Markers 
Haplotype 
Related Gene(s)/Region(s) 
Overlap with SZ 
Statistical Results 
Description 
Result Category 
Reference 

rs2439300  rs2439286  rs10095694  rs2919390 

NRG1


rs2439305  rs2439300  rs2439286  rs10095694 

NRG1


rs2919390  rs6988339 

NRG1


rs2919390  rs6988339  rs3757930 

NRG1

Pvalue = 0.0001 fo......
Pvalue = 0.0001 for SZ, Pvalue = 0.0001 for SCZ and BP
More...

the most significan......
the most significant haplotype in SCZ was also nominally significant in the BP sample; this was the only haplotype to withstand permutation analysis in this study, identifying a new region of association with both schizophrenia and the combined case group in the Scottish population
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Positive 
Thomson, P. A., 2007 

rs2919390  rs6988339  rs3757930  rs10103750 

NRG1


(HTR4_SVRSNP1)  (HTR4_SVRSNP4) 
CG 
HTR4

Haplotype analysis:......
Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=19/18, chi square=0.03, Pvalue = 0.87
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Ohtsuki, T.,2002 

rs553950  rs327329  rs7007662 

NRG1


rs553950  rs327329  rs7007662  rs1481762 

NRG1


D4S2281  D4S1506 

4p16.1

Twomarker associat......
Twomarker association:Pvalue = 0.0009
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Als, T. D.,2004 

rs6988339  rs3757930 

NRG1


D4S2923  D4S2928  D4S1582 

4p16.1

Threemarker associ......
Threemarker association:Pvalue = 0.0005
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Als, T. D.,2004 

rs6988339  rs3757930  rs10103750 

NRG1


D4S394  D4S2983 

4p16.1

Twomarker associat......
Twomarker association:Pvalue = 0.0320
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Als, T. D.,2004 

rs6988339  rs3757930  rs10103750  rs10503932 

NRG1


D4S403  D4S3048 

4p16.1

Twomarker associat......
Twomarker association:Pvalue = 0.0101
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Als, T. D.,2004 

MDAAO4  MDAAO5  MDAAO6 
ACG 
DAO

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.042, individual Pvalue = 0.045, OR=1.29
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

MDAAO4  MDAAO5  MDAAO6 
ACT 
DAO

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.042, individual Pvalue = 0.903, OR=1
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

MDAAO4  MDAAO5  MDAAO6 
CCG 
DAO

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.042, individual Pvalue = 0.57, OR=1.18
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

MDAAO4  MDAAO5  MDAAO6 
CTT 
DAO

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.042, individual Pvalue = 0.019, OR=0.72
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

M12  M15  M23  M24 
TACT 
DAOA

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.032, individual Pvalue = 0.7, OR=1.07
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

M12  M15  M23  M24 
TATA 
DAOA

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.032, individual Pvalue = 0.093, OR=1.31
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

M12  M15  M23  M24 
CGCT 
DAOA

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.032, individual Pvalue = 0.07, OR=1.29
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

rs7452939  rs6903874  rs6937506 

TAAR6

Global X<sup>......
Global X<sup>2</sup>=18.49, df=3, Pvalue = 0.00042
More...

There were signific......
There were significant global differences in haplotype frequency between schizophrenia patients compared to controls.
More...

Positive 
Pae, C. U., 2008 

M12  M15  M23  M24 
CGTA 
DAOA

Haplotype analysis:......
Haplotype analysis:allele, global Pvalue = 0.032, individual Pvalue = 0.00023, OR=0.57
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Schumacher, J.,2004 

rs7452939  rs6903874  rs6937506 
GCT 
TAAR6

X<sup>2</s......
X<sup>2</sup>=12.87, df=1, Pvalue = 0.0003
More...

The GCT haplotype w......
The GCT haplotype was significantly overrepresented in the patients with schizophrenia compared to controls.
More...

Positive 
Pae, C. U., 2008 

rs16944  (IL1RN_intron 2_VNTR) 
CVNTR(A2) 
IL1B
IL1RN

Haplotype analysis:......
Haplotype analysis:Schizophrenia v controls: chi square= 12.70, global Pvalue = 0.012; chi square= 9.99, individual Pvalue = 0.0015; OR = 2.49(95% CI: 1.33 to 4.64).
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Papiol, S.,2004 

rs646558  rs2303377 
CT, C(T/C), (C/A)(T/C) 
NCAM1

CT, C(T/C), (C/A)......
CT, C(T/C), (C/A)(T/C); chisquare Pvalue = <0.0001, X<sup>2</sup>=28.04, d.f.=3; chisquare Pvalue = <0.0001, X<sup>2</sup>=27.90, d.f.=2 for BD and SZ
More...

Three of the two ma......
Three of the two marker haplotypes for rs646558 and rs2303377 showed varying frequencies between schizophrenia and controls.
More...

Positive 
Atz, M. E., 2007 

rs737865  rs165599 
GG 
COMT

OR (95% CI)=1.27 (1......
OR (95% CI)=1.27 (1.081.50) of males, OR (95% CI)=1.51 (1.201.90) of females
More...

previously found to......
previously found to be associated with schizophrenia
More...

Positive 
Shifman, S., 2004 

rs363387  rs363343  rs363272 
TAG 
SLC18A2

OR=3.817 (95%CI: 1.......
OR=3.817 (95%CI: 1.609.09) in SZ cases; OR=4.1 (95%CI: 1.839.21) in SZ and BD combined group; Likelihood ratio chisquared Pvalue < E06 in BD cases and in BD and SZ combined group
More...

The estimation of h......
The estimation of haplotype effects using the UNPHASED software showed an increased risk, compared to controls, for both bipolar disorder and/or schizophrenia in carriers of TAG haplotype
More...

Positive 
Gutierrez, B., 2007 

rs737865  rs165688  rs165599 
GGG 
COMT

OR (95% CI)=1.36 (1......
OR (95% CI)=1.36 (1.151.61) of males, OR (95% CI)=1.57 (1.251.98) of females
More...

previously found to......
previously found to be associated with schizophrenia
More...

Positive 
Shifman, S., 2004 

rs363387  rs363343  rs363272 
CCA 
SLC18A2

OR=2.775 (95%CI: 0.......
OR=2.775 (95%CI: 0.987.85) in SZ cases; OR=2.336 (95%CI: 1.284.26) in SZ and BD combined group; Likelihood ratio chisquared Pvalue < E06 in BD cases and in BD and SZ combined group
More...

a trend association......
a trend association was also found for CCA combination in SZ cases, which reached significance when patients with bipolar disorder and schizophrenia were grouped together
More...

Positive 
Gutierrez, B., 2007 

rs363387  rs363343  rs363272 
TCA 
SLC18A2

Likelihood ratio c......
Likelihood ratio chisquared Pvalue < E06 in BD cases and in BD and SZ combined group
More...

significantly more ......
significantly more common among controls compared to patients' groups
More...

Positive 
Gutierrez, B., 2007 

rs363387  rs363343  rs363272 
CAG 
SLC18A2

Likelihood ratio c......
Likelihood ratio chisquared Pvalue < E06 in BD cases and in BD and SZ combined group
More...

significantly more ......
significantly more common among controls compared to patients' groups
More...

Positive 
Gutierrez, B., 2007 

rs363387  rs363420  rs363272 

SLC18A2

Global Pvalue <......
Global Pvalue < E04
More...

yielded globally si......
yielded globally significant evidence for association in SZ cases, and BD and SZ combined group
More...

Positive 
Gutierrez, B., 2007 

rs363387  rs363420  rs363343 

SLC18A2

Global Pvalue <......
Global Pvalue < E04
More...

yielded globally si......
yielded globally significant evidence for association in SZ cases, and BD and SZ combined group
More...

Positive 
Gutierrez, B., 2007 

rs363387  rs363420  rs363343  rs363272 

SLC18A2

Global Pvalue <......
Global Pvalue < E06
More...

The result revealed......
The result revealed highly significant differences in haplotype distributions between schizophrenic patients and between BD and SZ combined group and controls
More...

Positive 
Gutierrez, B., 2007 

rs363420  rs363272 

SLC18A2

Global Pvalue <......
Global Pvalue < 0.0001 in SZ cases; Global Pvalue < E06 in BD and SZ combined group
More...

the 2marker haplot......
the 2marker haplotype yielded globally significant evidence for association in SZ cases and BD and SZ combined group
More...

Positive 
Gutierrez, B., 2007 

rs363420  rs363343 

SLC18A2

Global Pvalue <......
Global Pvalue < E06
More...

the 2marker haplot......
the 2marker haplotype yielded globally significant evidence for association in SZ cases and BD and SZ combined group
More...

Positive 
Gutierrez, B., 2007 

rs363420  rs363343  rs363272 

SLC18A2

Global Pvalue <......
Global Pvalue < E04
More...

yielded globally si......
yielded globally significant evidence for association in SZ cases, and BD and SZ combined group
More...

Positive 
Gutierrez, B., 2007 

rs6265  microsatellite (GT)n 
A(GT1) 
BDNF

For SZ, X<sup>......
For SZ, X<sup>2</sup>=29.85; Pvalue < 4.65E08 (P<4.65E07 after Bonferroni correction); OR=0.30; upper 95% CI=0.46; lower CI=0.77
More...

Association was obs......
Association was observed in SZ.
More...

Positive 
NevesPereira, M.,2005 

rs6265  microsatellite (GT)n 
G(GT1) 
BDNF

For SZ, X<sup>......
For SZ, X<sup>2</sup>=8.38; Pvalue = 0.0038 (P=0.04 after Bonferroni correction); OR=2.18; upper 95% CI=3.71; lower CI=1.31.
More...

Association was obs......
Association was observed in SZ.
More...

Positive 
NevesPereira, M.,2005 

rs1538977  rs2492367  rs2812393 
TTG 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.039(all), 0.48(male), 0.1(female); individual Pvalue = 0.0062(all)
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

rs1538977  rs2492367  rs2812393  rs1322784 
TTGT 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.0056(all), 0.84(male), 0.032(female); individual Pvalue = 0.0075(all)
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

rs1954175  rs1538977  rs2492367  rs2812393 
ACCG 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, individual Pvalue = 0.00048(male)
More...

Significant associa......
Significant association was found in individual Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

478B14848  420M91395  SNP8NRG221533 
572 
NRG1

Haplotype analysis:......
Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual Pvalue = 0.739015
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Voineskos, D.,2009 

rs1954175  rs1538977  rs2492367  rs2812393 
GTTG 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.0064(all), 0.0046(male), 0.31(female); individual Pvalue = 0.005(all)
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

478B14848  420M91395  SNP8NRG221533 
641 
NRG1

Haplotype analysis:......
Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual Pvalue = 0.000581
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Voineskos, D.,2009 

rs2492367  rs2812393  rs1322784 
CCC 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.0079(all), 0.32(male), 0.021(female); individual Pvalue = 0.0044(all)
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

478B14848  420M91395  SNP8NRG221533 
642 
NRG1

Haplotype analysis:......
Haplotype analysis:FBAT, Global X<sup>2</sup>= 13.949, 3df, P = 0.003; individual Pvalue = 0.155978
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Voineskos, D.,2009 

rs2492367  rs2812393  rs1322784  rs2759346 

TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.043(all), 0.24(male), 0.0074(female);
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

rs2812393  rs1322784 
CC 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.0044(all), 0.21(male), 0.018(female); individual Pvalue = 0.0036(all)
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Thomson, P. A.,2005(a) 

rs10939038  rs3756207 

PI4K2B

haplotype analysis:......
haplotype analysis:global Pvalue = 0.005, permuted global Pvalue = 0.039, SE:0.006 in the schizophrenia sample
More...

Schizophrenia showe......
Schizophrenia showed association with a twomarker haplotype in schizophrenia but not bipolar disorder.
More...

Positive 
Houlihan, L.M.,2009 

rs17408391  rs10939038 

PI4K2B

haplotype analysis:......
haplotype analysis:global Pvalue = 0.005, permuted global Pvalue = 0.039, SE:0.006 in the schizophrenia sample
More...

Schizophrenia showe......
Schizophrenia showed association with a twomarker haplotype in schizophrenia but not bipolar disorder.
More...

Positive 
Houlihan, L.M.,2009 

rs988748  BDNF_(GT)n  rs6265 
C166bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.134
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs988748  BDNF_(GT)n  rs6265 
C168bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.232
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs988748  BDNF_(GT)n  rs6265 
C170bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.944
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138820  rs4468 
CC 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.0027 calculated using PLINK.
More...

'Risk'' haplotypes ......
'Risk'' haplotypes overrepresented among patients with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
C172bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.821
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138820  rs4468 
TT 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.041 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
C174bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.0033
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138820  rs4468  rs138841 
CCA 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.0074 calculated using PLINK.
More...

'Risk'' haplotypes ......
'Risk'' haplotypes overrepresented among patients with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
G170bpA 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.037
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138820  rs4468  rs138841 
TTC 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.044 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
G174bpA 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.0024
More...

Significant associa......
Significant association was found in both global Pvalue and individual Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138841  rs138855 
CG 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.017 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
G174bpG 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.067
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138841  rs138855  rs138864 
CGG 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.0081 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs988748  BDNF_(GT)n  rs6265 
G176bpA 
BDNF

Haplotypic associat......
Haplotypic association:in Bonn sample, for Schizophrenia, global Pvalue = 0.016, BonferroniCorrected Pvalue = 0.192, individual Pvalue = 0.627
More...

Significant associa......
Significant association was found in global Pvalue.
More...

Positive 
Schumacher, J.,2005 

rs138864  rs2239848 
GG 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.048 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs4468 rs138841 
CA 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.0073 calculated using PLINK.
More...

'Risk'' haplotypes ......
'Risk'' haplotypes overrepresented among patients with SZ
More...

Positive 
Nyegaard, M., 2010 

rs4468 rs138841 
TC 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.043 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs4468  rs138841  rs138855 
TCG 
BRD1

Empirical haplotype......
Empirical haplotypespecific Pvalue = 0.042 calculated using PLINK.
More...

'Protective'' haplo......
'Protective'' haplotypes overrepresented among controls with SZ
More...

Positive 
Nyegaard, M., 2010 

rs1130233  rs3730358 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0247
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs1130233  rs3730358  rs1130214 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0021
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs1130233  rs3730358  rs1130214  rs3803300 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0018
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs2494732  rs1130233 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0394
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs2494732  rs1130233  rs3730358 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0147
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs2494732  rs1130233  rs3730358  rs1130214 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.000211
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs2494732  rs1130233  rs3730358  rs1130214  rs3803300 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.000593
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs11736084  rs1282  rs17844778  rs9685931 
TCCG 
GPR78

Global test Pvalue......
Global test Pvalue (permuted Pvalue, s.e.)=0.015 (0.044, 0.002), Individual test Pvalue (permuted Pvalue, s.e.)=0.003 (0.048, 0.002), OR (95% CI)=0.547 (0.3670.815) in all female affected
More...

No haplotype tested......
No haplotype tested by either the global or individual test maintained its significance after permutation analysis. However, the global test Pvalues of two related haplotypes remained significant in both the BPAD females and all affected females.
More...

Positive 
Underwood, S. L., 2006 

rs11736084  rs1282  rs17844778  rs9685931  rs9799720 
TCCGC 
GPR78

Global test Pvalue......
Global test Pvalue (permuted Pvalue, s.e.)=0.017 (0.033, 0.002), Individual test Pvalue (permuted Pvalue, s.e.)=0.004 (0.070, 0.003), OR (95% CI)=0.562 (0.3750.842) in all female affected
More...

No haplotype tested......
No haplotype tested by either the global or individual test maintained its significance after permutation analysis. However, the global test Pvalues of two related haplotypes remained significant in both the BPAD females and all affected females.
More...

Positive 
Underwood, S. L., 2006 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
TCC 
GRIN2B

Pvalue = 0.97519, ......
Pvalue = 0.97519, Z=0.031 in schizophrenia family sample; Pvalue = 0.01 in schizophrenia casecontrols sample
More...

Haplotype analyses ......
Haplotype analyses on the schizophrenia casecontrol sample also showed significant elevation in the frequency of haplotype GCT in schizophrenia, and TCC in controls. The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Positive 
Martucci, L., 2006 

rs2498804  rs2494732  rs1130233  rs3730358  rs1130214 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0048
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs2498804  rs2494732  rs1130233  rs3730358  rs1130214  rs3803300 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0026
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs3730358  rs1130214 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0013
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

rs3730358  rs1130214  rs3803300 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0035
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Karege, F.,2010 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
GCT 
GRIN2B

Pvalue = 0.995395,......
Pvalue = 0.995395, Z=0.006 in schizophrenia family sample; Pvalue = 0.008 in schizophrenia casecontrols sample
More...

Haplotype analyses ......
Haplotype analyses on the schizophrenia casecontrol sample also showed significant elevation in the frequency of haplotype GCT in schizophrenia, and TCC in controls. The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Positive 
Martucci, L., 2006 

D22S279  rs909669 

ADSL

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0805, CLUMP T4 Pvalue = 0.0501 in BPD and SZ, CLUMP T1 Pvalue = 0.0447, CLUMP T4 Pvalue = 0.008 in SZ; Empirical overall Pvalue = 0.049 in BPD and SZ, Empirical overall Pvalue = 0.0012 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

D22S279  rs133068  rs133069  rs133070  rs133073 
7CCAT 
MCHR1


D22S279  rs133068  rs133069  rs133070  rs133073 
6/7CCAT 
MCHR1


rs133068  D22S279 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.1818, CLUMP T4 Pvalue = 0.127 in BPD and SZ, CLUMP T1 Pvalue = 0.0542, CLUMP T4 Pvalue = 0.0476 in SZ; Empirical overall Pvalue = 0.1821 in BPD and SZ, Empirical overall Pvalue = 0.0054 in SZ
More...


Positive 
Severinsen, J. E., 2006 (a) 

rs133069  rs133068 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0716, CLUMP T4 Pvalue = 0.1107 in BPD and SZ, CLUMP T1 Pvalue = 0.0469, CLUMP T4 Pvalue = 0.0353 in SZ; Empirical overall Pvalue = 0.1791 in BPD and SZ, Empirical overall Pvalue = 0.1238 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133069  rs133068  D22S279 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.2017, CLUMP T4 Pvalue = 0.2023 in BPD and SZ, CLUMP T1 Pvalue = 0.187, CLUMP T4 Pvalue = 0.1727 in SZ; Empirical overall Pvalue = 0.3066 in BPD and SZ, Empirical overall Pvalue = 0.0005 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133069  rs133070 
AG 
MCHR1

CLUMP Pvalue = 0.3......
CLUMP Pvalue = 0.3279 in SZ, Pvalue = 0.0364 in BPD and SZ; protective haplotype
More...

The same specific 2......
The same specific 2 and 3marker haplotypes covering rs133069 to rs133073 as seen in BPD showed Pvalues as low as 0.0183 in the combined sample.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133070  rs133069 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0145, CLUMP T4 Pvalue = 0.0828 in BPD and SZ, CLUMP T1 Pvalue = 0.3299, CLUMP T4 Pvalue = 0.3299 in SZ; Empirical overall Pvalue = 0.4592 in BPD and SZ, Empirical overall Pvalue = 0.0618 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs1503491  rs553950 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.024 for Scottish 1, Pvalue = 0.87 for Scottish 2, Pvalue = 0.096 for merged Scottish
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs1503491  rs553950  rs327329 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.00032 for Scottish 1, Pvalue = 0.61 for Scottish 2, Pvalue = 0.028 for merged Scottish
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs133070  rs133069  rs133068  D22S279 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0064, CLUMP T4 Pvalue = 0.0023 in BPD and SZ, CLUMP T1 Pvalue = 0.0426, CLUMP T4 Pvalue = 0.0367 in SZ; Empirical overall Pvalue = 0.3363 in BPD and SZ, Empirical overall Pvalue = 0.0053 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs2919390  rs6988339 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.0012 for Scottish 1, Pvalue = 0.31 for German
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs133070  rs133073 
AC 
MCHR1

CLUMP Pvalue = 1 i......
CLUMP Pvalue = 1 in SZ, Pvalue = 0.0234 in BPD and SZ; risk haplotype
More...

The same specific 2......
The same specific 2 and 3marker haplotypes covering rs133069 to rs133073 as seen in BPD showed Pvalues as low as 0.0183 in the combined sample.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs2919390  rs6988339  rs3757930 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.00014 for Scottish 1, Pvalue = 0.17 for German
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs133070  rs133073 
GC 
MCHR1

CLUMP Pvalue = 0.3......
CLUMP Pvalue = 0.3286 in SZ, Pvalue = 0.0183 in BPD and SZ; protective haplotype
More...

The same specific 2......
The same specific 2 and 3marker haplotypes covering rs133069 to rs133073 as seen in BPD showed Pvalues as low as 0.0183 in the combined sample.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs553950  rs327329 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.0085 for Scottish 1, Pvalue = 0.68 for Scottish 2, Pvalue = 0.074 for merged Scottish
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs133073  rs133070 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.004, CLUMP T4 Pvalue = 0.0188 in BPD and SZ, CLUMP T1 Pvalue = 0.5104, CLUMP T4 Pvalue = 0.5104 in SZ; Empirical overall Pvalue = 0.0262 in BPD and SZ, Empirical overall Pvalue = 0.1879 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs6988339  rs3757930 

NRG1

Haplotypic associat......
Haplotypic association:Pvalue = 0.0014 for Scottish 1, Pvalue = 0.48 for Scottish 2, Pvalue = 0.26 for German, Pvalue = 0.0037 for merged Scottish, Pvalue = 0.098 for merged all
More...

Significant associa......
Significant association was found in SZ.
More...

Positive 
Walker, R. M.,2010 

rs133073  rs133070  rs133069 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0268, CLUMP T4 Pvalue = 0.0626 in BPD and SZ, CLUMP T1 Pvalue = 0.3269, CLUMP T4 Pvalue = 0.3269 in SZ; Empirical overall Pvalue = 0.0155 in BPD and SZ, Empirical overall Pvalue = 0.0148 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133073  rs133070  rs133069  rs133068 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0479, CLUMP T4 Pvalue = 0.1278 in BPD and SZ, CLUMP T1 Pvalue = 0.4486, CLUMP T4 Pvalue = 0.4486 in SZ; Empirical overall Pvalue = 0.0184 in BPD and SZ, Empirical overall Pvalue = 0.0135 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133068  D22S279  rs909669 

MCHR1
ADSL

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.4823, CLUMP T4 Pvalue = 0.3996 in BPD and SZ, CLUMP T1 Pvalue = 0.099, CLUMP T4 Pvalue = 0.0353 in SZ; Empirical overall Pvalue = 0.0319 in BPD and SZ, Empirical overall Pvalue = 0.0015 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs133069  rs133068  D22S279  rs909669 

MCHR1
ADSL

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.2672, CLUMP T4 Pvalue = 0.2064 in BPD and SZ, CLUMP T1 Pvalue = 0.1481, CLUMP T4 Pvalue = 0.0495 in SZ; Empirical overall Pvalue = 0.0591 in BPD and SZ, Empirical overall Pvalue = 0.0012 in SZ
More...

Similarly, comparin......
Similarly, comparing controls to the combined group of cases revealed significant associations with 2, 3, 4, and 5marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs1170099  rs9566940 
GT 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.0002, permutated Pvalue = 0.002 for SCZ
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Zeng, Z.,2011 

rs133070  rs133069  rs133068  D22S279  rs909669 

MCHR1
ADSL

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0059, CLUMP T4 Pvalue = 0.0031 in BPD and SZ, CLUMP T1 Pvalue = 0.0156, CLUMP T4 Pvalue = 0.0054 in SZ; Empirical overall Pvalue = 0.339 in BPD and SZ, Empirical overall Pvalue = 0.0497 in SZ
More...

When comparing cont......
When comparing controls to SZ unequal haplotype distribution was observed for 2, 3, 4, and 5marker haplotypes spanning all four SNPs in GPR24 in addition to rs909669 in ADSL with a 5 marker haplotype showing a T4 Pvalue of 0.0054.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs909669  D22S279  rs133068  rs133069  rs133070 
C7CCA 
MCHR1
ADSL

CLUMP Pvalue = 5E......
CLUMP Pvalue = 5E06 in SZ, Pvalue = 0.0006 in BPD and SZ; risk haplotype
More...

The specific 5mark......
The specific 5marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aPvalue of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C6/7CCA were overrepresented in cases with a frequency of 75% against only 22% in controls.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs909669  D22S279  rs133068  rs133069  rs133070 
C6/7CCA 
MCHR1
ADSL

CLUMP Pvalue = 0.0......
CLUMP Pvalue = 0.0002 in SZ, Pvalue = 7E05 in BPD and SZ; risk haplotype
More...

The specific 5mark......
The specific 5marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aPvalue of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C6/7CCA were overrepresented in cases with a frequency of 75% against only 22% in controls.
More...

Positive 
Severinsen, J. E., 2006 (a) 

rs9315885  rs9532988  rs1012053 
TAA 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.0005, permutated Pvalue = 0.005 for SCZ
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Zeng, Z.,2011 

rs12778366  rs2273773  rs4746720  rs10997875 
TTCT 
SIRT1

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=8.19, OR=0.25, 95%CI=0.1810.345, individual Pvalue = 0.00421, corrected Pvalue = 0.0211 for SZ
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Kishi, T.,2011(a) 

rs1954787  rs4935752 

GRIK4

Pvalue = 0.008 bet......
Pvalue = 0.008 between SCZ cases and controls; Pvalue = 0.088 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs1954787  rs4935752  rs6589846 

GRIK4

Pvalue = 0.024 bet......
Pvalue = 0.024 between SCZ cases and controls; Pvalue = 0.287 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs12778366  rs2273773  rs4746720  rs10997875 
TTTT 
SIRT1

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=77.1, OR=1, 95%CI=1.001.00, individual Pvalue = 1.63E17, corrected Pvalue = 8.15E17 for SZ
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Kishi, T.,2011(a) 

rs2156635  rs949056 

GRIK4

Pvalue = 0.004 bet......
Pvalue = 0.004 between SCZ cases and controls; Pvalue = 0.027 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs2156635  rs949056  rs949054 

GRIK4

Pvalue = 0.04 betw......
Pvalue = 0.04 between SCZ cases and controls; Pvalue = 0.129 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs2284031  rs909486  rs738149 
CTG 
CSF2RB

Haplotype analysis:......
Haplotype analysis:for SZ, Pvalue(odds ratio)=0.014(0.85)
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Chen, P.,2011 

rs2284031  rs909486  rs738149 
TCA 
CSF2RB

Haplotype analysis:......
Haplotype analysis:for SZ, Pvalue(odds ratio)=0.006(1.37)
More...

Significant associa......
Significant association was observed in SZ.
More...

Positive 
Chen, P.,2011 

rs2282586  rs1944522 

GRIK4

Pvalue = 0.708 bet......
Pvalue = 0.708 between SCZ cases and controls; Pvalue = 0.048 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs766288  rs3738401  rs2812393  rs821616 
CGGT 
TSNAX
DISC1

Pvalue=0.0189 for ......
Pvalue=0.0189 for SCZ, Pvalue=0.0065 for BPAD&SCZ, Pvalue=0.0205 for BPAD males & SCZ males
More...

CGGT haplotype s......
CGGT haplotype showed relatively lesser frequency in BPAD (P=0.028), SCZ (P=0.0189) and combined cases of BPAD or SCZ (P=0.0065) and combined males of BPAD or SCZ (P=0.0205) compared with controls.
More...

Positive 
Ram Murthy, A., 2012 

rs2852217  rs879602  rs1954787 

GRIK4

Pvalue = 0.03 betw......
Pvalue = 0.03 between SCZ cases and controls; Pvalue = 0.039 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs766288  rs3738401  rs2812393  rs821616 
AGGT 
TSNAX
DISC1

Pvalue=0.0469 for ......
Pvalue=0.0469 for BPAD&SZ, Pvalue=0.0209 for BPAD females &SCZ females
More...

Haplotype AGGT w......
Haplotype AGGT was also underrepresented in combined cases of BPAD or SCZ (P=0.0469), BPAD females (P=0.0273) and pooled females of BPAD or SCZ (P=0.0209).
More...

Positive 
Ram Murthy, A., 2012 

rs2852217  rs879602  rs1954787  rs4935752 

GRIK4

Pvalue = 0.006 bet......
Pvalue = 0.006 between SCZ cases and controls; Pvalue = 0.041 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs766288  rs821616 
CA 
TSNAX
DISC1

Pvalue=0.082 for S......
Pvalue=0.082 for SCZ, Pvalue=0.019 for combined cases, Pvalue=0.011 for SCZ females, Pvalue=0.004 for combined females, Pvalue=0.901 for SCZ males, Pvalue=0.589 for combined males
More...

Allelic combination......
Allelic combination CA (P=0.004) in the female cases with combined phenotype showed significant association when multiple corrections were performed for all tests within each stratified gender (combined, females, males).
More...

Positive 
Ram Murthy, A., 2012 

rs766288  rs821616 
AA 
TSNAX
DISC1

Pvalue=0.42 for SC......
Pvalue=0.42 for SCZ, Pvalue=0.831 for combined cases, Pvalue=0.074 for SCZ females, Pvalue=0.022 for combined females, Pvalue=0.016 for SCZ males, Pvalue=0.028 for combined males
More...

Few additional comb......
Few additional combinations that were found to be significantly associated after multiple corrections (n=12) were AT in BPAD females (P=0.012, protective combination); CA (P=0.014, risk combination), CA in SCZ females (P=0.011, risk combination), AT in combined female cases (P=0.012, protective combination) and AA in combined female cases (P=0.022, protective combination) compared with control females. However nominal significance observed in BPAD (CA, P=0.024, risk combination), cases with the combined phenotype (CA, P=0.019, risk combination), SCZ males (AA, P=0.016, risk combination) and males with the combined phenotype (AA, P=0.028, risk combination), which did not withstand the multiple corrections.
More...

Positive 
Ram Murthy, A., 2012 

rs766288  rs821616 
AT 
TSNAX
DISC1

Pvalue=0.577 for S......
Pvalue=0.577 for SCZ, Pvalue=0.215 for combined cases, Pvalue=0.097 for SCZ females, Pvalue=0.012 for combined females, Pvalue=0.476 for SCZ males, Pvalue=0.606 for combined males
More...

Few additional comb......
Few additional combinations that were found to be significantly associated after multiple corrections (n=12) were AT in BPAD females (P=0.012, protective combination); CA (P=0.014, risk combination), CA in SCZ females (P=0.011, risk combination), AT in combined female cases (P=0.012, protective combination) and AA in combined female cases (P=0.022, protective combination) compared with control females. However nominal significance observed in BPAD (CA, P=0.024, risk combination), cases with the combined phenotype (CA, P=0.019, risk combination), SCZ males (AA, P=0.016, risk combination) and males with the combined phenotype (AA, P=0.028, risk combination), which did not withstand the multiple corrections.
More...

Positive 
Ram Murthy, A., 2012 

rs766288  rs2812393 
CC 
TSNAX
DISC1

Pvalue=0.099 for S......
Pvalue=0.099 for SCZ, Pvalue=0.016 for combined cases, Pvalue=0.011 for SCZ females, Pvalue=0.001 for combined females, Pvalue=0.993 for SCZ males, Pvalue=0.703 for combined males
More...

Analyses of these t......
Analyses of these two SNPs showed significant associations with allelic combination CC (P=0.009) in the BPAD phenotype when multiple corrections were performed for all tests within each stratified gender (combined, females, males).
More...

Positive 
Ram Murthy, A., 2012 

rs766288  rs2812393 
AG 
TSNAX
DISC1

Pvalue=0.62 for SC......
Pvalue=0.62 for SCZ, Pvalue=0.551 for combined cases, Pvalue=0.016 for SCZ females, Pvalue=0.013 for combined females, Pvalue=0.174 for SCZ males, Pvalue=0.212 for combined males
More...

Other combinations ......
Other combinations in BPAD females (CC, P=0.003, risk combination) and SCZ females (CC, P=0.011, risk combination; AG, P=0.016, protective combination), combined female cases (AG, P=0.013, protective combination; CC, P=0.001, risk combination) were found to be significantly associated after FDR corrections.
More...

Positive 
Ram Murthy, A., 2012 

rs2812393  rs821616 
GT 
DISC1

Pvalue=0 for SCZ, ......
Pvalue=0 for SCZ, Pvalue=0.001 for combined cases, Pvalue=0.007 for SCZ females, Pvalue=0.005 for combined females, Pvalue=0.02 for SCZ males, Pvalue=0.039 for combined males
More...

Allelic combination......
Allelic combinations of GT in SCZ (P=0), combined cases of BPAD or SCZ (P=0.001), SCZ females (P=0.007) and combined females (P=0.005) were observed to be protective combination of alleles. These combinations survived multiple corrections. In addition allelic combinations of GT showed nominal significance, but did not withstand FDR corrections.
More...

Positive 
Ram Murthy, A., 2012 

rs4586379  rs2035645  rs4777974  rs11637898  rs11074070  rs3784735 
AAGGAA 
ST8SIA2

Pvalue = 0.004, X&......
Pvalue = 0.004, X<sup>2</sup>=8.41, OR (95% CI)=1.82 (1.22.74) in Aus SZ
More...

We found that the s......
We found that the specific AAGGAA risk haplotype was significantly overrepresented in schizophrenia cases compared to controls when a conditional analysis was performed.
More...

Positive 
McAuley, E. Z., 2012 

rs4586379  rs2035645  rs4777974  rs11637898  rs11074070  rs3784735 
GCAACC 
ST8SIA2

Pvalue = 0.021, X&......
Pvalue = 0.021, X<sup>2</sup>=5.30, OR (95% CI)=0.515 (0.290.92) in Aus SZ
More...

the protective hapl......
the protective haplotype was overrepresented in controls on conditional haplotype analysis
More...

Positive 
McAuley, E. Z., 2012 

rs4935752  rs6589846 

GRIK4

Pvalue = 0.005 bet......
Pvalue = 0.005 between SCZ cases and controls; Pvalue = 0.103 between all cases and controls
More...

These positionally ......
These positionally bipartite findings were further supported by a sliding window global analysis of haplotypes of lengths two to four, such that distinct clusters of significant Pvalues were observed in schizophrenia (best global haplotype, SNPs 15 and 16; P = 0.005).
More...

Positive 
Pickard, B. S., 2006 

rs4935752  rs6589846  rs4430518 

GRIK4

Pvalue = 0.015 bet......
Pvalue = 0.015 between SCZ cases and controls; Pvalue = 0.16 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs4935752  rs6589846  rs4430518  rs433110 

GRIK4

Pvalue = 0.016 bet......
Pvalue = 0.016 between SCZ cases and controls; Pvalue = 0.128 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs6589846  rs4430518 

GRIK4

Pvalue = 0.007 bet......
Pvalue = 0.007 between SCZ cases and controls; Pvalue = 0.115 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs7111184  rs2156635  rs949056 

GRIK4

Pvalue = 0.045 bet......
Pvalue = 0.045 between SCZ cases and controls; Pvalue = 0.173 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs879602  rs1954787  rs4935752  rs6589846 

GRIK4

Pvalue = 0.028 bet......
Pvalue = 0.028 between SCZ cases and controls; Pvalue = 0.176 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

rs948028  rs2852217  rs879602  rs1954787 

GRIK4

Pvalue = 0.043 bet......
Pvalue = 0.043 between SCZ cases and controls; Pvalue = 0.005 between all cases and controls
More...


Positive 
Pickard, B. S., 2006 

D22S922  D22S1169  rs4468 
23C 
BRD1


rs138855  rs138880 
GC 
BRD1

Pvalue = 1E06 in ......
Pvalue = 1E06 in BD, Pvalue = 2.8E07 in BD and SZ
More...

Removing the rare m......
Removing the rare middle SNP rs2239848 from the analysis resulted in a reduced 2marker 'risk' haplotype (GC) showing a frequency of ~10% in cases versus ~1% in controls.
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Positive 
Severinsen, J. E., 2006 (b) 

rs138855  rs138880  rs138881 
GCA 
BRD1


rs138855  rs138880  rs138881 
GCG 
BRD1


rs138855  rs2239848  rs138880 
GGC 
BRD1

Pvalue = 4E06 in ......
Pvalue = 4E06 in BD, Pvalue = 1E06 in BD and SZ
More...

A 3marker core hap......
A 3marker core haplotype spanning BRD1 SNPs rs138855, rs2239848 and rs138880 had a frequency of around 9% in cases against only 1% in controls, producing a haplotype specific Pvalue of order 1E06.
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Positive 
Severinsen, J. E., 2006 (b) 

rs138855  rs2239848  rs138880  rs138881 
GGCA 
BRD1


rs138880  rs2239848 

BRD1


rs138880  rs2239848  rs138855 

BRD1

Pvalue = 0.00001 i......
Pvalue = 0.00001 in SZ, Pvalue = 0.00005 in BD and SZ
More...

Highly significant ......
Highly significant overall Pvalues (as low as 0.00001) were observed in especially the 3 and 4marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881.
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Positive 
Severinsen, J. E., 2006 (b) 

rs138880  rs2239848  rs138855  rs4468 

BRD1


rs138881  rs138880  rs2239848  rs138855 

BRD1

Pvalue = 0.0002 in......
Pvalue = 0.0002 in SZ, Pvalue = 0.0003 in BD and SZ
More...

Highly significant ......
Highly significant overall Pvalues (as low as 0.00001) were observed in especially the 3 and 4marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881.
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Positive 
Severinsen, J. E., 2006 (b) 

rs2239848  rs138855  rs4468 

BRD1


rs2239848  rs138855  rs4468  D22S1169 

BRD1


rs4468  D22S1169 

BRD1


rs4468  D22S1169  D22S922  rs132234 

BRD1
FAM19A5


D22S1169  D22S922  rs132234 

FAM19A5


D22S1169  D22S922 



rs10095694  rs2919390 

NRG1


rs10095694  rs2919390  rs6988339 

NRG1


rs10095694  rs2919390  rs6988339  rs3757930 

NRG1


rs10113797  rs10954811  rs1503491  rs553950 

NRG1


rs10954811  rs1503491  rs553950 

NRG1


rs10954811  rs1503491  rs553950  rs327329 

NRG1


rs1503491  rs553950 

NRG1


rs1503491  rs553950  rs327329 
TTT 
NRG1

Pvalue = 0.0003 fo......
Pvalue = 0.0003 for SZ, Pvalue = 0.0017 for SZ and BP combined
More...

3SNP haplotype is ......
3SNP haplotype is nominally significant with SCZ alone, but it does not withstand permutation analysis
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Positive 
Thomson, P. A., 2007 

rs1503491  rs553950  rs327329  rs7007662 

NRG1


rs2439286  rs10095694 

NRG1


rs2439286  rs10095694  rs2919390 

NRG1


rs2439286  rs10095694  rs2919390  rs6988339 

NRG1


(RGS4_SNP1)  (RGS4_SNP4)  (RGS4_SNP7)  (RGS4_SNP18) 

RGS4

Estimated haplotype......
Estimated haplotype frequencies among cases and unrelated controls:P>0.05
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No significant asso......
No significant association was observed in SZ.
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Negative 
Chowdari, K. V.,2002 

(HTR4_SVRSNP1)  (HTR4_SVRSNP4) 
CA 
HTR4

Haplotype analysis:......
Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=16/20, chi square=0.4, Pvalue = 0.5
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Ohtsuki, T.,2002 

(HTR4_SVRSNP1)  (HTR4_SVRSNP4) 
TG 
HTR4

Haplotype analysis:......
Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=25/21, chi square=0.35, Pvalue = 0.56
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Ohtsuki, T.,2002 

(GPR50_502505)  rs13440581 

GPR50

Haplotypic associat......
Haplotypic association:, for SCZ, Pvalue = 0.18(all), 0.3(female)
More...

No association was ......
No association was observed.
More...

Negative 
Thomson, P. A.,2005(b) 

rs2072621  (GPR50_502505) 

GPR50

Haplotypic associat......
Haplotypic association:, for SCZ, Pvalue = 0.16(all), 0.3(female)
More...

No association was ......
No association was observed.
More...

Negative 
Thomson, P. A.,2005(b) 

rs2072621  (GPR50_502505)  rs13440581 

GPR50

Haplotypic associat......
Haplotypic association:, for SCZ, Pvalue = 0.078(all), 0.068(female)
More...

No association was ......
No association was observed.
More...

Negative 
Thomson, P. A.,2005(b) 

rs2072621  rs13440581 

GPR50

Haplotypic associat......
Haplotypic association:, for SCZ, Pvalue = 0.63(all), 0.76(female)
More...

No association was ......
No association was observed.
More...

Negative 
Thomson, P. A.,2005(b) 

rs2271309  rs12601930  rs907094  rs3764352 

PPP1R1B

Global Pvalue = 0.......
Global Pvalue = 0.697
More...

Haplotypic analyses......
Haplotypic analyses of four SNPs in a sample set showed that PPP1R1B polymorphisms were not significantly associated with schizophrenia.
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Negative 
Yoshimi, A., 2008 

rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 

PAWR


rs960914  rs2241802  rs2323019  rs352203 

FZD3

Haplotypic associat......
Haplotypic association:global Pvalues>0.2
More...

No significant ass......
No significant association was found .
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Negative 
Hashimoto, R.,2005(b) 

rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 
GAGTA 
PAWR


RGS4_SNP1  RGS4_SNP4  RGS4_SNP17  RGS4_SNP18 
GGGG 
RGS4

Haplotypic associat......
Haplotypic association:Familybased analysis:TDT:X<sup>2</sup>=2.67, Pvalue = 0.102 in SZ
More...

No significant ass......
No significant association was found .
More...

Negative 
Cordeiro, Q.,2005 

rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 
GAACG 
PAWR


rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 
ATGCA 
PAWR


rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 
GAGCG 
PAWR


rs1954175  rs1538977  rs2492367 

TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.19(all), 0.037(male), 0.81(female);
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Thomson, P. A.,2005(a) 

rs2463169  rs2400546  rs17005769  rs4842318  rs7305141 
AAGCA 
PAWR


rs2492367  rs2812393  rs1322784 
CGT 
TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue > 0.05(all)
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Thomson, P. A.,2005(a) 

rs11939815  rs11931061  rs11133385  rs3736544  rs1801260  rs3749474 

CLOCK

likelihood ratio te......
likelihood ratio test:haplotype(GAAGTT):1.total samples:Global Pvalue = 0.340 in SCZ 2. male samples:Global Pvalue = 0.464 in SCZ 3. female samples:Global Pvalue = 0.0362, Corrected Pvalue = 0.0724 in SCZ
More...

Only one associatio......
Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724).
More...

Negative 
Kishi, T.,2009(a) 

rs2812393  rs1322784  rs2759346  rs6675281 

TSNAX
DISC1

Global association ......
Global association test:for SCZ, Pvalue = 0.15(all), 0.84(male), 0.04(female);
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Thomson, P. A.,2005(a) 

rs2076127  ss16339182 
AT 
MLC1

Haplotypic associat......
Haplotypic association:for SCZ, global Pvalue > 0.05, individual Pvalue > 0.05, odds ratio=0.95, 95%CI=0.631.44
More...

No significant ass......
No significant association was found .
More...

Negative 
Verma, R.,2005(b) 

rs2076127  ss16339182 
GC 
MLC1

Haplotypic associat......
Haplotypic association:for SCZ, global Pvalue > 0.05, individual Pvalue > 0.05, odds ratio=1.2, 95%CI=0.791.82
More...

No significant ass......
No significant association was found .
More...

Negative 
Verma, R.,2005(b) 

rs2076127  ss16339182 
GT 
MLC1

Haplotypic associat......
Haplotypic association:for SCZ, global Pvalue > 0.05, individual Pvalue > 0.05, odds ratio=0.98, 95%CI=0.701.37
More...

No significant ass......
No significant association was found .
More...

Negative 
Verma, R.,2005(b) 

rs1050565  rs2020934 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.651
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

rs1050565  rs2020934  SLC6A4_5HTTVNTR 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.376
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

rs1050565  rs2020934  SLC6A4_5HTTVNTR  rs3813034 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.715
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

rs2020934  SLC6A4_5HTTVNTR 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.701
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

rs2020934  SLC6A4_5HTTVNTR  rs3813034 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.545
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

SLC6A4_5HTTVNTR  rs3813034 

SLC6A4

global Pvalue = 0.......
global Pvalue = 0.151
More...

We found no associa......
We found no association with SCZ in the haplotypewise association analysis.
More...

Negative 
Ikeda, M., 2006 

PRODH1945  PRODH1482 

PRODH

Haplotypic associat......
Haplotypic association:Global Pvalue = 0.339(based on 100, 000 replications) for SZ.
More...

No significant ass......
No significant association was found .
More...

Negative 
Abou Jamra, R.,2005(a) 

rs1130214  rs3803300 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.605
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Karege, F.,2010 

PRODH2026  PRODH1945 

PRODH

Haplotypic associat......
Haplotypic association:Global Pvalue = 0.641(based on 100, 000 replications) for SZ.
More...

No significant ass......
No significant association was found .
More...

Negative 
Abou Jamra, R.,2005(a) 

PRODH2026  PRODH1945  PRODH1482 

PRODH

Haplotypic associat......
Haplotypic association:Global Pvalue = 0.458(based on 100, 000 replications) for SZ.
More...

No significant ass......
No significant association was found .
More...

Negative 
Abou Jamra, R.,2005(a) 

32416574(G/A)  IVS4+1008ins(T)/del(T) 

SLC12A6

Association test fo......
Association test for heterogeneity, for SZ, empirical Pvalue = 0.2176
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Meyer, J.,2005 

32418760(G/A)  32416574(G/A) 

SLC12A6

Association test fo......
Association test for heterogeneity, for SZ, empirical Pvalue = 0.2467
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Meyer, J.,2005 

32418760(G/A)  32416574(G/A)  IVS4+1008ins(T)/del(T) 

SLC12A6

Association test fo......
Association test for heterogeneity, for SZ, empirical Pvalue = 0.1382
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Meyer, J.,2005 

32418760(G/A)  IVS4+1008ins(T)/del(T) 

SLC12A6

Association test fo......
Association test for heterogeneity, for SZ, empirical Pvalue = 0.0751
More...

No significant asso......
No significant associations were found in SZ.
More...

Negative 
Meyer, J.,2005 

GSK3 beta_1727A/T  GSK3 beta_50C/T 
AC, AT, TC, TT 
GSK3B

Pvalue = 0.81 for ......
Pvalue = 0.81 for BD, Pvalue = 0.54 for BD and SZ
More...

There was no differ......
There was no difference in the haplotype frequency combination between the patient and control groups.
More...

Negative 
Lee, K. Y., 2006 (b) 

rs2498804  rs2494732 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.0861
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Karege, F.,2010 

rs2498804  rs2494732  rs1130233 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.395
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Karege, F.,2010 

rs2498804  rs2494732  rs1130233  rs3730358 

AKT1

multilocus associa......
multilocus association analyses:global Pvalue = 0.197
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Karege, F.,2010 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
TAC 
GRIN2B

Pvalue = 0.242452,......
Pvalue = 0.242452, Z=1.169 in schizophrenia family sample; Pvalue = 0.116 in schizophrenia casecontrols sample
More...

The overall differe......
The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Negative 
Martucci, L., 2006 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
GCC 
GRIN2B

Pvalue = 0.650714,......
Pvalue = 0.650714, Z=0.453 in schizophrenia family sample; Pvalue = 0.104 in schizophrenia casecontrols sample
More...

The overall differe......
The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Negative 
Martucci, L., 2006 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
GAC 
GRIN2B

Pvalue = 0.324213,......
Pvalue = 0.324213, Z=0.986 in schizophrenia family sample; Pvalue = 0.013 in schizophrenia casecontrols sample
More...

The overall differe......
The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Negative 
Martucci, L., 2006 

GRIN2B_T200G  GRIN2B_A5806C  GRIN2B_T5988C 
TCT 
GRIN2B

Pvalue = 0.102451,......
Pvalue = 0.102451, Z=1.633 in schizophrenia family sample; Pvalue = 0.271 in schizophrenia casecontrols sample
More...

The overall differe......
The overall difference in haplotype transmission between cases and controls is statistically significant (p =0.005).
More...

Negative 
Martucci, L., 2006 

D22S279  rs133068  rs133069  rs133070  rs133073 
6CCAT 
MCHR1


rs133069  rs133070  rs133073 
AGC 
MCHR1

CLUMP Pvalue = 0.3......
CLUMP Pvalue = 0.3279 in SZ, Pvalue = 0.0526 in BPD and SZ; protective haplotype
More...

The same specific 2......
The same specific 2 and 3marker haplotypes covering rs133069 to rs133073 as seen in BPD showed Pvalues as low as 0.0183 in the combined sample.
More...

Negative 
Severinsen, J. E., 2006 (a) 

rs133070  rs133069  rs133068 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0525, CLUMP T4 Pvalue = 0.1831 in BPD and SZ, CLUMP T1 Pvalue = 0.4456, CLUMP T4 Pvalue = 0.4456 in SZ; Empirical overall Pvalue = 0.5945 in BPD and SZ, Empirical overall Pvalue = 0.0691 in SZ
More...


Negative 
Severinsen, J. E., 2006 (a) 

rs133073  rs133070  rs133069  rs133068  D22S279 

MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.0063, CLUMP T4 Pvalue = 0.0023 in BPD and SZ, CLUMP T1 Pvalue = 0.0432, CLUMP T4 Pvalue = 0.0375 in SZ; Empirical overall Pvalue = 0.1747 in BPD and SZ, Empirical overall Pvalue = 0.0189 in SZ
More...


Negative 
Severinsen, J. E., 2006 (a) 

rs6295  rs878567 
CC 
HTR1A

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.9711.47, individual Pvalue = 0.0921; global Pvalue = 0.0935
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Kishi, T.,2011(b) 

rs6295  rs878567 
GC 
HTR1A

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:OR=1.20, 95%CI=0.9711.47, individual Pvalue = 0.0921; global Pvalue = 0.0935
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Kishi, T.,2011(b) 

rs1170099  rs9566940 
AC 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.364, permutated Pvalue = 0.993 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs1170099  rs9566940 
AT 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.179, permutated Pvalue = 0.859 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs716934  rs9566931  rs9315897  rs2122246 
AACG 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 1, permutated Pvalue = 1 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs716934  rs9566931  rs9315897  rs2122246 
AATG 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.623, permutated Pvalue = 1 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs909669  D22S279  rs133068  rs133069  rs133070 
C6CCA 
MCHR1
ADSL

CLUMP Pvalue = 0.5......
CLUMP Pvalue = 0.5569 in SZ, Pvalue = 0.3176 in BPD and SZ; risk haplotype
More...

The specific 5mark......
The specific 5marker haplotype straddling rs909660 to rs133070 as seen inSZ (C7CCA) showed aPvalue of 0.0006 in the combined sample, and together with a variant of this haplotype (C6CCA) the haplotypes C6/7CCA were overrepresented in cases with a frequency of 75% against only 22% in controls.
More...

Negative 
Severinsen, J. E., 2006 (a) 

rs716934  rs9566931  rs9315897  rs2122246 
TATA 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.243, permutated Pvalue = 0.945 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs716934  rs9566931  rs9315897  rs2122246 
TATG 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.219, permutated Pvalue = 0.924 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs1573745  rs710193 

ST13


rs716934  rs9566931  rs9315897  rs2122246 
TGTG 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.297, permutated Pvalue = 0.976 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs1573745  rs710193  rs133073 

ST13
MCHR1


rs9315885  rs9532988  rs1012053 
CAA 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.018, permutated Pvalue = 0.147 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs1573745  rs710193  rs133073  rs133070 

ST13
MCHR1


rs9315885  rs9532988  rs1012053 
CAC 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.116, permutated Pvalue = 0.719 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs1573745  rs710193  rs133073  rs133070  rs133069 

ST13
MCHR1


rs710193  rs133073 

ST13
MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.4522, CLUMP T4 Pvalue = 0.4361 in BPD and SZ, CLUMP T1 Pvalue = 0.3844, CLUMP T4 Pvalue = 0.3368 in SZ; Empirical overall Pvalue = 0.1247 in BPD and SZ, Empirical overall Pvalue = 0.3269 in SZ
More...


Negative 
Severinsen, J. E., 2006 (a) 

rs9315885  rs9532988  rs1012053 
TGA 
DGKH

Haplotypic associat......
Haplotypic association:Pvalue = 0.446, permutated Pvalue = 0.998 for SCZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Zeng, Z.,2011 

rs710193  rs133073  rs133070 

ST13
MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.1158, CLUMP T4 Pvalue = 0.1697 in BPD and SZ, CLUMP T1 Pvalue = 0.3917, CLUMP T4 Pvalue = 0.5842 in SZ; Empirical overall Pvalue = 0.0715 in BPD and SZ, Empirical overall Pvalue = 0.224 in SZ
More...


Negative 
Severinsen, J. E., 2006 (a) 

rs12778366  rs2273773  rs4746720  rs10997875 
CTTT 
SIRT1

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=2.02, OR=0.307, 95%CI=0.2170.434, individual Pvalue = 0.155 for SZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Kishi, T.,2011(a) 

rs710193  rs133073  rs133070  rs133069 

ST13
MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.1755, CLUMP T4 Pvalue = 0.2417 in BPD and SZ, CLUMP T1 Pvalue = 0.3957, CLUMP T4 Pvalue = 0.5862 in SZ; Empirical overall Pvalue = 0.079 in BPD and SZ, Empirical overall Pvalue = 0.1069 in SZ
More...


Negative 
Severinsen, J. E., 2006 (a) 

rs12778366  rs2273773  rs4746720  rs10997875 
TCTT 
SIRT1

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=0.269, OR=0.271, 95%CI=0.1960.375, individual Pvalue = 0.604 for SZ
More...

No significant asso......
No significant association was observed in SZ.
More...

Negative 
Kishi, T.,2011(a) 

rs710193  rs133073  rs133070  rs133069  rs133068 

ST13
MCHR1

CLUMP T1 Pvalue = ......
CLUMP T1 Pvalue = 0.1722, CLUMP T4 Pvalue = 0.239 in BPD and SZ, CLUMP T1 Pvalue = 0.3932, CLUMP T4 Pvalue = 0.5852 in SZ; Empirical overall Pvalue = 0.1895 in BPD and SZ, Empirical overall Pvalue = 0.146 in SZ
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Negative 
Severinsen, J. E., 2006 (a) 

rs12778366  rs2273773  rs4746720  rs10997875 
TTTC 
SIRT1

Haplotype analysis:......
Haplotype analysis:likelihood ratio test:X<sup>2</sup>(1df)=0.525, OR=0.264, 95%CI=0.1890.371, individual Pvalue = 0.469 for SZ
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No significant asso......
No significant association was observed in SZ.
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Negative 
Kishi, T.,2011(a) 

rs1954787  rs4935752  rs6589846  rs4430518 

GRIK4

Pvalue = 0.068 bet......
Pvalue = 0.068 between SCZ cases and controls; Pvalue = 0.32 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs11759115  rs7769372 
CC 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.1223, individual Pvalue = 0.046
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs2000869  rs7479743 

GRIK4

Pvalue = 0.538 bet......
Pvalue = 0.538 between SCZ cases and controls; Pvalue = 0.448 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs11759115  rs7769372 
TC 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.1223, individual Pvalue = 0.3551
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs2000869  rs7479743  rs6589832 

GRIK4

Pvalue = 0.466 bet......
Pvalue = 0.466 between SCZ cases and controls; Pvalue = 0.391 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs11759115  rs7769372 
TT 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.1223, individual Pvalue = 0.9978
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs2000869  rs7479743  rs6589832  rs7925270 

GRIK4

Pvalue = 0.365 bet......
Pvalue = 0.365 between SCZ cases and controls; Pvalue = 0.483 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs1883901  rs10807187  rs9462343 
AGG 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.404, individual Pvalue = 0.0732
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs1883901  rs10807187  rs9462343 
GGA 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.404, individual Pvalue = 1
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs1883901  rs10807187  rs9462343 
GGG 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.404, individual Pvalue = 0.4639
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs2156635  rs949056  rs949054  rs602104 

GRIK4

Pvalue = 0.091 bet......
Pvalue = 0.091 between SCZ cases and controls; Pvalue = 0.117 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs1883901  rs10807187  rs9462343 
GTG 
MDGA1

Haplotype analysis:......
Haplotype analysis:for SZ, global Pvalue = 0.404, individual Pvalue = 0.9998
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No significant asso......
No significant association was observed in SZ.
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Negative 
Li, J.,2011(a) 

rs2187495  rs3132780 

GRIK4

Pvalue = 0.819 bet......
Pvalue = 0.819 between SCZ cases and controls; Pvalue = 0.495 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2284031  rs909486  rs738149 
CTA 
CSF2RB

Haplotype analysis:......
Haplotype analysis:for SZ, Pvalue(odds ratio)=0.998(1)
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No significant asso......
No significant association was observed in SZ.
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Negative 
Chen, P.,2011 

rs2187495  rs3132780  rs948028 

GRIK4

Pvalue = 0.713 bet......
Pvalue = 0.713 between SCZ cases and controls; Pvalue = 0.508 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2187495  rs3132780  rs948028  rs2852217 

GRIK4

Pvalue = 0.827 bet......
Pvalue = 0.827 between SCZ cases and controls; Pvalue = 0.774 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2276319  rs513548 

GRIK4

Pvalue = 0.643 bet......
Pvalue = 0.643 between SCZ cases and controls; Pvalue = 0.472 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2284031  rs909486  rs738149 
TCG 
CSF2RB

Haplotype analysis:......
Haplotype analysis:for SZ, Pvalue(odds ratio)=0.263(1.1)
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No significant asso......
No significant association was observed in SZ.
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Negative 
Chen, P.,2011 

rs2276319  rs513548  rs2282586 

GRIK4

Pvalue = 0.496 bet......
Pvalue = 0.496 between SCZ cases and controls; Pvalue = 0.186 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs7090018  rs11199993 
TG 
FGFR2

Pvalue = 0.835, Pe......
Pvalue = 0.835, Permutated Pvalue = 1.000
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No significant asso......
No significant association was found
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Negative 
Wang, T.,2012 

rs2276319  rs513548  rs2282586  rs1944522 

GRIK4

Pvalue = 0.781 bet......
Pvalue = 0.781 between SCZ cases and controls; Pvalue = 0.113 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs7090018  rs11199993 
TC 
FGFR2

Pvalue = 0.112, Pe......
Pvalue = 0.112, Permutated Pvalue = 0.698
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No significant asso......
No significant association was found
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Negative 
Wang, T.,2012 

rs7090018  rs11199993 
GG 
FGFR2

Pvalue = 0.103, Pe......
Pvalue = 0.103, Permutated Pvalue = 0.664
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No significant asso......
No significant association was found
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Negative 
Wang, T.,2012 

rs2852217  rs879602 

GRIK4

Pvalue = 0.825 bet......
Pvalue = 0.825 between SCZ cases and controls; Pvalue = 0.232 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs3132780  rs948028 

GRIK4

Pvalue = 0.619 bet......
Pvalue = 0.619 between SCZ cases and controls; Pvalue = 0.779 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs3132780  rs948028  rs2852217 

GRIK4

Pvalue = 0.696 bet......
Pvalue = 0.696 between SCZ cases and controls; Pvalue = 0.543 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs766288  rs821616 
CT 
TSNAX
DISC1

Pvalue=0.093 for S......
Pvalue=0.093 for SCZ, Pvalue=0.115 for combined cases, Pvalue=0.307 for SCZ females, Pvalue=0.489 for combined females, Pvalue=0.177 for SCZ males, Pvalue=0.138 for combined males
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Negative 
Ram Murthy, A., 2012 

rs3132780  rs948028  rs2852217  rs879602 

GRIK4

Pvalue = 0.905 bet......
Pvalue = 0.905 between SCZ cases and controls; Pvalue = 0.171 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs3133226  rs2187495 

GRIK4

Pvalue = 0.98 betw......
Pvalue = 0.98 between SCZ cases and controls; Pvalue = 0.492 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs3133226  rs2187495  rs3132780 

GRIK4

Pvalue = 0.84 betw......
Pvalue = 0.84 between SCZ cases and controls; Pvalue = 0.564 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs3133226  rs2187495  rs3132780  rs948028 

GRIK4

Pvalue = 0.767 bet......
Pvalue = 0.767 between SCZ cases and controls; Pvalue = 0.597 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs766288  rs2812393 
CG 
TSNAX
DISC1

Pvalue=0.46 for SC......
Pvalue=0.46 for SCZ, Pvalue=0.703 for combined cases, Pvalue=0.626 for SCZ females, Pvalue=0.969 for combined females, Pvalue=0.639 for SCZ males, Pvalue=0.672 for combined males
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Negative 
Ram Murthy, A., 2012 

rs3133855  rs3133226 

GRIK4

Pvalue = 0.985 bet......
Pvalue = 0.985 between SCZ cases and controls; Pvalue = 0.971 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs766288  rs2812393 
AC 
TSNAX
DISC1

Pvalue=0.529 for S......
Pvalue=0.529 for SCZ, Pvalue=0.632 for combined cases, Pvalue=0.626 for SCZ females, Pvalue=0.216 for combined females, Pvalue=0.175 for SCZ males, Pvalue=0.099 for combined males
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Negative 
Ram Murthy, A., 2012 

rs3133855  rs3133226  rs2187495 

GRIK4

Pvalue = 0.999 bet......
Pvalue = 0.999 between SCZ cases and controls; Pvalue = 0.885 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2812393  rs821616 
CA 
DISC1

Pvalue=0.236 for S......
Pvalue=0.236 for SCZ, Pvalue=0.125 for combined cases, Pvalue=0.078 for SCZ females, Pvalue=0.077 for combined females, Pvalue=0.931 for SCZ males, Pvalue=0.673 for combined males
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Negative 
Ram Murthy, A., 2012 

rs3133855  rs3133226  rs2187495  rs3132780 

GRIK4

Pvalue = 0.965 bet......
Pvalue = 0.965 between SCZ cases and controls; Pvalue = 0.824 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2812393  rs821616 
GA 
DISC1

Pvalue=0.976 for S......
Pvalue=0.976 for SCZ, Pvalue=0.806 for combined cases, Pvalue=0.958 for SCZ females, Pvalue=0.834 for combined females, Pvalue=0.941 for SCZ males, Pvalue=0.898 for combined males
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Negative 
Ram Murthy, A., 2012 

rs4245040  rs7928347 

GRIK4

Pvalue = 0.364 bet......
Pvalue = 0.364 between SCZ cases and controls; Pvalue = 0.089 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs4245040  rs7928347  rs2000869 

GRIK4

Pvalue = 0.704 bet......
Pvalue = 0.704 between SCZ cases and controls; Pvalue = 0.288 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs2812393  rs821616 
CT 
DISC1

Pvalue=0.381 for S......
Pvalue=0.381 for SCZ, Pvalue=0.531 for combined cases, Pvalue=0.659 for SCZ females, Pvalue=0.642 for combined females, Pvalue=0.119 for SCZ males, Pvalue=0.206 for combined males
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Negative 
Ram Murthy, A., 2012 

rs4245040  rs7928347  rs2000869  rs7479743 

GRIK4

Pvalue = 0.484 bet......
Pvalue = 0.484 between SCZ cases and controls; Pvalue = 0.221 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs433110  rs7111184 

GRIK4

Pvalue = 0.149 bet......
Pvalue = 0.149 between SCZ cases and controls; Pvalue = 0.606 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs4586379  rs8025225  rs11074066  rs11074067  rs2035645 
TTAGT 
ST8SIA2

Pvalue = 0.129, X&......
Pvalue = 0.129, X<sup>2</sup>=2.30, OR (95% CI)=1.09 (0.971.23) in NIMH SZ
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This haplotype also......
This haplotype also showed the same direction of effect in the NIMH cases with schizophrenia compared to controls, although it did not reach statistical significance.
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Negative 
McAuley, E. Z., 2012 

rs433110  rs7111184  rs2156635 

GRIK4

Pvalue = 0.419 bet......
Pvalue = 0.419 between SCZ cases and controls; Pvalue = 0.57 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs433110  rs7111184  rs2156635  rs949056 

GRIK4

Pvalue = 0.305 bet......
Pvalue = 0.305 between SCZ cases and controls; Pvalue = 0.707 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs4586379  rs8025225  rs11074066  rs11074067  rs2035645 
CCCCG 
ST8SIA2

Pvalue = 0.408, X&......
Pvalue = 0.408, X<sup>2</sup>=0.68, OR (95% CI)=0.938 (0.811.09) in NIMH SZ
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No significant asso......
No significant association was reported in this study.
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Negative 
McAuley, E. Z., 2012 

rs4430518  rs433110 

GRIK4

Pvalue = 0.14 betw......
Pvalue = 0.14 between SCZ cases and controls; Pvalue = 0.769 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs4430518  rs433110  rs7111184 

GRIK4

Pvalue = 0.135 bet......
Pvalue = 0.135 between SCZ cases and controls; Pvalue = 0.855 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs4430518  rs433110  rs7111184  rs2156635 

GRIK4

Pvalue = 0.367 bet......
Pvalue = 0.367 between SCZ cases and controls; Pvalue = 0.758 between all cases and controls
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Negative 
Pickard, B. S., 2006 

rs7171233  rs7165988  rs2172835 
TCC 
C15orf53

CHI SQUARE = 1.077,......
CHI SQUARE = 1.077,Pvalue = 0.2993
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No significant asso......
No significant association was observed.
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Negative 
Kranz, T. M.,2012 

rs7171233  rs7165988  rs2172835 
AGT 
C15orf53

CHI SQUARE = 0.206,......
CHI SQUARE = 0.206,Pvalue = 0.6502
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No significant asso......
No significant association was observed.
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Negative 
Kranz, T. M.,2012 

rs7090018  rs11199993 
TG 
FGFR2

Pvalue=0.835, Perm......
Pvalue=0.835, Permutated Pvalue=1
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