Gene Report

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Basic Info

Approved Symbol	KIF13B
Symbol Alias	GAKIN, KIAA0639
Approved Name	kinesin family member 13B
Location	8p21
Position	chr8:29067279-29263124, -1
External Links	HGNC: 14405 Entrez Gene: 23303 Ensembl: ENSG00000197892 UCSC: uc003xhh.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs1471054	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[10859302]	322
GO:0019901	protein kinase binding	molecular function	IPI[10859302]	29
GO:0005874	microtubule	cellular component	IEA	24
GO:0008152	metabolic process	biological process	IEA; NAS[10859302]	50
GO:0005871	kinesin complex	cellular component	IEA	6
GO:0071889	14-3-3 protein binding	molecular function	IDA[20194617]	7
GO:0007018	microtubule-based movement	biological process	TAS[10859302]	7
GO:0006605	protein targeting	biological process	TAS[10859302]	5
GO:0050770	regulation of axonogenesis	biological process	IDA[20194617]	7
GO:0030424	axon	cellular component	IDA[20194617]	39
GO:0042110	T cell activation	biological process	NAS[12496241]	9
GO:0005524	ATP binding	molecular function	IEA	118
GO:0003777	microtubule motor activity	molecular function	NAS[10859302]	8
GO:0007165	signal transduction	biological process	NAS[10859302]	136
GO:0005515	protein binding	molecular function	IPI[10859302]	563
GO:0008017	microtubule binding	molecular function	IEA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KIF13B	DLG4	NO	in vitro	10859302

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1471054	chr8:29211670 - 29211670(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs17059715	chr8:29156300 - 29156300(1)	intron_variant; NMD_transcript_variant
rs17059791	chr8:29209714 - 29209714(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4732915	chr8:29189543 - 29189543(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p12	chr8:29000000-36700000	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
15303102	Genes altered in major depressive disorder	Pos	KIF13B

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Region: chr8:29067279..29263124 View in gBrowse