Gene Report

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Basic Info

Approved Symbol	PPP2R2A
Symbol Alias	PR52A, PR55A, B55A
Approved Name	protein phosphatase 2, regulatory subunit B, alpha
Previous Name	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform, "protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform"
Name Alias	PP2A subunit B isoform alpha
Location	8p21.2
Position	chr8:26291491-26372680, 1
External Links	HGNC: 9304 Entrez Gene: 5520 Ensembl: ENSG00000221914
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs7005099	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007084	mitotic nuclear envelope reassembly	biological process	TAS	1
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological process	TAS	3
GO:0010467	gene expression	biological process	TAS	41
GO:0043278	response to morphine	biological process	IEA	9
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0005515	protein binding	molecular function	IPI[15761952]	563
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0050790	regulation of catalytic activity	biological process	IEA; TAS[1849734]	11
GO:0000159	protein phosphatase type 2A complex	cellular component	IDA[17245430]	5
GO:0007165	signal transduction	biological process	IEA	136
GO:0006470	protein dephosphorylation	biological process	IDA[1849734]	10
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	TAS[1849734]	5
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0004722	protein serine/threonine phosphatase activity	molecular function	IDA[1849734]; TAS	4
GO:0005829	cytosol	cellular component	TAS	223

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in BDgene
hsa04530	Tight junction	18
hsa04730	Long-term depression	15
hsa04350	TGF-beta signaling pathway	10

ID	Name	No. of Genes in BDgene	Brief Description
hsa04310	Wnt signaling pathway	20

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP2R2A	CHEK2	NO	in vitro;in vivo;yeast 2-hybrid	15380617
PPP2R2A	PPP2R1B	YES	in vitro;in vivo	1328247 , 17540176
PPP2R2A	TGFBR1	NO	in vitro;in vivo	9774674
PPP2R2A	NDRG1	NO	in vivo	17220478
PPP2R2A	GRIN2D	YES	in vivo	10862698
PPP2R2A	PPP2CA	NO	in vitro	1328247
PPP2R2A	STRN3	NO	in vivo	10681496
PPP2R2A	PPP2R1A	NO	in vivo	17540176
PPP2R2A	GRIN1	YES	in vivo	10862698

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7005099	chr8:26302499 - 26302499(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs17055141	chr8:26341231 - 26341231(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3808574	chr8:26339107 - 26339107(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs9644113	chr8:26337670 - 26337670(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs1821391	chr8:26314664 - 26314664(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs6988876	chr8:26294208 - 26294208(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr8:26291491..26372680 View in gBrowse