BDgene

SNP Report

Basic Info
Name rs2304865 dbSNP Ensembl
Location chr4:186604209 - 186604209(1)
Variant Alleles C/G
Ancestral Allele C
Minor Allele G
Minor Allele Frequence 0.263179
Functional Annotation intron_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000441802, ENST00000614102); upstream_gene_variant(ENST00000503253)
No. of Studies 3 (Positive: 2; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Yosifova, A.,2009 C/G Allelic association: P-value = 0.38 Allelic association: P-value = 0.38 No significant association was observed No significant association was observed Negative
Abou Jamra, R, 2008 (a) C/G allelic P-value = 0.03737; OR=1.36 allelic P-value = 0.03737; OR=1.36 showed association with bipolar affective disorder showed association with bipolar affective disorder Positive
Blair, I. P., 2006 Allelic P-value = 0.007, genotypic P-value = 0.009 in Aust c...... Allelic P-value = 0.007, genotypic P-value = 0.009 in Aust case-control; Allelic P-value = 0.274, genotypic P-value = 0.542 in UK case-control for overall; Allelic P-value = 0.007, genotypic P-value = 0.006 in Aust case-control; Allelic P-value = 0.007, genotypic P-value = 0.025 in UK case-control with positive family history; Allelic P-value = 0.31, genotypic P-value = 0.528 in Aust case-control; Allelic P-value = 0.841, genotypic P-value = 0.975 in UK case-control with negative family history; Allelic P-value = 0.092, genotypic P-value = 0.176 in Aust case-control; Allelic P-value = 0.466, genotypic P-value = 0.487 in UK case-control with lifetime psychotic episode; Allelic P-value = 0.012, genotypic P-value = 0.011 in Aust case-control; Allelic P-value = 0.085, genotypic P-value = 0.079 in UK case-control with no psychotic episode; pooled P-value = 0.0002, OR=2.31 More... The SNP provided statistically significant evidence for asso...... The SNP provided statistically significant evidence for association in the Australian case-control cohort. In the pooled data analysis, SNP rs2304865 showed significant evidence for association (P=0.0002) with a summary odds ratio (OR) of 2.31 and remained significant after applying a Bonferroni correction for multiple testing. No case-control cohort showed evidence for association among psychosis or non-psychosis subsets. More... Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
CD36 CD36 molecule (thrombospondin receptor) 7q11.2 3(2/1/0)
FAT1 FAT atypical cadherin 1 4q35.2 Mapped by Literature SNP

SNPs in LD with rs2304865 (count: 0) View in gBrowse (chr4:186604209..186604209 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)