BDgene

BD & SZ shared haplotype from cross-disorder studies

Total result: 369

Markers Haplotype Related Gene(s)/Region(s) Overlap with SZ
Statistical Results Description Result Category Reference
rs2439300 - rs2439286 - rs10095694 - rs2919390 NRG1
P-value = 0.0097 fo...... P-value = 0.0097 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs2439305 - rs2439300 - rs2439286 - rs10095694 NRG1
P-value = 0.0098 fo...... P-value = 0.0098 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs2919390 - rs6988339 NRG1
P-value = 0.0012 fo...... P-value = 0.0012 for SZ, P-value = 0.0008 for SCZ and BP More... Positive Thomson, P. A., 2007
rs2919390 - rs6988339 - rs3757930 NRG1
P-value = 0.0001 fo...... P-value = 0.0001 for SZ, P-value = 0.0001 for SCZ and BP More... the most significan...... the most significant haplotype in SCZ was also nominally significant in the BP sample; this was the only haplotype to withstand permutation analysis in this study, identifying a new region of association with both schizophrenia and the combined case group in the Scottish population More... Positive Thomson, P. A., 2007
rs2919390 - rs6988339 - rs3757930 - rs10103750 NRG1
P-value = 0.0003 fo...... P-value = 0.0003 for SZ, P-value = 0.0001 for SCZ and BP More... Positive Thomson, P. A., 2007
(HTR4_SVRSNP1) - (HTR4_SVRSNP4) C-G HTR4
Haplotype analysis:...... Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=19/18, chi square=0.03, P-value = 0.87 More... Significant associa...... Significant association was found in SZ. More... Positive Ohtsuki, T.,2002
rs553950 - rs327329 - rs7007662 NRG1
P-value = 0.0099 fo...... P-value = 0.0099 for SZ, P-value = 0.0034 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs553950 - rs327329 - rs7007662 - rs1481762 NRG1
P-value = 0.0167 fo...... P-value = 0.0167 for SZ, P-value = 0.0145 for SZ and BP combined More... Positive Thomson, P. A., 2007
D4S2281 - D4S1506 4p16.1
Two-marker associat...... Two-marker association:P-value = 0.0009 More... Significant associa...... Significant association was found in SZ. More... Positive Als, T. D.,2004
rs6988339 - rs3757930 NRG1
P-value = 0.0014 fo...... P-value = 0.0014 for SZ, P-value = 0.0004 for SCZ and BP More... Positive Thomson, P. A., 2007
D4S2923 - D4S2928 - D4S1582 4p16.1
Three-marker associ...... Three-marker association:P-value = 0.0005 More... Significant associa...... Significant association was found in SZ. More... Positive Als, T. D.,2004
rs6988339 - rs3757930 - rs10103750 NRG1
P-value = 0.002 for...... P-value = 0.002 for SZ, P-value = 0.0005 for SCZ and BP More... Positive Thomson, P. A., 2007
D4S394 - D4S2983 4p16.1
Two-marker associat...... Two-marker association:P-value = 0.0320 More... Significant associa...... Significant association was found in SZ. More... Positive Als, T. D.,2004
rs6988339 - rs3757930 - rs10103750 - rs10503932 NRG1
P-value = 0.0048 fo...... P-value = 0.0048 for SZ, P-value = 0.002 for SCZ and BP More... Positive Thomson, P. A., 2007
D4S403 - D4S3048 4p16.1
Two-marker associat...... Two-marker association:P-value = 0.0101 More... Significant associa...... Significant association was found in SZ. More... Positive Als, T. D.,2004
MDAAO4 - MDAAO5 - MDAAO6 A-C-G DAO
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.042, individual P-value = 0.045, OR=1.29 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
MDAAO4 - MDAAO5 - MDAAO6 A-C-T DAO
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.042, individual P-value = 0.903, OR=1 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
MDAAO4 - MDAAO5 - MDAAO6 C-C-G DAO
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.042, individual P-value = 0.57, OR=1.18 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
MDAAO4 - MDAAO5 - MDAAO6 C-T-T DAO
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.042, individual P-value = 0.019, OR=0.72 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
M12 - M15 - M23 - M24 T-A-C-T DAOA
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.032, individual P-value = 0.7, OR=1.07 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
M12 - M15 - M23 - M24 T-A-T-A DAOA
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.032, individual P-value = 0.093, OR=1.31 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
M12 - M15 - M23 - M24 C-G-C-T DAOA
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.032, individual P-value = 0.07, OR=1.29 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
rs7452939 - rs6903874 - rs6937506 TAAR6
Global X<sup>...... Global X<sup>2</sup>=18.49, df=3, P-value = 0.00042 More... There were signific...... There were significant global differences in haplotype frequency between schizophrenia patients compared to controls. More... Positive Pae, C. U., 2008
M12 - M15 - M23 - M24 C-G-T-A DAOA
Haplotype analysis:...... Haplotype analysis:allele, global P-value = 0.032, individual P-value = 0.00023, OR=0.57 More... Significant associa...... Significant association was found in SZ. More... Positive Schumacher, J.,2004
rs7452939 - rs6903874 - rs6937506 GCT TAAR6
X<sup>2</s...... X<sup>2</sup>=12.87, df=1, P-value = 0.0003 More... The GCT haplotype w...... The GCT haplotype was significantly over-represented in the patients with schizophrenia compared to controls. More... Positive Pae, C. U., 2008
rs16944 - (IL1RN_intron 2_VNTR) C-VNTR(A2) IL1B IL1RN
Haplotype analysis:...... Haplotype analysis:Schizophrenia v controls: chi square= 12.70, global P-value = 0.012; chi square= 9.99, individual P-value = 0.0015; OR = 2.49(95% CI: 1.33 to 4.64). More... Significant associa...... Significant association was found in SZ. More... Positive Papiol, S.,2004
rs646558 - rs2303377 C-T, C-(T/C), (C/A)-(T/C) NCAM1
C-T, C-(T/C), (C/A)...... C-T, C-(T/C), (C/A)-(T/C); chi-square P-value = <0.0001, X<sup>2</sup>=28.04, d.f.=3; chi-square P-value = <0.0001, X<sup>2</sup>=27.90, d.f.=2 for BD and SZ More... Three of the two ma...... Three of the two marker haplotypes for rs646558 and rs2303377 showed varying frequencies between schizophrenia and controls. More... Positive Atz, M. E., 2007
rs737865 - rs165599 G-G COMT
OR (95% CI)=1.27 (1...... OR (95% CI)=1.27 (1.08-1.50) of males, OR (95% CI)=1.51 (1.20-1.90) of females More... previously found to...... previously found to be associated with schizophrenia More... Positive Shifman, S., 2004
rs363387 - rs363343 - rs363272 T-A-G SLC18A2
OR=3.817 (95%CI: 1....... OR=3.817 (95%CI: 1.60-9.09) in SZ cases; OR=4.1 (95%CI: 1.83-9.21) in SZ and BD combined group; Likelihood ratio chi-squared P-value < E-06 in BD cases and in BD and SZ combined group More... The estimation of h...... The estimation of haplotype effects using the UNPHASED software showed an increased risk, compared to controls, for both bipolar disorder and/or schizophrenia in carriers of TAG haplotype More... Positive Gutierrez, B., 2007
rs737865 - rs165688 - rs165599 G-G-G COMT
OR (95% CI)=1.36 (1...... OR (95% CI)=1.36 (1.15-1.61) of males, OR (95% CI)=1.57 (1.25-1.98) of females More... previously found to...... previously found to be associated with schizophrenia More... Positive Shifman, S., 2004
rs363387 - rs363343 - rs363272 C-C-A SLC18A2
OR=2.775 (95%CI: 0....... OR=2.775 (95%CI: 0.98-7.85) in SZ cases; OR=2.336 (95%CI: 1.28-4.26) in SZ and BD combined group; Likelihood ratio chi-squared P-value < E-06 in BD cases and in BD and SZ combined group More... a trend association...... a trend association was also found for CCA combination in SZ cases, which reached significance when patients with bipolar disorder and schizophrenia were grouped together More... Positive Gutierrez, B., 2007
rs363387 - rs363343 - rs363272 T-C-A SLC18A2
Likelihood ratio c...... Likelihood ratio chi-squared P-value < E-06 in BD cases and in BD and SZ combined group More... significantly more ...... significantly more common among controls compared to patients' groups More... Positive Gutierrez, B., 2007
rs363387 - rs363343 - rs363272 C-A-G SLC18A2
Likelihood ratio c...... Likelihood ratio chi-squared P-value < E-06 in BD cases and in BD and SZ combined group More... significantly more ...... significantly more common among controls compared to patients' groups More... Positive Gutierrez, B., 2007
rs363387 - rs363420 - rs363272 SLC18A2
Global P-value <...... Global P-value < E-04 More... yielded globally si...... yielded globally significant evidence for association in SZ cases, and BD and SZ combined group More... Positive Gutierrez, B., 2007
rs363387 - rs363420 - rs363343 SLC18A2
Global P-value <...... Global P-value < E-04 More... yielded globally si...... yielded globally significant evidence for association in SZ cases, and BD and SZ combined group More... Positive Gutierrez, B., 2007
rs363387 - rs363420 - rs363343 - rs363272 SLC18A2
Global P-value <...... Global P-value < E-06 More... The result revealed...... The result revealed highly significant differences in haplotype distributions between schizophrenic patients and between BD and SZ combined group and controls More... Positive Gutierrez, B., 2007
rs363420 - rs363272 SLC18A2
Global P-value <...... Global P-value < 0.0001 in SZ cases; Global P-value < E-06 in BD and SZ combined group More... the 2-marker haplot...... the 2-marker haplotype yielded globally significant evidence for association in SZ cases and BD and SZ combined group More... Positive Gutierrez, B., 2007
rs363420 - rs363343 SLC18A2
Global P-value <...... Global P-value < E-06 More... the 2-marker haplot...... the 2-marker haplotype yielded globally significant evidence for association in SZ cases and BD and SZ combined group More... Positive Gutierrez, B., 2007
rs363420 - rs363343 - rs363272 SLC18A2
Global P-value <...... Global P-value < E-04 More... yielded globally si...... yielded globally significant evidence for association in SZ cases, and BD and SZ combined group More... Positive Gutierrez, B., 2007
rs6265 - microsatellite (GT)n A-(GT1) BDNF
For SZ, X<sup>...... For SZ, X<sup>2</sup>=29.85; P-value < 4.65E-08 (P<4.65E-07 after Bonferroni correction); OR=0.30; upper 95% CI=0.46; lower CI=-0.77 More... Association was obs...... Association was observed in SZ. More... Positive Neves-Pereira, M.,2005
rs6265 - microsatellite (GT)n G-(GT1) BDNF
For SZ, X<sup>...... For SZ, X<sup>2</sup>=8.38; P-value = 0.0038 (P=0.04 after Bonferroni correction); OR=2.18; upper 95% CI=3.71; lower CI=1.31. More... Association was obs...... Association was observed in SZ. More... Positive Neves-Pereira, M.,2005
rs1538977 - rs2492367 - rs2812393 T-T-G TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.039(all), 0.48(male), 0.1(female); individual P-value = 0.0062(all) More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Thomson, P. A.,2005(a)
rs1538977 - rs2492367 - rs2812393 - rs1322784 T-T-G-T TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.0056(all), 0.84(male), 0.032(female); individual P-value = 0.0075(all) More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Thomson, P. A.,2005(a)
rs1954175 - rs1538977 - rs2492367 - rs2812393 A-C-C-G TSNAX DISC1
Global association ...... Global association test:for SCZ, individual P-value = 0.00048(male) More... Significant associa...... Significant association was found in individual P-value. More... Positive Thomson, P. A.,2005(a)
478B14-848 - 420M9-1395 - SNP8NRG221533 5-7-2 NRG1
Haplotype analysis:...... Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual P-value = 0.739015 More... Significant associa...... Significant association was found in global P-value. More... Positive Voineskos, D.,2009
rs1954175 - rs1538977 - rs2492367 - rs2812393 G-T-T-G TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.0064(all), 0.0046(male), 0.31(female); individual P-value = 0.005(all) More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Thomson, P. A.,2005(a)
478B14-848 - 420M9-1395 - SNP8NRG221533 6-4-1 NRG1
Haplotype analysis:...... Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual P-value = 0.000581 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Voineskos, D.,2009
rs2492367 - rs2812393 - rs1322784 C-C-C TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.0079(all), 0.32(male), 0.021(female); individual P-value = 0.0044(all) More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Thomson, P. A.,2005(a)
478B14-848 - 420M9-1395 - SNP8NRG221533 6-4-2 NRG1
Haplotype analysis:...... Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual P-value = 0.155978 More... Significant associa...... Significant association was found in global P-value. More... Positive Voineskos, D.,2009
rs2492367 - rs2812393 - rs1322784 - rs2759346 TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.043(all), 0.24(male), 0.0074(female); More... Significant associa...... Significant association was found in global P-value. More... Positive Thomson, P. A.,2005(a)
rs2812393 - rs1322784 C-C TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.0044(all), 0.21(male), 0.018(female); individual P-value = 0.0036(all) More... Significant associa...... Significant association was found in global P-value. More... Positive Thomson, P. A.,2005(a)
rs10939038 - rs3756207 PI4K2B
haplotype analysis:...... haplotype analysis:global P-value = 0.005, permuted global P-value = 0.039, SE:0.006 in the schizophrenia sample More... Schizophrenia showe...... Schizophrenia showed association with a two-marker haplotype in schizophrenia but not bipolar disorder. More... Positive Houlihan, L.M.,2009
rs17408391 - rs10939038 PI4K2B
haplotype analysis:...... haplotype analysis:global P-value = 0.005, permuted global P-value = 0.039, SE:0.006 in the schizophrenia sample More... Schizophrenia showe...... Schizophrenia showed association with a two-marker haplotype in schizophrenia but not bipolar disorder. More... Positive Houlihan, L.M.,2009
rs988748 - BDNF_(GT)n - rs6265 C-166bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.134 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs988748 - BDNF_(GT)n - rs6265 C-168bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.232 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs988748 - BDNF_(GT)n - rs6265 C-170bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.944 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs138820 - rs4468 CC BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.0027 calculated using PLINK. More... 'Risk'' haplotypes ...... 'Risk'' haplotypes over-represented among patients with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 C-172bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.821 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs138820 - rs4468 TT BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.041 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 C-174bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.0033 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Schumacher, J.,2005
rs138820 - rs4468 - rs138841 CCA BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.0074 calculated using PLINK. More... 'Risk'' haplotypes ...... 'Risk'' haplotypes over-represented among patients with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 G-170bp-A BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.037 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Schumacher, J.,2005
rs138820 - rs4468 - rs138841 TTC BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.044 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 G-174bp-A BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.0024 More... Significant associa...... Significant association was found in both global P-value and individual P-value. More... Positive Schumacher, J.,2005
rs138841 - rs138855 CG BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.017 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 G-174bp-G BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.067 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs138841 - rs138855 - rs138864 CGG BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.0081 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs988748 - BDNF_(GT)n - rs6265 G-176bp-A BDNF
Haplotypic associat...... Haplotypic association:in Bonn sample, for Schizophrenia, global P-value = 0.016, Bonferroni-Corrected P-value = 0.192, individual P-value = 0.627 More... Significant associa...... Significant association was found in global P-value. More... Positive Schumacher, J.,2005
rs138864 - rs2239848 GG BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.048 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs4468 rs138841 CA BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.0073 calculated using PLINK. More... 'Risk'' haplotypes ...... 'Risk'' haplotypes over-represented among patients with SZ More... Positive Nyegaard, M., 2010
rs4468 rs138841 TC BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.043 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs4468 - rs138841 - rs138855 TCG BRD1
Empirical haplotype...... Empirical haplotype-specific P-value = 0.042 calculated using PLINK. More... 'Protective'' haplo...... 'Protective'' haplotypes over-represented among controls with SZ More... Positive Nyegaard, M., 2010
rs1130233 - rs3730358 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0247 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs1130233 - rs3730358 - rs1130214 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0021 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs1130233 - rs3730358 - rs1130214 - rs3803300 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0018 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs2494732 - rs1130233 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0394 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs2494732 - rs1130233 - rs3730358 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0147 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs2494732 - rs1130233 - rs3730358 - rs1130214 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.000211 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs2494732 - rs1130233 - rs3730358 - rs1130214 - rs3803300 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.000593 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs11736084 - rs1282 - rs17844778 - rs9685931 T-C-C-G GPR78
Global test P-value...... Global test P-value (permuted P-value, s.e.)=0.015 (0.044, 0.002), Individual test P-value (permuted P-value, s.e.)=0.003 (0.048, 0.002), OR (95% CI)=0.547 (0.367-0.815) in all female affected More... No haplotype tested...... No haplotype tested by either the global or individual test maintained its significance after permutation analysis. However, the global test P-values of two related haplotypes remained significant in both the BPAD females and all affected females. More... Positive Underwood, S. L., 2006
rs11736084 - rs1282 - rs17844778 - rs9685931 - rs9799720 T-C-C-G-C GPR78
Global test P-value...... Global test P-value (permuted P-value, s.e.)=0.017 (0.033, 0.002), Individual test P-value (permuted P-value, s.e.)=0.004 (0.070, 0.003), OR (95% CI)=0.562 (0.375-0.842) in all female affected More... No haplotype tested...... No haplotype tested by either the global or individual test maintained its significance after permutation analysis. However, the global test P-values of two related haplotypes remained significant in both the BPAD females and all affected females. More... Positive Underwood, S. L., 2006
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C T-C-C GRIN2B
P-value = 0.97519, ...... P-value = 0.97519, Z=-0.031 in schizophrenia family sample; P-value = 0.01 in schizophrenia case-controls sample More... Haplotype analyses ...... Haplotype analyses on the schizophrenia case-control sample also showed significant elevation in the frequency of haplotype G-C-T in schizophrenia, and T-C-C in controls. The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Positive Martucci, L., 2006
rs2498804 - rs2494732 - rs1130233 - rs3730358 - rs1130214 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0048 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs2498804 - rs2494732 - rs1130233 - rs3730358 - rs1130214 - rs3803300 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0026 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs3730358 - rs1130214 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0013 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
rs3730358 - rs1130214 - rs3803300 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0035 More... Significant associa...... Significant association was found in SZ. More... Positive Karege, F.,2010
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C G-C-T GRIN2B
P-value = 0.995395,...... P-value = 0.995395, Z=0.006 in schizophrenia family sample; P-value = 0.008 in schizophrenia case-controls sample More... Haplotype analyses ...... Haplotype analyses on the schizophrenia case-control sample also showed significant elevation in the frequency of haplotype G-C-T in schizophrenia, and T-C-C in controls. The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Positive Martucci, L., 2006
D22S279 - rs909669 ADSL
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0805, CLUMP T4 P-value = 0.0501 in BPD and SZ, CLUMP T1 P-value = 0.0447, CLUMP T4 P-value = 0.008 in SZ; Empirical overall P-value = 0.049 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
D22S279 - rs133068 - rs133069 - rs133070 - rs133073 7-C-C-A-T MCHR1
CLUMP P-value = 0.0...... CLUMP P-value = 0.0013 in SZ, P-value = 0.0139 in BPD and SZ; risk haplotype More... Positive Severinsen, J. E., 2006 (a)
D22S279 - rs133068 - rs133069 - rs133070 - rs133073 6/7-C-C-A-T MCHR1
CLUMP P-value = 0.0...... CLUMP P-value = 0.0013 in SZ, P-value = 0.0005 in BPD and SZ; risk haplotype More... Positive Severinsen, J. E., 2006 (a)
rs133068 - D22S279 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.1818, CLUMP T4 P-value = 0.127 in BPD and SZ, CLUMP T1 P-value = 0.0542, CLUMP T4 P-value = 0.0476 in SZ; Empirical overall P-value = 0.1821 in BPD and SZ, Empirical overall P-value = 0.0054 in SZ More... Positive Severinsen, J. E., 2006 (a)
rs133069 - rs133068 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0716, CLUMP T4 P-value = 0.1107 in BPD and SZ, CLUMP T1 P-value = 0.0469, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.1791 in BPD and SZ, Empirical overall P-value = 0.1238 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs133069 - rs133068 - D22S279 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.2017, CLUMP T4 P-value = 0.2023 in BPD and SZ, CLUMP T1 P-value = 0.187, CLUMP T4 P-value = 0.1727 in SZ; Empirical overall P-value = 0.3066 in BPD and SZ, Empirical overall P-value = 0.0005 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs133069 - rs133070 A-G MCHR1
CLUMP P-value = 0.3...... CLUMP P-value = 0.3279 in SZ, P-value = 0.0364 in BPD and SZ; protective haplotype More... The same specific 2...... The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... Positive Severinsen, J. E., 2006 (a)
rs133070 - rs133069 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0145, CLUMP T4 P-value = 0.0828 in BPD and SZ, CLUMP T1 P-value = 0.3299, CLUMP T4 P-value = 0.3299 in SZ; Empirical overall P-value = 0.4592 in BPD and SZ, Empirical overall P-value = 0.0618 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs1503491 - rs553950 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.024 for Scottish 1, P-value = 0.87 for Scottish 2, P-value = 0.096 for merged Scottish More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs1503491 - rs553950 - rs327329 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.00032 for Scottish 1, P-value = 0.61 for Scottish 2, P-value = 0.028 for merged Scottish More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs133070 - rs133069 - rs133068 - D22S279 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0064, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0426, CLUMP T4 P-value = 0.0367 in SZ; Empirical overall P-value = 0.3363 in BPD and SZ, Empirical overall P-value = 0.0053 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs2919390 - rs6988339 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.0012 for Scottish 1, P-value = 0.31 for German More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs133070 - rs133073 A-C MCHR1
CLUMP P-value = 1 i...... CLUMP P-value = 1 in SZ, P-value = 0.0234 in BPD and SZ; risk haplotype More... The same specific 2...... The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... Positive Severinsen, J. E., 2006 (a)
rs2919390 - rs6988339 - rs3757930 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.00014 for Scottish 1, P-value = 0.17 for German More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs133070 - rs133073 G-C MCHR1
CLUMP P-value = 0.3...... CLUMP P-value = 0.3286 in SZ, P-value = 0.0183 in BPD and SZ; protective haplotype More... The same specific 2...... The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... Positive Severinsen, J. E., 2006 (a)
rs553950 - rs327329 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.0085 for Scottish 1, P-value = 0.68 for Scottish 2, P-value = 0.074 for merged Scottish More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs133073 - rs133070 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.004, CLUMP T4 P-value = 0.0188 in BPD and SZ, CLUMP T1 P-value = 0.5104, CLUMP T4 P-value = 0.5104 in SZ; Empirical overall P-value = 0.0262 in BPD and SZ, Empirical overall P-value = 0.1879 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs6988339 - rs3757930 NRG1
Haplotypic associat...... Haplotypic association:P-value = 0.0014 for Scottish 1, P-value = 0.48 for Scottish 2, P-value = 0.26 for German, P-value = 0.0037 for merged Scottish, P-value = 0.098 for merged all More... Significant associa...... Significant association was found in SZ. More... Positive Walker, R. M.,2010
rs133073 - rs133070 - rs133069 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0268, CLUMP T4 P-value = 0.0626 in BPD and SZ, CLUMP T1 P-value = 0.3269, CLUMP T4 P-value = 0.3269 in SZ; Empirical overall P-value = 0.0155 in BPD and SZ, Empirical overall P-value = 0.0148 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs133073 - rs133070 - rs133069 - rs133068 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0479, CLUMP T4 P-value = 0.1278 in BPD and SZ, CLUMP T1 P-value = 0.4486, CLUMP T4 P-value = 0.4486 in SZ; Empirical overall P-value = 0.0184 in BPD and SZ, Empirical overall P-value = 0.0135 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs133068 - D22S279 - rs909669 MCHR1 ADSL
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.099, CLUMP T4 P-value = 0.0353 in SZ; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.0015 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs133069 - rs133068 - D22S279 - rs909669 MCHR1 ADSL
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.1481, CLUMP T4 P-value = 0.0495 in SZ; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.0012 in SZ More... Similarly, comparin...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... Positive Severinsen, J. E., 2006 (a)
rs1170099 - rs9566940 G-T DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.0002, permutated P-value = 0.002 for SCZ More... Significant associa...... Significant association was observed in SZ. More... Positive Zeng, Z.,2011
rs133070 - rs133069 - rs133068 - D22S279 - rs909669 MCHR1 ADSL
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.0156, CLUMP T4 P-value = 0.0054 in SZ; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.0497 in SZ More... When comparing cont...... When comparing controls to SZ unequal haplotype distribution was observed for 2-, 3-, 4-, and 5-marker haplotypes spanning all four SNPs in GPR24 in addition to rs909669 in ADSL with a 5- marker haplotype showing a T4 P-value of 0.0054. More... Positive Severinsen, J. E., 2006 (a)
rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-7-C-C-A MCHR1 ADSL
CLUMP P-value = 5E-...... CLUMP P-value = 5E-06 in SZ, P-value = 0.0006 in BPD and SZ; risk haplotype More... The specific 5-mark...... The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. More... Positive Severinsen, J. E., 2006 (a)
rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-6/7-C-C-A MCHR1 ADSL
CLUMP P-value = 0.0...... CLUMP P-value = 0.0002 in SZ, P-value = 7E-05 in BPD and SZ; risk haplotype More... The specific 5-mark...... The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. More... Positive Severinsen, J. E., 2006 (a)
rs9315885 - rs9532988 - rs1012053 T-A-A DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.0005, permutated P-value = 0.005 for SCZ More... Significant associa...... Significant association was observed in SZ. More... Positive Zeng, Z.,2011
rs12778366 - rs2273773 - rs4746720 - rs10997875 T-T-C-T SIRT1
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=8.19, OR=0.25, 95%CI=0.181-0.345, individual P-value = 0.00421, corrected P-value = 0.0211 for SZ More... Significant associa...... Significant association was observed in SZ. More... Positive Kishi, T.,2011(a)
rs1954787 - rs4935752 GRIK4
P-value = 0.008 bet...... P-value = 0.008 between SCZ cases and controls; P-value = 0.088 between all cases and controls More... Positive Pickard, B. S., 2006
rs1954787 - rs4935752 - rs6589846 GRIK4
P-value = 0.024 bet...... P-value = 0.024 between SCZ cases and controls; P-value = 0.287 between all cases and controls More... Positive Pickard, B. S., 2006
rs12778366 - rs2273773 - rs4746720 - rs10997875 T-T-T-T SIRT1
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=77.1, OR=1, 95%CI=1.00-1.00, individual P-value = 1.63E-17, corrected P-value = 8.15E-17 for SZ More... Significant associa...... Significant association was observed in SZ. More... Positive Kishi, T.,2011(a)
rs2156635 - rs949056 GRIK4
P-value = 0.004 bet...... P-value = 0.004 between SCZ cases and controls; P-value = 0.027 between all cases and controls More... Positive Pickard, B. S., 2006
rs2156635 - rs949056 - rs949054 GRIK4
P-value = 0.04 betw...... P-value = 0.04 between SCZ cases and controls; P-value = 0.129 between all cases and controls More... Positive Pickard, B. S., 2006
rs2284031 - rs909486 - rs738149 C-T-G CSF2RB
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.014(0.85) More... Significant associa...... Significant association was observed in SZ. More... Positive Chen, P.,2011
rs2284031 - rs909486 - rs738149 T-C-A CSF2RB
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.006(1.37) More... Significant associa...... Significant association was observed in SZ. More... Positive Chen, P.,2011
rs2282586 - rs1944522 GRIK4
P-value = 0.708 bet...... P-value = 0.708 between SCZ cases and controls; P-value = 0.048 between all cases and controls More... Positive Pickard, B. S., 2006
rs766288 - rs3738401 - rs2812393 - rs821616 C-G-G-T TSNAX DISC1
P-value=0.0189 for ...... P-value=0.0189 for SCZ, P-value=0.0065 for BPAD&SCZ, P-value=0.0205 for BPAD males & SCZ males More... C-G-G-T haplotype s...... C-G-G-T haplotype showed relatively lesser frequency in BPAD (P=0.028), SCZ (P=0.0189) and combined cases of BPAD or SCZ (P=0.0065) and combined males of BPAD or SCZ (P=0.0205) compared with controls. More... Positive Ram Murthy, A., 2012
rs2852217 - rs879602 - rs1954787 GRIK4
P-value = 0.03 betw...... P-value = 0.03 between SCZ cases and controls; P-value = 0.039 between all cases and controls More... Positive Pickard, B. S., 2006
rs766288 - rs3738401 - rs2812393 - rs821616 A-G-G-T TSNAX DISC1
P-value=0.0469 for ...... P-value=0.0469 for BPAD&SZ, P-value=0.0209 for BPAD females &SCZ females More... Haplotype A-G-G-T w...... Haplotype A-G-G-T was also underrepresented in combined cases of BPAD or SCZ (P=0.0469), BPAD females (P=0.0273) and pooled females of BPAD or SCZ (P=0.0209). More... Positive Ram Murthy, A., 2012
rs2852217 - rs879602 - rs1954787 - rs4935752 GRIK4
P-value = 0.006 bet...... P-value = 0.006 between SCZ cases and controls; P-value = 0.041 between all cases and controls More... Positive Pickard, B. S., 2006
rs766288 - rs821616 C-A TSNAX DISC1
P-value=0.082 for S...... P-value=0.082 for SCZ, P-value=0.019 for combined cases, P-value=0.011 for SCZ females, P-value=0.004 for combined females, P-value=0.901 for SCZ males, P-value=0.589 for combined males More... Allelic combination...... Allelic combination C-A (P=0.004) in the female cases with combined phenotype showed significant association when multiple corrections were performed for all tests within each stratified gender (combined, females, males). More... Positive Ram Murthy, A., 2012
rs766288 - rs821616 A-A TSNAX DISC1
P-value=0.42 for SC...... P-value=0.42 for SCZ, P-value=0.831 for combined cases, P-value=0.074 for SCZ females, P-value=0.022 for combined females, P-value=0.016 for SCZ males, P-value=0.028 for combined males More... Few additional comb...... Few additional combinations that were found to be significantly associated after multiple corrections (n=12) were A-T in BPAD females (P=0.012, protective combination); C-A (P=0.014, risk combination), C-A in SCZ females (P=0.011, risk combination), A-T in combined female cases (P=0.012, protective combination) and A-A in combined female cases (P=0.022, protective combination) compared with control females. However nominal significance observed in BPAD (C-A, P=0.024, risk combination), cases with the combined phenotype (C-A, P=0.019, risk combination), SCZ males (A-A, P=0.016, risk combination) and males with the combined phenotype (A-A, P=0.028, risk combination), which did not withstand the multiple corrections. More... Positive Ram Murthy, A., 2012
rs766288 - rs821616 A-T TSNAX DISC1
P-value=0.577 for S...... P-value=0.577 for SCZ, P-value=0.215 for combined cases, P-value=0.097 for SCZ females, P-value=0.012 for combined females, P-value=0.476 for SCZ males, P-value=0.606 for combined males More... Few additional comb...... Few additional combinations that were found to be significantly associated after multiple corrections (n=12) were A-T in BPAD females (P=0.012, protective combination); C-A (P=0.014, risk combination), C-A in SCZ females (P=0.011, risk combination), A-T in combined female cases (P=0.012, protective combination) and A-A in combined female cases (P=0.022, protective combination) compared with control females. However nominal significance observed in BPAD (C-A, P=0.024, risk combination), cases with the combined phenotype (C-A, P=0.019, risk combination), SCZ males (A-A, P=0.016, risk combination) and males with the combined phenotype (A-A, P=0.028, risk combination), which did not withstand the multiple corrections. More... Positive Ram Murthy, A., 2012
rs766288 - rs2812393 C-C TSNAX DISC1
P-value=0.099 for S...... P-value=0.099 for SCZ, P-value=0.016 for combined cases, P-value=0.011 for SCZ females, P-value=0.001 for combined females, P-value=0.993 for SCZ males, P-value=0.703 for combined males More... Analyses of these t...... Analyses of these two SNPs showed significant associations with allelic combination C-C (P=0.009) in the BPAD phenotype when multiple corrections were performed for all tests within each stratified gender (combined, females, males). More... Positive Ram Murthy, A., 2012
rs766288 - rs2812393 A-G TSNAX DISC1
P-value=0.62 for SC...... P-value=0.62 for SCZ, P-value=0.551 for combined cases, P-value=0.016 for SCZ females, P-value=0.013 for combined females, P-value=0.174 for SCZ males, P-value=0.212 for combined males More... Other combinations ...... Other combinations in BPAD females (C-C, P=0.003, risk combination) and SCZ females (C-C, P=0.011, risk combination; A-G, P=0.016, protective combination), combined female cases (A-G, P=0.013, protective combination; C-C, P=0.001, risk combination) were found to be significantly associated after FDR corrections. More... Positive Ram Murthy, A., 2012
rs2812393 - rs821616 G-T DISC1
P-value=0 for SCZ, ...... P-value=0 for SCZ, P-value=0.001 for combined cases, P-value=0.007 for SCZ females, P-value=0.005 for combined females, P-value=0.02 for SCZ males, P-value=0.039 for combined males More... Allelic combination...... Allelic combinations of G-T in SCZ (P=0), combined cases of BPAD or SCZ (P=0.001), SCZ females (P=0.007) and combined females (P=0.005) were observed to be protective combination of alleles. These combinations survived multiple corrections. In addition allelic combinations of G-T showed nominal significance, but did not withstand FDR corrections. More... Positive Ram Murthy, A., 2012
rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735 A-A-G-G-A-A ST8SIA2
P-value = 0.004, X&...... P-value = 0.004, X<sup>2</sup>=8.41, OR (95% CI)=1.82 (1.2-2.74) in Aus SZ More... We found that the s...... We found that the specific AAGGAA risk haplotype was significantly over-represented in schizophrenia cases compared to controls when a conditional analysis was performed. More... Positive McAuley, E. Z., 2012
rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735 G-C-A-A-C-C ST8SIA2
P-value = 0.021, X&...... P-value = 0.021, X<sup>2</sup>=5.30, OR (95% CI)=0.515 (0.29-0.92) in Aus SZ More... the protective hapl...... the protective haplotype was over-represented in controls on conditional haplotype analysis More... Positive McAuley, E. Z., 2012
rs4935752 - rs6589846 GRIK4
P-value = 0.005 bet...... P-value = 0.005 between SCZ cases and controls; P-value = 0.103 between all cases and controls More... These positionally ...... These positionally bi-partite findings were further supported by a sliding window global analysis of haplotypes of lengths two to four, such that distinct clusters of significant P-values were observed in schizophrenia (best global haplotype, SNPs 15 and 16; P = 0.005). More... Positive Pickard, B. S., 2006
rs4935752 - rs6589846 - rs4430518 GRIK4
P-value = 0.015 bet...... P-value = 0.015 between SCZ cases and controls; P-value = 0.16 between all cases and controls More... Positive Pickard, B. S., 2006
rs4935752 - rs6589846 - rs4430518 - rs433110 GRIK4
P-value = 0.016 bet...... P-value = 0.016 between SCZ cases and controls; P-value = 0.128 between all cases and controls More... Positive Pickard, B. S., 2006
rs6589846 - rs4430518 GRIK4
P-value = 0.007 bet...... P-value = 0.007 between SCZ cases and controls; P-value = 0.115 between all cases and controls More... Positive Pickard, B. S., 2006
rs7111184 - rs2156635 - rs949056 GRIK4
P-value = 0.045 bet...... P-value = 0.045 between SCZ cases and controls; P-value = 0.173 between all cases and controls More... Positive Pickard, B. S., 2006
rs879602 - rs1954787 - rs4935752 - rs6589846 GRIK4
P-value = 0.028 bet...... P-value = 0.028 between SCZ cases and controls; P-value = 0.176 between all cases and controls More... Positive Pickard, B. S., 2006
rs948028 - rs2852217 - rs879602 - rs1954787 GRIK4
P-value = 0.043 bet...... P-value = 0.043 between SCZ cases and controls; P-value = 0.005 between all cases and controls More... Positive Pickard, B. S., 2006
D22S922 - D22S1169 - rs4468 2-3-C BRD1
P-value = 0.0120 in...... P-value = 0.0120 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138855 - rs138880 G-C BRD1
P-value = 1E-06 in ...... P-value = 1E-06 in BD, P-value = 2.8E-07 in BD and SZ More... Removing the rare m...... Removing the rare middle SNP rs2239848 from the analysis resulted in a reduced 2-marker 'risk' haplotype (G-C) showing a frequency of ~10% in cases versus ~1% in controls. More... Positive Severinsen, J. E., 2006 (b)
rs138855 - rs138880 - rs138881 G-C-A BRD1
P-value = 2E-04 in ...... P-value = 2E-04 in BD, P-value = 4E-05 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138855 - rs138880 - rs138881 G-C-G BRD1
P-value = 0.0015 in...... P-value = 0.0015 in BD, P-value = 0.0022 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138855 - rs2239848 - rs138880 G-G-C BRD1
P-value = 4E-06 in ...... P-value = 4E-06 in BD, P-value = 1E-06 in BD and SZ More... A 3-marker core hap...... A 3-marker core haplotype spanning BRD1 SNPs rs138855, rs2239848 and rs138880 had a frequency of around 9% in cases against only 1% in controls, producing a haplotype specific P-value of order 1E-06. More... Positive Severinsen, J. E., 2006 (b)
rs138855 - rs2239848 - rs138880 - rs138881 G-G-C-A BRD1
P-value = 2E-04 in ...... P-value = 2E-04 in BD, P-value = 2E-05 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138880 - rs2239848 BRD1
P-value = 0.161 in ...... P-value = 0.161 in SZ, P-value = 0.0381 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138880 - rs2239848 - rs138855 BRD1
P-value = 0.00001 i...... P-value = 0.00001 in SZ, P-value = 0.00005 in BD and SZ More... Highly significant ...... Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. More... Positive Severinsen, J. E., 2006 (b)
rs138880 - rs2239848 - rs138855 - rs4468 BRD1
P-value = 0.0203 in...... P-value = 0.0203 in SZ, P-value = 0.0607 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs138881 - rs138880 - rs2239848 - rs138855 BRD1
P-value = 0.0002 in...... P-value = 0.0002 in SZ, P-value = 0.0003 in BD and SZ More... Highly significant ...... Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. More... Positive Severinsen, J. E., 2006 (b)
rs2239848 - rs138855 - rs4468 BRD1
P-value = 0.047 in ...... P-value = 0.047 in SZ, P-value = 0.2092 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs2239848 - rs138855 - rs4468 - D22S1169 BRD1
P-value = 0.0095 in...... P-value = 0.0095 in SZ, P-value = 0.263 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs4468 - D22S1169 BRD1
P-value = 0.0184 in...... P-value = 0.0184 in SZ, P-value = 0.3317 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs4468 - D22S1169 - D22S922 - rs132234 BRD1 FAM19A5
P-value = 0.0228 in...... P-value = 0.0228 in SZ, P-value = 0.1853 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
D22S1169 - D22S922 - rs132234 FAM19A5
P-value = 0.0426 in...... P-value = 0.0426 in SZ, P-value = 0.4635 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
D22S1169 - D22S922
P-value = 0.0194 in...... P-value = 0.0194 in SZ, P-value = 0.427 in BD and SZ More... Positive Severinsen, J. E., 2006 (b)
rs10095694 - rs2919390 NRG1
P-value = 0.002 for...... P-value = 0.002 for SZ, P-value = 0.0016 for SCZ and BP More... Positive Thomson, P. A., 2007
rs10095694 - rs2919390 - rs6988339 NRG1
P-value = 0.0002 fo...... P-value = 0.0002 for SZ, P-value = 0.0002 for SCZ and BP More... Positive Thomson, P. A., 2007
rs10095694 - rs2919390 - rs6988339 - rs3757930 NRG1
P-value = 0.0003 fo...... P-value = 0.0003 for SZ, P-value = 0.0003 for SCZ and BP More... Positive Thomson, P. A., 2007
rs10113797 - rs10954811 - rs1503491 - rs553950 NRG1
P-value = 0.0071 fo...... P-value = 0.0071 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs10954811 - rs1503491 - rs553950 NRG1
P-value = 0.0146 fo...... P-value = 0.0146 for SZ, P-value = 0.0078 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs10954811 - rs1503491 - rs553950 - rs327329 NRG1
P-value = 0.0003 fo...... P-value = 0.0003 for SZ, P-value = 0.0018 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs1503491 - rs553950 NRG1
P-value = 0.0243 fo...... P-value = 0.0243 for SZ, P-value = 0.0117 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs1503491 - rs553950 - rs327329 T-T-T NRG1
P-value = 0.0003 fo...... P-value = 0.0003 for SZ, P-value = 0.0017 for SZ and BP combined More... 3-SNP haplotype is ...... 3-SNP haplotype is nominally significant with SCZ alone, but it does not withstand permutation analysis More... Positive Thomson, P. A., 2007
rs1503491 - rs553950 - rs327329 - rs7007662 NRG1
P-value = 0.0007 fo...... P-value = 0.0007 for SZ, P-value = 0.0029 for SZ and BP combined More... Positive Thomson, P. A., 2007
rs2439286 - rs10095694 NRG1
P-value = 0.0037 fo...... P-value = 0.0037 for SZ, P-value = 0.0028 for SCZ and BP More... Positive Thomson, P. A., 2007
rs2439286 - rs10095694 - rs2919390 NRG1
P-value = 0.0017 fo...... P-value = 0.0017 for SCZ and BP More... Positive Thomson, P. A., 2007
rs2439286 - rs10095694 - rs2919390 - rs6988339 NRG1
P-value = 0.0003 fo...... P-value = 0.0003 for SZ, P-value = 0.0002 for SCZ and BP More... Positive Thomson, P. A., 2007
(RGS4_SNP1) - (RGS4_SNP4) - (RGS4_SNP7) - (RGS4_SNP18) RGS4
Estimated haplotype...... Estimated haplotype frequencies among cases and unrelated controls:P>0.05 More... No significant asso...... No significant association was observed in SZ. More... Negative Chowdari, K. V.,2002
(HTR4_SVRSNP1) - (HTR4_SVRSNP4) C-A HTR4
Haplotype analysis:...... Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=16/20, chi square=0.4, P-value = 0.5 More... No significant asso...... No significant association was observed in SZ. More... Negative Ohtsuki, T.,2002
(HTR4_SVRSNP1) - (HTR4_SVRSNP4) T-G HTR4
Haplotype analysis:...... Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=25/21, chi square=0.35, P-value = 0.56 More... No significant asso...... No significant association was observed in SZ. More... Negative Ohtsuki, T.,2002
(GPR50_502-505) - rs13440581 GPR50
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.18(all), 0.3(female) More... No association was ...... No association was observed. More... Negative Thomson, P. A.,2005(b)
rs2072621 - (GPR50_502-505) GPR50
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.16(all), 0.3(female) More... No association was ...... No association was observed. More... Negative Thomson, P. A.,2005(b)
rs2072621 - (GPR50_502-505) - rs13440581 GPR50
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.078(all), 0.068(female) More... No association was ...... No association was observed. More... Negative Thomson, P. A.,2005(b)
rs2072621 - rs13440581 GPR50
Haplotypic associat...... Haplotypic association:, for SCZ, P-value = 0.63(all), 0.76(female) More... No association was ...... No association was observed. More... Negative Thomson, P. A.,2005(b)
rs2271309 - rs12601930 - rs907094 - rs3764352 PPP1R1B
Global P-value = 0....... Global P-value = 0.697 More... Haplotypic analyses...... Haplotypic analyses of four SNPs in a sample set showed that PPP1R1B polymorphisms were not significantly associated with schizophrenia. More... Negative Yoshimi, A., 2008
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 PAWR
Global P-value = 0....... Global P-value = 0.142 for SZ More... Negative Kishi, T., 2008 (a)
rs960914 - rs2241802 - rs2323019 - rs352203 FZD3
Haplotypic associat...... Haplotypic association:global P-values>0.2 More... No significant ass...... No significant association was found . More... Negative Hashimoto, R.,2005(b)
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGTA PAWR
P-value = 0.572 for...... P-value = 0.572 for SZ More... Negative Kishi, T., 2008 (a)
RGS4_SNP1 - RGS4_SNP4 - RGS4_SNP17 - RGS4_SNP18 G-G-G-G RGS4
Haplotypic associat...... Haplotypic association:Family-based analysis:TDT:X<sup>2</sup>=2.67, P-value = 0.102 in SZ More... No significant ass...... No significant association was found . More... Negative Cordeiro, Q.,2005
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAACG PAWR
P-value = 0.078 for...... P-value = 0.078 for SZ More... Negative Kishi, T., 2008 (a)
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 ATGCA PAWR
P-value = 0.910 for...... P-value = 0.910 for SZ More... Negative Kishi, T., 2008 (a)
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGCG PAWR
P-value = 0.247 for...... P-value = 0.247 for SZ More... Negative Kishi, T., 2008 (a)
rs1954175 - rs1538977 - rs2492367 TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.19(all), 0.037(male), 0.81(female); More... No significant asso...... No significant associations were found in SZ. More... Negative Thomson, P. A.,2005(a)
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 AAGCA PAWR
P-value = 0.621 for...... P-value = 0.621 for SZ More... Negative Kishi, T., 2008 (a)
rs2492367 - rs2812393 - rs1322784 C-G-T TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value > 0.05(all) More... No significant asso...... No significant associations were found in SZ. More... Negative Thomson, P. A.,2005(a)
rs11939815 - rs11931061 - rs11133385 - rs3736544 - rs1801260 - rs3749474 CLOCK
likelihood ratio te...... likelihood ratio test:haplotype(G-A-A-G-T-T):1.total samples:Global P-value = 0.340 in SCZ 2. male samples:Global P-value = 0.464 in SCZ 3. female samples:Global P-value = 0.0362, Corrected P-value = 0.0724 in SCZ More... Only one associatio...... Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). More... Negative Kishi, T.,2009(a)
rs2812393 - rs1322784 - rs2759346 - rs6675281 TSNAX DISC1
Global association ...... Global association test:for SCZ, P-value = 0.15(all), 0.84(male), 0.04(female); More... No significant asso...... No significant associations were found in SZ. More... Negative Thomson, P. A.,2005(a)
rs2076127 - ss16339182 A-T MLC1
Haplotypic associat...... Haplotypic association:for SCZ, global P-value > 0.05, individual P-value > 0.05, odds ratio=0.95, 95%CI=0.63-1.44 More... No significant ass...... No significant association was found . More... Negative Verma, R.,2005(b)
rs2076127 - ss16339182 G-C MLC1
Haplotypic associat...... Haplotypic association:for SCZ, global P-value > 0.05, individual P-value > 0.05, odds ratio=1.2, 95%CI=0.79-1.82 More... No significant ass...... No significant association was found . More... Negative Verma, R.,2005(b)
rs2076127 - ss16339182 G-T MLC1
Haplotypic associat...... Haplotypic association:for SCZ, global P-value > 0.05, individual P-value > 0.05, odds ratio=0.98, 95%CI=0.70-1.37 More... No significant ass...... No significant association was found . More... Negative Verma, R.,2005(b)
rs1050565 - rs2020934 SLC6A4
global P-value = 0....... global P-value = 0.651 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
rs1050565 - rs2020934 - SLC6A4_5HTTVNTR SLC6A4
global P-value = 0....... global P-value = 0.376 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
rs1050565 - rs2020934 - SLC6A4_5HTTVNTR - rs3813034 SLC6A4
global P-value = 0....... global P-value = 0.715 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
rs2020934 - SLC6A4_5HTTVNTR SLC6A4
global P-value = 0....... global P-value = 0.701 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
rs2020934 - SLC6A4_5HTTVNTR - rs3813034 SLC6A4
global P-value = 0....... global P-value = 0.545 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
SLC6A4_5HTTVNTR - rs3813034 SLC6A4
global P-value = 0....... global P-value = 0.151 More... We found no associa...... We found no association with SCZ in the haplotype-wise association analysis. More... Negative Ikeda, M., 2006
PRODH1945 - PRODH1482 PRODH
Haplotypic associat...... Haplotypic association:Global P-value = 0.339(based on 100, 000 replications) for SZ. More... No significant ass...... No significant association was found . More... Negative Abou Jamra, R.,2005(a)
rs1130214 - rs3803300 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.605 More... No significant asso...... No significant association was observed in SZ. More... Negative Karege, F.,2010
PRODH2026 - PRODH1945 PRODH
Haplotypic associat...... Haplotypic association:Global P-value = 0.641(based on 100, 000 replications) for SZ. More... No significant ass...... No significant association was found . More... Negative Abou Jamra, R.,2005(a)
PRODH2026 - PRODH1945 - PRODH1482 PRODH
Haplotypic associat...... Haplotypic association:Global P-value = 0.458(based on 100, 000 replications) for SZ. More... No significant ass...... No significant association was found . More... Negative Abou Jamra, R.,2005(a)
32416574(G/A) - IVS4+1008ins(T)/del(T) SLC12A6
Association test fo...... Association test for heterogeneity, for SZ, empirical P-value = 0.2176 More... No significant asso...... No significant associations were found in SZ. More... Negative Meyer, J.,2005
32418760(G/A) - 32416574(G/A) SLC12A6
Association test fo...... Association test for heterogeneity, for SZ, empirical P-value = 0.2467 More... No significant asso...... No significant associations were found in SZ. More... Negative Meyer, J.,2005
32418760(G/A) - 32416574(G/A) - IVS4+1008ins(T)/del(T) SLC12A6
Association test fo...... Association test for heterogeneity, for SZ, empirical P-value = 0.1382 More... No significant asso...... No significant associations were found in SZ. More... Negative Meyer, J.,2005
32418760(G/A) - IVS4+1008ins(T)/del(T) SLC12A6
Association test fo...... Association test for heterogeneity, for SZ, empirical P-value = 0.0751 More... No significant asso...... No significant associations were found in SZ. More... Negative Meyer, J.,2005
GSK-3 beta_-1727A/T - GSK-3 beta_-50C/T A-C, A-T, T-C, T-T GSK3B
P-value = 0.81 for ...... P-value = 0.81 for BD, P-value = 0.54 for BD and SZ More... There was no differ...... There was no difference in the haplotype frequency combination between the patient and control groups. More... Negative Lee, K. Y., 2006 (b)
rs2498804 - rs2494732 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.0861 More... No significant asso...... No significant association was observed in SZ. More... Negative Karege, F.,2010
rs2498804 - rs2494732 - rs1130233 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.395 More... No significant asso...... No significant association was observed in SZ. More... Negative Karege, F.,2010
rs2498804 - rs2494732 - rs1130233 - rs3730358 AKT1
multi-locus associa...... multi-locus association analyses:global P-value = 0.197 More... No significant asso...... No significant association was observed in SZ. More... Negative Karege, F.,2010
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C T-A-C GRIN2B
P-value = 0.242452,...... P-value = 0.242452, Z=1.169 in schizophrenia family sample; P-value = 0.116 in schizophrenia case-controls sample More... The overall differe...... The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Negative Martucci, L., 2006
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C G-C-C GRIN2B
P-value = 0.650714,...... P-value = 0.650714, Z=-0.453 in schizophrenia family sample; P-value = 0.104 in schizophrenia case-controls sample More... The overall differe...... The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Negative Martucci, L., 2006
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C G-A-C GRIN2B
P-value = 0.324213,...... P-value = 0.324213, Z=0.986 in schizophrenia family sample; P-value = 0.013 in schizophrenia case-controls sample More... The overall differe...... The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Negative Martucci, L., 2006
GRIN2B_T200G - GRIN2B_A5806C - GRIN2B_T5988C T-C-T GRIN2B
P-value = 0.102451,...... P-value = 0.102451, Z=-1.633 in schizophrenia family sample; P-value = 0.271 in schizophrenia case-controls sample More... The overall differe...... The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005). More... Negative Martucci, L., 2006
D22S279 - rs133068 - rs133069 - rs133070 - rs133073 6-C-C-A-T MCHR1
CLUMP P-value = 1 i...... CLUMP P-value = 1 in SZ, P-value = 0.2166 in BPD and SZ; risk haplotype More... Negative Severinsen, J. E., 2006 (a)
rs133069 - rs133070 - rs133073 A-G-C MCHR1
CLUMP P-value = 0.3...... CLUMP P-value = 0.3279 in SZ, P-value = 0.0526 in BPD and SZ; protective haplotype More... The same specific 2...... The same specific 2- and 3-marker haplotypes covering rs133069 to rs133073 as seen in BPD showed P-values as low as 0.0183 in the combined sample. More... Negative Severinsen, J. E., 2006 (a)
rs133070 - rs133069 - rs133068 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0525, CLUMP T4 P-value = 0.1831 in BPD and SZ, CLUMP T1 P-value = 0.4456, CLUMP T4 P-value = 0.4456 in SZ; Empirical overall P-value = 0.5945 in BPD and SZ, Empirical overall P-value = 0.0691 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs133073 - rs133070 - rs133069 - rs133068 - D22S279 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.0063, CLUMP T4 P-value = 0.0023 in BPD and SZ, CLUMP T1 P-value = 0.0432, CLUMP T4 P-value = 0.0375 in SZ; Empirical overall P-value = 0.1747 in BPD and SZ, Empirical overall P-value = 0.0189 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs6295 - rs878567 C-C HTR1A
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.971-1.47, individual P-value = 0.0921; global P-value = 0.0935 More... No significant asso...... No significant association was observed in SZ. More... Negative Kishi, T.,2011(b)
rs6295 - rs878567 G-C HTR1A
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.971-1.47, individual P-value = 0.0921; global P-value = 0.0935 More... No significant asso...... No significant association was observed in SZ. More... Negative Kishi, T.,2011(b)
rs1170099 - rs9566940 A-C DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.364, permutated P-value = 0.993 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs1170099 - rs9566940 A-T DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.179, permutated P-value = 0.859 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs716934 - rs9566931 - rs9315897 - rs2122246 A-A-C-G DGKH
Haplotypic associat...... Haplotypic association:P-value = 1, permutated P-value = 1 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs716934 - rs9566931 - rs9315897 - rs2122246 A-A-T-G DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.623, permutated P-value = 1 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs909669 - D22S279 - rs133068 - rs133069 - rs133070 C-6-C-C-A MCHR1 ADSL
CLUMP P-value = 0.5...... CLUMP P-value = 0.5569 in SZ, P-value = 0.3176 in BPD and SZ; risk haplotype More... The specific 5-mark...... The specific 5-marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aP-value of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C-6/7-CCA were over-represented in cases with a frequency of 75% against only 22% in controls. More... Negative Severinsen, J. E., 2006 (a)
rs716934 - rs9566931 - rs9315897 - rs2122246 T-A-T-A DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.243, permutated P-value = 0.945 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs716934 - rs9566931 - rs9315897 - rs2122246 T-A-T-G DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.219, permutated P-value = 0.924 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs1573745 - rs710193 ST13
Empirical overall P...... Empirical overall P-value = 0.4429 in BPD and SZ, Empirical overall P-value = 0.1394 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs716934 - rs9566931 - rs9315897 - rs2122246 T-G-T-G DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.297, permutated P-value = 0.976 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs1573745 - rs710193 - rs133073 ST13 MCHR1
Empirical overall P...... Empirical overall P-value = 0.0632 in BPD and SZ, Empirical overall P-value = 0.2105 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs9315885 - rs9532988 - rs1012053 C-A-A DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.018, permutated P-value = 0.147 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs1573745 - rs710193 - rs133073 - rs133070 ST13 MCHR1
Empirical overall P...... Empirical overall P-value = 0.1346 in BPD and SZ, Empirical overall P-value = 0.2465 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs9315885 - rs9532988 - rs1012053 C-A-C DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.116, permutated P-value = 0.719 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 ST13 MCHR1
Empirical overall P...... Empirical overall P-value = 0.2604 in BPD and SZ, Empirical overall P-value = 0.1871 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs710193 - rs133073 ST13 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.4522, CLUMP T4 P-value = 0.4361 in BPD and SZ, CLUMP T1 P-value = 0.3844, CLUMP T4 P-value = 0.3368 in SZ; Empirical overall P-value = 0.1247 in BPD and SZ, Empirical overall P-value = 0.3269 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs9315885 - rs9532988 - rs1012053 T-G-A DGKH
Haplotypic associat...... Haplotypic association:P-value = 0.446, permutated P-value = 0.998 for SCZ More... No significant asso...... No significant association was observed in SZ. More... Negative Zeng, Z.,2011
rs710193 - rs133073 - rs133070 ST13 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.1158, CLUMP T4 P-value = 0.1697 in BPD and SZ, CLUMP T1 P-value = 0.3917, CLUMP T4 P-value = 0.5842 in SZ; Empirical overall P-value = 0.0715 in BPD and SZ, Empirical overall P-value = 0.224 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs12778366 - rs2273773 - rs4746720 - rs10997875 C-T-T-T SIRT1
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=2.02, OR=0.307, 95%CI=0.217-0.434, individual P-value = 0.155 for SZ More... No significant asso...... No significant association was observed in SZ. More... Negative Kishi, T.,2011(a)
rs710193 - rs133073 - rs133070 - rs133069 ST13 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.3957, CLUMP T4 P-value = 0.5862 in SZ; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.1069 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs12778366 - rs2273773 - rs4746720 - rs10997875 T-C-T-T SIRT1
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=0.269, OR=0.271, 95%CI=0.196-0.375, individual P-value = 0.604 for SZ More... No significant asso...... No significant association was observed in SZ. More... Negative Kishi, T.,2011(a)
rs710193 - rs133073 - rs133070 - rs133069 - rs133068 ST13 MCHR1
CLUMP T1 P-value = ...... CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.3932, CLUMP T4 P-value = 0.5852 in SZ; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.146 in SZ More... Negative Severinsen, J. E., 2006 (a)
rs12778366 - rs2273773 - rs4746720 - rs10997875 T-T-T-C SIRT1
Haplotype analysis:...... Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=0.525, OR=0.264, 95%CI=0.189-0.371, individual P-value = 0.469 for SZ More... No significant asso...... No significant association was observed in SZ. More... Negative Kishi, T.,2011(a)
rs1954787 - rs4935752 - rs6589846 - rs4430518 GRIK4
P-value = 0.068 bet...... P-value = 0.068 between SCZ cases and controls; P-value = 0.32 between all cases and controls More... Negative Pickard, B. S., 2006
rs11759115 - rs7769372 C-C MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.046 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs2000869 - rs7479743 GRIK4
P-value = 0.538 bet...... P-value = 0.538 between SCZ cases and controls; P-value = 0.448 between all cases and controls More... Negative Pickard, B. S., 2006
rs11759115 - rs7769372 T-C MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.3551 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs2000869 - rs7479743 - rs6589832 GRIK4
P-value = 0.466 bet...... P-value = 0.466 between SCZ cases and controls; P-value = 0.391 between all cases and controls More... Negative Pickard, B. S., 2006
rs11759115 - rs7769372 T-T MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.1223, individual P-value = 0.9978 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs2000869 - rs7479743 - rs6589832 - rs7925270 GRIK4
P-value = 0.365 bet...... P-value = 0.365 between SCZ cases and controls; P-value = 0.483 between all cases and controls More... Negative Pickard, B. S., 2006
rs1883901 - rs10807187 - rs9462343 A-G-G MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.0732 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs1883901 - rs10807187 - rs9462343 G-G-A MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 1 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs1883901 - rs10807187 - rs9462343 G-G-G MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.4639 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs2156635 - rs949056 - rs949054 - rs602104 GRIK4
P-value = 0.091 bet...... P-value = 0.091 between SCZ cases and controls; P-value = 0.117 between all cases and controls More... Negative Pickard, B. S., 2006
rs1883901 - rs10807187 - rs9462343 G-T-G MDGA1
Haplotype analysis:...... Haplotype analysis:for SZ, global P-value = 0.404, individual P-value = 0.9998 More... No significant asso...... No significant association was observed in SZ. More... Negative Li, J.,2011(a)
rs2187495 - rs3132780 GRIK4
P-value = 0.819 bet...... P-value = 0.819 between SCZ cases and controls; P-value = 0.495 between all cases and controls More... Negative Pickard, B. S., 2006
rs2284031 - rs909486 - rs738149 C-T-A CSF2RB
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.998(1) More... No significant asso...... No significant association was observed in SZ. More... Negative Chen, P.,2011
rs2187495 - rs3132780 - rs948028 GRIK4
P-value = 0.713 bet...... P-value = 0.713 between SCZ cases and controls; P-value = 0.508 between all cases and controls More... Negative Pickard, B. S., 2006
rs2187495 - rs3132780 - rs948028 - rs2852217 GRIK4
P-value = 0.827 bet...... P-value = 0.827 between SCZ cases and controls; P-value = 0.774 between all cases and controls More... Negative Pickard, B. S., 2006
rs2276319 - rs513548 GRIK4
P-value = 0.643 bet...... P-value = 0.643 between SCZ cases and controls; P-value = 0.472 between all cases and controls More... Negative Pickard, B. S., 2006
rs2284031 - rs909486 - rs738149 T-C-G CSF2RB
Haplotype analysis:...... Haplotype analysis:for SZ, P-value(odds ratio)=0.263(1.1) More... No significant asso...... No significant association was observed in SZ. More... Negative Chen, P.,2011
rs2276319 - rs513548 - rs2282586 GRIK4
P-value = 0.496 bet...... P-value = 0.496 between SCZ cases and controls; P-value = 0.186 between all cases and controls More... Negative Pickard, B. S., 2006
rs7090018 - rs11199993 T-G FGFR2
P-value = 0.835, Pe...... P-value = 0.835, Permutated P-value = 1.000 More... No significant asso...... No significant association was found More... Negative Wang, T.,2012
rs2276319 - rs513548 - rs2282586 - rs1944522 GRIK4
P-value = 0.781 bet...... P-value = 0.781 between SCZ cases and controls; P-value = 0.113 between all cases and controls More... Negative Pickard, B. S., 2006
rs7090018 - rs11199993 T-C FGFR2
P-value = 0.112, Pe...... P-value = 0.112, Permutated P-value = 0.698 More... No significant asso...... No significant association was found More... Negative Wang, T.,2012
rs7090018 - rs11199993 G-G FGFR2
P-value = 0.103, Pe...... P-value = 0.103, Permutated P-value = 0.664 More... No significant asso...... No significant association was found More... Negative Wang, T.,2012
rs2852217 - rs879602 GRIK4
P-value = 0.825 bet...... P-value = 0.825 between SCZ cases and controls; P-value = 0.232 between all cases and controls More... Negative Pickard, B. S., 2006
rs3132780 - rs948028 GRIK4
P-value = 0.619 bet...... P-value = 0.619 between SCZ cases and controls; P-value = 0.779 between all cases and controls More... Negative Pickard, B. S., 2006
rs3132780 - rs948028 - rs2852217 GRIK4
P-value = 0.696 bet...... P-value = 0.696 between SCZ cases and controls; P-value = 0.543 between all cases and controls More... Negative Pickard, B. S., 2006
rs766288 - rs821616 C-T TSNAX DISC1
P-value=0.093 for S...... P-value=0.093 for SCZ, P-value=0.115 for combined cases, P-value=0.307 for SCZ females, P-value=0.489 for combined females, P-value=0.177 for SCZ males, P-value=0.138 for combined males More... Negative Ram Murthy, A., 2012
rs3132780 - rs948028 - rs2852217 - rs879602 GRIK4
P-value = 0.905 bet...... P-value = 0.905 between SCZ cases and controls; P-value = 0.171 between all cases and controls More... Negative Pickard, B. S., 2006
rs3133226 - rs2187495 GRIK4
P-value = 0.98 betw...... P-value = 0.98 between SCZ cases and controls; P-value = 0.492 between all cases and controls More... Negative Pickard, B. S., 2006
rs3133226 - rs2187495 - rs3132780 GRIK4
P-value = 0.84 betw...... P-value = 0.84 between SCZ cases and controls; P-value = 0.564 between all cases and controls More... Negative Pickard, B. S., 2006
rs3133226 - rs2187495 - rs3132780 - rs948028 GRIK4
P-value = 0.767 bet...... P-value = 0.767 between SCZ cases and controls; P-value = 0.597 between all cases and controls More... Negative Pickard, B. S., 2006
rs766288 - rs2812393 C-G TSNAX DISC1
P-value=0.46 for SC...... P-value=0.46 for SCZ, P-value=0.703 for combined cases, P-value=0.626 for SCZ females, P-value=0.969 for combined females, P-value=0.639 for SCZ males, P-value=0.672 for combined males More... Negative Ram Murthy, A., 2012
rs3133855 - rs3133226 GRIK4
P-value = 0.985 bet...... P-value = 0.985 between SCZ cases and controls; P-value = 0.971 between all cases and controls More... Negative Pickard, B. S., 2006
rs766288 - rs2812393 A-C TSNAX DISC1
P-value=0.529 for S...... P-value=0.529 for SCZ, P-value=0.632 for combined cases, P-value=0.626 for SCZ females, P-value=0.216 for combined females, P-value=0.175 for SCZ males, P-value=0.099 for combined males More... Negative Ram Murthy, A., 2012
rs3133855 - rs3133226 - rs2187495 GRIK4
P-value = 0.999 bet...... P-value = 0.999 between SCZ cases and controls; P-value = 0.885 between all cases and controls More... Negative Pickard, B. S., 2006
rs2812393 - rs821616 C-A DISC1
P-value=0.236 for S...... P-value=0.236 for SCZ, P-value=0.125 for combined cases, P-value=0.078 for SCZ females, P-value=0.077 for combined females, P-value=0.931 for SCZ males, P-value=0.673 for combined males More... Negative Ram Murthy, A., 2012
rs3133855 - rs3133226 - rs2187495 - rs3132780 GRIK4
P-value = 0.965 bet...... P-value = 0.965 between SCZ cases and controls; P-value = 0.824 between all cases and controls More... Negative Pickard, B. S., 2006
rs2812393 - rs821616 G-A DISC1
P-value=0.976 for S...... P-value=0.976 for SCZ, P-value=0.806 for combined cases, P-value=0.958 for SCZ females, P-value=0.834 for combined females, P-value=0.941 for SCZ males, P-value=0.898 for combined males More... Negative Ram Murthy, A., 2012
rs4245040 - rs7928347 GRIK4
P-value = 0.364 bet...... P-value = 0.364 between SCZ cases and controls; P-value = 0.089 between all cases and controls More... Negative Pickard, B. S., 2006
rs4245040 - rs7928347 - rs2000869 GRIK4
P-value = 0.704 bet...... P-value = 0.704 between SCZ cases and controls; P-value = 0.288 between all cases and controls More... Negative Pickard, B. S., 2006
rs2812393 - rs821616 C-T DISC1
P-value=0.381 for S...... P-value=0.381 for SCZ, P-value=0.531 for combined cases, P-value=0.659 for SCZ females, P-value=0.642 for combined females, P-value=0.119 for SCZ males, P-value=0.206 for combined males More... Negative Ram Murthy, A., 2012
rs4245040 - rs7928347 - rs2000869 - rs7479743 GRIK4
P-value = 0.484 bet...... P-value = 0.484 between SCZ cases and controls; P-value = 0.221 between all cases and controls More... Negative Pickard, B. S., 2006
rs433110 - rs7111184 GRIK4
P-value = 0.149 bet...... P-value = 0.149 between SCZ cases and controls; P-value = 0.606 between all cases and controls More... Negative Pickard, B. S., 2006
rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645 T-T-A-G-T ST8SIA2
P-value = 0.129, X&...... P-value = 0.129, X<sup>2</sup>=2.30, OR (95% CI)=1.09 (0.97-1.23) in NIMH SZ More... This haplotype also...... This haplotype also showed the same direction of effect in the NIMH cases with schizophrenia compared to controls, although it did not reach statistical significance. More... Negative McAuley, E. Z., 2012
rs433110 - rs7111184 - rs2156635 GRIK4
P-value = 0.419 bet...... P-value = 0.419 between SCZ cases and controls; P-value = 0.57 between all cases and controls More... Negative Pickard, B. S., 2006
rs433110 - rs7111184 - rs2156635 - rs949056 GRIK4
P-value = 0.305 bet...... P-value = 0.305 between SCZ cases and controls; P-value = 0.707 between all cases and controls More... Negative Pickard, B. S., 2006
rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645 C-C-C-C-G ST8SIA2
P-value = 0.408, X&...... P-value = 0.408, X<sup>2</sup>=0.68, OR (95% CI)=0.938 (0.81-1.09) in NIMH SZ More... No significant asso...... No significant association was reported in this study. More... Negative McAuley, E. Z., 2012
rs4430518 - rs433110 GRIK4
P-value = 0.14 betw...... P-value = 0.14 between SCZ cases and controls; P-value = 0.769 between all cases and controls More... Negative Pickard, B. S., 2006
rs4430518 - rs433110 - rs7111184 GRIK4
P-value = 0.135 bet...... P-value = 0.135 between SCZ cases and controls; P-value = 0.855 between all cases and controls More... Negative Pickard, B. S., 2006
rs4430518 - rs433110 - rs7111184 - rs2156635 GRIK4
P-value = 0.367 bet...... P-value = 0.367 between SCZ cases and controls; P-value = 0.758 between all cases and controls More... Negative Pickard, B. S., 2006
rs7171233 - rs7165988 - rs2172835 T-C-C C15orf53
CHI SQUARE = 1.077,...... CHI SQUARE = 1.077,P-value = 0.2993 More... No significant asso...... No significant association was observed. More... Negative Kranz, T. M.,2012
rs7171233 - rs7165988 - rs2172835 A-G-T C15orf53
CHI SQUARE = 0.206,...... CHI SQUARE = 0.206,P-value = 0.6502 More... No significant asso...... No significant association was observed. More... Negative Kranz, T. M.,2012
rs7090018 - rs11199993 T-G FGFR2
P-value=0.835, Perm...... P-value=0.835, Permutated P-value=1 More...