Gene Report

Basic Info
Approved Symbol NAPG
Approved Name N-ethylmaleimide-sensitive factor attachment protein, gamma
Name Alias gamma SNAP
Location 18p11.21
Position chr18:10525905-10552761, 1
External Links HGNC: 7642
Entrez Gene: 8774
Ensembl: ENSG00000134265
UCSC: uc002kon.3
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Li, X.,2009 SNP: rs2290279, rs473938, rs495484, rs510110
Haplotype: rs2290279 - rs495484(), rs2290279 - rs495484 - rs510110(), rs2290279 - rs510110(), rs473938 - rs2290279(), rs473938 - rs2290279 - rs495484(), rs473938 - rs2290279 - rs495484 - rs510110(), rs473938 - rs2290279 - rs510110(), rs473938 - rs495484(), rs473938 - rs495484 - rs510110(), rs473938 - rs510110()
In summary, our study supports NAPG as a candidate gene in the predisposition to bipolar disorder. Positive Comment on Study
Weller, A. E., 2006 SNP: rs2290279, rs473938, rs495484, rs510110, rs617040 The results of this study suggest that polymorphisms in the human NAPG gene may represent risk factors for the development of bipolar disorder, but before such a role can be established, the results of this study must be confirmed in additional populations of bipolar disorder patients and controls. Positive Comment on Study
Yosifova, A.,2009 SNP: rs2290279, rs495484, rs510110 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 0)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 34)

Literature-origin SNPs (count: 5)

LD-proxies (count: 29)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:10525905..10552761 View in gBrowse
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