BDgene

Study Report

Basic Info
Reference
Citation Ohtsuki, T., H. Ishiguro, et al. (2002). "Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees." Mol Psychiatry 7(9): 954-961.
Disease Type Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 53 patients with bipolar disorder, 58 patients with depressive disorder (recurrent major depression), 96 patients with schizophrenia and 187 control subjects
SNP/Region/Marker Size 12 variants
Predominant Ethnicity
Population Japanese and NIMH collections
Gender Male/female:patients with bipolar disorder(30 men, 23 women), patients with depressive disorder(23 men, 35 women), 96 patients with schizophrenia (56 men, 40 women),and control subjects (103 men, 84 women)
Age Group Adults : patients with bipolar disorder(age 32-77 years (mean 55.2 years)), patients with depressive disorder(age 27-77 years (mean 58.7 years)), patients with schizophrenia (age 18-80 years (mean 51.4 years)),and control subjects ( age 35-74 (mean 53.6 years))

Detail Info

Genetic factors reported by this study for BD
Haplotypes reported by this study for BD (count: 3)

Other variants reported by this study for BD (count: 8)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ (HTR4_SVRSNP1) - (HTR4_SVRSNP4) C-A HTR4 Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=16/20, chi square=0.4, P-value = 0.5 No significant association was observed in SZ. Negative
SZ (HTR4_SVRSNP1) - (HTR4_SVRSNP4) C-G HTR4 Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=19/18, chi square=0.03, P-value = 0.87 Significant association was found in SZ. Positive
SZ (HTR4_SVRSNP1) - (HTR4_SVRSNP4) T-G HTR4 Haplotype analysis:Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=25/21, chi square=0.35, P-value = 0.56 No significant association was observed in SZ. Negative

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ HTR4 SVRSNP1 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.48, allele P-value = 0.28, OR=1.2OR(95%CI)=0.9-1.7;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=43/50, chi square=0.53, P-value = 0.47 No significant association was observed in SZ. Negative
SZ HTR4 IVS4+36T/C HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.47, allele P-value = 0.66, OR=1.1OR(95%CI)=0.7-1.7 No significant association was observed in SZ. Negative
SZ HTR4 SVRSNP3 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.19, allele P-value = 0.12, OR=1.4OR(95%CI)=0.9-2.1 No significant association was observed in SZ. Negative
SZ HTR4 SVRSNP2 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.55, allele P-value = 1, OR=1OR(95%CI)=0.6-1.7 No significant association was observed in SZ. Negative
SZ HTR4 IVS1+15T/C HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.28, allele P-value = 0.62, OR=0.8OR(95%CI)=0.3-2.1 No significant association was observed in SZ. Negative
SZ HTR4 IVS3+6G/A HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.97, allele P-value = 0.81, OR=1.1OR(95%CI)=0.7-1.7 No significant association was observed in SZ. Negative
SZ HTR4 IVS3+63C/T HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.65, allele P-value = 0.42, OR=1.3OR(95%CI)=0.8-2.2 No significant association was observed in SZ. Negative
SZ HTR4 SVRSNP4 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.34, allele P-value = 0.16, OR=1.3OR(95%CI)=0.9-2.0;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=34/45, chi square=1.53, P-value = 0.22 No significant association was observed in SZ. Negative
MDD HTR4 SVRSNP1 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.001, allele P-value = 0.0007, OR=2.1OR(95%CI)=1.4-3.2 Significant associations were found in MDD. Positive
MDD HTR4 IVS4+36T/C HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.49, allele P-value = 0.6, OR=1.3OR(95%CI)=0.6-2.6 No significant association was observed in MDD. Negative
MDD HTR4 SVRSNP3 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.09, allele P-value = 0.1, OR=1.7OR(95%CI)=0.9-3.3 No significant association was observed in MDD. Negative
MDD HTR4 SVRSNP2 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.08, allele P-value = 0.68, OR=0.2OR(95%CI)=0.5-2.6 No significant association was observed in MDD. Negative
MDD HTR4 IVS1+15T/C HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.47, allele P-value = 0.69, OR=0.4OR(95%CI)=0.1-3.4 No significant association was observed in MDD. Negative
MDD HTR4 IVS3+6G/A HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 1, allele P-value = 1, OR=0.97OR(95%CI)=0.5-2.0 No significant association was observed in MDD. Negative
MDD HTR4 IVS3+63C/T HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.8, allele P-value = 0.84, OR=0.9OR(95%CI)=0.4-2.0 No significant association was observed in MDD. Negative
MDD HTR4 SVRSNP4 HTR4 point mutation Association analysis:Fisher's exact test, genotype P-value = 0.03, allele P-value = 0.15, OR=1.4OR(95%CI)=0.9-2.3 Significant associations were found in MDD. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ HTR4 These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder. Negative
MDD HTR4 These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder. Positive