Gene Report

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Basic Info

Approved Symbol	ACOXL
Symbol Alias	FLJ11042
Approved Name	acyl-CoA oxidase-like
Previous Name	acyl-Coenzyme A oxidase-like
Location	2q13
Position	chr2:110732573-111118222, 1
External Links	HGNC: 25621 Entrez Gene: 55289 Ensembl: ENSG00000153093 UCSC: uc010yxk.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs729386, rs1439287	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study
Xu, W., 2014	SNP: rs17549841	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003997	acyl-CoA oxidase activity	molecular function	IEA	1
GO:0005575	cellular_component	cellular component	ND	19
GO:0006635	fatty acid beta-oxidation	biological process	IEA	3
GO:0003674	molecular_function	molecular function	ND	24
GO:0005777	peroxisome	cellular component	IEA	5
GO:0003995	acyl-CoA dehydrogenase activity	molecular function	IEA	1
GO:0008150	biological_process	biological process	ND	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 19)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs729386	chr2:110948161 - 110948161(1)	intron_variant	1(0/1/0)
rs17549841	chr2:111068812 - 111068812(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs4849303	chr2:110970905 - 110970905(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs1439287	chr2:111114320 - 111114320(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs13015135	chr2:111084442 - 111084442(1)	intron_variant; NMD_transcript_variant
rs13023650	chr2:111073031 - 111073031(1)	intron_variant; NMD_transcript_variant
rs2118908	chr2:111067015 - 111067015(1)	intron_variant; NMD_transcript_variant
rs1905358	chr2:110966253 - 110966253(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs1905357	chr2:110966042 - 110966042(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs4849301	chr2:110965891 - 110965891(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs13386443	chr2:110964541 - 110964541(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs1017866	chr2:110973407 - 110973407(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs1126260	chr2:110972722 - 110972722(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs3789103	chr2:110966762 - 110966762(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs13013329	chr2:111059463 - 111059463(1)	intron_variant; NMD_transcript_variant
rs2118906	chr2:111066085 - 111066085(1)	intron_variant; NMD_transcript_variant
rs13024581	chr2:111066258 - 111066258(1)	intron_variant; NMD_transcript_variant
rs13032068	chr2:111065460 - 111065460(1)	intron_variant; NMD_transcript_variant
rs2118905	chr2:111066072 - 111066072(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
2p13	chr2:108700000-112200000	2 (2/0/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:110732573..111118222 View in gBrowse