Study Report

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Basic Info

Reference	Lee, K. Y., 2006 (b) PMID: 16289845
Citation	Lee, K. Y., Y. M. Ahn, et al. (2006). "No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population." Neurosci Lett 395(2): 175-178.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	138 schizophrenia and 120 bipolar disorder patients, 350 controls
SNP/Region/Marker Size	2 SNPs
Predominant Ethnicity	Mongloid
Population	Korean
Gender	144 male and 114 female patients, 174 male and 176 female controls
Age Group	adults : mean age=34.8 (SD=9.3) years of patients, mean age=25.9 (SD=6.6) years of controls

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All patients with schizophrenia or bipolar disorder were randomly collected from the Seoul National University Hospital and several psychiatric clinics in Korea. The subjects with a history of having any kind of organic abnormality of brain, alcohol problem, drug abuse, or other physical conditions possibly manifesting psychiatric symptoms were not included in this study. The final analyses were thereby based on 258 patients (138 schizophrenia and 120 bipolar disorder). Among the total 138 schizophrenic patients, 79 were classified into paranoid type and 59 into non-paranoid type. In the case of bipolar disorders, 93 met the DSM-IV diagnostic criteria for bipolar I disorder and 27 for bipolar II disorder.
Technique	PCR amplification using specific restriction endonucleases and genotyping using TaqMan
Statistical Method	Contingency chi-square tests or Fisher's exact test were performed for the comparison of allele and genotype frequencies between the patients and controls.
Result Summary	The results showed that allele, genotype and haplotype distributions for the two SNPs do not differ between the controls and neither schizophrenia nor bipolar disorder patients. We also analyzed the association between the controls and the combined samples of schizophrenia and bipolar disorder, but no association was found. In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population.

Genetic factors reported by this study for BD

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
GSK-3 beta_-1727A/T - GSK-3 beta_-50C/T	A-C, A-T, T-C, T-T	GSK3B	P-value = 0.68 for BD, P-value = 0.54 for BD and SZ	There was no difference in the haplotype frequency combinati...... There was no difference in the haplotype frequency combination between the patient and control groups. More...	Negative

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
GSK3B -50T/C	GSK3B	point mutation	C/T		allelic P-value = 0.45, genotypic P-value = 0.55 for BD patients, allelic P-value = 0.62, genotypic P-value = 0.53 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association...... Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls. More...	Negative
GSK3B -1727A/T	GSK3B	point mutation	A/T		allelic P-value = 0.58, genotypic P-value = 0.10 for BD patients, allelic P-value = 0.82, genotypic P-value = 0.34 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association...... Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
GSK3B	In conclusion, these results suggest that the GSK-3 beta is not associated with the development of s...... In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
SZ	GSK-3 beta_-1727A/T - GSK-3 beta_-50C/T	A-C, A-T, T-C, T-T	GSK3B	P-value = 0.81 for BD, P-value = 0.54 for BD and SZ	There was no difference in the haplotype frequency combination between the patient and control groups.	Negative

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
SZ	GSK3B -1727A/T	GSK3B	point mutation	allelic P-value = 0.86, genotypic P-value = 1.00 for SZ patients, allelic P-value = 0.82, genotypic P-value = 0.34 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls.	Negative
SZ	GSK3B -50T/C	GSK3B	point mutation	allelic P-value = 0.94, genotypic P-value = 0.76 for SZ patients, allelic P-value = 0.62, genotypic P-value = 0.53 for BD and SZ patients	Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	GSK3B	In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population.	Negative