SNP Report

Basic Info

Name	rs7256349 dbSNP Ensembl
Location	chr19:58206902 - 58206902(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.122404
Functional Annotation	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000326804, ENST00000345813, ENST00000424679, ENST00000594839, ENST00000610905, ENST00000617501) SIFT Annotation: tolerated(ENST00000326804, ENST00000345813, ENST00000424679, ENST00000594839, ENST00000610905, ENST00000617501)
Consequence to Transcript	downstream_gene_variant(ENST00000601995); missense_variant(ENST00000326804, ENST00000345813, ENST00000424679, ENST00000594839, ENST00000610905, ENST00000617501); non_coding_transcript_exon_variant(ENST00000615675, ENST00000619307, ENST00000621145); non_coding_transcript_variant(ENST00000615675, ENST00000619307, ENST00000621145); upstream_gene_variant(ENST00000595146)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Xu, W., 2014	A/G		P(unadj)-value=4.09E-05,Â OR (unadj)=1.349,Â P(adj)-value=4....... P(unadj)-value=4.09E-05,Â OR (unadj)=1.349,Â P(adj)-value=4.51E-05,Â OR (adj)=1.359 More...	Top 68 SNPs (showing suggestive association to BD: p<0.0001)...... Top 68 SNPs (showing suggestive association to BD: p<0.0001) in our combined (CAMH and IoP) GWAS. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ZNF274	zinc finger protein 274	19q13.43	2(1/1/0)

SNPs in LD with rs7256349 (count: 6) View in gBrowse (chr19:58177063..58207332 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs11672645	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs12982863	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.946[CEU]
rs2062251	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.948[CEU]
rs12975369	upstream_gene_variant	0.948[CEU]; 0.95[TSI]
rs7250280	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	0.845[CEU]; 0.901[TSI]
rs12977929		0.897[CEU]; 0.95[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)