Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MAP2K6
Previous Symbol	PRKMK6
Symbol Alias	MEK6, MKK6, SAPKK3, MAPKK6
Approved Name	mitogen-activated protein kinase kinase 6
Name Alias	protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
Location	17q
Position	chr17:69414698-69543331, 1
External Links	HGNC: 6846 Entrez Gene: 5608 Ensembl: ENSG00000108984 UCSC: uc002jij.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs11869073	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 44)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49

GO terms by database search (count: 43)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000187	activation of MAPK activity	biological process	TAS	14
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS	8
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	TAS	5
GO:0005524	ATP binding	molecular function	IEA	118
GO:0004702	receptor signaling protein serine/threonine kinase activity	molecular function	IBA	5
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS	8
GO:0042692	muscle cell differentiation	biological process	TAS	5
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0034162	toll-like receptor 9 signaling pathway	biological process	TAS	7
GO:0002931	response to ischemia	biological process	IEA	4
GO:0042493	response to drug	biological process	IEA	57
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0051403	stress-activated MAPK cascade	biological process	TAS	8
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	8
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	8
GO:0060048	cardiac muscle contraction	biological process	IEA	5
GO:0005829	cytosol	cellular component	TAS	223
GO:0006975	DNA damage induced protein phosphorylation	biological process	TAS[10848581]	2
GO:0072709	cellular response to sorbitol	biological process	IEA	1
GO:0034146	toll-like receptor 5 signaling pathway	biological process	TAS	6
GO:0007050	cell cycle arrest	biological process	TAS[10848581]	10
GO:0004708	MAP kinase kinase activity	molecular function	IBA	2
GO:0034166	toll-like receptor 10 signaling pathway	biological process	TAS	6
GO:0007165	signal transduction	biological process	TAS[8621675]	136
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	biological process	IEA	4
GO:0051149	positive regulation of muscle cell differentiation	biological process	TAS	2
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	10
GO:0019901	protein kinase binding	molecular function	IPI[11279118]	29
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	IEA	12
GO:0004713	protein tyrosine kinase activity	molecular function	IEA	9
GO:0009405	pathogenesis	biological process	TAS	13
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS	7
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS	7
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS	7
GO:0006915	apoptotic process	biological process	IEA	39
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological process	TAS	2
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	8
GO:0032308	positive regulation of prostaglandin secretion	biological process	IEA	4
GO:0005515	protein binding	molecular function	IPI[12052864]	563
GO:0022602	ovulation cycle process	biological process	IEA	1
GO:0043065	positive regulation of apoptotic process	biological process	IEA	25

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04664	Fc epsilon RI signaling pathway	13
hsa04912	GnRH signaling pathway	17
hsa04620	Toll-like receptor signaling pathway	10

Gene related BioCarta pathways (count: 11)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
fMLPpathway	fMLP induced chemokine gene expression in HMC-1 cells	4

BioCarta pathways by database search (count: 10)

ID	Name	No. of Genes in BDgene
hcmvPathway	Human Cytomegalovirus and Map Kinase Pathways	5
tollPathway	Toll-Like Receptor Pathway	2
il1rPathway	Signal transduction through IL1R	5
p38mapkPathway	p38 MAPK Signaling Pathway	3
stressPathway	TNF/Stress Related Signaling	2
keratinocytePathway	Keratinocyte Differentiation	5
mapkPathway	MAPKinase Signaling Pathway	4
IL12Pathway	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	2
nthiPathway	NFkB activation by Nontypeable Hemophilus influenzae	5
hdacPathway	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)	10

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MAP2K6	SMAD7	NO	in vivo	12589052
MAP2K6	MAP3K5	NO	yeast 2-hybrid	15866172
MAP2K6	TRAF6	NO	in vitro	16313339
MAP2K6	MAP3K7	NO	in vitro	11460167
MAP2K6	MAPK14	NO	in vitro;in vivo	8626699 , 7750576 , 8622669 , 16342939 , 9808624
MAP2K6	STAT4	NO	in vitro;in vivo	10961885
MAP2K6	RELA	NO	in vitro	16498455
MAP2K6	MAPK12	NO	in vitro	11062067
MAP2K6	MAPK13	NO	in vitro	9218798
MAP2K6	MAP3K4	NO	in vitro;in vivo	9841871
MAP2K6	PKN1	NO	in vitro;in vivo	12761180
MAP2K6	DCTN1	NO	in vitro;yeast 2-hybrid	15375157
MAP2K6	PLCB2	YES	in vitro;in vivo	12054652

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11869073	chr17:69480672 - 69480672(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs12945375		chr17:69473307 - 69473307(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17q23-q24	chr17:59500000-72900000	1 (0/1/0)
17q11-25	chr17:25100000-83257441	1 (1/0/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:69414698..69543331 View in gBrowse