Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TRAIP
Symbol Alias	TRIP, RNF206
Approved Name	TRAF interacting protein
Name Alias	ring finger protein 206
Location	3p21.31
Position	chr3:49828599-49856574, -1
External Links	HGNC: 30764 Entrez Gene: 10293 Ensembl: ENSG00000183763 UCSC: uc003cxs.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hamshere, M. L.,2009	SNP: rs2352974	the nearest gene of one independently associated SNP rs2352974 that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots)	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

GO terms by PBA (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006915	apoptotic process	biological process	TAS[9104814]	39
GO:0035556	intracellular signal transduction	biological process	IEA	38
GO:0016567	protein ubiquitination	biological process	IEA	18
GO:0007165	signal transduction	biological process	TAS[9104814]	136
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0016874	ligase activity	molecular function	IEA	16
GO:0004842	ubiquitin-protein transferase activity	molecular function	IEA	12
GO:0008283	cell proliferation	biological process	TAS[9104814]	37
GO:0005515	protein binding	molecular function	IPI[17474147]	563
GO:0005057	receptor signaling protein activity	molecular function	IEA	7
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	biological process	IDA[19151749]	1
GO:0005730	nucleolus	cellular component	IEA	28

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRAIP	FLII	NO	in vitro;yeast 2-hybrid	9671805
TRAIP	TRAF1	NO	in vitro;in vivo;yeast 2-hybrid	9104814
TRAIP	CYLD	NO	in vitro;in vivo;yeast 2-hybrid	14676304
TRAIP	TRAF2	NO	in vitro;in vivo;yeast 2-hybrid	9104814
TRAIP	TNFRSF1B	NO	in vitro;in vivo;yeast 2-hybrid	9104814

Related other genetic factors

Gene related SNPs (count: 11)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2352974	chr3:49853180 - 49853180(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 10)

rs_ID	Location	Functional Annotation
rs2681781	chr3:49860840 - 49860840(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant
rs2777888	chr3:49860567 - 49860567(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2681780	chr3:49860397 - 49860397(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2246832	chr3:49843701 - 49843701(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2271961	chr3:49840680 - 49840680(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2271960	chr3:49840645 - 49840645(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs695238	chr3:49831725 - 49831725(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs7645061	chr3:49831409 - 49831409(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs7648987	chr3:49831022 - 49831022(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs1128535	chr3:49828959 - 49828959(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p21	chr3:43600000-54400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:49828599..49856574 View in gBrowse