SNP Report

Basic Info

Name	rs749909 dbSNP Ensembl
Location	chr21:44434924 - 44434924(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.13738
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000300481, ENST00000300482, ENST00000397928, ENST00000397932, ENST00000490982, ENST00000498430, ENST00000621064); non_coding_transcript_variant(ENST00000490982, ENST00000498430); upstream_gene_variant(ENST00000581669, ENST00000583496)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Xu, C., 2006	A/G		allelic P-value = 0.013, X²=6.19, genotypic P-val...... allelic P-value = 0.013, X²=6.19, genotypic P-value = 0.02, X²=7.85 in BD; allelic P-value = 0.019, X²=5.48, genotypic P-value = 0.008, X²=9.74 in BD-I ; allelic P-value = 0.151, X²=2.07, genotypic P-value = 0.188, X²=3.35 in BD-II More...		Positive
Xu, C.,2009		G	TDT: in BD families, X²=0.06, P-value = 0.803; in...... TDT: in BD families, X²=0.06, P-value = 0.803; in BD-I families, X²=0.38, P-value = 0.536; in BD-II families, X²=0.38, P-value = 0.537 More...	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TRPM2	transient receptor potential cation channel, subfamily M, member 2	21q22.3	5(3/2/0)

SNPs in LD with rs749909 (count: 1) View in gBrowse (chr21:44434503..44434924 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2003775		intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)