BDgene

Study Report

Basic Info
Reference
Citation Pae, C. U., A. Drago, et al. (2010). "Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders." Am J Med Genet B Neuropsychiatr Genet 153B(2): 680-683.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Genetic interaction study
Sample Size 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients,and 288 controls
SNP/Region/Marker Size 8 SNPs
Predominant Ethnicity Mongloid
Population Korean

Detail Info

Genetic factors reported by this study for BD
Haplotypes reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 2)

Gene-gene interactions reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
MDD rs4305745 - rs562047 - rs452939 TAAR6, HPS70 Epistasis between TAAr6 and HSP-70 variations distinguishes MDD patients from controls. CV consistency=9/10; P<0.0010; testing balancing accuracy=0.62. Heterozygosis or homozygosis for the T allele at rs4305745 turned out to be at risk of depressive disorder in the co-occurrence of the C allele at rs562047 and heterozygosis at rs452939. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD TAAR6 A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. Positive
MDD HSPA1A A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. Positive

Gene-gene interactions reported by this study for SZ/MDD
Disease Gene Group Markers Statistical Values Description Result Category
MDD rs4305745 - rs562047 - rs452939 Epistasis between TAAr6 and HSP-70 variations distinguishes MDD patients from controls. CV consistency=9/10; P<0.0010; testing balancing accuracy=0.62. Heterozygosis or homozygosis for the T allele at rs4305745 turned out to be at risk of depressive disorder in the co-occurrence of the C allele at rs562047 and heterozygosis at rs452939. Positive