SNP Report

Basic Info
Name rs749909 dbSNP Ensembl
Location chr21:44434924 - 44434924(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.13738
Functional Annotation intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000300481, ENST00000300482, ENST00000397928, ENST00000397932, ENST00000490982, ENST00000498430, ENST00000621064); non_coding_transcript_variant(ENST00000490982, ENST00000498430); upstream_gene_variant(ENST00000581669, ENST00000583496)
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Xu, C., 2006 A/G allelic P-value = 0.013, X2=6.19, genotypic P-val...... allelic P-value = 0.013, X2=6.19, genotypic P-value = 0.02, X2=7.85 in BD; allelic P-value = 0.019, X2=5.48, genotypic P-value = 0.008, X2=9.74 in BD-I ; allelic P-value = 0.151, X2=2.07, genotypic P-value = 0.188, X2=3.35 in BD-II More... Positive
Xu, C.,2009 G TDT: in BD families, X2=0.06, P-value = 0.803; in...... TDT: in BD families, X2=0.06, P-value = 0.803; in BD-I families, X2=0.38, P-value = 0.536; in BD-II families, X2=0.38, P-value = 0.537 More... No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TRPM2 transient receptor potential cation channel, subfamily M, member 2 21q22.3 5(3/2/0)

SNPs in LD with rs749909 (count: 1) View in gBrowse (chr21:44434503..44434924 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)