SNP Report

Basic Info

Name	rs662515 dbSNP Ensembl
Location	chr18:11886564 - 11886564(1)
Variant Alleles	C/G
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.497404
Functional Annotation	downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000317251, ENST00000344987, ENST00000496196, ENST00000587724, ENST00000588072, ENST00000592306, ENST00000592977) SIFT Annotation: tolerated(ENST00000317251, ENST00000344987, ENST00000496196, ENST00000587724, ENST00000588072, ENST00000592306, ENST00000592977)
Consequence to Transcript	downstream_gene_variant(ENST00000334049, ENST00000423027, ENST00000586364, ENST00000588186, ENST00000588191, ENST00000589267, ENST00000592331); intron_variant(ENST00000309976, ENST00000317235); missense_variant(ENST00000317251, ENST00000344987, ENST00000496196, ENST00000587724, ENST00000588072, ENST00000592306, ENST00000592977); NMD_transcript_variant(ENST00000317251, ENST00000496196, ENST00000592306); non_coding_transcript_exon_variant(ENST00000589731, ENST00000592447, ENST00000592894); non_coding_transcript_variant(ENST00000589731, ENST00000592447, ENST00000592894); upstream_gene_variant(ENST00000592755)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Yosifova, A.,2009	C/G		Allelic association: P-value = 0.06 Allelic association: P-value = 0.06	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MPPE1	metallophosphoesterase 1	18p11.21	2(2/0/0)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	2(0/2/0)

SNPs in LD with rs662515 (count: 2) View in gBrowse (chr18:11886564..11888096 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs605961		downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.841[CEU]
rs689057		downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.93[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)