BDgene

SNP Report

Basic Info
Name rs4411993 dbSNP Ensembl
Location chr4:7464739 - 7464739(1)
Variant Alleles T/C
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.149561
Functional Annotation downstream_gene_variant; intron_variant; non_coding_transcript_variant.
Consequence to Transcript downstream_gene_variant(ENST00000579577); intron_variant(ENST00000329016, ENST00000507866, ENST00000511199); non_coding_transcript_variant(ENST00000511199)
No. of Studies 5 (Positive: 1; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Ollila, H. M.,2009 C/T FBAT: P-value = 0.006045 FBAT: P-value = 0.006045 Significant association was observed Significant association was observed Positive
Baum, A. E., 2008 (a) C P-value = 0.003 when genotyped individually in the test samp...... P-value = 0.003 when genotyped individually in the test sample (NIMH); P-value = 0.03 when individually genotyped in the Replication sample (German); P-value = 0.0005 in the combined dataset. OR (95% CI)=1.35 (1.14-1.61) More... significant at the P < 0.05 level in both samples. significant at the P < 0.05 level in both samples. Negative
Takata, A.,2011(a) T/C Fisher's exact test: allele P-value = 0.5703, genotype P-val...... Fisher's exact test: allele P-value = 0.5703, genotype P-value = 0.6969 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Yosifova, A.,2009 C/T Allelic association: P-value = 1 Allelic association: P-value = 1 No significant association was observed No significant association was observed Negative
Baum, A. E., 2008 (b) C Random effects P-value = 0.054; DerSimonian-Laird (random e...... Random effects P-value = 0.054; DerSimonian-Laird (random effects) OR (95% CI)=1.23 (1.00-1.52) More... Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MIR4274 microRNA 4274 4 Mapped by Literature SNP
SORCS2 sortilin-related VPS10 domain containing receptor 2 4p16.1 5(3/2/0)

SNPs in LD with rs4411993 (count: 7) View in gBrowse (chr4:7464739..7472625 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 7)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)