Study Report

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Basic Info

Reference	Xu, W., 2014 PMID: 24387768
Citation	Xu, W., et al. (2014). "Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1." BMC Med Genet 15: 2.
Disease Type	Bipolar Disorder
Study Design	case-control and family-based
Study Type	Genome-wide association study
Sample Size	From Toronto constituting: 431 cases and 440 controls; from UK: 538 cases and 513 controls.
SNP/Region/Marker Size	510,740 SNPs in discovery dataset and 440,794 SNPs in the validation dataset.
Predominant Ethnicity	Caucasian
Population	UK, Canadian
Gender	For the total 1922 samples, there are 871 samples from Toronto constituting 431 cases (160 males and 271 females) and 440 controls (176 males and 264 females); there are 1051 samples from UK including 538 cases (180 males and 358 females) and 513 controls (192 males and 321 females).
Age Group	adults

Detail Info

Sample Diagnosis	DSM-IV/ICD 10
Sample Status	Inclusion criteria for patients: a) diagnosed with DSMIV/ICD 10 BD I or II; b) 18 years old or over; c) Caucasian, of Northern and Western European origin, and three out of four grand-parents also N.W. European Caucasian.
Replication Size	An independent BD cohort: 229 parent/affected offspring trio families also collected in the Toronto area
Technique	Genome-wide genotyping was performed for the Toronto and London case/control cohorts using the Illumina-Sentrix Human Hap550 BeadChip (Illumina Inc., SanDiego, CA, USA). Data was extracted by the IlluminaÂ¨ Beadstudio software from data files created by the IlluminaBead Array reader. Mainly, these were genotyped by Illumina Inc. (San Diego, CA, USA) however 280 samples (97 cases and 183 controls) from the Toronto cohort were genotyped at the Genome Quebec facility. For the Toronto parent-offspring trio family cohort, Affymetrix 5.0 arrays (Affymetrix, Santa Clara, CA, USA) were used, and genotyped by the London Regional Genomics Centre (London, Ontario).
Statistical Method	After genotyping, the discovery cohort samples were subject to a battery of a quality control (QC) tests. Reported and genetic gender were examined using X-chromosome linked SNPs. Relatedness between samples, sample contaminations, mis-identification and duplications were tested using genome-wide identity-by-descent (IBD) estimation; inconsistent samples were dropped from the analysis. Separate QC was applied on the validation cohort including the 229 Toronto parent-offspring trio families. SNPs were subject to QC before analysis. Samples and markers with call rates below 95% were excluded from analysis. We removed SNPs with minor allele frequencies below 1%. To minimize genotyping errors we excluded SNPs with p-value <10-5 for HWE of control samples. PLINK software was used for quality control steps described above. Principal component analysis was conducted with EIGENSTRAT on the discovery cohort with SNPs selected after QC filtering. To ensure the most homogeneous groups for association analysis, we excluded subjects with outliers defined by EIGENSTRAT. Principal components (PCs) were selected based on analysis of the scree plot. For the genetic association analysis, the selected principal components were adjusted in the logistic regression model to correct for population stratification. We did not apply principle component analysis on the validation cohort since the family-based association tests are robust against population substructure.
Result Summary	Although no genome-wide significant markers were identified, the combined GWAS findings have pointed to several genes of interest that support GWAS findings for BD from other groups or consortia, such as at SYNE1 on 6q25, PPP2R2C on 4p16.1, ZNF659 on 3p24.3, CNTNAP5 (2q14.3), and CDH13 (16q23.3). This apparent corroboration across multiple sites gives much confidence to the likelihood of genetic involvement in BD at these loci. In particular, our two-stage strategy found association in both our combined case/control analysis and the family-based analysis on 1q21.2 (closest gene: sphingosine-1-phosphate receptor 1 gene, S1PR1) and on 1q24.1 near the gene TMCO1,and at CSMD1 on 8p23.2, supporting several previous GWAS reports for BD and for schizophrenia. Pathway analysis suggests association of pathways involved in calcium signalling, neuropathic pain signalling, CREB signalling in neurons, glutamate receptor signalling and axonal guidance signalling.

SNPs reported by this study for BD (count: 319)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs6878196	ADCY2		P(unadj)-value=0.000698,Â OR (unadj)=0.795,Â P(adj)-value=0.00176,Â OR(adj)=0.8106	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6897843	PRR16	A/G	P-value=1.18E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6908216	TBC1D22B	T/G	P-value=6.02E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6957744	WDR60		P(unadj)-value=0.000164,Â OR (unadj)=1.409,Â P(adj)-value=0.00029,Â OR(adj)=1.4	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6969594		C/T	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6981847	PRSS55 PRSS51	C/T	P(unadj)-value=7.24E-05,Â OR (unadj)=1.422,Â P(adj)-value=3.57E-05,Â OR (adj)=1.464	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs7003289	NCALD		P(unadj)-value=0.000821,Â OR (unadj)=0.7988,Â P(adj)-value=0.001294,Â OR(adj)=0.7991	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs7005099	PPP2R2A	T/C	P(unadj)-value=5.40E-05,Â OR (unadj)=0.4588,Â P(adj)-value=6.33E-05,Â OR (adj)=0.4505	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs7074934	GAD2	A/G	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7134603		T/G	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7149343	RAD51B	G/A	P-value=3.18E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7186123	CDH13	G/T	P-value=7.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7201194	CDH13	A/G	Adjusted P (ADD)=1.74E-04ï¼ŒÂ OR=1.315	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7213832	RABEP1 NUP88	G/A	Adjusted P (ADD)=9.74E-04ï¼ŒÂ OR=0.6785	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7214165		G/T	P-value=1.18E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7231636	WDR7	C/G	P-value=1.95E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6565063	CDH13	C/T	Adjusted P (ADD)=2.08E-04ï¼ŒÂ OR=1.354	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs6495504	ARNT2	G/A	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6597678	NUP214	G/C	P-value=5.75E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs656750	CCBE1		P(unadj)-value=0.000142,Â OR (unadj)=0.7721,Â P(adj)-value=0.000581,Â OR(adj)=0.7899	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6651493	RPL8 ZNF34 RN7SL395P	C/T	P-value=3.38E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs663824	EBNA1BP2 WDR65 CFAP57		P(unadj)-value=5.96E-05,Â OR (unadj)=0.7607,Â P(adj)-value=0.000116,Â OR(adj)=0.7672	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs667482	CCBE1		P(unadj)-value=0.000337,Â OR (unadj)=0.7848,Â P(adj)-value=0.001136,Â OR(adj)=0.801	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6670779	RLF	T/C	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs668432	CCBE1		P(unadj)-value=0.001359,Â OR (unadj)=1.253,Â P(adj)-value=0.001935,Â OR(adj)=1.248	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6681627	RABGAP1L	A/C	P(unadj)-value=1.23E-04,Â OR (unadj)=0.6952,Â P(adj)-value=5.03E-05,Â OR (adj)=0.6735	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs6735700	SPAG16	C/T	P-value=9.89E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6726093		C/T	P(unadj)-value=5.68E-05,Â OR (unadj)=0.722,Â P(adj)-value=2.23E-05,Â OR (adj)=0.7056	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs6788209	EGFEM1P	G/A	P-value=7.44E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6738031	SCN7A		P(unadj)-value=0.000589,Â OR (unadj)=0.7816,Â P(adj)-value=0.001265,Â OR(adj)=0.7927	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6860892		A/G	P-value=2.67E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6790743		C/A	Adjusted P (ADD)=1.66E-03ï¼ŒÂ OR=0.8006	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs575056	PDE4B	C/T	P-value=9.5E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs585632	CCBE1		P(unadj)-value=0.000269,Â OR (unadj)=0.7847,Â P(adj)-value=0.000762,Â OR(adj)=0.7969	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs538336	PDE4B	G/A	P-value=7.45E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs548978	SYNE1	G/A	Adjusted P (ADD)=1.40E-04ï¼ŒÂ OR=1.364	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs6077589		T/C	P-value=7.45E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6132109		G/A	P(unadj)-value=1.88E-05,Â OR (unadj)=0.7106,Â P(adj)-value=9.01E-05,Â OR (adj)=0.7288	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs602435	ALKBH8	T/C	P-value=5.7E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs6060612	PHF20	A/G	P(unadj)-value=5.59E-04,Â OR (unadj)=0.6824,Â P(adj)-value=4.42E-05,Â OR (adj)=0.6299	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs639476	EBNA1BP2 CFAP57		P(unadj)-value=0.000232,Â OR (unadj)=0.7794,Â P(adj)-value=0.000429,Â OR(adj)=0.7879	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6428445	NEK7		P(unadj)-value=0.000368,Â OR (unadj)=1.32,Â P(adj)-value=0.000179,Â OR(adj)=1.342	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6140884	RSPO4	T/C	P(unadj)-value=1.41E-04,Â OR (unadj)=1.548,Â P(adj)-value=5.48E-05,Â OR (adj)=1.611	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs619037	CCBE1		P(unadj)-value=0.001389,Â OR (unadj)=1.261,Â P(adj)-value=0.00198,Â OR(adj)=1.255	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs644856	CCBE1		P(unadj)-value=0.000162,Â OR (unadj)=0.7777,Â P(adj)-value=0.000551,Â OR(adj)=0.7931	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6469241	TRHR NUDCD1	C/T	P(unadj)-value=1.18E-04,Â OR (unadj)=0.7741,Â P(adj)-value=8.98E-05,Â OR (adj)=0.7754	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6435818	SPAG16		P(unadj)-value=0.001161,Â OR (unadj)=1.365,Â P(adj)-value=0.000797,Â OR(adj)=1.389	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs6437143	CCDC148 CCDC148-AS1	A/G	P-value=1.54E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs4734525	RNU7-67P	T/C	P(unadj)-value=4.58E-05,Â OR (unadj)=0.7625,Â P(adj)-value=7.99E-05,Â OR (adj)=0.7678	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs4734194	TRHR NUDCD1	T/G	P(unadj)-value=8.78E-05,Â OR (unadj)=0.7701,Â P(adj)-value=6.65E-05,Â OR (adj)=0.7715	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4707111		A/G	P-value=9.64E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs4689410	PPP2R2C	A/G	P(unadj)-value=2.04E-05,Â OR (unadj)=0.7418,Â P(adj)-value=5.96E-06,Â OR (adj)=0.7264	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4805574	ZNF536	G/A	Adjusted P (ADD)=8.38E-04ï¼ŒÂ OR=1.53	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4805573	ZNF536	T/C	Adjusted P (ADD)=8.87E-04ï¼ŒÂ OR=1.533	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4782731	CDH13	G/A	Adjusted P (ADD)=1.19E-03ï¼ŒÂ OR=1.353	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4734606	NCALD		P(unadj)-value=0.001296,Â OR (unadj)=1.242,Â P(adj)-value=0.003033,Â OR(adj)=1.226	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs496499	INO80 CYCSP2	T/C	P-value=8.2E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs4959793	SLC22A23 PSMG4		P(unadj)-value=3.68E-05,Â OR (unadj)=0.6584,Â P(adj)-value=0.000149,Â OR(adj)=0.6792	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4865174	IGFBP7 UBE2CP3	G/A	Adjusted P (ADD)=7.65E-04ï¼ŒÂ OR=1.366	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4816165		T/C	P-value=8.08E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs532644		T/C	P-value=3.09E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs520570	KHDC1 RPSAP41 EIF3EP1	T/A	P-value=6.25E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs517811	NCALD		P(unadj)-value=0.001183,Â OR (unadj)=0.8009,Â P(adj)-value=0.001368,Â OR(adj)=0.7982	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs507998	C9orf171	A/G	P(unadj)-value=2.21E-04,Â OR (unadj)=0.7532,Â P(adj)-value=1.21E-05,Â OR (adj)=0.7094	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs9897202	MFSD11 SRSF2	G/A	P-value=7.1E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs9654726	WDR60		P(unadj)-value=0.000138,Â OR (unadj)=1.414,Â P(adj)-value=0.00024,Â OR(adj)=1.407	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs9501975	SLC22A23 PSMG4		P(unadj)-value=0.000373,Â OR (unadj)=0.6286,Â P(adj)-value=0.001102,Â OR(adj)=0.6514	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs989423	RABGAP1L	T/C	P(unadj)-value=1.40E-04,Â OR (unadj)=0.7388,Â P(adj)-value=4.17E-05,Â OR (adj)=0.7189	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs9819195	DOCK3	G/A	Adjusted P (ADD)=1.09E-03ï¼ŒÂ OR=0.4297	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs907290	HIGD1AP6 CASC9	G/A	P-value=4.72E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs922790	CSMD1	C/T	Adjusted P (ADD)=8.76E-04ï¼ŒÂ OR=0.7941	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs899305	RBFOX1	C/T	Adjusted P (ADD)=3.38E-04ï¼ŒÂ OR=1.303	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs906168	XKR4	T/C	Adjusted P (ADD)=7.57E-04ï¼ŒÂ OR=0.8003	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs8140359	MYO18B	A/G	P-value=7.44E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs894962		T/C	P(unadj)-value=1.06E-04,Â OR (unadj)=0.7727,Â P(adj)-value=9.25E-05,Â OR (adj)=0.7701	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs8112504	MYH14 MYH7B		P(unadj)-value=1.15E-05,Â OR (unadj)=0.7185,Â P(adj)-value=0.000103,Â OR(adj)=0.7476	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs8112720	MYH14 MYH7B		P(unadj)-value=1.64E-05,Â OR (unadj)=0.7219,Â P(adj)-value=0.000138,Â OR(adj)=0.7508	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs9458854	QKI	T/C	P(unadj)-value=4.18E-05,Â OR (unadj)=0.4817,Â P(adj)-value=5.21E-05,Â OR (adj)=0.4707	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs9495760		C/G	P-value=1.41E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs9385507		T/C	P(unadj)-value=4.32E-05,Â OR (unadj)=0.7112,Â P(adj)-value=5.21E-05,Â OR (adj)=0.7057	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs9385517		A/G	P(unadj)-value=3.29E-05,Â OR (unadj)=0.7077,Â P(adj)-value=3.73E-05,Â OR (adj)=0.7019	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs9328157	SLC22A23 PSMG4		P(unadj)-value=3.68E-05,Â OR (unadj)=0.6584,Â P(adj)-value=0.000149,Â OR(adj)=0.6792	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs9343332	IMPG1	A/G	P-value=7.44E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs9288627		G/T	P(unadj)-value=1.30E-04,Â OR (unadj)=0.7037,Â P(adj)-value=5.11E-05,Â OR (adj)=0.6862	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs932051		A/G	P-value=7.5E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7561066	SPAG16		P(unadj)-value=0.000289,Â OR (unadj)=1.3,Â P(adj)-value=0.000462,Â OR(adj)=1.286	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs7538610	JAK1	G/A	P-value=5.7E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7518687		A/T	P-value=7.06E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7461611	OC90	A/G	P-value=5.9E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs736624	TRRAP	C/T	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7333854		G/T	Adjusted P (ADD)=9.83E-04ï¼ŒÂ OR=0.6741	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7307637		G/A	P-value=9.64E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7256349	ZNF274	A/G	P(unadj)-value=4.09E-05,Â OR (unadj)=1.349,Â P(adj)-value=4.51E-05,Â OR (adj)=1.359	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs8055744	RBFOX1	A/G	Adjusted P (ADD)=6.19E-04ï¼ŒÂ OR=1.334	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7864144	GABBR2	G/A	P(unadj)-value=4.85E-04,Â OR (unadj)=0.7059,Â P(adj)-value=8.05E-05,Â OR (adj)=0.6674	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7842590	HHLA1	A/G	Adjusted P (ADD)=1.70E-04ï¼ŒÂ OR=0.6008	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs7716014		T/A	P-value=5.7E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7677236		C/T	P-value=1.55E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs7620240	GBE1		P(unadj)-value=0.000498,Â OR (unadj)=1.277,Â P(adj)-value=0.00117,Â OR(adj)=1.263	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs7597971	SCN7A		P(unadj)-value=0.000546,Â OR (unadj)=0.7806,Â P(adj)-value=0.00117,Â OR(adj)=0.7912	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs7565062	SCN7A		P(unadj)-value=0.000654,Â OR (unadj)=0.782,Â P(adj)-value=0.001399,Â OR(adj)=0.7927	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10038294	NIPBL	G/A	P-value=3.82E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10023321	MARCH1	T/G	P-value=3.38E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10117817	FRMD3	T/C	Adjusted P (ADD)=3.96E-04ï¼ŒÂ OR=0.7292	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs10102339		A/G	P(unadj)-value=5.09E-04,Â OR (unadj)=1.269,Â P(adj)-value=9.70E-05,Â OR (adj)=1.313	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs10089209	CSMD1	T/C	Adjusted P (ADD)=1.01E-03ï¼ŒÂ OR=0.7984	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs10048784	ARHGAP15	T/C	P(unadj)-value=3.65E-05,Â OR (unadj)=1.352,Â P(adj)-value=1.58E-05,Â OR (adj)=1.38 for the	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10275341	WDR60		P(unadj)-value=0.000151,Â OR (unadj)=1.411,Â P(adj)-value=0.000271,Â OR(adj)=1.402	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10173568	FEZ2	C/T	P(unadj)-value=1.05E-04,Â OR (unadj)=0.7707,Â P(adj)-value=3.07E-05,Â OR (adj)=0.7529	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs10151270	RBM23	G/C	P-value=9.45E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1013512		T/C	P-value=3.22E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10402864	PIAS4 ZBTB7A	G/A	P(unadj)-value=5.81E-05,Â OR (unadj)=0.6904,Â P(adj)-value=5.19E-05,Â OR (adj)=0.683	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs10458086	LYRM4		P(unadj)-value=9.05E-05,Â OR (unadj)=0.7704,Â P(adj)-value=0.000263,Â OR(adj)=0.7793	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10279428	WDR60		P(unadj)-value=0.000147,Â OR (unadj)=1.412,Â P(adj)-value=0.000254,Â OR(adj)=1.405	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1030143	SPAG16		P(unadj)-value=0.000508,Â OR (unadj)=1.348,Â P(adj)-value=0.001394,Â OR(adj)=1.313	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10508054	NALCN	C/A	Adjusted P (ADD)=2.12E-03ï¼ŒÂ OR=0.7002	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs10514629	SPAG16		P(unadj)-value=0.00046,Â OR (unadj)=1.4,Â P(adj)-value=0.001906,Â OR(adj)=1.349	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10477273		A/C	P-value=3.61E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10490354		A/G	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10798301	RC3H1	G/A	P(unadj)-value=1.82E-04,Â OR (unadj)=0.7444,Â P(adj)-value=8.77E-05,Â OR (adj)=0.7303	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs10803491	ARHGAP15		P(unadj)-value=0.000989,Â OR (unadj)=1.277,Â P(adj)-value=0.000522,Â OR(adj)=1.303	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10746698	FRMD3	T/C	Adjusted P (ADD)=4.55E-04ï¼ŒÂ OR=0.7317	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs10780579	FRMD3	T/C	Adjusted P (ADD)=3.85E-04ï¼ŒÂ OR=0.7287	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs10922418	NEK7		P(unadj)-value=0.001194,Â OR (unadj)=1.271,Â P(adj)-value=0.000352,Â OR(adj)=1.305	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs10984823		A/G	P-value=9.45E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10877947	RSL24D1P5	C/A	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs10906418	PRPF18	A/G	P-value=9.96E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs12448273	CDH13	A/G	Adjusted P (ADD)=2.46E-04ï¼ŒÂ OR=1.319	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12443555	CMIP	A/G	P(unadj)-value=5.72E-06,Â OR (unadj)=0.3172,Â P(adj)-value=8.44E-05,Â OR (adj)=0.345	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs12245803	KIAA1462	T/A	P-value=3.96E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs12189243	ADCY2		P(unadj)-value=0.000714,Â OR (unadj)=1.253,Â P(adj)-value=0.001734,Â OR(adj)=1.226	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs12186377	ADCY2		P(unadj)-value=0.000253,Â OR (unadj)=1.287,Â P(adj)-value=0.000507,Â OR(adj)=1.269	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs12154715	WDR60		P(unadj)-value=0.00015,Â OR (unadj)=1.411,Â P(adj)-value=0.000261,Â OR(adj)=1.402	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs12134034		A/G	P(unadj)-value=4.12E-04,Â OR (unadj)=1.268,Â P(adj)-value=6.37E-05,Â OR (adj)=1.312	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs12056919	CSMD1	A/G	Adjusted P (ADD)=5.15E-04ï¼ŒÂ OR=1.271	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs1274270	ZBTB20	T/C	P-value=3.44E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1269713	NCALD		P(unadj)-value=0.000684,Â OR (unadj)=0.7701,Â P(adj)-value=0.001242,Â OR(adj)=0.7762	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs12615880	ARHGAP15		P(unadj)-value=0.000368,Â OR (unadj)=1.305,Â P(adj)-value=0.000176,Â OR(adj)=1.326	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs12610463	ZNF536	A/G	Adjusted P (ADD)=1.12E-03ï¼ŒÂ OR=1.484	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12609580	ZNF536	T/C	Adjusted P(ADD)-value=2.46E-04ï¼ŒÂ OR=1.575	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12494223	ZNF385D ZNF385D-AS1	T/C	Adjusted P (ADD)=1.44E-04ï¼ŒÂ OR=0.7548	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12485389	PLCL2	G/A	P(unadj)-value=7.11E-04,Â OR (unadj)=1.508,Â P(adj)-value=8.20E-05,Â OR (adj)=1.64	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs12475889	SCN7A		P(unadj)-value=0.000266,Â OR (unadj)=0.775,Â P(adj)-value=0.000361,Â OR(adj)=0.7774	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs13331266	ABCC12	G/C	P-value=9.64E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs13409895		A/G	P(unadj)-value=7.49E-06,Â OR (unadj)=0.7406,Â P(adj)-value=9.05E-06,Â OR (adj)=0.7415	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1328179		T/C	P(unadj)-value=3.09E-05,Â OR (unadj)=1.322,Â P(adj)-value=6.52E-05,Â OR (adj)=1.313	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1329524	GPR115	T/C	P-value=1.31E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs13004397	ARHGAP15		P(unadj)-value=0.000371,Â OR (unadj)=1.306,Â P(adj)-value=0.000123,Â OR(adj)=1.341	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1323771	FRMD3	A/G	Adjusted P (ADD)=3.40E-04ï¼ŒÂ OR=0.747	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12773173	SVIL	T/C	P(unadj)-value=1.26E-05,Â OR (unadj)=0.6902,Â P(adj)-value=6.56E-05,Â OR (adj)=0.7054	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs12879582		A/G	P-value=8.87E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1418707		C/T	P(unadj)-value=1.92E-05,Â OR (unadj)=0.6884,Â P(adj)-value=3.01E-05,Â OR (adj)=0.6895	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1425328	KCNIP4	A/G	P-value=7.11E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs140673	GABRG3	C/A	P-value=3.83E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1411792	ADAMTSL1	C/T	P-value=3.37E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1375086	GBE1		P(unadj)-value=0.000124,Â OR (unadj)=0.7739,Â P(adj)-value=0.00104,Â OR(adj)=0.801	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1401319	FBXO28	G/A	P-value=1.29E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs13417240		C/T	P-value=5.31E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1351063	NCALD		P(unadj)-value=0.000552,Â OR (unadj)=0.7921,Â P(adj)-value=0.002153,Â OR(adj)=0.8141	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11090591	MTMR3	C/A	P-value=2.37E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11090364	KIAA1671	A/G	P-value=3.78E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11210072		C/T	P(unadj)-value=4.68E-04,Â OR (unadj)=1.265,Â P(adj)-value=7.46E-05,Â OR (adj)=1.308	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs11160805	RNU6-684P	A/G	P-value=7.52E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11022428		T/C	P(unadj)-value=8.85E-05,Â OR (unadj)=0.6814,Â P(adj)-value=7.03E-05,Â OR (adj)=0.6702	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs11013266	ARMC3	C/A	P-value=8.2E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11065615	ATP2A2	T/C	P-value=2.67E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11056473	PTPRO	C/T	P-value=7.44E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11578058	KLHL20	T/C	P(unadj)-value=1.30E-04,Â OR (unadj)=0.6925,Â P(adj)-value=6.46E-05,Â OR (adj)=0.6715	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1154037	CSMD1	C/T	Adjusted P (ADD)=7.50E-04ï¼ŒÂ OR=0.5986	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs11644289	CDH13	C/T	P(unadj)-value=6.55E-05,Â OR (unadj)=1.332,Â P(adj)-value=9.83E-05,Â OR (adj)=1.331	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs11640984	CDH13	C/A	Adjusted P (ADD)=1.61E-03ï¼ŒÂ OR=1.29	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs9501963	PSMG4		P(unadj)-value=0.000472,Â OR (unadj)=0.6937,Â P(adj)-value=0.000811,Â OR(adj)=0.7032	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11210815	EBNA1BP2 WDR65 CFAP57		P(unadj)-value=0.000733,Â OR (unadj)=0.7726,Â P(adj)-value=0.001196,Â OR(adj)=0.7757	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1131960	ARL6IP5 LMOD3	G/T	P-value=3.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1127473	SLC22A23 PSMG4		P(unadj)-value=0.000962,Â OR (unadj)=0.6506,Â P(adj)-value=0.002483,Â OR(adj)=0.6742	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1172384	SCN7A		P(unadj)-value=0.000701,Â OR (unadj)=0.7841,Â P(adj)-value=0.001487,Â OR(adj)=0.7943	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11735322	GABRA2	C/T	P-value=1.14E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11771168	FOXP2	T/C	P(unadj)-value=1.12E-05,Â OR (unadj)=1.407,Â P(adj)-value=1.06E-05,Â OR (adj)=1.405	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs11787406		T/G	P(unadj)-value=2.18E-06,Â OR (unadj)=1.497,Â P(adj)-value=2.35E-06,Â OR (adj)=1.519	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs11649622	CDH13	A/G	Adjusted P (ADD)=7.23E-04ï¼ŒÂ OR=0.7482	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs11680245	ARHGAP15		P(unadj)-value=0.000278,Â OR (unadj)=1.314,Â P(adj)-value=0.000117,Â OR(adj)=1.345	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11680933	LRRFIP1	G/T	P(unadj)-value=4.17E-05,Â OR (unadj)=1.38,Â P(adj)-value=3.50E-05,Â OR (adj)=1.394	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11708571	ZNF385D ZNF385D-AS1	G/A	P(unadj)-value=1.82E-04,Â OR (unadj)=0.7633,Â P(adj)-value=8.66E-05,Â OR (adj)=0.7485	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs11887857	SPAG16		P(unadj)-value=0.001161,Â OR (unadj)=1.365,Â P(adj)-value=0.000646,Â OR(adj)=1.394	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11960716		T/C	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs12022258		C/T	P(unadj)-value=8.75E-05,Â OR (unadj)=1.355,Â P(adj)-value=7.32E-05,Â OR (adj)=1.365	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs12025074	NEK7		P(unadj)-value=0.000413,Â OR (unadj)=1.318,Â P(adj)-value=0.00019,Â OR(adj)=1.342	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs11821204	OR8B6P	A/T	P-value=7.12E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11840233		C/T	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11856465	AK094352	G/C	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs11869073	MAP2K6	C/A	P(unadj)-value=5.45E-05,Â OR (unadj)=0.7057,Â P(adj)-value=2.52E-05,Â OR (adj)=0.6911	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs17141755	LINC00992	C/A	P-value=9.05E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17161272	TBXAS1	G/A	P-value=9.55E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17139748	LYRM4		P(unadj)-value=0.001012,Â OR (unadj)=0.7734,Â P(adj)-value=0.001095,Â OR(adj)=0.7703	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs17140395		A/G	P-value=4.83E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17432461	LOC145845	T/C	P-value=3.94E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17549841	ACOXL	A/G	P-value=4.2E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17231256		T/C	P-value=3.14E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1726144		A/G	P-value=8.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17063147	CSMD1	C/A	Adjusted P (ADD)=9.97E-04ï¼ŒÂ OR=0.7162	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs17064692		C/A	P-value=3.14E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17056765	TRPC4	C/T	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17058466		T/C	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17118807		T/C	P-value=3.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17131451		A/G	P-value=8.77E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17093782	ATRNL1	C/T	P-value=3.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17118780		A/G	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1954209	CGRRF1	A/G	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs193858	CDHR3	T/C	P-value=3.86E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs190183		G/T	P-value=3.61E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1893050	DLG2	C/T	P-value=5.31E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2037596		A/G	P(unadj)-value=1.88E-04,Â OR (unadj)=0.7225,Â P(adj)-value=6.57E-05,Â OR (adj)=0.7049	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2014425	SLC4A11	A/G	P-value=3.22E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2013210	CCBE1		P(unadj)-value=0.001044,Â OR (unadj)=1.265,Â P(adj)-value=0.001474,Â OR(adj)=1.263	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2012647		C/T	P-value=2.38E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17761193	SPAG16		P(unadj)-value=0.000601,Â OR (unadj)=1.353,Â P(adj)-value=0.00211,Â OR(adj)=1.31	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs17649473	OR1B1	A/G	P(unadj)-value=4.30E-06,Â OR (unadj)=0.5445,Â P(adj)-value=1.04E-05,Â OR (adj)=0.5491	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs17647803	NRG3	G/A	P-value=5.53E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17617913	ZNF804A	C/T	Adjusted P (ADD)=7.46E-04ï¼ŒÂ OR=1.419	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs1882844	C14orf166B LRRC74A	C/T	P-value=3.22E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1858886		A/G	P(unadj)-value=4.12E-05,Â OR (unadj)=1.314,Â P(adj)-value=6.25E-05,Â OR (adj)=1.313	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1783678		G/A	P(unadj)-value=5.19E-05,Â OR (unadj)=1.32,Â P(adj)-value=5.32E-05,Â OR (adj)=1.322	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs17813827		T/G	P-value=8.57E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1510548	SPAG16		P(unadj)-value=0.000902,Â OR (unadj)=1.285,Â P(adj)-value=0.001005,Â OR(adj)=1.28	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1565853	LRRFIP1		P(unadj)-value=0.000215,Â OR (unadj)=1.281,Â P(adj)-value=0.000364,Â OR(adj)=1.275	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1569812		G/C	P-value=1.49E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1670725	MYH14 MYH7B		P(unadj)-value=6.09E-05,Â OR (unadj)=0.6919,Â P(adj)-value=0.000726,Â OR(adj)=0.7332	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs16822430	ARHGAP15	C/T	P(unadj)-value=3.25E-05,Â OR (unadj)=1.392,Â P(adj)-value=1.76E-05,Â OR (adj)=1.417	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs16847635		T/C	P-value=0.000061	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16848204		G/C	P-value=2.1E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16851487	SPAG16		P(unadj)-value=0.00026,Â OR (unadj)=1.399,Â P(adj)-value=0.001194,Â OR(adj)=1.352	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs1457582	ZNF385D ZNF385D-AS1	T/C	Adjusted P (ADD)=9.56E-04ï¼ŒÂ OR=0.7996	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs1459005	CSMD3	G/A	P-value=9.45E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1459481		A/T	P-value=9.58E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1471054	KIF13B	A/T	P-value=8.77E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1476470		T/C	P(unadj)-value=3.07E-05,Â OR (unadj)=1.32,Â P(adj)-value=4.48E-05,Â OR (adj)=1.32	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1479755	KIAA1239	T/C	P-value=3.22E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs1483651	ZNF274	C/A	P(unadj)-value=9.70E-06,Â OR (unadj)=1.389,Â P(adj)-value=7.55E-06,Â OR (adj)=1.41	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs1492336		G/T	P-value=4.26E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16953278		A/G	P-value=8.22E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16911839	TEAD1	C/G	P-value=8.19E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16961283	FBN1	G/C	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16961083	SHISA9	A/G	P-value=3.38E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17012341	AFF1	A/T	P-value=5.31E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16977404		T/C	P-value=5.7E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17046894		G/A	P-value=2.39E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs17017240		G/A	P-value=7.1E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16873052		C/T	P-value=3.19E-07	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Trend
rs16851781	DNAJC16	T/C	P-value=5.31E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16889548		A/G	P-value=2.1E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16887512		T/C	P-value=5.02E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16903467	TRIO	G/A	P-value=7.44E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16898411	SUCLG2P4	C/G	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16907590		T/C	P-value=2.21E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs16904075	CCDC26	C/T	P(unadj)-value=1.22E-04,Â OR (unadj)=0.5533,Â P(adj)-value=5.83E-05,Â OR (adj)=0.5296	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs419778	LYRM4		P(unadj)-value=0.00059,Â OR (unadj)=0.7649,Â P(adj)-value=0.00072,Â OR(adj)=0.7636	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4246073	LYRM4		P(unadj)-value=0.001193,Â OR (unadj)=0.7768,Â P(adj)-value=0.001369,Â OR(adj)=0.7752	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4145554	NCALD		P(unadj)-value=0.001093,Â OR (unadj)=1.247,Â P(adj)-value=0.002117,Â OR(adj)=1.237	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs416803	LYRM4		P(unadj)-value=0.000903,Â OR (unadj)=0.7747,Â P(adj)-value=0.000894,Â OR(adj)=0.7697	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3922851	DIP2C	A/G	Adjusted P (ADD)=3.43E-04ï¼ŒÂ OR=0.7817	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4129682	TRHR NUDCD1		P(unadj)-value=0.000659,Â OR (unadj)=0.7969,Â P(adj)-value=0.000591,Â OR(adj)=0.7965	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3860582	ZNF385D	T/C	Adjusted P (ADD)=1.37E-04ï¼ŒÂ OR=0.7617	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs3860595	GBE1		P(unadj)-value=0.001474,Â OR (unadj)=1.245,Â P(adj)-value=0.002935,Â OR(adj)=1.231	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3821298	BAZ2B	G/T	P(unadj)-value=2.30E-05,Â OR (unadj)=1.327,Â P(adj)-value=8.90E-05,Â OR (adj)=1.309	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs3846013		G/A	P-value=3.74E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs3820588	EBNA1BP2 WDR65 CFAP57	T/C	P(unadj)-value=2.51E-05,Â OR (unadj)=0.7158,Â P(adj)-value=2.12E-05,Â OR (adj)=0.7039	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3820813	LRRFIP1	C/T	P(unadj)-value=9.05E-05,Â OR (unadj)=1.361,Â P(adj)-value=6.76E-05,Â OR (adj)=1.38	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3769086	LRRFIP1	A/G	P(unadj)-value=7.37E-05,Â OR (unadj)=1.366,Â P(adj)-value=5.98E-05,Â OR (adj)=1.379	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3772902	GBE1		P(unadj)-value=6.08E-05,Â OR (unadj)=0.7659,Â P(adj)-value=0.000577,Â OR(adj)=0.7917	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3751112	RAB17 LRRFIP1		P(unadj)-value=0.001342,Â OR (unadj)=1.322,Â P(adj)-value=0.004075,Â OR(adj)=1.289	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs3766084	NME7	C/T	P-value=9.89E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs4688994	PPP2R2C	T/C	Adjusted P (ADD)=2.27E-04ï¼ŒÂ OR=0.7509	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4673807	SPAG16		P(unadj)-value=0.000643,Â OR (unadj)=1.261,Â P(adj)-value=0.00071,Â OR(adj)=1.26	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4673558		T/C	P(unadj)-value=1.80E-05,Â OR (unadj)=0.7181,Â P(adj)-value=1.26E-05,Â OR (adj)=0.705	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs4638738	PRLH RNU6-1140P LRRFIP1		P(unadj)-value=0.000485,Â OR (unadj)=1.337,Â P(adj)-value=0.001024,Â OR(adj)=1.319	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4602754	PSMG4		P(unadj)-value=0.000116,Â OR (unadj)=0.7125,Â P(adj)-value=0.000794,Â OR(adj)=0.7433	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4485795	NPFFR2	C/G	P-value=6.33E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs445711	LYRM4		P(unadj)-value=0.001168,Â OR (unadj)=0.7788,Â P(adj)-value=0.001183,Â OR(adj)=0.7744	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4445096	PSMG4		P(unadj)-value=0.001477,Â OR (unadj)=0.7513,Â P(adj)-value=0.004136,Â OR(adj)=0.7716	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4444432	ZNF274	G/T	P(unadj)-value=5.58E-06,Â OR (unadj)=1.402,Â P(adj)-value=4.85E-06,Â OR (adj)=1.419	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs4430884	ARHGAP15	C/A	P(unadj)-value=3.41E-05,Â OR (unadj)=1.392,Â P(adj)-value=1.69E-05,Â OR (adj)=1.419	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4421240	PSMG4		P(unadj)-value=0.000116,Â OR (unadj)=0.7125,Â P(adj)-value=0.000794,Â OR(adj)=0.7433	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4412625	NEK7		P(unadj)-value=0.000876,Â OR (unadj)=1.28,Â P(adj)-value=0.000259,Â OR(adj)=1.313	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4292336	SORCS2	G/A	Adjusted P (ADD)=1.48E-03ï¼ŒÂ OR=0.7444	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs4289537	ADCY2		P(unadj)-value=0.000242,Â OR (unadj)=1.291,Â P(adj)-value=0.000492,Â OR(adj)=1.272	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs4279792		G/C	P-value=6.25E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs4268468	NAALAD2	T/C	P-value=6.08E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2420864	CNTNAP5	T/C	Adjusted P (ADD)=5.45E-04ï¼ŒÂ OR=0.5887	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs2422320		C/T	P(unadj)-value=4.12E-04,Â OR (unadj)=1.268,Â P(adj)-value=6.37E-05,Â OR (adj)=1.312	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2492922	GUCA1A	A/G	P-value=5.54E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2594547	GBE1		P(unadj)-value=7.65E-05,Â OR (unadj)=0.7678,Â P(adj)-value=0.000678,Â OR(adj)=0.7949	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2283436	ABHD2	C/T	P-value=9.62E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs238157	DDX27 ZNFX1	T/C	P-value=9.49E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2403733	HHLA1	G/A	Adjusted P (ADD)=1.99E-04ï¼ŒÂ OR=0.6013	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs2410806	XXYLT1	A/G	P(unadj)-value=8.18E-05,Â OR (unadj)=1.536,Â P(adj)-value=6.69E-06,Â OR (adj)=1.644	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2141150	SYNE1	C/A	P(unadj)-value=1.73E-05,Â OR (unadj)=1.419,Â P(adj)-value=3.33E-06,Â OR (adj)=1.476	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs214950	SYNE1	A/G	Adjusted P (ADD)=2.81E-04ï¼ŒÂ OR=1.345	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs214972	SYNE1	T/C	P(unadj)-value=4.73E-05,Â OR (unadj)=1.383,Â P(adj)-value=1.66E-05,Â OR (adj)=1.419	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs215006	SYNE1	A/G	P(unadj)-value=2.78E-04,Â OR (unadj)=1.335,Â P(adj)-value=7.83E-05,Â OR (adj)=1.38	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs2047169	LRRFIP1		P(unadj)-value=0.000183,Â OR (unadj)=1.345,Â P(adj)-value=0.000126,Â OR(adj)=1.362	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2064072	STX12	C/T	P-value=1.46E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2116397		T/C	P(unadj)-value=1.37E-04,Â OR (unadj)=1.362,Â P(adj)-value=9.66E-05,Â OR (adj)=1.38	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2119226	NCALD		P(unadj)-value=0.001482,Â OR (unadj)=0.8095,Â P(adj)-value=0.001461,Â OR(adj)=0.8019	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs31874	PCDHA6 PCDHA8 PCDHA5 PCDHA2 PCDHA7 PCDHA1 PCDHA4 PCDHA9 PCDHA3 PCDHA10 PCDHA12 PCDHAC1 PCDHA13 PCDHAC2 PCDHA11	C/T	P-value=8.29E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs3104794	CASC16	C/G	P-value=7.12E-06	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs3745504	MYH14 MYH7B		P(unadj)-value=2.88E-05,Â OR (unadj)=0.7561,Â P(adj)-value=0.000235,Â OR(adj)=0.7803	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs35703899		C/T	P-value=4.48E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2973331	ADCY2		P(unadj)-value=0.000195,Â OR (unadj)=1.296,Â P(adj)-value=0.000458,Â OR(adj)=1.275	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2866972	ZNF536	G/A	Adjusted P (ADD)=5.86E-04ï¼ŒÂ OR=1.435	SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD,...... SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs2981434	FGFR2	T/C	P-value=8.77E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2980619	NUDCD1 TRHR		P(unadj)-value=0.001089,Â OR (unadj)=1.245,Â P(adj)-value=0.000699,Â OR(adj)=1.256	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2813164		C/T	P(unadj)-value=3.75E-04,Â OR (unadj)=1.295,Â P(adj)-value=5.67E-05,Â OR (adj)=1.349	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2773294	LYRM4		P(unadj)-value=0.001153,Â OR (unadj)=0.781,Â P(adj)-value=0.001621,Â OR(adj)=0.7826	Listing suggestive significant genic SNPs for combined Toron...... Listing suggestive significant genic SNPs for combined Toronto and London GWAS for which there are 4 or more suggestive significant SNPs among the top 1000, and for which no other positive reports have been published to date. More...	Negative
rs2852571	GRIK2 GRIK5	T/G	P-value=4.18E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2837475	DSCAM	G/A	P(unadj)-value=1.11E-04,Â OR (unadj)=1.362,Â P(adj)-value=3.16E-05,Â OR (adj)=1.401	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative
rs2623966	SYNE1	C/T	P(unadj)-value=1.50E-05,Â OR (unadj)=1.424,Â P(adj)-value=3.02E-06,Â OR (adj)=1.481	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs260632	EDAR	G/A	P-value=3.94E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative
rs2695261	SYNE1	C/T	P(unadj)-value=2.32E-05,Â OR (unadj)=1.417,Â P(adj)-value=4.12E-06,Â OR (adj)=1.476	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative
rs2623971	SYNE1	A/G	P(unadj)-value=1.86E-05,Â OR (unadj)=1.42,Â P(adj)-value=3.52E-06,Â OR (adj)=1.481	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. SNPs from top 1000 from our combined CAMH/IoP GWAS for BPAD, for which at least one other non-overlapping GWAS also shows association at same gene. More...	Negative

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
FAM83F rs3021268	FAM83F	single nucleotide variation	A/G		P-value=7.02E-05	Top 132 SNPs (showing suggestive association to BD in our CA...... Top 132 SNPs (showing suggestive association to BD in our CAMH family cohort: p<0.0001). More...	Negative

Genes reported by this study for BD (count: 119)

Gene	Statistical Values/Author Comments	Result Category
ZNF536	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ZNF804A	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ZNF274	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ZNF385D	A single SNP in ZNF659 on 3p24.3 was among the top 68, but did not achieve genome-wide significance....... A single SNP in ZNF659 on 3p24.3 was among the top 68, but did not achieve genome-wide significance. More...	Negative
XXYLT1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ZBTB20	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PSMG4	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PRSS55	The most significant SNP was rs11787406, which is located just downstream of the gene PRSS55 on 8p23...... The most significant SNP was rs11787406, which is located just downstream of the gene PRSS55 on 8p23.1 (p = 2.35E-6). More...	Negative
PRR16	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PRPF18	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RABGAP1L	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RABEP1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
QKI	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PTPRO	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RLF	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RC3H1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RBM23	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
RAD51B	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SLC4A11	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SHISA9	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SCN7A	A number of genes with no previous association to BD have multiple SNPs with suggestive association,...... A number of genes with no previous association to BD have multiple SNPs with suggestive association, including the brain-expressed gene SCN7A. More...	Negative
RSPO4	3 SNPs among the top 68 situated within the ZNF274 gene (rs4444432: p = 4.85E-6) on 19q13. 3 SNPs among the top 68 situated within the ZNF274 gene (rs4444432: p = 4.85E-6) on 19q13.	Negative
STX12	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SVIL	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SORCS2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SPAG16	A number of genes with no previous association to BD have multiple SNPs with suggestive association,...... A number of genes with no previous association to BD have multiple SNPs with suggestive association, including the brain-expressed gene SPAG16. More...	Negative
TBXAS1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
TEAD1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
SYNE1	6 SNPs within the gene SYNE1 on 6q25, with lowest p = 3.02E-6 6 SNPs within the gene SYNE1 on 6q25, with lowest p = 3.02E-6	Negative
TBC1D22B	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
TRRAP	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NALCN	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
TRHR	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
TRIO	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
WDR7	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
XKR4	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
WDR60	A number of genes with no previous association to BD have multiple SNPs with suggestive association,...... A number of genes with no previous association to BD have multiple SNPs with suggestive association, including the brain-expressed gene WDR60. More...	Negative
CFAP57	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
KCNIP4	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
JAK1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
KIAA1462	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
KHDC1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
KLHL20	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
KIF13B	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
LOC145845	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
LMOD3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MAP2K6	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
LRRFIP1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MFSD11	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MARCH1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MYH14	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MTMR3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NAALAD2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
MYO18B	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NCALD	A number of genes with no previous association to BD have multiple SNPs with suggestive association,...... A number of genes with no previous association to BD have multiple SNPs with suggestive association, including the brain-expressed gene NCALD. More...	Negative
NEK7	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NIPBL	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NME7	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NPFFR2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NRG3	SNPs were identified with suggestive association at a number of other genes with plausible biologica...... SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as NRG3 (p=5.53Ã—10-6). More...	Negative
NUDCD1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
NUP214	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
OC90	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
OR1B1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PCDHA@	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PDE4B	Other SNPs showing suggestive association included SNPs within known candidate genes for BD, such as...... Other SNPs showing suggestive association included SNPs within known candidate genes for BD, such as PDE4B (p = 7.45Ã—10-5). More...	Negative
PHF20	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PLCL2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PPP2R2A	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
PPP2R2C	We also see suggestive association at rs4689410, within the PPP2R2C gene on 4p16.1 (p = 5.96E-6), wh...... We also see suggestive association at rs4689410, within the PPP2R2C gene on 4p16.1 (p = 5.96E-6), which was previously reported to be associated to bipolar disorder. More...	Negative
CSMD3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CSMD1	These include SNP rs1154037 in CSMD1, for which the intronic SNP rs4875310 was suggestive significan...... These include SNP rs1154037 in CSMD1, for which the intronic SNP rs4875310 was suggestive significant in the Sklar et al. 2008 study (p = 3.74Ã—10-5). More...	Negative
CNTNAP5	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CMIP	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CGRRF1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CDHR3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CDH13	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CCDC148	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
EDAR	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DSCAM	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DOCK3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DNAJC16	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DLG3	SNPs were identified with suggestive association at a number of other genes with plausible biologica...... SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as the synapseassociated protein 102 gene, DLG3 (p = 5.31Ã—10-5). More...	Negative
DLG2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DIP2C	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
DDX27	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FRMD3	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
GABBR2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FGFR2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FOXP2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FBN1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FBXO28	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
EGFEM1P	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
FAM83F	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
IMPG1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
INO80	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
GUCA1A	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
IGFBP7	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
GBE1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
GRIK2	SNPs were identified with suggestive association at a number of other genes with plausible biologica...... SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as GRIK2 (p=4.18Ã—10-5). More...	Negative
GABRG3	SNPs were identified with suggestive association at a number of other genes with plausible biologica...... SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as GABRG3 (p=3.83Ã—10-5). More...	Negative
GAD2	SNPs were identified with suggestive association at a number of other genes with plausible biologica...... SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as GAD2 (p=2.21Ã—10-5). More...	Negative
RBFOX1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
AFF1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
AK094352	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ALKBH8	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ARHGAP15	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ABCC12	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ABHD2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ACOXL	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ADCY2	A number of genes with no previous association to BD have multiple SNPs with suggestive association,...... A number of genes with no previous association to BD have multiple SNPs with suggestive association, including the brain-expressed gene ADCY2. More...	Negative
LINC00992	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
LRRC74A	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
C9orf171	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
CCBE1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ARNT2	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
ATP2A2	In addition, a SNP in ATP2A2, the Darier disease gene (MIM#124200) also showed suggestive associatio...... In addition, a SNP in ATP2A2, the Darier disease gene (MIM#124200) also showed suggestive association (p = 2.67Ã—10-5). More...	Negative
ATRNL1	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative
BAZ2B	The SNP within or near this gene did not achieve genome-wide significance. The SNP within or near this gene did not achieve genome-wide significance.	Negative