Study Report

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Basic Info

Reference	Yosifova, A.,2009 PMID: 19328558
Citation	Yosifova, A., T. Mushiroda, et al. (2009). Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J Affect Disord 117(1-2): 87-97.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	94 BAD cases and 184 controls
SNP/Region/Marker Size	191 SNPs
Predominant Ethnicity	Caucasian
Population	Bulgarian
Gender	54 males and 118 females in BAD patients,289 males and 267 females in controls
Age Group	Adults : mean age :43.5 years in patients and 50.3 years in controls

Detail Info

Sample Diagnosis	DSM
Sample Status	Samples from individuals with BAD were collected from University Psychiatric Clinics in Plovdiv, Sofia, Blagoevgrad and Radnevo in Bulgaria. Patients were screened by two experienced psychiatrists independently. After the detailed interviews diagnoses were reached by consensus between the two psychiatrists and made according to the DSM-IV criteria. Information for the participants was given and written Informed consent was obtained from each of all patients prior to obtaining blood samples.The control group consists of 556 unrelated healthy control subjects of Bulgarian origin (the mean age of 50.3 years old in 289 males and 267 females) to whom information for the participants were also provided. Written informed consent was obtained from all control subjects. In order to exclude anyone currently on medication or with a history of treatment for psychiatric disorder an interview by a physician was conducted and additional information concerning their age, ethnos and gender was obtained.
Replication Size	78 BAD cases and 372 controls
Technique	genotyping
Statistical Method	A two-tailed Fisher's exact test in allelic, dominant- and recessive-inheritance models was applied to assess allele and genotype distributions between the cases and controls.Hardy-Weinberg equilibrium (HWE) tests were performed on both controls and cases, using HAPLOVIEW 4.0 program(Broad Institute of MIT & Harvard, Cambridge. MA, http://www.broad.mit.edu/mpg/haploview/). The putative block structure was explored using HAPLOVIEW 4.0 and solid spine of linkage disequilibrium (LD) approach. Haplotype analyses were performed using SNPAlyze version 3.2 software (Dynacom,Japan).
Result Summary	RESULTS: After applying the Bonferonni correction on genotyping results of 172 cases and 556 controls, only one SNP, rs1800883, in the HTR5A gene revealed a significant level of P value (P=0.000097; odds ratio=1.80 (95%CI, 1.27-2.54); corrected P=0.017). CONCLUSIONS: Our findings suggest that HTR5A gene could play an important role in the pathogenesis of bipolar disorder in our population. However these findings should be viewed with caution and replication studies in other populations are necessary in support of these findings.

SNPs reported by this study for BD (count: 171)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs3734234	KIF13A	A/G	Allelic association: P-value = 0.12	No significant association was observed No significant association was observed	Negative
rs362043	TUBA8 PEX26	G/T	Allelic association: P-value = 0.1	No significant association was observed No significant association was observed	Negative
rs3761418	BCR BCRP8	A/G	Allelic association: P-value = 0.38	No significant association was observed No significant association was observed	Negative
rs3749034	GAD1	A/G	Allelic association: P-value = 0.37	No significant association was observed No significant association was observed	Negative
rs2859388	PER3	A/G	Allelic association: P-value = 0.31	No significant association was observed No significant association was observed	Negative
rs2839350	S100B	A/G	Allelic association: P-value = 0.11	No significant association was observed No significant association was observed	Negative
rs327232	DPYSL2	A/G	Allelic association: P-value = 0.09	No significant association was observed No significant association was observed	Negative
rs2919390	NRG1	A/C	Allelic association: P-value = 0.24	No significant association was observed No significant association was observed	Negative
rs3788266	S100B	A/G	Allelic association: P-value = 0.48	No significant association was observed No significant association was observed	Negative
rs3783006	STK24 FARP1	C/G	Allelic association: P-value = 0.35	No significant association was observed No significant association was observed	Negative
rs3798529	GRM4	A/C	Allelic association: 1st screening: P-value = 0.0063, 2nd screening: P-value = 0.73, total: P-value = 0.064	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs3789327	ARNTL	G/A	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs3782206	NOS1	C/T	Allelic association: P-value = 0.12	No significant association was observed No significant association was observed	Negative
rs3778068	GRM4	C/G	Allelic association: P-value = 0.28	No significant association was observed No significant association was observed	Negative
rs3782221	NOS1	A/G	Allelic association: P-value = 0.23	No significant association was observed No significant association was observed	Negative
rs3782219	NOS1	C/T	Allelic association: P-value = 0.42	No significant association was observed No significant association was observed	Negative
rs2299213	GRM3	C/T	Allelic association: P-value = 0.77	No significant association was observed No significant association was observed	Negative
rs2301363	GRIN1	T/C	Allelic association: P-value = 0.17	No significant association was observed No significant association was observed	Negative
rs2304042	CAMK2A	A/G	Allelic association: P-value = 0.37	No significant association was observed No significant association was observed	Negative
rs2304865	FAT1 CD36	C/G	Allelic association: P-value = 0.38	No significant association was observed No significant association was observed	Negative
rs228942	IL2RB	T/G	Allelic association: P-value = 0.48	No significant association was observed No significant association was observed	Negative
rs2290279	NAPG	A/G	Allelic association: P-value = 0.29	No significant association was observed No significant association was observed	Negative
rs2293051	NOS1	C/G	Allelic association: P-value = 0.21	No significant association was observed No significant association was observed	Negative
rs2296197	KIF13A	C/T	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs2637777	FAT1 CD36	A/C	Allelic association: P-value = 0.43	No significant association was observed No significant association was observed	Negative
rs2682826	NOS1	A/G	Allelic association: P-value = 0.2	No significant association was observed No significant association was observed	Negative
rs278109	CIT	C/T	Allelic association: P-value = 0.43	No significant association was observed No significant association was observed	Negative
rs2812393	DISC1 TSNAX	C/G	Allelic association: P-value = 0.78	No significant association was observed No significant association was observed	Negative
rs2306990	FAT1 CD36	C/T	Allelic association: P-value = 0.41	No significant association was observed No significant association was observed	Negative
rs2438146	PDLIM5	C/T	Allelic association: P-value = 0.22	No significant association was observed No significant association was observed	Negative
rs2492367	DISC1 TSNAX	C/T	Allelic association: P-value = 0.23	No significant association was observed No significant association was observed	Negative
rs2499724	GRM4	A/C	Allelic association: P-value = 0.85	No significant association was observed No significant association was observed	Negative
rs2279574	DUSP6	A/C	Allelic association: 1st screening: P-value = 0.0041, 2nd screening: P-value = 0.43, total: P-value = 0.026	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs2278749	ARNTL	T/C	Allelic association: P-value = 0.43	No significant association was observed No significant association was observed	Negative
rs2278392	HTR4	C/T	Allelic association: P-value = 0.3	No significant association was observed No significant association was observed	Negative
rs2267020	BCR	G/T	Allelic association: P-value = 0.29	No significant association was observed No significant association was observed	Negative
rs2267015	BCR	A/T	Allelic association: P-value = 0.89	No significant association was observed No significant association was observed	Negative
rs2267013	BCR	A/G	Allelic association: P-value = 0.72	No significant association was observed No significant association was observed	Negative
rs2237555	GRM3	A/G	Allelic association: P-value = 0.39	No significant association was observed No significant association was observed	Negative
rs2237554	GRM3	A/C	Allelic association: P-value = 0.39	No significant association was observed No significant association was observed	Negative
rs2288799	CAMK2A	A/G	Allelic association: P-value = 0.65	No significant association was observed No significant association was observed	Negative
rs228729	VAMP3 PER3	T/C	Allelic association: P-value = 0.14	No significant association was observed No significant association was observed	Negative
rs228697	PER3	C/G	Allelic association: P-value = 0.46	No significant association was observed No significant association was observed	Negative
rs228666	PER3	C/T	Allelic association: P-value = 0.18	No significant association was observed No significant association was observed	Negative
rs228642	PER3	C/T	Allelic association: P-value = 0.52	No significant association was observed No significant association was observed	Negative
rs2285595	CIT	A/G	Allelic association: P-value = 0.69	No significant association was observed No significant association was observed	Negative
rs2282586	GRIK4	A/G	Allelic association: P-value = 0.27	No significant association was observed No significant association was observed	Negative
rs2279709	SLC18A1	G/T	Allelic association: P-value = 0.16	No significant association was observed No significant association was observed	Negative
rs203368	CIT	C/T	Allelic association: P-value = 0.47	No significant association was observed No significant association was observed	Negative
rs2049045	BDNF BDNF-AS	C/G	Allelic association: P-value = 0.011	Significant association was observed Significant association was observed	Positive
rs1978340	GAD1	A/G	Allelic association: P-value = 0.62	No significant association was observed No significant association was observed	Negative
rs1982350	ARNTL	G/A	Allelic association: P-value = 0.12	No significant association was observed No significant association was observed	Negative
rs1895689	GNAL	A/C	Allelic association: P-value = 0.31	No significant association was observed No significant association was observed	Negative
rs1944522	GRIK4	C/T	Allelic association: P-value = 0.26	No significant association was observed No significant association was observed	Negative
rs1805502	GRIN2B	A/G	Allelic association: P-value = 0.066	No significant association was observed No significant association was observed	Negative
rs1806201	GRIN2B	A/G	Allelic association: P-value = 0.44	No significant association was observed No significant association was observed	Negative
rs2230912	P2RX7	A/G	Allelic association: P-value = 0.17	No significant association was observed No significant association was observed	Negative
rs2236225	MTHFD1	A/G	Allelic association: P-value = 0.87	No significant association was observed No significant association was observed	Negative
rs2189813	GRM3	C/T	Allelic association: P-value = 0.39	No significant association was observed No significant association was observed	Negative
rs2213172	BCR	C/G	Allelic association: P-value = 0.77	No significant association was observed No significant association was observed	Negative
rs2076127	MLC1	C/T	Allelic association: P-value = 0.51	No significant association was observed No significant association was observed	Negative
rs2156921	BCR	A/G	Allelic association: P-value = 0.88	No significant association was observed No significant association was observed	Negative
rs2073778	DGCR8	C/T	Allelic association: 1st screening: P-value = 0.019, 2nd screening: P-value = 0.51, total: P-value = 0.35	Significant association was observed in 1st screening. Significant association was observed in 1st screening.	Positive
rs2074052	CIT	C/G	Allelic association: P-value = 0.88	No significant association was observed No significant association was observed	Negative
rs9799720	GPR78	G/C	Allelic association: 1st screening: P-value = 0.038, 2nd screening: P-value = 0.66, total: P-value = 0.035	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs9685931	GPR78	A/G	Allelic association: P-value = 0.094	No significant association was observed No significant association was observed	Negative
rs988713	SLC18A1	C/T	Allelic association: P-value = 0.42	No significant association was observed No significant association was observed	Negative
rs982339	GRM3	A/G	Allelic association: P-value = 0.46	No significant association was observed No significant association was observed	Negative
rs816363	NOS1	C/G	Allelic association: P-value = 0.78	No significant association was observed No significant association was observed	Negative
rs84459	IL2RB	C/T	Allelic association: P-value = 0.61	No significant association was observed No significant association was observed	Negative
rs84460	IL2RB	G/A	Allelic association: P-value = 0.8	No significant association was observed No significant association was observed	Negative
rs906807	NDUFV2	A/G	Allelic association: P-value = 0.48	No significant association was observed No significant association was observed	Negative
rs909669	ADSL	C/T	Allelic association: P-value = 0.65	No significant association was observed No significant association was observed	Negative
rs909685	SYNGR1	A/T	Allelic association: 1st screening: P-value = 0.1, 2nd screening: P-value = 0.16, total: P-value = 0.9	No significant association was observed No significant association was observed	Negative
rs920697	DPYSL2	A/G	Allelic association: P-value = 0.25	No significant association was observed No significant association was observed	Negative
rs9315897	DGKH	C/T	Allelic association: P-value = 0.22	No significant association was observed No significant association was observed	Negative
rs9325202	TPH2	A/G	Allelic association: P-value = 0.13	No significant association was observed No significant association was observed	Negative
rs933305	CUX2	A/G	Allelic association: P-value = 0.24	No significant association was observed No significant association was observed	Negative
rs942376	KIF13A	A/G	Allelic association: P-value = 0.056	No significant association was observed No significant association was observed	Negative
rs9517312	STK24 FARP1	A/G	Allelic association: P-value = 0.25	No significant association was observed No significant association was observed	Negative
rs9517313	STK24 FARP1	C/G	Allelic association: P-value = 0.091	No significant association was observed No significant association was observed	Negative
rs9517328	STK24	A/T	Allelic association: P-value = 0.44	No significant association was observed No significant association was observed	Negative
rs9525570	DGKH	C/T	Allelic association: P-value = 0.28	No significant association was observed No significant association was observed	Negative
rs9556964	STK24	C/T	Allelic association: P-value = 0.64	No significant association was observed No significant association was observed	Negative
rs662515	GNAL MPPE1	C/G	Allelic association: P-value = 0.06	No significant association was observed No significant association was observed	Negative
rs646558	NCAM1	A/C	Allelic association: P-value = 1	No significant association was observed No significant association was observed	Negative
rs6313	HTR2A	A/G	Allelic association: P-value = 0.071	No significant association was observed No significant association was observed	Negative
rs6265	BDNF BDNF-AS	C/T	Allelic association: 1st screening: P-value = 0.0079, 2nd screening: P-value = 0.14, total: P-value = 0.0033	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs6988339	NRG1	A/G	Allelic association: P-value = 0.23	No significant association was observed No significant association was observed	Negative
rs686050	NCAM1	C/G	Allelic association: P-value = 0.92	No significant association was observed No significant association was observed	Negative
rs6797699	SST	C/T	Allelic association: P-value = 0.31	No significant association was observed No significant association was observed	Negative
rs673735	MPPE1	C/T	Allelic association: P-value = 0.056	No significant association was observed No significant association was observed	Negative
rs7324994	STK24	C/T	Allelic association: P-value = 0.82	No significant association was observed No significant association was observed	Negative
rs7305115	TPH2	A/G	Allelic association: P-value = 0.49	No significant association was observed No significant association was observed	Negative
rs7301328	GRIN2B	G/C	Allelic association: P-value = 0.73	No significant association was observed No significant association was observed	Negative
rs715505	SYNGR1	G/C	Allelic association: 1st screening: P-value = 0.33, 2nd screening: P-value = 0.69, total: P-value = 0.89	No significant association was observed No significant association was observed	Negative
rs8097892	MPPE1	C/T	Allelic association: P-value = 0.12	No significant association was observed No significant association was observed	Negative
rs769390	GAD1	A/C	Allelic association: P-value = 0.21	No significant association was observed No significant association was observed	Negative
rs760761	DTNBP1	G/A	Allelic association: P-value = 0.14	No significant association was observed No significant association was observed	Negative
rs733457	GRM4	G/T	Allelic association: P-value = 0.61	No significant association was observed No significant association was observed	Negative
rs3974590	MPPE1	A/G	Allelic association: 1st screening: P-value = 0.00059, 2nd screening: P-value = 0.45, total: P-value = 0.1	Significant association was observed in 1st screening. Significant association was observed in 1st screening.	Positive
rs4131348	TBC1D15 TPH2	C/T	Allelic association: P-value = 0.14	No significant association was observed No significant association was observed	Negative
rs3847953	CUX2	C/T	Allelic association: P-value = 0.31	No significant association was observed No significant association was observed	Negative
rs391957	HSPA5	T/C	Allelic association: P-value = 0.9	No significant association was observed No significant association was observed	Negative
rs435136	CIT	A/G	Allelic association: P-value = 0.26	No significant association was observed No significant association was observed	Negative
rs4411993	SORCS2 MIR4274	C/T	Allelic association: P-value = 1	No significant association was observed No significant association was observed	Negative
rs420259	PALB2	A/G	Allelic association: P-value = 0.052	No significant association was observed No significant association was observed	Negative
rs4290270	TPH2	A/T	Allelic association: P-value = 0.72	No significant association was observed No significant association was observed	Negative
rs495484	NAPG	A/T	Allelic association: P-value = 0.25	No significant association was observed No significant association was observed	Negative
rs510110	NAPG	C/A	Allelic association: P-value = 0.25	No significant association was observed No significant association was observed	Negative
rs4766951	CIT	C/T	Allelic association: P-value = 0.13	No significant association was observed No significant association was observed	Negative
rs4923463	BDNF BDNF-AS	A/G	Allelic association: P-value = 0.015	Significant association was observed Significant association was observed	Positive
rs561712	NOS1	T/C	Allelic association: P-value = 0.21	No significant association was observed No significant association was observed	Negative
rs602201	GNAL MPPE1	A/T	Allelic association: P-value = 0.24	No significant association was observed No significant association was observed	Negative
rs532967	NOS1	A/G	Allelic association: 1st screening: P-value = 0.1, 2nd screening: P-value = 0.00084, total: P-value = 0.33	Significant association was observed in 1st screening and 2n...... Significant association was observed in 1st screening and 2nd screening. More...	Positive
rs5443	GNB3	C/T	Allelic association: 1st screening: P-value = 0.57, 2nd screening: P-value = 0.017, total: P-value = 0.018	Significant association was observed in 2nd screening and to...... Significant association was observed in 2nd screening and total sample. More...	Positive
rs1405874	GRM3	C/T	Allelic association: P-value = 0.82	No significant association was observed No significant association was observed	Negative
rs140504	BCR	G/A	Allelic association: P-value = 0.9	No significant association was observed No significant association was observed	Negative
rs1390938	SLC18A1	A/G	Allelic association: P-value = 0.38	No significant association was observed No significant association was observed	Negative
rs138880	BRD1	A/C	Allelic association: P-value = 0.38	No significant association was observed No significant association was observed	Negative
rs1565366	GRM4	A/G	Allelic association: 1st screening: P-value = 0.029, 2nd screening: P-value = 0.72, total: P-value = 0.17	Significant association was observed in 1st screening. Significant association was observed in 1st screening.	Positive
rs1538977	DISC1 TSNAX	A/G	Allelic association: P-value = 0.27	No significant association was observed No significant association was observed	Negative
rs1485171	GRM7	C/A	Allelic association: P-value = 0.41	No significant association was observed No significant association was observed	Negative
rs140681	GABRB3 GABRA5	A/G	Allelic association: 1st screening: P-value = 0.048, 2nd screening: P-value = 0.32, total: P-value = 0.55	Significant association was observed in 1st screening. Significant association was observed in 1st screening.	Positive
rs133070	MCHR1 GAPDHP37	A/G	Allelic association: P-value = 0.51	No significant association was observed No significant association was observed	Negative
rs133069	MCHR1 GAPDHP37	A/C	Allelic association: P-value = 0.4	No significant association was observed No significant association was observed	Negative
rs133068	MCHR1 GAPDHP37	C/G	Allelic association: P-value = 0.46	No significant association was observed No significant association was observed	Negative
rs1322784	DISC1 TSNAX	A/G	Allelic association: P-value = 0.45	No significant association was observed No significant association was observed	Negative
rs1386494	TPH2	T/C	Allelic association: P-value = 0.051	No significant association was observed No significant association was observed	Negative
rs1365111	SST	G/A	Allelic association: P-value = 0.55	No significant association was observed No significant association was observed	Negative
rs13360565	CAMK2A	G/T	Allelic association: P-value = 0.48	No significant association was observed No significant association was observed	Negative
rs133073	MCHR1	C/T	Allelic association: P-value = 0.43	No significant association was observed No significant association was observed	Negative
rs1786581	GNAL CHMP1B	C/T	Allelic association: P-value = 0.1	No significant association was observed No significant association was observed	Negative
rs1800629	LTA TNF	A/G	Allelic association: P-value = 0.79	No significant association was observed No significant association was observed	Negative
rs1786568	GNAL	C/G	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs1786569	GNAL	A/G	Allelic association: P-value = 0.35	No significant association was observed No significant association was observed	Negative
rs1801260	CLOCK TMEM165	A/G	Allelic association: P-value = 0.47	No significant association was observed No significant association was observed	Negative
rs1805087	MTR	A/G	Allelic association: P-value = 0.44	No significant association was observed No significant association was observed	Negative
rs1800883	HTR5A HTR5A-AS1	C/G	Allelic association: 1st screening: P-value = 0.005, 2nd screening: P-value = 0.0038, total: P-value = 0.000097	Significant association was observed in 1st screening, 2nd s...... Significant association was observed in 1st screening, 2nd screening and total sample. More...	Positive
rs1801133	MTHFR	G/A	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs17126	GRM3	A/G	Allelic association: P-value = 0.31	No significant association was observed No significant association was observed	Negative
rs1718119	P2RX7	A/G	Allelic association: P-value = 0.24	No significant association was observed No significant association was observed	Negative
rs169068	SSTR5 SSTR5-AS1	C/T	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs17116138	HTR3B	A/G	Allelic association: P-value = 1	No significant association was observed No significant association was observed	Negative
rs17840761	HSPA5	G/A	Allelic association: P-value = 0.068	No significant association was observed No significant association was observed	Negative
rs17844778	GPR78	A/C	Allelic association: P-value = 0.39	No significant association was observed No significant association was observed	Negative
rs17666	DPYSL2	C/T	Allelic association: 1st screening: P-value = 0.0019, 2nd screening: P-value = 0.31, total: P-value = 0.0045	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs17712679	SLC6A7 CAMK2A	A/T	Allelic association: P-value = 0.34	No significant association was observed No significant association was observed	Negative
rs10008257	PDLIM5	A/G	Allelic association: P-value = 0.073	No significant association was observed No significant association was observed	Negative
rs1012053	DGKH	A/C	Allelic association: P-value = 0.74	No significant association was observed No significant association was observed	Negative
rs1007023	TPH2	G/T	Allelic association: 1st screening: P-value = 0.069, 2nd screening: P-value = 1, total: P-value = 0.12	Significant association was observed Significant association was observed	Positive
rs1044654	KIF13A	C/A	Allelic association: P-value = 0.15	No significant association was observed No significant association was observed	Negative
rs1024516	GRM3	A/C	Allelic association: P-value = 0.66	No significant association was observed No significant association was observed	Negative
rs10778502	RFX4	C/T	Allelic association: P-value = 0.28	No significant association was observed No significant association was observed	Negative
rs1053454	PIP4K2A	C/A	Allelic association: P-value = 0.38	No significant association was observed No significant association was observed	Negative
rs11736084	GPR78	C/T	Allelic association: P-value = 0.29	No significant association was observed No significant association was observed	Negative
rs1176744	HTR3B	A/C	Allelic association: P-value = 0.5	No significant association was observed No significant association was observed	Negative
rs11863	DPYSL2	C/T	Allelic association: 1st screening: P-value = 0.0028, 2nd screening: P-value = 0.93, total: P-value = 0.055	Significant association was observed in 1st screening and to...... Significant association was observed in 1st screening and total sample. More...	Positive
rs12009	HSPA5 RABEPK	G/A	Allelic association: P-value = 0.09	No significant association was observed No significant association was observed	Negative
rs1282	GPR78	C/T	Allelic association: P-value = 0.12	No significant association was observed No significant association was observed	Negative
rs1298865	FAT1 CD36	A/G	Allelic association: P-value = 0.51	No significant association was observed No significant association was observed	Negative
rs131690	BCR	A/G	Allelic association: P-value = 0.58	No significant association was observed No significant association was observed	Negative
rs131702	BCR	G/T	Allelic association: P-value = 0.89	No significant association was observed No significant association was observed	Negative
rs2230469	PIP4K2A	C/T	Allelic association: P-value = 0.42	No significant association was observed No significant association was observed	Negative
rs11146020	GRIN1	G/C	Allelic association: 1st screening: P-value = 0.068, 2nd screening: P-value = 0.65, total: P-value = 0.082	Significant association was observed Significant association was observed	Positive
rs1126442	GRIN1	G/A	Allelic association: P-value = 0.28	No significant association was observed No significant association was observed	Negative
rs1126667	ALOX12	A/G	Allelic association: P-value = 0.69	No significant association was observed No significant association was observed	Negative
rs1140763	HSPA5 RABEPK	G/A	Allelic association: P-value = 0.084	No significant association was observed No significant association was observed	Negative
rs769404	GAD1	C/T	Allelic association: P-value = 0.2	No significant association was observed No significant association was observed	Negative
rs11568190	MLC1	A/G	Allelic association: P-value = 0.28	No significant association was observed No significant association was observed	Negative
rs1170191	DGKH	A/G	Allelic association: P-value = 0.91	No significant association was observed No significant association was observed	Negative

Haplotypes reported by this study for BD (count: 2)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1800883 - rs2581841 - rs10254608	G-T-A	HTR5A	Haplotypic association:P-value = 0.00045, Odds ratio (95% CI)=1.6 (1.22-1.99)	Significant association was found. Significant association was found.	Positive
rs1800883 - rs2581841 - rs10254608	C-C-C	HTR5A	Haplotypic association:P-value = 0.00041, Odds ratio (95% CI)=0.6 (0.43-0.78)	Significant association was found. Significant association was found.	Positive

Genes reported by this study for BD (count: 62)

Gene	Statistical Values/Author Comments	Result Category
GRIN2B	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
TPH2	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
MTR	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
CIT	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
CLOCK	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GRIN1	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
SSTR5	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
SST	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GRIK4	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
PALB2	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GRM4	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
MTHFD1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
MTHFR	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
S100B	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GRM3	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
IL2RB	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
MPPE1	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
PDLIM5	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
SORCS2	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
MLC1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GNAL	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
MCHR1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
PER3	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
ADSL	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
TUBA8	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GPR78	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
SYNGR1	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
DTNBP1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
DISC1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
ALOX12	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
SLC18A1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GNB3	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
HTR5A	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
DGCR8	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
HTR4	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
DUSP6	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
PIP4K2A	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
DGKH	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
HTR3B	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
STK24	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
CAMK2A	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
HSPA5	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GABRA5	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
ARNTL	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
NOS1	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
DPYSL2	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
NRG1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
HTR2A	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GAD1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
CHMP1B	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
KIF13A	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
NDUFV2	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
NCAM1	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
TNF	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
GRM7	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
CD36	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
BCR	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
RFX4	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
NAPG	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
P2RX7	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative
BDNF	Significant association of SNP in this gene with BD in our population was observed. Significant association of SNP in this gene with BD in our population was observed.	Positive
CUX2	No SNP of this gene had significant association with BD in our population. No SNP of this gene had significant association with BD in our population.	Negative