Study Report

Basic Info

Reference	Pae, C. U.,2010 PMID: 19582769
Citation	Pae, C. U., A. Drago, et al. (2010). "Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders." Am J Med Genet B Neuropsychiatr Genet 153B(2): 680-683.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Genetic interaction study
Sample Size	187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients,and 288 controls
SNP/Region/Marker Size	8 SNPs
Predominant Ethnicity	Mongloid
Population	Korean

Detail Info

Sample Diagnosis	DSM
Sample Status	Sample characteristics, inclusion and exclusion criteria, battery test, and the timing of the study have been described elsewhere along with the details related to the genotyping and the rational of the selection of the investigated variations (187 MDD patients,171 BD patients, and 288 controls) [Pae et al., 2007, 2008].Patients with any additional axis I disorders were excluded.
Technique	genotyping
Statistical Method	The multifactor dimensionality reduction (MDR) method was employed to investigate the gene-gene interactions [Lou et al., 2007].
Result Summary	A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P?

Genetic factors reported by this study for BD

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs4305745 - rs562047 - rs452939		TAAR6, HPS70	Epistasis between TAAr6 and HSP-70 variations distinguishes BD patients from controls. CV consistency?9/10; P<0.0010; testing balancing accuracy=0.65.	Homozygosis of the T allele at the rs4305745 was at risk of ...... Homozygosis of the T allele at the rs4305745 was at risk of BP only when co-occurring with the homozygosis for the C allele at rs562047 and A allele at rs452939. More...	Positive

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
TAAR6	A significant predictive value of specific interactions between genotypes located in the investigate...... A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. More...	Positive
HSPA1A	A significant predictive value of specific interactions between genotypes located in the investigate...... A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
TAAR6 HSPA1A	rs4305745 - rs562047 - rs452939	Epistasis between TAAr6 and HSP-70 variations distinguishes BD patients from controls. CV consistency?9/10; P<0.0010; testing balancing accuracy=0.65.	Homozygosis of the T allele at the rs4305745 was at risk of ...... Homozygosis of the T allele at the rs4305745 was at risk of BP only when co-occurring with the homozygosis for the C allele at rs562047 and A allele at rs452939. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
MDD	rs4305745 - rs562047 - rs452939		TAAR6, HPS70	Epistasis between TAAr6 and HSP-70 variations distinguishes MDD patients from controls. CV consistency=9/10; P<0.0010; testing balancing accuracy=0.62.	Heterozygosis or homozygosis for the T allele at rs4305745 turned out to be at risk of depressive disorder in the co-occurrence of the C allele at rs562047 and heterozygosis at rs452939.	Positive

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	TAAR6	A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders.	Positive
MDD	HSPA1A	A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders.	Positive

Gene-gene interactions reported by this study for SZ/MDD

Disease	Gene Group	Markers	Statistical Values	Description	Result Category
MDD		rs4305745 - rs562047 - rs452939	Epistasis between TAAr6 and HSP-70 variations distinguishes MDD patients from controls. CV consistency=9/10; P<0.0010; testing balancing accuracy=0.62.	Heterozygosis or homozygosis for the T allele at rs4305745 turned out to be at risk of depressive disorder in the co-occurrence of the C allele at rs562047 and heterozygosis at rs452939.	Positive