SNP Report

Basic Info

Name	rs733457 dbSNP Ensembl
Location	chr6:34100631 - 34100631(1)
Variant Alleles	G/A/T
Ancestral Allele	T
Minor Allele	G
Minor Allele Frequence	0.40016
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000374177, ENST00000374181, ENST00000455714, ENST00000535756, ENST00000538487, ENST00000544773, ENST00000607916, ENST00000609222, ENST00000609278, ENST00000609973); NMD_transcript_variant(ENST00000609278); non_coding_transcript_variant(ENST00000607916, ENST00000609973); upstream_gene_variant(ENST00000609443)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Shi, J., 2008 (b)	A/C	C	Allelic association of neurotransmission systems genes with ...... Allelic association of neurotransmission systems genes with bipolar disorder: TDT P-value = 0.0249, Gene-wide P-value = 0.1399 (P values were based on permutation for all SNPs in each gene). More...		Positive
Yosifova, A.,2009	G/T		Allelic association: P-value = 0.61 Allelic association: P-value = 0.61	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GRM4	glutamate receptor, metabotropic 4	6p21.3	2(2/0/0)

SNPs in LD with rs733457 (count: 4) View in gBrowse (chr6:34100015..34101285 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs3887555	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.96[CEU]
rs9380406	5_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]
rs745501	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.889[CEU]
rs2395555	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)