Gene Report

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Basic Info

Approved Symbol	RSPO4
Previous Symbol	C20orf182
Symbol Alias	dJ824F16.3
Approved Name	R-spondin 4
Previous Name	chromosome 20 open reading frame 182, "R-spondin family, member 4"
Location	20p13
Position	chr20:958452-1002264, -1
External Links	HGNC: 16175 Entrez Gene: 343637 Ensembl: ENSG00000101282 UCSC: uc002wej.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6140884	3 SNPs among the top 68 situated within the ZNF274 gene (rs4444432: p = 4.85E-6) on 19q13.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016055	Wnt signaling pathway	biological process	IEA	12
GO:0005615	extracellular space	cellular component	IBA	85
GO:0001664	G-protein coupled receptor binding	molecular function	IBA	9
GO:0005576	extracellular region	cellular component	TAS	97
GO:0008201	heparin binding	molecular function	IEA	8
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	IBA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6140884	chr20:988249 - 988249(1)	intron_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs6086801		chr20:989920 - 989920(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20pter-p12.3	chr20:0-9200000	1 (0/1/0)
20p13	chr20:0-5100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:958452..1002264 View in gBrowse