BDgene

SNP Report

Basic Info
Name rs1298865 dbSNP Ensembl
Location chr4:186595726 - 186595726(1)
Variant Alleles A/G
Ancestral Allele G
Minor Allele G
Minor Allele Frequence 0.491813
Functional Annotation 5_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant.
Consequence to Transcript 5_prime_UTR_variant(ENST00000509537); downstream_gene_variant(ENST00000503253, ENST00000507662, ENST00000512347); NMD_transcript_variant(ENST00000509537); non_coding_transcript_exon_variant(ENST00000500085); non_coding_transcript_variant(ENST00000500085); synonymous_variant(ENST00000441802, ENST00000507105, ENST00000509927, ENST00000512772, ENST00000614102)
No. of Studies 3 (Positive: 2; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Yosifova, A.,2009 A/G Allelic association: P-value = 0.51 Allelic association: P-value = 0.51 No significant association was observed No significant association was observed Negative
Abou Jamra, R, 2008 (a) A/G allelic P-value = 0.00079; OR=1.69 allelic P-value = 0.00079; OR=1.69 showed association with bipolar affective disorder showed association with bipolar affective disorder Positive
Blair, I. P., 2006 Allelic P-value = 0.072, genotypic P-value = 0.044 in Aust c...... Allelic P-value = 0.072, genotypic P-value = 0.044 in Aust case-control; Allelic P-value = 0.838, genotypic P-value = 0.147 in UK case-control for overall; Allelic P-value = 0.01, genotypic P-value = 0.007 in Aust case-control; Allelic P-value = 0.038, genotypic P-value = 0.078 in UK case-control with positive family history; Allelic P-value = 0.98, genotypic P-value = 0.639 in Aust case-control; Allelic P-value = 0.082, genotypic P-value = 0.02 in UK case-control with negative family history; Allelic P-value = 0.197, genotypic P-value = 0.382 in Aust case-control; Allelic P-value = 0.512, genotypic P-value = 0.194 in UK case-control with lifetime psychotic episode; Allelic P-value = 0.029, genotypic P-value = 0.009 in Aust case-control; Allelic P-value = 0.729, genotypic P-value = 0.272 in UK case-control with no psychotic episode; pooled P-value = 0.003, OR=1.44 More... The SNP provided statistically significant evidence for asso...... The SNP provided statistically significant evidence for association in the Australian case-control cohort. In the pooled data analysis, SNP rs1298865 also showed significant evidence for association (P=0.003) with a summary OR of 1.44 (95% CI: 1.13-1.83)and remained significant after applying a Bonferroni correction for multiple testing. No case-control cohort showed evidence for association among psychosis or non-psychosis subsets. More... Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
CD36 CD36 molecule (thrombospondin receptor) 7q11.2 3(2/1/0)
FAT1 FAT atypical cadherin 1 4q35.2 Mapped by Literature SNP

SNPs in LD with rs1298865 (count: 0) View in gBrowse (chr4:186595726..186595726 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)