BDgene

SNP Report

Basic Info
Name rs2049045 dbSNP Ensembl
Location chr11:27672694 - 27672694(1)
Variant Alleles G/C
Ancestral Allele G
Minor Allele C
Minor Allele Frequence 0.0628994
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000314915, ENST00000356660, ENST00000395978, ENST00000395980, ENST00000395981, ENST00000395983, ENST00000395986, ENST00000418212, ENST00000420794, ENST00000438929, ENST00000499008, ENST00000499568, ENST00000500662, ENST00000501176, ENST00000501663, ENST00000502161, ENST00000525950, ENST00000530686, ENST00000530786, ENST00000530861, ENST00000532997, ENST00000533131, ENST00000533246, ENST00000584049); NMD_transcript_variant(ENST00000530786); non_coding_transcript_variant(ENST00000499008, ENST00000499568, ENST00000500662, ENST00000501176, ENST00000501663, ENST00000502161, ENST00000530686, ENST00000584049)
No. of Studies 3 (Positive: 2; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Neves, F. S.,2011 G/C chi-square test: allele, P-value = 0.654, OR(95%CI)=0.89(0.5...... chi-square test: allele, P-value = 0.654, OR(95%CI)=0.89(0.56-1.43), genotype, P-value = 0.479 More... No significant association was observed. No significant association was observed. Negative
Yosifova, A.,2009 C/G Allelic association: P-value = 0.011 Allelic association: P-value = 0.011 Significant association was observed Significant association was observed Positive
Muller, D. J., 2006 G/C TDTPHASE P-value = 0.009, df=1, LRS=6.67 TDTPHASE P-value = 0.009, df=1, LRS=6.67 Significant association between the total sample and the BDN...... Significant association between the total sample and the BDNF gene was found for rs2049045. Over-transmission was observed for the G allele of rs2049045. More... Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
BDNF brain-derived neurotrophic factor 11p14.1 37(24/12/1)
BDNF-AS BDNF antisense RNA 11p14.1 Mapped by Literature SNP

SNPs in LD with rs2049045 (count: 14) View in gBrowse (chr11:27550056..27706992 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 14)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)