Study Report
Basic Info
| Reference |
Wang, Y. S., 2013 PMID: 23835015
|
| Citation |
Wang, Y. S., S. Y. Lee, et al. (2013). "Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder." Eur Psychiatry.
|
| Disease Type |
bipolar II disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
335 BP-II without AD patients, 127 BP-II with AD patients, and 348 healthy controls |
| SNP/Region/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Age Group |
adults
:
54% female and 46% male BP-II without AD, 50.4% female and 49.6% male BP-II with AD, 27.3% female and 72.7 male controls
|
Detail Info
| Sample Diagnosis |
DSM-IV-TR |
| Sample Status |
The sample consisted of a total 462 patients with a DSM-IV-TR diagnosis of bipolar II disorder (335 BP-II without AD; 127 BP-II with AD) and 348 normal controls. The subjects were recruited from the outpatient and inpatient settings of both Tri-Service General Hospital and National Cheng Kung University Hospital. |
| Technique |
genotyping using a polymerase chain reaction-restriction length polymorphism (PCR-RFLP) assay |
| Statistical Method |
Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR=2.231, P=0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR=5.623, P=0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD. |
Genes reported by this study for BD (count: 2)
| Gene |
Statistical Values/Author Comments |
Result Category |
| DRD2 |
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD wa......
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls
More...
|
Positive
|
| ALDH2 |
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD wa......
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls
More...
|
Positive
|
Gene-gene interactions reported by this study for BD (count: 1)
| Gene Group |
Markers |
Statistical Values |
Author Comments |
Result Category |
|
DRD2
ALDH2
|
DRD2_Taq-I A1/A1_ALDH2*1*1 |
P-value=0.001, X2=10.506, OR=5.623
|
a significant interaction of the DRD2 Taq-I A1/A1 and the AL......
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls
More...
|
Positive
|
