YES | YES | |
| INPP1 | inositol polyphosphate-1-phosphatase | 2q32 | 1(0/1/0) | YES | YES | |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 16q12-q22 | 1(0/1/0) | YES | YES | |
| RGMA | repulsive guidance molecule family member a | 15q26.1 | 1(1/0/0) | YES | YES | |
| GRM2 | glutamate receptor, metabotropic 2 | 3p21.2 | 1(0/1/0) | YES | YES | |
| SYN2 | synapsin II | 3p25.2 | 1(0/1/0) | YES | YES | |
| GRIK3 | glutamate receptor, ionotropic, kainate 3 | 1p34.3 | 1(1/0/0) | YES | YES | |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 4q31 | 1(1/0/0) | YES | YES | |
| SLC18A2 | solute carrier family 18 (vesicular monoamine transporter), member 2 | 10q25 | 1(1/0/0) | YES | YES | |
| CCKBR | cholecystokinin B receptor | 11p15.4 | 1(1/0/0) | YES | YES | |
| PAWR | PRKC, apoptosis, WT1, regulator | 12q21.2 | 1(0/1/0) | YES | YES | |
| HTR1D | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | 1p36.3-p34.3 | 1(0/1/0) | YES | YES | |
| INS | insulin | 11p15.5 | 1(0/1/0) | YES | YES | |
| GRIA3 | glutamate receptor, ionotropic, AMPA 3 | Xq25 | 1(0/1/0) | YES | YES | |
| GNAS | GNAS complex locus | 20q13.2-q13.3 | 1(0/1/0) | YES | YES | |
| KLK8 | kallikrein-related peptidase 8 | 19q13 | 1(1/0/0) | YES | YES | |
| EGR1 | early growth response 1 | 5q23-q31 | 1(0/1/0) | YES | YES | |
| APOE | apolipoprotein E | 19q13.31 | 1(1/0/0) | YES | YES | |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 7q21.12 | 1(1/0/0) | YES | YES | |
| GDNF | glial cell derived neurotrophic factor | 5p13.1-p12 | 1(1/0/0) | YES | YES | |
| GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 10p13-p11.2 | 1(0/1/0) | YES | YES | |
| IL6 | interleukin 6 | 7p21-p15 | 1(0/1/0) | YES | YES | |
| VIPR2 | vasoactive intestinal peptide receptor 2 | 7q36.3 | 1(1/0/0) | YES | YES | |
| IL10 | interleukin 10 | 1q31-q32 | 1(0/1/0) | YES | YES | |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 11p15.5-p14 | 1(0/1/0) | YES | YES | |
| ESR1 | estrogen receptor 1 | 6q24-q27 | 1(0/1/0) | YES | YES | |
| SST | somatostatin | 3q28 | 1(0/1/0) | YES | YES | |
| USP46 | ubiquitin specific peptidase 46 | 4q12 | 1(0/1/0) | YES | YES | |
| MBP | myelin basic protein | 18q23 | 1(1/0/0) | YES | YES | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | 1(1/0/0) | YES | YES | |
| ADRA2A | adrenoceptor alpha 2A | 10q25.2 | 1(0/1/0) | YES | YES | |
| PENK | proenkephalin | 8q23-q24 | 1(0/1/0) | YES | YES | |
| GFAP | glial fibrillary acidic protein | 17q21 | 1(1/0/0) | YES | YES | |
| OXTR | oxytocin receptor | 3p25 | 1(0/1/0) | YES | YES | |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | 3p21.1 | 1(1/0/0) | YES | YES | |
| QKI | QKI, KH domain containing, RNA binding | 6q26 | 1(0/1/0) | YES | YES | |
| SIRT1 | sirtuin 1 | 10q21 | 1(0/1/0) | YES | YES | |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16p13.2 | 1(1/0/0) | YES | YES | |
| IL1B | interleukin 1, beta | 2q14 | 1(1/0/0) | YES | YES | |
| PCNT | pericentrin | 21q22.3 | 1(0/1/0) | YES | YES | |
| SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 11p13-p12 | 1(1/0/0) | YES | YES | |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 6p22.3 | 1(0/1/0) | YES | YES | |
| GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 | 5q34 | 1(1/0/0) | YES | YES | |
| SLIT3 | slit homolog 3 (Drosophila) | 5q35 | 1(1/0/0) | YES | YES | |
| APOD | apolipoprotein D | 3q29 | 1(0/1/0) | YES | YES | |
| MED12 | mediator complex subunit 12 | Xq13 | 1(0/1/0) | YES | YES |