BDgene

GO Report

Basic Info
ID GO:0007165
Name signal transduction
Type biological process
No. of Genes in BDgene  136
Source Pathway by Database Search

PBA Result

GO related genes in BDgene (count: 136)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) Evidence[PMID]
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 5q34 1(0/1/0) TAS[8632757]
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 4p12 3(2/0/1) TAS[2465923]
PDE10A phosphodiesterase 10A 6q26 1(0/1/0) IEA
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0) TAS[21432781]
RGS5 regulator of G-protein signaling 5 1q23.1 1(0/0/1) IEA
CASP1 caspase 1, apoptosis-related cysteine peptidase 11q23 1(0/0/1) TAS[1373520]
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 15q12 3(1/2/0) TAS[1664410]
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0) TAS[7769088]
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(1/0/0) TAS[3037703]
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 10q22.2 2(1/1/0) NAS[8978785]
TENM4 teneurin transmembrane protein 4 11q13 6(4/2/0) IEA
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 22q11.21 3(1/2/0) NAS[7961848]
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 1(0/1/0) TAS[7958835]
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) IDA[8906617]
ARNTL aryl hydrocarbon receptor nuclear translocator-like 11p15 7(5/2/0) IEA
PRKCZ protein kinase C, zeta 1p36.33-p36.2 1(1/0/0) TAS[8224878]
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14q32.33 1(1/0/0) NAS[11470816]
NPAS3 neuronal PAS domain protein 3 14q13.1 2(1/1/0) IEA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 1(0/1/0) NAS[7877627]
PER2 period circadian clock 2 2q37.3 7(1/6/0) IEA
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 8p21-p11.2 1(0/1/0) TAS[8692981]
PER1 period circadian clock 1 17p13.1 5(2/3/0) IEA
ADCY8 adenylate cyclase 8 (brain) 8q24 4(2/1/1) TAS
NCK2 NCK adaptor protein 2 2q12 1(1/0/0) TAS[9737977]
INPP1 inositol polyphosphate-1-phosphatase 2q32 1(0/1/0) TAS[8390685]
GDNF glial cell derived neurotrophic factor 5p13.1-p12 1(1/0/0) TAS[7830769]
CHL1 cell adhesion molecule L1-like 3p26 1(1/0/0) TAS[9799093]
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 19q13.33 1(1/0/0) NAS[9480759]
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 8q21.1-q21.3 1(0/1/0) IMP[1377913]
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 17p13.1 1(1/0/0) IMP[8872460]
CHRM3 cholinergic receptor, muscarinic 3 1q43 1(0/1/0) TAS[10940357]
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 11q13.3 1(1/0/0) TAS[7796809]
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 2(0/2/0) TAS[8243272]
DPYSL2 dihydropyrimidinase-like 2 8p22-p21 2(1/0/1) TAS[8973361]
ANXA1 annexin A1 9q21.13 1(0/0/1) TAS[16130169]
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 10q26.3 1(0/0/1) IEA
PLCG1 phospholipase C, gamma 1 20q12-q13.1 1(0/1/0) NAS[7681365]; TAS
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 12p12.2-p11.2 3(1/2/0) IEA
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0) IDA[10572067]
NPHP4 nephronophthisis 4 1p36 1(1/0/0) NAS[12244321]
AKAP10 A kinase (PRKA) anchor protein 10 17p11.1 1(1/0/0) TAS[9326583]
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 4p16.1 2(1/1/0) IEA
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 22q12.3 2(1/1/0) NAS[1702217]
MAPK10 mitogen-activated protein kinase 10 4q22-q23 1(0/1/0) TAS[8654373]
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 6p22.3 1(0/1/0) TAS[7962207]
TENM2 teneurin transmembrane protein 2 5q35 1(0/0/1) IEA
KIF13B kinesin family member 13B 8p21 1(0/1/0) NAS[10859302]
PLA2G1B phospholipase A2, group IB (pancreas) 12q24.31 4(1/3/0) TAS[9886417]
CLOCK clock circadian regulator 4q12 12(5/7/0) IEA
EDAR ectodysplasin A receptor 2q13 1(0/1/0) IEA
ADM adrenomedullin 11p15.4 1(1/0/0) TAS[10822232]
MAP2K6 mitogen-activated protein kinase kinase 6 17q 1(0/1/0) TAS[8621675]
PTPRT protein tyrosine phosphatase, receptor type, T 20q12-q13 2(0/1/1) NAS[16973135]
NPAS2 neuronal PAS domain protein 2 2q11.2 5(3/2/0) IEA
NTS neurotensin 12q21.31 1(0/1/0) NAS[8954810]
ADRA1A adrenoceptor alpha 1A 8p21.2 2(0/2/0) TAS[8396931]
PNOC prepronociceptin 8p21 1(0/1/0) TAS[9521323]
ADCY2 adenylate cyclase 2 (brain) 5p15.3 2(1/1/0) TAS
CREBBP CREB binding protein 16p13.3 1(0/1/0) NAS[15261140]
CSNK2A1 casein kinase 2, alpha 1 polypeptide 20p13 2(0/2/0) TAS[2174700]
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 2p23 1(0/1/0) TAS[9737713]
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 8p22 1(0/1/0) TAS[8906617]
ESR1 estrogen receptor 1 6q24-q27 1(0/1/0) TAS[10749889]
GJA1 gap junction protein, alpha 1, 43kDa 6q22.31 1(1/0/0) IDA[1696265]
CCK cholecystokinin 3p22.1 2(0/1/1) TAS[10320330]
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 18p11.2 1(1/0/0) IMP[12761501]
AHRR aryl-hydrocarbon receptor repressor 5p15.33 1(1/0/0) IEA
IL1B interleukin 1, beta 2q14 1(1/0/0) TAS[10786823]
PER3 period circadian clock 3 1p36.23 7(3/4/0) IEA
CCL2 chemokine (C-C motif) ligand 2 17q11.2-q21.1 3(1/2/0) NAS[10770925]
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 17(13/3/1) IEA
CARTPT CART prepropeptide 5q13.2 1(0/1/0) TAS[8647455]
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 17q24.2 1(1/0/0) TAS
IL15RA interleukin 15 receptor, alpha 10p15.1 1(1/0/0) TAS[8530383]
CREM cAMP responsive element modulator 10p12.1-p11.1 1(0/1/0) TAS[7916662]
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) TAS[10049777]
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 12q24.32 1(0/1/0) IDA[9016352]
EGFR epidermal growth factor receptor 7p12 1(0/0/1) IDA[10572067]; TAS
CREB1 cAMP responsive element binding protein 1 2q34 2(1/1/0) TAS
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 15q24 3(2/1/0) NAS[9009220]
INTS6 integrator complex subunit 6 13q14.3 1(1/0/0) TAS[10467397]
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 2q24.3 3(2/0/1) IEA
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1p32.3 1(1/0/0) TAS[10380922]
ROR2 receptor tyrosine kinase-like orphan receptor 2 9q22 1(0/1/0) TAS[1334494]
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 15q25.1 1(0/1/0) IEA
VIPR2 vasoactive intestinal peptide receptor 2 7q36.3 1(1/0/0) TAS[7811244]
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 8p21.2 1(0/1/0) IEA
ITK IL2-inducible T-cell kinase 5q31-q32 1(1/0/0) TAS[8364206]
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1p36 1(0/0/1) NAS[15539461]
IL2RB interleukin 2 receptor, beta 22q13 2(1/1/0) TAS[2785715]
CRHBP corticotropin releasing hormone binding protein 5q13.3 1(0/1/0) TAS[7477348]
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 17q12 1(0/1/0) TAS[10604473]
TRAIP TRAF interacting protein 3p21.31 1(0/0/1) TAS[9104814]
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 5p13.1 1(1/0/0) IEA
CTNND2 catenin (cadherin-associated protein), delta 2 5p15.2 1(0/1/0) TAS[9223106]
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 15q12 6(6/0/0) TAS[1321750]
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 1(0/1/0) TAS[3443095]
GRIA1 glutamate receptor, ionotropic, AMPA 1 5q33 2(2/0/0) TAS[1311100]
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 14q32.32 1(0/1/0) TAS[9418861]
TRH thyrotropin-releasing hormone 3q13.3-q21 1(1/0/0) TAS[2126343]
PILRA paired immunoglobin-like type 2 receptor alpha 7q22.1 1(0/0/1) IDA[10903717]
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2q31.1 2(0/1/1) TAS[7619526]
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2q11.2 1(0/0/1) TAS[7608176]
STK24 serine/threonine kinase 24 13q31.2-q32.3 2(1/1/0) TAS[9353338]
ZDHHC13 zinc finger, DHHC-type containing 13 11p15.1 1(0/0/1) IMP[12761501]
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 1(1/0/0) IDA[8906617]
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1p36.1 1(0/1/0) TAS
KCNK10 potassium channel, two pore domain subfamily K, member 10 14q31 1(1/0/0) NAS[10880510]
IGF1 insulin-like growth factor 1 (somatomedin C) 12q23.2 1(1/0/0) TAS[10448861]
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2q13 1(0/1/0) IMP[12761501]
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1q21.3 1(1/0/0) IDA[8906617]
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 8p21 3(0/3/0) IDA[8906617]
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 14q32.31 1(0/1/0) NAS[8703017]
EDARADD EDAR-associated death domain 1q42.3 1(1/0/0) IEA
GUCA1A guanylate cyclase activator 1A (retina) 6p21.1 2(0/1/1) NAS[7983048]
ADRBK2 adrenergic, beta, receptor kinase 2 22q11 3(2/1/0) IEA
CSNK1D casein kinase 1, delta 17q25 4(2/2/0) TAS[8786104]
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 18p11.2 4(2/2/0) TAS[9322233]
CHRM4 cholinergic receptor, muscarinic 4 11p12-p11.2 1(0/1/0) TAS[9603968]
GRN granulin 17q21.32 2(2/0/0) NAS[1542665]
NRGN neurogranin (protein kinase C substrate, RC3) 11q24 2(1/1/0) TAS[10075657]
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 15q24 2(1/1/0) IDA[8906617]
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 3(1/2/0) IDA[8906617]
OR3A1 olfactory receptor, family 3, subfamily A, member 1 17p13.3 1(0/0/1) NAS[8921386]
ADCY9 adenylate cyclase 9 16p13.3 2(1/1/0) TAS
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3p21.31 1(0/1/0) TAS[7961880]
BCR breakpoint cluster region 22q11 2(1/1/0) TAS[1657398]
PRKCE protein kinase C, epsilon 2p21 1(0/1/0) TAS
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 8p11.21 3(1/2/0) TAS[7690916]
CRH corticotropin releasing hormone 8q13 2(1/1/0) TAS[7867564]
PENK proenkephalin 8q23-q24 1(0/1/0) TAS[7057924]
CSNK1E casein kinase 1, epsilon 22q13.1 5(1/3/1) TAS[7797465]
ADRA2A adrenoceptor alpha 2A 10q25.2 1(0/1/0) TAS[10896916]
CXCL12 chemokine (C-X-C motif) ligand 12 10q11.1 1(0/0/1) TAS[10491003]
NAMPT nicotinamide phosphoribosyltransferase 7q22.3 1(1/0/0) TAS[8289818]
OPTN optineurin 10p14 1(0/0/1) TAS[9488477]