BDgene

Study Report

Basic Info
Reference
Citation Lee, K. Y., Y. M. Ahn, et al. (2006). "No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population." Neurosci Lett 395(2): 175-178.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 138 schizophrenia and 120 bipolar disorder patients, 350 controls
SNP/Region/Marker Size 2 SNPs
Predominant Ethnicity Mongloid
Population Korean
Gender 144 male and 114 female patients, 174 male and 176 female controls
Age Group adults : mean age=34.8 (SD=9.3) years of patients, mean age=25.9 (SD=6.6) years of controls

Detail Info

Genetic factors reported by this study for BD
Haplotypes reported by this study for BD (count: 1)

Other variants reported by this study for BD (count: 2)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ GSK-3 beta_-1727A/T - GSK-3 beta_-50C/T A-C, A-T, T-C, T-T GSK3B P-value = 0.81 for BD, P-value = 0.54 for BD and SZ There was no difference in the haplotype frequency combination between the patient and control groups. Negative

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ GSK3B -1727A/T GSK3B point mutation allelic P-value = 0.86, genotypic P-value = 1.00 for SZ patients, allelic P-value = 0.82, genotypic P-value = 0.34 for BD and SZ patients Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls. Negative
SZ GSK3B -50T/C GSK3B point mutation allelic P-value = 0.94, genotypic P-value = 0.76 for SZ patients, allelic P-value = 0.62, genotypic P-value = 0.53 for BD and SZ patients Whether allele- or genotype-wise, no evidence of association with either samples of schizophrenia and bipolar disorder could be detected. Same results were obtained when the combined samples of schizophrenia and bipolar disorder were compared to healthy controls. When the samples were compared by each sex, there was also no evidence of association between patients and controls. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ GSK3B In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population. Negative