BDgene

SNP Report

Basic Info
Name rs4290270 dbSNP Ensembl
Location chr12:72022455 - 72022455(1)
Variant Alleles A/T
Ancestral Allele A
Minor Allele T
Minor Allele Frequence 0.48722
Functional Annotation synonymous_variant.
Consequence to Transcript synonymous_variant(ENST00000333850)
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Harvey, M., 2007 A/T FBAT P-value = 0.0041, corrected P-value = 0.049, Z=2.866 fo...... FBAT P-value = 0.0041, corrected P-value = 0.049, Z=2.866 for T allele under a recessive model, FBAT P-value = 0.4435, Z=-0.766 for A allele, FBAT P-value = 0.3969, Z=-0.847 for AA genotype, FBAT P-value = 0.0702, Z=-1.811 for AT genotype, FBAT P-value = 0.0042, corrected P-value = 0.050, Z=2.860 for TT genotype More... Evidence of allelic and genotypic association is found at th...... Evidence of allelic and genotypic association is found at the rs4290270 locus. More... Positive
Yosifova, A.,2009 A/T Allelic association: P-value = 0.72 Allelic association: P-value = 0.72 No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0)

SNPs in LD with rs4290270 (count: 14) View in gBrowse (chr12:72016002..72022455 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 14)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016