Gene Report

Basic Info
Approved Symbol PPP2R2C
Symbol Alias PR52, IMYPNO, MGC33570, PR55G
Approved Name protein phosphatase 2, regulatory subunit B, gamma
Previous Name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform, "protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform"
Name Alias PP2A subunit B isoform gamma
Location 4p16.1
Position chr4:6320578-6563600, -1
External Links HGNC: 9306
Entrez Gene: 5522
Ensembl: ENSG00000074211
UCSC: uc011bwd.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Borsotto, M., 2007 Haplotype: PPP2R2C_Intron1d_99-24169/139 - PPP2R2C_Intron4_24-247/216((99-24169/139)-(24-247/216)), PPP2R2C_Intron5_24-257/320 - PPP2R2C_Intron5_99-24175/218((24-257/320)-(99-24175/218))
Other variant: PPP2R2C_Intron4_24-247/216, PPP2R2C_Intron5_24-257/320, PPP2R2C_Intron1d_99-24169/139, PPP2R2C_Intron5_99-24175/218
Single nucleotide polymorphisms and risk haplotypes for the PPP2R2C gene are associated to BD in two different populations. The PP2A-Bgamma subunit significantly increases the current generated by KCNQ2wt, a channel normally inhibited by phosphorylation. Positive Comment on Study
Xu, W., 2014 SNP: rs4688994, rs4689410 We also see suggestive association at rs4689410, within the PPP2R2C gene on 4p16.1 (p = 5.96E-6), which was previously reported to be associated to bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 5)

GO terms by PBA (count: 0)

GO terms by database search (count: 5)

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 5)

Literature-origin SNPs (count: 2)

LD-proxies (count: 3)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:6320578..6563600 View in gBrowse
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