BDgene

SNP Report

Basic Info
Name rs760761 dbSNP Ensembl
Location chr6:15650901 - 15650901(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.244808
Functional Annotation intron_variant; NMD_transcript_variant.
Consequence to Transcript intron_variant(ENST00000338950, ENST00000344537, ENST00000355917, ENST00000506844, ENST00000510395, ENST00000511762, ENST00000513680, ENST00000515875, ENST00000622898, LRG_588t1, LRG_588t2); NMD_transcript_variant(ENST00000506844, ENST00000510395, ENST00000513680, ENST00000515875)
No. of Studies 5 (Positive: 3; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Breen, G., 2006 P-value < 0.04, OR=0.33, 95% CI=0.12-0.93, X2=4.3...... P-value < 0.04, OR=0.33, 95% CI=0.12-0.93, X2=4.39, df=1 More... Under this recessive genotypic model, P1320 was most signifi...... Under this recessive genotypic model, P1320 was most significant, with an odds ratio of 0.33. More... Positive
Pae, C. U., 2007 (a) COCAPHASE P-value > 0.05 COCAPHASE P-value > 0.05 No significant association was observed in single marker ana...... No significant association was observed in single marker analyses More... Negative
Joo, E. J., 2007 C/T Fisher's exact test, allelic P-value = 0.084 for BPD I, P-va...... Fisher's exact test, allelic P-value = 0.084 for BPD I, P-value = 0.408 for BPD I and II, P-value = 0.76 for BPD I, II and SA; genotypic P-value = 0.022 for BPD I, P-value = 0.058 for BPD I and II, P-value = 0.13 for BPD I, II and SA More... Significant genotypic association with P1320 was observed in...... Significant genotypic association with P1320 was observed in the bipolar I group, Significance decreased as the phenotype was broadened to include bipolar II disorder and schizoaffective disorder. More... Positive
Gaysina, D.,2009 C/T chi-square test: 1.Between Bipolar Disorder and Control Grou...... chi-square test: 1.Between Bipolar Disorder and Control Groups: genotype: X2=9.83, P-value = 0.007, borderline significant after Bonferroni correction; allele: X2=5.41, P-value = 0.02, OR=1.26, 95%CI 1.03-1.54, lost after Bonferroni correction; 2.In Bipolar I Disorder (BID) and Bipolar II Disorder (BIID) Groups: allele: X2=0.006, P-value = 0.939 More... No significant differences was observed between the groups o...... No significant differences was observed between the groups of BD-I and BD-II.Significant association was observed in the BD group. More... Positive
Yosifova, A.,2009 G/A Allelic association: P-value = 0.14 Allelic association: P-value = 0.14 No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DTNBP1 dystrobrevin binding protein 1 6p22.3 8(4/3/1)

SNPs in LD with rs760761 (count: 73) View in gBrowse (chr6:15525222..15657981 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 73)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)