BDgene

SNP Report

Basic Info
Name rs1386494 dbSNP Ensembl
Location chr12:71958763 - 71958763(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele T
Minor Allele Frequence 0.143171
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000333850, ENST00000546576); non_coding_transcript_variant(ENST00000546576)
No. of Studies 3 (Positive: 0; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Lopez, V. A., 2007 A/G FBAT P-value = 0.106, Z=-1.616 in the NIMH 'Wave 3' Sample FBAT P-value = 0.106, Z=-1.616 in the NIMH 'Wave 3' Sample did not show significant association with BPAD or with SA in...... did not show significant association with BPAD or with SA in the individual marker tests More... Negative
Chen, S., 2014 A/G Allele frequency: P-value=0.277428, Permutated P-value=0.698...... Allele frequency: P-value=0.277428, Permutated P-value=0.6982; Genotype frequency: P-value=0.440348, H-W P-value=0.603372(case), H-W P-value=0.643185(control). More... No significant associations were observed. No significant associations were observed. Negative
Yosifova, A.,2009 T/C Allelic association: P-value = 0.051 Allelic association: P-value = 0.051 No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0)

SNPs in LD with rs1386494 (count: 22) View in gBrowse (chr12:71950838..71989834 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 22)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)