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Gene-gene interaction Search Result
Total result: 48
| Reference | Gene Group
|
Markers
|
Haplotype | Statistical Values | Author Comments | Result Category
|
|---|---|---|---|---|---|---|
| Schosser, A., 2010 | TSNAX DISC1 | rs766288 - rs2492367 | A-C | Individual P-value = 0.004, global P-value = 0.019 Individual P-value = 0.004, global P-value = 0.019 | showed global haplotype associations. Individual haplotype a...... showed global haplotype associations. Individual haplotype analyses showed that the A-C haplotypes of these two-marker combinations were under-represented in BD. More... | Positive |
| Palo, O. M., 2007 | TSNAX DISC1 | rs1655285 - rs751229; rs1615409 - rs1655285 - rs751229; rs1655285 - rs751229 - rs3738401 | G-T; C-G-T; G-T-A | Haplotype cross these two genes were tested. For haplotype "...... Haplotype cross these two genes were tested. For haplotype "rs1655285-rs751229(G-T)": Individual P-value = 0.399 in all, P-value = 0.704 in males, P-value = 0.418 in females; global P-value = 0.188 in all, P-value = 0.427 in males, P-value = 0.047 in females, with bipolar spectrum disorder; For haplotype "rs1615409 - rs1655285 - rs751229(C-G-T)": Individual P-value = 0.085 in all, P-value = 0.234 in males, P-value = 0.204 in females; global P-value = 0.114 in all, P-value = 0.287 in males, P-value = 0.106 in females, with bipolar spectrum disorder; For haplotype "rs1655285 - rs751229 - rs3738401(G-T-A)": Individual P-value = 0.261 in all, P-value = 0.039 in males, P-value = 0.965 in females; global P-value = 0.42 in all, P-value = 0.183 in males, P-value = 0.426 in females, with bipolar spectrum disorder. More... | Significant association were found in rs1655285-rs751229 an...... Significant association were found in rs1655285-rs751229 and rs1655285-rs751229-rs3738401. More... | Positive |
| Ram Murthy, A., 2012 | TSNAX DISC1 | rs766288 - rs3738401 - rs2812393 - rs821616; rs766288 - rs821616; rs766288 - rs2812393 | C-G-G-T; A-G-G-T; C-A | P-value < 0.05 for markers "rs766288-rs3738401-rs2812393-rs8...... P-value < 0.05 for markers "rs766288-rs3738401-rs2812393-rs821616" with haplotype "C-G-G-T" and "A-G-G-T", "rs766288-rs821616" with haplotype "C-A", "A-A" and "A-T", "rs766288-rs2812393" with haplotype "C-C" and "A-G" for BPAD or BPAD&SZ. More... | Several markers among thest two genes were tested associated...... Several markers among thest two genes were tested associated with BPAD or BPAD&SZ. More... | Positive |
| Lin, Y. M., 2007 | TPH1 TPH2 | TPH1_-346G - rs4570625 - rs11178997 - rs11178998 | G-T-A-G | Haplotype cross these two genes were tested. P-value < 0.001...... Haplotype cross these two genes were tested. P-value < 0.001, OR (95% CI) = 4.81 (2.62-8.83) More... | Of those with the TPH2 TAG haplotype, the risk was 4.81 time...... Of those with the TPH2 TAG haplotype, the risk was 4.81 times greater for individuals who also had the TPH1-346G allele More... | Positive |
| Pae, C. U.,2010 | TAAR6 HSPA1A | rs4305745 - rs562047 - rs452939 | Epistasis between TAAr6 and HSP-70 variations distinguishes ...... Epistasis between TAAr6 and HSP-70 variations distinguishes BD patients from controls. CV consistency?9/10; P<0.0010; testing balancing accuracy=0.65. More... | Homozygosis of the T allele at the rs4305745 was at risk of ...... Homozygosis of the T allele at the rs4305745 was at risk of BP only when co-occurring with the homozygosis for the C allele at rs562047 and A allele at rs452939. More... | Positive | |
| Severinsen, J. E., 2006 (a) | ST13 MCHR1 | rs710193 - rs133073; rs710193 - rs133073 - rs133070; rs710193 - rs133073 - rs133070 - rs133069; rs710193 - rs133073 - rs133070 - rs133069 - rs133068; rs1573745 - rs710193 - rs133073; rs1573745 - rs710193 - rs133073 - rs133070; rs1573745 - rs710193 - rs133073 - rs133070 - rs133069 | For markers "rs710193 - rs133073 - rs133070 - rs133069", CLU...... For markers "rs710193 - rs133073 - rs133070 - rs133069", CLUMP T1 P-value = 0.1755, CLUMP T4 P-value = 0.2417 in BPD and SZ, CLUMP T1 P-value = 0.1753, CLUMP T4 P-value = 0.2821 in BPD; Empirical overall P-value = 0.079 in BPD and SZ, Empirical overall P-value = 0.0252 in BPD.For markers "rs710193 - rs133073 - rs133070 - rs133069 - rs133068", CLUMP T1 P-value = 0.1722, CLUMP T4 P-value = 0.239 in BPD and SZ, CLUMP T1 P-value = 0.1745, CLUMP T4 P-value = 0.2831 in BPD; Empirical overall P-value = 0.1895 in BPD and SZ, Empirical overall P-value = 0.0018 in BPD. More... | Positive | ||
| Wang, T. Y., 2013 | SLC6A4 DRD2 | rs1800497 | S+_A1/A1; S+_A1/A2 | For haplotype "S+_A1/A1": P-value=0.001, OR=0.16 for all BP-...... For haplotype "S+_A1/A1": P-value=0.001, OR=0.16 for all BP-I, P-value=0.003, OR=0.12 for male BP-I, P-value=0.08, OR=0.19 for female BP-I; P-value<0.001, OR=0.13 for all BP-II, P-value=0.001, OR=0.10 for male BP-II, P-value=0.01, OR=0.15 for female BP-II. For haplotype "S+_A1/A2": P-value=0.70, OR=1.14 for all BP-I, P-value=0.45, OR=0.71 for male BP-I, P-value=0.28, OR=1.82 for female BP-I; P-value=0.55, OR=0.83 for all BP-II, P-value=0.49, OR=0.74 for male BP-II, P-value=0.90, OR=0.07 for female BP-II. More... | There was a significant interaction between the DRD2/ANKK1 T...... There was a significant interaction between the DRD2/ANKK1 Taq-IA and 5-HTTLPR polymorphisms in BP-I and BP-II. The association between DRD2, 5-HTTLPR, and the gene-to-gene interaction effect for BP-I was found in male patients but not in female patients. There were both main effects and an interaction effect of the DRD2 and SLC6A4 genes for the risk of BP-II in male patients, although not in female patients with BP-II. More... | Positive |
| Prabhu, S.,2012 | RYR2 CACNA2D4 | rs10925490 - rs2041140; rs677730 - rs11062012 | Interaction P-value:LD-contrast test = 4.61E-14;Logistic Reg...... Interaction P-value:LD-contrast test = 4.61E-14;Logistic Regression P-value = 1.28E-09 More... | We found a significant interaction between SNPs located with...... We found a significant interaction between SNPs located within genes encoding two calcium channel subunits: RYR2 on chr1q43 and CACNA2D4 on chr12p13 (LD-contrast test, ) More... | Positive | |
| Xu, C.,2012 | PLA2G6 TRPM2 | rs749909 | Interaction: Logistic Regression P-value = 0.009 Interaction: Logistic Regression P-value = 0.009 | A borderline interaction was found between rs749909 within T...... A borderline interaction was found between rs749909 within TRPM2 and rs4375 within iPLA2beta. More... | Positive | |
| Dmitrzak-Weglarz, M. P., 2014 | PER3 CLOCK | rs10462021 - rs6849474; rs10462021 - rs12649507 | P-value<0.01 P-value<0.01 | Significant SNPs pair interactions with P-value<0.01 in BD (...... Significant SNPs pair interactions with P-value<0.01 in BD (BD I but not BD II). More... | Positive | |
| Dmitrzak-Weglarz, M. P., 2014 | PER3 ARNTL | rs2172563 - rs4146388; rs2172563 - rs7107287 | P-value<0.01 P-value<0.01 | Significant SNPs pair interactions with P-value<0.01 in BD (...... Significant SNPs pair interactions with P-value<0.01 in BD (BD I and BD II). More... | Positive | |
| Emily, M.,2009 | PDGFRB KITLG | rs2237091 - rs1798011 | SNP-SNP interaction analysis:allelic X2 test:Marg...... SNP-SNP interaction analysis:allelic X2 test:Marginal effect 1, Pval=0.86, RR=1.01;Marginal effect 2, Pval=0.69, RR=1.02;Interaction test, P-value = 1.13E-09 More... | Significant association was found. Significant association was found. | Positive | |
| Barden, N., 2006 | P2RX7 CAMKK2 | rs1653625 - rs28360463 - rs1653622 - rs11065500 - rs11065501 - rs4980999 - rs3817190 | A-A-G-G-C-T-T; A-C-A-A-C-C-A; A-C-A-A-C-C-T; A-C-A-A-C-T-T; A-C-A-A-G-C-A; A-C-A-A-G-C-T; A-C-G-A-C-C-A; A-C-G-A-C-C-T; C-C-A-A-C-C-T | Haplotype cross these two genes were tested. For haplotype "...... Haplotype cross these two genes were tested. For haplotype "A-A-G-G-C-T-T", chi-square P-value = 0.362, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-A-A-C-C-A", chi-square P-value = 0.685, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-A-A-C-C-T", chi-square P-value = 0.487, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-A-A-C-T-T", chi-square P-value = 0.544, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-A-A-G-C-A", chi-square P-value = 0.106, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-A-A-G-C-T", chi-square P-value = 0.073, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "A-C-G-A-C-C-A", chi-square P-value = 0.163, LRS (global P-value) = 0.0249 with a sliding window strategy; For markers "A-C-G-A-C-C-T", chi-square P-value = 0.327, LRS (global P-value) = 0.0249 with a sliding window strategy; For haplotype "C-C-A-A-C-C-T", chi-square P-value = 0.012, LRS (global P-value) = 0.0249 with a sliding window strategy. More... | The other 7-SNP positively associated window bordered by mar...... The other 7-SNP positively associated window bordered by markers P2RX7-UTR3A and CAMKK2-E01B comprises blocks 3 and 4 and the associated marker P2RX4-UTR3A. More... | Positive |
| Barden, N., 2006 | P2RX4 CAMKK2 | rs1653625 - rs4980999 - rs3817190 - rs28360477 | C-C-T-C; C-C-A-C; G-C-T-C; C-T-T-C; G-C-A-T; G-C-A-C | Haplotype cross these two genes were tested. For haplotype "...... Haplotype cross these two genes were tested. For haplotype "C-C-T-C", chi-square P-value = 0.012, LRS (global P-value) = 0.039; For haplotype "C-C-A-C", chi-square P-value = 0.314, LRS (global P-value) = 0.039; For haplotype "G-C-T-C", chi-square P-value = 0.065, LRS (global P-value) = 0.039; For haplotype "C-T-T-C", chi-square P-value = 0.179, LRS (global P-value) = 0.039; For haplotype "G-C-A-T", chi-square P-value = 0.235, LRS (global P-value) = 0.039; For haplotype "G-C-A-C", chi-square P-value = 0.411, LRS (global P-value) = 0.039. More... | We identified global significant P-values for blocks 4 with ...... We identified global significant P-values for blocks 4 with P-value = 0.0390. The haplotype block 4 encloses the associated SNP P2RX4-UTR3A, hence supporting the prior single marker analysis. More... | Positive |
| Severinsen, J. E., 2006 (b) | MOV10L1 MLC1 | rs3810971 - rs137932; rs3810971 - rs137932 - rs137931; rs2272843 - rs3810971 - rs137932; rs3810971 - rs137932 - rs137931 - rs6010260; rs2272843 - rs3810971 - rs137932 - rs137931 | For markers "rs3810971 - rs137932", P-value = 0.8155 in BD, ...... For markers "rs3810971 - rs137932", P-value = 0.8155 in BD, P-value = 0.9882 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931", P-value = 0.8016 in BD, P-value = 0.8355 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932", P-value = 0.328 in BD, P-value = 0.4691 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931 - rs6010260", P-value = 0.7716 in BD, P-value = 0.2924 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932 - rs137931", P-value = 0.3263 in BD, P-value = 0.4295 in BD and SZ. More... | Negative | ||
| Severinsen, J. E., 2006 (b) | MLC1 BRD1 | rs6010260 - rs138881; rs6010260 - rs138881 - rs138880; rs137931 - rs6010260 - rs138881; rs6010260 - rs138881 - rs138880 - rs2239848; rs137931 - rs6010260 - rs138881 - rs138880; rs137932 - rs137931 - rs6010260 - rs138881 | For markers "rs6010260 - rs138881", P-value = 0.6883 in BD, ...... For markers "rs6010260 - rs138881", P-value = 0.6883 in BD, P-value = 0.4043 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880", P-value = 0.6108 in BD, P-value = 0.2102 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881", P-value = 0.1011 in BD, P-value = 0.1926 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880 - rs2239848", P-value = 0.5603 in BD, P-value = 0.3086 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881 - rs138880", P-value = 0.443 in BD, P-value = 0.2358 in BD and SZ; For markers "rs137932 - rs137931 - rs6010260 - rs138881", P-value = 0.2014 in BD, P-value = 0.3061 in BD and SZ. More... | Negative | ||
| Severinsen, J. E., 2006 (a) | MCHR1 ADSL | rs133068 - D22S279 - rs909669; rs133069 - rs133068 - D22S279 - rs909669; rs133070 - rs133069 - rs133068 - D22S279 - rs909669; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070; rs909669 - D22S279 - rs133068 - rs133069 - rs133070 | For markers "rs133068 - D22S279 - rs909669": CLUMP T1 P-valu...... For markers "rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.4823, CLUMP T4 P-value = 0.3996 in BPD and SZ, CLUMP T1 P-value = 0.8745, CLUMP T4 P-value = 0.7353 in BPD; Empirical overall P-value = 0.0319 in BPD and SZ, Empirical overall P-value = 0.3278 in BPD; For markers "rs133069 - rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.2672, CLUMP T4 P-value = 0.2064 in BPD and SZ, CLUMP T1 P-value = 0.7976, CLUMP T4 P-value = 0.5424 in BPD; Empirical overall P-value = 0.0591 in BPD and SZ, Empirical overall P-value = 0.5948 in BPD; For markers "rs133070 - rs133069 - rs133068 - D22S279 - rs909669": CLUMP T1 P-value = 0.0059, CLUMP T4 P-value = 0.0031 in BPD and SZ, CLUMP T1 P-value = 0.2957, CLUMP T4 P-value = 0.1557 in BPD; Empirical overall P-value = 0.339 in BPD and SZ, Empirical overall P-value = 0.4471 in BPD; For haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A)": CLUMP P-value = 0.1179 in BPD, P-value = 0.0006 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 -rs133069 - rs133070(C-6-C-C-A)": CLUMP P-value = 0.0406 in BPD, P-value = 0.3176 in BPD and SZ; For risk haplotype "rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A)": CLUMP P-value = 0.0026 in BPD, P-value = 7E-05 in BPD and SZ. More... | Similarly, comparing controls to the combined group of cases...... Similarly, comparing controls to the combined group of cases revealed significant associations with 2-, 3-, 4-, and 5-marker haplotypes spanning the SNPs in GPR24 as well as rs909669 in ADSL. More... | Positive | |
| Severinsen, J. E., 2006 (b) | MAPK8IP2 MOV10L1 | rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971; rs916005 - rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971 - rs137932; rs916005 - rs715519 - rs2272843 - rs3810971 | For markers "rs715519 - rs2272843", P-value = 0.6392 in BD, ...... For markers "rs715519 - rs2272843", P-value = 0.6392 in BD, P-value = 0.7516 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971", P-value = 0.3063 in BD, P-value = 0.4568 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843", P-value = 0.8328 in BD, P-value = 0.9786 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971 - rs137932", P-value = 0.4475 in BD, P-value = 0.4123 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843 - rs3810971", P-value = 0.3167 in BD, P-value = 0.7152 in BD and SZ. More... | Negative | ||
| Papiol, S.,2004 | IL1B IL1RN | rs16944 - (IL1RN_intron 2_VNTR) | C-VNTR(A2) | Haplotype analysis: Bipolar disorder v controls: chi square=...... Haplotype analysis: Bipolar disorder v controls: chi square= 9.81, global P-value = 0.043; chi square= 8.09, individual P-value = 0.004; OR = 2.26(95% CI: 1.22 to 4.17). Bipolar disorder FH+ v controls: chi square = 15.90, global P-value = 0.0031; chi square= 15.41, individual P-value = 0.00009; OR= 3.18 (95% CI: 1.66 to 6.05). More... | Significant association was found in BD. Significant association was found in BD. | Positive |
| Mohammadynejad, P.,2011 | GSTM1 GSTT1 | (GSTM1_positive/null) - (GSTT1_positive/null) | (GSTM1_positive) - (GSTT1_null); (GSTM1_null) - (GSTT1_positive); (GSTM1_null) - (GSTT1_null) | For markers "(GSTM1_positive) - (GSTT1_null)": For early ons...... For markers "(GSTM1_positive) - (GSTT1_null)": For early onset BPD, X2 test: genotype P-value = 0.032. For late onset BPD, X2 test: genotype P-value = 0.639; For markers "(GSTM1_null) - (GSTT1_positive)": For early onset BPD, X2 test: genotype P-value = 0.137.For late onset BPD, X2 test: genotype P-value = 0.755; For markers "(GSTM1_null) - (GSTT1_null)": For early onset BPD, X2 test: genotype P-value = 0.331. For late onset BPD, X2 test: genotype P-value = 0.336. More... | Significant association was found in early-onset BD. Significant association was found in early-onset BD. | Positive |
| Fullerton, J. M.,2010 | GPX3 SOD2 | rs3792797 - rs4880; rs3792797 - rs5746136 | Interaction analysis: for makers "rs3792797 - rs4880", genot...... Interaction analysis: for makers "rs3792797 - rs4880", genotype, at narrow additive interaction model (P-value = 0.008), after Bonferroni correction for multiple testing (P-value = 0.055); for markers "(rs3792797-rs8177435) - (rs5746136-rs4880)", OR = 2.247, X2 = 9.526, P-value = 0.002026, corrected P-value = 0.029. More... | Significant association was found in BD. Significant association was found in BD. | Positive | |
| Geller, B., 2008 | GAD1 BDNF | rs2241165 - BDNF_Val66Met | no P-value given in the original article no P-value given in the original article | No significant interaction was found between the GAD1 and BD...... No significant interaction was found between the GAD1 and BDNF alleles in this sample. More... | Negative | |
| Szczepankiewicz A., 2014 | FKBP5 NR3C1 | rs4713916 - rs6196; rs4713916 - rs3800373 - rs6196 | P-value=0.559 for markers rs4713916 - rs6196; P-value=0.430 ...... P-value=0.559 for markers rs4713916 - rs6196; P-value=0.430 for markers rs4713916 - rs3800373 - rs6196. More... | The best (but not significant) combinations of possibly inte...... The best (but not significant) combinations of possibly interactive polymorphisms in predicting bipolar disorder were observed for rs4713916 of FKBP5 and rs6196 of NR3C1 for 2-locus model, and rs4713916 and rs3800373 of FKBP5 and rs6196 of NR3C1 for 3-locus model. More... | Negative | |
| Lin, C. I.,2010 | DRD3 SLC6A4 | (DRD3_Ser9Gly) - (5-HTTLPR) | multiple regression: BP-I vs. control group, OR(95%CI)=0.144...... multiple regression: BP-I vs. control group, OR(95%CI)=0.144(0.014-1.479), P-value = 0.103; BP-II vs. control group, OR(95%CI) = 1.231(0.173-8.767), P-value = 0.835; BP-I vs. BP-II, OR(95%CI) = 0.154(0.023-1.032), P-value = 0.054. More... | No significant association was found . No significant association was found . | Negative | |
| Van Den Bogaert, A., 2006 (b) | DRD3 SLC6A4 | DRD3 (TT) - 5-HTT (ii); DRD3 (CT) - 5-HTT (di); DRD3 (CT) - 5-HTT (dd); DRD3 (CC) - 5-HTT (di); DRD3 (CC) - 5-HTT (dd) | For markers "DRD3 (TT) - 5-HTT (ii)", P-value = 0.3; For mar...... For markers "DRD3 (TT) - 5-HTT (ii)", P-value = 0.3; For markers "DRD3 (CT) - 5-HTT (di)", P-value = 0.4, OR=0.67, 95% CI = 0.27-1.66; For markers "DRD3 (CT) - 5-HTT (dd)", P-value = 0.3, OR = 0.52, 95%CI = 0.15-1.82; For markers "DRD3 (CC) - 5-HTT (di)", P-value = 0.7, OR=0.75, 95% CI=0.19-2.96; For markers "DRD3 (CC) - 5-HTT (dd)", P-value = 0.2, OR = 4.13, 95% CI = 0.5-33.88. More... | no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More... | Negative | |
| Hu, M. C.,2012 | DRD2 MAOA | DRD2_TaqI Polymorphism - MAOA_promoter_3 repeat; DRD2_TaqI Polymorphism - MAOA_promoter_4 repeat | Pearson’s chi-square test: chi square = 11.268, P-value = ...... Pearson’s chi-square test: chi square = 11.268, P-value = 0.004 for DRD2_TaqI Polymorphism-MAOA_promoter_3 repeat; chi square = 0.271,P-value = 0.873 for DRD2_TaqI Polymorphism-MAOA_promoter_4 repeat. More... | The MAOA-uVNTR 3-repeat had a significant protective effect ...... The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. No evidence support the association of DRD2_TaqI Polymorphism-MAOA_promoter_4 repeat with BD. More... | Positive | |
| Wang, Y. S., 2013 | DRD2 ALDH2 | DRD2_Taq-I A1/A1_ALDH2*1*1 | DRD2_Taq-I A1/A1_ALDH2*1*1 | P-value=0.001, X2=10.506, OR=5.623 P-value=0.001, X2=10.506, OR=5.623 | a significant interaction of the DRD2 Taq-I A1/A1 and the AL...... a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls More... | Positive |
| Shi, J., 2008 (d) | DEC1 TMEM165 CSNK1E | rs6442925 - rs534654 - rs1534891; rs6442925 - rs534654 - rs135757 | For markers "rs6442925 - rs534654 - rs1534891", FDR-cutoff P...... For markers "rs6442925 - rs534654 - rs1534891", FDR-cutoff P-value = 1.77E-06; FITF P-value = 1.72E-06. For markers "rs6442925 - rs534654 - rs135757", FDR-cutoff P-value = 1.77E-06; FITF P-value = 2.62E-05. More... | A significant multi-locus interaction between rs6442925 in B...... A significant multi-locus interaction between rs6442925 in BHLHB2, rs1534891 in CSNK1E, and rs534654 near 3' of CLOCK gene was identified in Sample II, which remained significant after correction for multiple testing using a false discovery rate method. More... | Positive | |
| Shi, J., 2008 (d) | DEC1 CRY1 NR1D1 | rs6442925 - rs714359 - rs16965644 | FDR-cutoff P-value = 1.77E-06; FITF P-value = 8.88E-06 FDR-cutoff P-value = 1.77E-06; FITF P-value = 8.88E-06 | Negative | ||
| Shi, J., 2008 (d) | DEC1 CLOCK CSNK1E | rs2137947 - rs6850524 - rs1534891 | FDR-cutoff P-value = 1.77E-06; FITF P-value = 7.59E-05 FDR-cutoff P-value = 1.77E-06; FITF P-value = 7.59E-05 | Negative | ||
| Gaysina, D.,2010 | DAOA DAO | rs3916965 - rs3741775; rs1935062 - rs3741775 | Interaction analysis: For markers "rs3916965 - rs3741775", P...... Interaction analysis: For markers "rs3916965 - rs3741775", P-value = 0.048(>0.05 after correction) in the UK sample. Form markers "rs1935062 - rs3741775", P-value = 0.027(>0.05 after correction) in the UK sample. More... | No significant association was found . No significant association was found . | Negative | |
| Van Den Bogaert, A., 2006 (b) | COMT SLC6A4 | COMT (AA) - 5-HTT (ii); COMT (AG) - 5-HTT (di); COMT (AG) - 5-HTT (dd); COMT (GG) - 5-HTT (di); COMT (GG) - 5-HTT (dd) | For markers "COMT (AA) - 5-HTT (ii)", P-value = 0.2; For mar...... For markers "COMT (AA) - 5-HTT (ii)", P-value = 0.2; For markers "COMT (AG) - 5-HTT (di)", P-value = 0.2, OR = 0.5, 95% CI = 0.19-1.31; For markers "COMT (AG) - 5-HTT (dd)", P-value = 0.2, OR=0.37, 95% CI=0.1-1.45; For markers "COMT (GG) - 5-HTT (di)", P-value = 0.8, OR=0.82, 95% CI=0.23-2.87; For markers "COMT (GG) - 5-HTT (dd)", P-value = 0.5, OR=1.77, 95% CI=0.37-8.36. More... | no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More... | Negative | |
| Wang, L. J., 2015 | COMT MTHFR | COMT_Val158Met, MTHFR_C677T | COMT_Val/Val_MTHFR C/T+T/T | P-value=0.034, OR (95% CI)=0.58 (0.35-0.96);P-value=0.039, O...... P-value=0.034, OR (95% CI)=0.58 (0.35-0.96);P-value=0.039, OR (95% CI)=0.57 (0.33-0.97) More... | Logistic regression analysis showed a significant interactio...... Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype for the protective effect on the odds of developing BP-II. More... | Positive |
| Van Den Bogaert, A., 2006 (b) | COMT DRD3 | COMT (AA) - DRD3 (TT); COMT (AG) - DRD3 (CT); COMT (AG) - DRD3 (CC); COMT (GG) - DRD3 (CT); COMT (GG) - DRD3 (CC) | For markers "COMT (AA) - DRD3 (TT)", P-value = 0.6; For mark...... For markers "COMT (AA) - DRD3 (TT)", P-value = 0.6; For markers "COMT (AG) - DRD3 (CT)", P-value = 0.4, OR=0.69, 95% CI = [0.28-1.72]; For markers "COMT (AG) - DRD3 (CC)", P-value = 0.9, OR = 0.93, 95% CI = 0.25-3.57; For markers "COMT (GG) - DRD3 (CT)", P-value = 0.4, OR = 1.71, 95% CI = 0.53-5.47; For markers "COMT (GG) - DRD3 (CC)", P-value = 0.8, OR=1.29, 95% CI = 0.21-7.94. More... | no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More... | Negative | |
| Jan, W. C., 2014 | CACNA1E CACNB2 CACNG2 CACNA1C | rs704326 - rs11013860 - rs5750285 - rs10848635 | Training Bal. Acc. (%) = 0.6681, Testing Bal. Acc. (%)= 0.45...... Training Bal. Acc. (%) = 0.6681, Testing Bal. Acc. (%)= 0.4525 More... | The 4-loci interaction model showed high training accuracy b...... The 4-loci interaction model showed high training accuracy but moderate cross validation consistency of 6 out of 10 tests. The four loci were rs704326, rs11013860, rs10848635, and rs5750285; three of them were reported to be associated with BP at single marker level. More... | Trend | |
| Jan, W. C., 2014 | CACNA1E CACNB2 CACNG2 | rs704326 - rs11013860 - rs5750285 | Training Bal. Acc. (%) = 0.6125, Testing Bal. Acc. (%)= 0.44...... Training Bal. Acc. (%) = 0.6125, Testing Bal. Acc. (%)= 0.4425 More... | Trend | ||
| Jan, W. C., 2014 | CACNA1E CACNB2 | rs704326 - rs11013860 | Training Bal. Acc. (%) = 0.5781, Testing Bal. Acc. (%)= 0.52...... Training Bal. Acc. (%) = 0.5781, Testing Bal. Acc. (%)= 0.5225 More... | The 2-locus model was considered the best model as it had th...... The 2-locus model was considered the best model as it had the highest cross-validation consistency and acceptable testing-balanced accuracy, involving rs704326 in CACNA1E and rs11013860 in CACNB2. Both of the two markers showed weak associations with BP-I in previous single locus association analysis. More... | Trend | |
| Severinsen, J. E., 2006 (b) | BRD1 FAM19A5 | rs4468 - D22S1169 - D22S922 - rs132234 | P-value = 0.7872 in BD, P-value = 0.1853 in BD and SZ P-value = 0.7872 in BD, P-value = 0.1853 in BD and SZ | Negative | ||
| Lee, S. Y.,2012(a) | BDNF DRD3 | DRD3_Ser/Gly - BDNF_Val/Met | DRD3_Ser/Ser-BDNF_Val/Val;DRD3_Ser/Gly-BDNF_Val/Val | DRD3_Ser/Ser-BDNF_Val/Val:OR = 0.10 ,95%CI = 0.01–0.78 ,P-...... DRD3_Ser/Ser-BDNF_Val/Val:OR = 0.10 ,95%CI = 0.01–0.78 ,P-value = 0.027;DRD3_Ser/Gly-BDNF_Val/Val:OR = 0.06 ,95%CI = 0.008–0.45 ,P-value = 0.006 More... | Significant association was observed in BP-II , but no signi...... Significant association was observed in BP-II , but no significant association was observed for other three haplotypes. More... | Positive |
| Chang, Y. H.,2013 | BDNF DRD3 | BDNF_Val66Met-DRD3_Ser9Gly | BDNF_Met/Val-DRD3_Ser/Gly; BDNF_Met/Val-DRD3_Gly/Gly; BDNF_Val/Val-DRD3_Ser/Gly; BDNF_Val/Val-DRD3_Gly/Gly | BDNF_Met/Val-DRD3_Ser/Gly: BD-II without AD, OR = 1.5, 95%CI...... BDNF_Met/Val-DRD3_Ser/Gly: BD-II without AD, OR = 1.5, 95%CI = 0.36–6.16, P-value = 0.58; BD-II without AD, OR = 0.71, 95%CI = 0.10–5.02, P-value = 0.73; BD-I without AD, OR = 0.84, 95%CI = 0.18–3.99, P-value = 0.83; BD-I without AD, OR = 3.7,95%CI = 0.09–147.14, P-value = 0.49. BDNF_Met/Val-DRD3_Gly/Gly: BD-II without AD, OR = 2.63, 95%CI = 0.63–11.06, P-value = 0.19; BD-II without AD, OR = 4.89,95%CI = 0.54–44.08, P-value = 0.16; BD-I without AD, OR = 1.9, 95%CI = 0.40–9.15, P-value = 0.42; BD-I without AD, OR = 0.78, 95%CI = 0.02–25.46, P-value = 0.89. BDNF_Val/Val-DRD3_Ser/Gly: BD-II without AD, OR = 2.48, 95%CI = 0.81–7.63, P-value = 0.11; BD-II without AD, OR = 2.58, 95%CI = 0.46–14.35, P-value = 0.28; BD-I without AD, OR = 3.2, 95%CI = 0.84–12.26, P-value = 0.09; BD-I without AD, OR = 191000000, 95%CI = 1.56E+07–2.32E+09, P-value = 0.0005. BDNF_Val/Val-DRD3_Gly/Gly: BD-II without AD, OR = 3.05,95%CI = 0.99-9.4, P-value = 0.05; BD-II without AD, OR = 11.52, 95%CI = 1.60–82.72, P-value = 0.02; BD-I without AD, OR = 3.18, 95%CI = 0.82–12.41, P-value = 0.1. More... | No significant association was observed for BDNF_Met/Val-DRD...... No significant association was observed for BDNF_Met/Val-DRD3_Ser/Gly and BDNF_Met/Val-DRD3_Gly/Gly. Significant association was observed for BDNF_Val/Val-DRD3_Ser/Gly and BDNF_Val/Val-DRD3_Gly/Gly. More... | Positive |
| Hamshere, M. L.,2012 | BDNF DRD2 | BDNF_Val66Met - DRD2_Taq-IA | BDNF Val/Val-(DRD2 Taq-IA A1/A1); BDNF Val/Val-(DRD2 Taq-IA A1/A2); BDNF Val/Met-(DRD2 Taq-IA A1/A1); BDNF Val/Met-(DRD2 Taq-IA A1/A2) | Logistic Regression Analysis: For haplotype "BDNF Val/Val-(D...... Logistic Regression Analysis: For haplotype "BDNF Val/Val-(DRD2 Taq-IA A1/A1)", OR=0.56, 95%CI=0.12-2.70, P-value = 0.47 in BP-I;;OR=1.21, 95%CI=0.26-5.59, P-value = 0.81 in BP-II. For haplotype "BDNF Val/Val-(DRD2 Taq-IA A1/A2)", OR=2.16, 95%CI=0.66-7.07, P-value = 0.2 in BP-I;OR=4.17, 95%CI=1.33-13.08, P-value = 0.015 in BP-II. For haplotype "BDNF Val/Met-(DRD2 Taq-IA A1/A1)", OR=0.4, 95%CI=0.10-1.62, P-value = 0.2 in BP-I;;OR=0.33, 95%CI=0.09-1.21, P-value = 0.09 in BP-II. For haplotype "BDNF Val/Met-(DRD2 Taq-IA A1/A2)", OR=1.33, 95%CI=0.46-3.88, P-value = 0.6 in BP-I;;OR=0.92, 95%CI=0.36-2.341, P-value = 0.87 in BP-II. More... | Significant association was observed in BP-II for haplotype ...... Significant association was observed in BP-II for haplotype "BDNF Val/Val-(DRD2 Taq-IA A1/A2)", but no significant association was observed for other three haplotypes. More... | Positive |
| Huang, C. C.,2012 | BDNF DRD2 | BDNF_Val/Val - DRD2_Taq-IA A1/A1; BDNF_Val/Val - DRD2_Taq-IA A1/A2; BDNF_Val/Met - DRD2_Taq-IA A1/A1; BDNF_Val/Met - DRD2_Taq-IA A1/A2 | Logistic Regression P-value=0.20, OR=2.16, 95% CI=0.66-7.07 ...... Logistic Regression P-value=0.20, OR=2.16, 95% CI=0.66-7.07 in BPI, P-value=0.015, OR=4.17, 95% CI=1.33-13.08 in BPII for markers "BDNF_Val/Val-DRD2_Taq-IA A1/A2" and negative for all other three groups of markers. More... | Moreover, in the BP-II group, the interaction between the A1...... Moreover, in the BP-II group, the interaction between the A1/ A2 genotype of the DRD2/ANKK1 Taq1A polymorphism and the Val/Val genotype of the BDNF Val66Met polymorphism were higher than in the Control group. More... | Positive | |
| Lee, S. Y.,2012(b) | BDNF COMT | COMT_Val/Met - BDNF_Val/Met | COMT_Met/Met-BDNF_Val/Val;COMT_Val/Met-BDNF_Val/Val | COMT_Met/Met-BDNF_Val/Val:OR = 0.23,95%CI = 0.05–0.99,P-va...... COMT_Met/Met-BDNF_Val/Val:OR = 0.23,95%CI = 0.05–0.99,P-value = 0.048;COMT_Val/Met-BDNF_Val/Val:OR = 0.31,95%CI = 0.13–0.73 ,P-value = 0.007 More... | Significant association was observed in BP-II , but no signi...... Significant association was observed in BP-II , but no significant association was observed for other haplotypes. More... | Positive |
| Hu, X.,2010 | ASTN2 SNAP29 | rs10124883 - rs178069; rs10123629 - rs165596; rs10123629 - rs178069; rs10124883 - rs165596; rs10124883 - rs178069 | SNP-SNP interaction: for markers "rs10124883 - rs178069", P-...... SNP-SNP interaction: for markers "rs10124883 - rs178069", P-value = 5.37E-12 for WTCCC data. For markers "rs10123629 - rs165596", P-value = 0.132 for replication study(Chinese sample). For markers "rs10123629 - rs178069", P-value = 0.021 for replication study(Chinese sample). For markers "rs10124883 - rs165596", P-value = 0.035 for replication study(Chinese sample). For markers "rs10124883 - rs178069", P-value = 0.031 for replication study(Chinese sample). More... | Significant association was found in BPD. Significant association was found in BPD. | Positive | |
| Hu, X.,2010 | ASTN2 PI4KA | rs10124883 - rs6004133; rs10123629 - rs6004133; rs10123629 - rs165730; rs10124883 - rs6004133; rs10124883 - rs165730 | SNP-SNP interaction: for markers "rs10124883 - rs6004133", P...... SNP-SNP interaction: for markers "rs10124883 - rs6004133", P-value = 6.49E-12 for WTCCC data. For markers "rs10123629 - rs6004133", P-value = 0.026 for replication study(Chinese sample). For markers "rs10123629 - rs165730", P-value = 0.085 for replication study(Chinese sample). For markers "rs10124883 - rs6004133", P-value = 0.027 for replication study(Chinese sample). For markers "rs10124883 - rs165730", P-value = 0.038 for replication study(Chinese sample). More... | Significant association was found in BPD. Significant association was found in BPD. | Positive | |
| Lee, S. Y., 2012 | ALDH2 HTR2A | ALDH2_*1*1* - HTR2A_-1438A/GA/A; ALDH2_*1*1* - HTR2A_-1438A/GA/G | For markers "ALDH2_*1*1* - HTR2A_-1438A/GA/A", P-value = 0.0...... For markers "ALDH2_*1*1* - HTR2A_-1438A/GA/A", P-value = 0.015, OR(95% CI)=0.27(0.09-0.77) in BP-I, P-value = 0.680, OR(95% CI)=0.83(0.35-1.98) in BP-II. For markers "ALDH2_*1*1* - HTR2A_-1438A/GA/G", P-value = 0.005, OR(95% CI)=0.22(0.08-0.64) in BP-I, P-value = 0.294, OR(95% CI)=0.64(0.28-1.47) in BP-II More... | a significant interaction between the ALDH2 and 5-HT2A-1438A...... a significant interaction between the ALDH2 and 5-HT2A-1438A/G polymorphisms was detected in BP-I. No associations were detected between the ALDH2 and 5-HT2A-1438A/G polymorphisms and BP-II. More... | Positive | |
| Lee, S. Y.,2010 | ALDH2 DRD2 | ALDH2_*1/*2 - rs1800497 | (ALDH2_1*1*)-(DRD2Taq-I A1/A1); (ALDH2_1*1*)-(DRD2 Taq-I A1/A2) | Logistic regression analysis: For haplotype "(ALDH2_1*1*) - ...... Logistic regression analysis: For haplotype "(ALDH2_1*1*) - (DRD2Taq-I A1/A1)", for BP-I, OR = 2.043, 95%CI = [0.622-6.710], P-value = 0.239; for BP-II, OR = 4.534, 95%CI = [1.455-14.129], P-value = 0.009; For haplotype" (ALDH2_1*1*) - (DRD2 Taq-I A1/A2)", for BP-I, OR = 1.201, 95%CI = [0.519-2.779], P-value = 0.669; for BP-II, OR = 1.353, 95%CI = [0.531-2.502], P-value = 0.719. More... | Significant association was found in BD-II. Significant association was found in BD-II. | Positive |
| Zandi, P. P., 2008 (b) | ADCY8 ST3GAL1 | rs1411187 - rs6986303 | Global X2=28.90; global P-value = 3.0E-04 Global X2=28.90; global P-value = 3.0E-04 | Multi-locus analyses suggested joint effects between ADCY8 a...... Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 , with at least one copy of the ''high risk'' allele required at both genes for association with BP. More... | Positive |