Gene Report

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Basic Info

Approved Symbol	TBC1D22B
Previous Symbol	C6orf197
Symbol Alias	FLJ20337, dJ744I24.2
Approved Name	TBC1 domain family, member 22B
Previous Name	chromosome 6 open reading frame 197
Location	6p21.2
Position	chr6:37257772-37332970, 1
External Links	HGNC: 21602 Entrez Gene: 55633 Ensembl: ENSG00000065491 UCSC: uc003onn.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6908216	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:1902017	regulation of cilium assembly	biological process	IMP[17646400]	2
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005096	GTPase activator activity	molecular function	IEA	19

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6908216	chr6:37290037 - 37290037(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs6905400	chr6:37301788 - 37301788(1)	intron_variant
rs7773273	chr6:37287900 - 37287900(1)	intron_variant
rs11548070	chr6:37279409 - 37279409(1)	synonymous_variant
rs11970265	chr6:37257365 - 37257365(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs7740399	chr6:37319037 - 37319037(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p21	chr6:30500000-46200000	1 (0/1/0)
6p21.2	chr6:36600000-40500000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:37257772..37332970 View in gBrowse