Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	IMPA1
Previous Symbol	IMPA
Approved Name	inositol(myo)-1(or 4)-monophosphatase 1
Location	8q21.1-q21.3
Position	chr8:81657961-81686693, -1
External Links	HGNC: 6050 Entrez Gene: 3612 Ensembl: ENSG00000133731 UCSC: uc011lfq.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sjoholt, G., 2004		No association was found between the IMPA1 polymorphisms and bipolar disorder, neither with respect to disease susceptibility nor with variation in lithium treatment response.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

GO terms by PBA (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	10
GO:0006796	phosphate-containing compound metabolic process	biological process	IMP[1377913]	6
GO:0031403	lithium ion binding	molecular function	IDA[9462881]	1
GO:0052834	inositol monophosphate phosphatase activity	molecular function	IDA[9462881]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0000287	magnesium ion binding	molecular function	IDA[23027737]	11
GO:0043647	inositol phosphate metabolic process	biological process	TAS	7
GO:0042802	identical protein binding	molecular function	IPI[16189514]	44
GO:0008934	inositol monophosphate 1-phosphatase activity	molecular function	IDA[17068342]; IMP[1377913]	2
GO:0042803	protein homodimerization activity	molecular function	IDA[17068342]	71
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0030145	manganese ion binding	molecular function	IDA[9462881]	5
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0052832	inositol monophosphate 3-phosphatase activity	molecular function	IEA	2
GO:0007165	signal transduction	biological process	IMP[1377913]	136
GO:0005737	cytoplasm	cellular component	IDA[1377913]	322
GO:0006021	inositol biosynthetic process	biological process	IEA	2
GO:0052833	inositol monophosphate 4-phosphatase activity	molecular function	IEA	2
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0046855	inositol phosphate dephosphorylation	biological process	IDA[17068342]	3
GO:0006661	phosphatidylinositol biosynthetic process	biological process	IMP[1377913]	13

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00562	Inositol phosphate metabolism	11
hsa04070	Phosphatidylinositol signaling system	16

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00521	Streptomycin biosynthesis	2

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IMPA1	CALB1	NO	in vitro	12176979

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q12.1-q22.1	chr8:54600000-97900000	1 (1/0/0)
8p11.21-q21.13	chr8:39900000-83500000	1 (1/0/0)
8q13.3-21.13	chr8:69600000-83500000	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:81657961..81686693 View in gBrowse