BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Van Den Bogaert, A., 2006 (b) PMID: 16969276
Citation	Van Den Bogaert, A., K. Sleegers, et al. (2006). "No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population." Psychiatr Genet 16(5): 209-212.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	182 BP patients and 364 controls
SNP/Region/Marker Size	37 variants
Predominant Ethnicity	Caucasian
Population	Swedish
Gender	96 women, 86 men BP patients; 202 women, 162 men controls
Age Group	adults : mean age=55.8 (SD=14.3) years of cases, mean age=58.0 (SD=13.0) years of controls

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	The mean age of disease onset for BP patients was 27.8 (SD 11.5) years. The following disease characteristics were gathered for the patient group: age of disease onset, first episode symptomatology (depression, hypomania/mania), heredity for affective disorders, and presence of phase-related psychotic symptoms, suicide attempts, mean follow-up age and inclusion age.
Technique	genotyping was performed by pyrosequencing on a PSQ HS96 pyrosequencer
Statistical Method	We calculated Hardy-Weinberg equilibrium, genotypic and allelic association in the association sample for all SNPs using Genepop. Gene-gene interactions were calculated using logistic regression with SPSS 12.0 for Windows.
Result Summary	Neither of these functional polymorphisms was associated with bipolar disorder in the northern Swedish patient-control sample nor did we find evidence of gene-gene interaction. Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.

Other variants reported by this study for BD (count: 3)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
COMT Val158Met	COMT	point mutation	A/G		genotypic P-value = 0.6, OR (95% CI)=1.16 (0.76-1.75) for A/G genotype, OR (95% CI)=0.82 (0.48-1.39) for G/G genotype; allelic P-value = 0.6	Genotypic and allelic marker analysis showed no evidence for...... Genotypic and allelic marker analysis showed no evidence for association with BP. More...	Negative
DRD3 Ser9Gly	DRD3	point mutation	C/T		genotypic P-value = 0.6, OR (95% CI)=1.15 (0.78-1.69) for C/T genotype, OR (95% CI)=1.13 (0.62-2.05) for C/C genotype; allelic P-value = 0.6	Genotypic and allelic marker analysis showed no evidence for...... Genotypic and allelic marker analysis showed no evidence for association with BP. More...	Negative
5HTTLPR	SLC6A4	microsatellite	del/ins		genotypic P-value = 0.6, OR (95% CI)=1.33 (0.89-1.97) for del/ins genotype, OR (95% CI)=1.02 (0.58-1.80) for del/del genotype; allelic P-value = 0.6	Genotypic and allelic marker analysis showed no evidence for...... Genotypic and allelic marker analysis showed no evidence for association with BP. More...	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
SLC6A4	Together, our data suggest that these functional variants are not involved in the etiology of bipola...... Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.. More...	Negative
DRD3	Together, our data suggest that these functional variants are not involved in the etiology of bipola...... Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.. More...	Negative
COMT	Together, our data suggest that these functional variants are not involved in the etiology of bipola...... Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.. More...	Negative

Gene-gene interactions reported by this study for BD (count: 3)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
COMT DRD3	COMT (AA) - DRD3 (TT); COMT (AG) - DRD3 (CT); COMT (AG) - DRD3 (CC); COMT (GG) - DRD3 (CT); COMT (GG) - DRD3 (CC)	For markers "COMT (AA) - DRD3 (TT)", P-value = 0.6; For markers "COMT (AG) - DRD3 (CT)", P-value = 0.4, OR=0.69, 95% CI = [0.28-1.72]; For markers "COMT (AG) - DRD3 (CC)", P-value = 0.9, OR = 0.93, 95% CI = 0.25-3.57; For markers "COMT (GG) - DRD3 (CT)", P-value = 0.4, OR = 1.71, 95% CI = 0.53-5.47; For markers "COMT (GG) - DRD3 (CC)", P-value = 0.8, OR=1.29, 95% CI = 0.21-7.94.	no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More...	Negative
COMT SLC6A4	COMT (AA) - 5-HTT (ii); COMT (AG) - 5-HTT (di); COMT (AG) - 5-HTT (dd); COMT (GG) - 5-HTT (di); COMT (GG) - 5-HTT (dd)	For markers "COMT (AA) - 5-HTT (ii)", P-value = 0.2; For markers "COMT (AG) - 5-HTT (di)", P-value = 0.2, OR = 0.5, 95% CI = 0.19-1.31; For markers "COMT (AG) - 5-HTT (dd)", P-value = 0.2, OR=0.37, 95% CI=0.1-1.45; For markers "COMT (GG) - 5-HTT (di)", P-value = 0.8, OR=0.82, 95% CI=0.23-2.87; For markers "COMT (GG) - 5-HTT (dd)", P-value = 0.5, OR=1.77, 95% CI=0.37-8.36.	no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More...	Negative
DRD3 SLC6A4	DRD3 (TT) - 5-HTT (ii); DRD3 (CT) - 5-HTT (di); DRD3 (CT) - 5-HTT (dd); DRD3 (CC) - 5-HTT (di); DRD3 (CC) - 5-HTT (dd)	For markers "DRD3 (TT) - 5-HTT (ii)", P-value = 0.3; For markers "DRD3 (CT) - 5-HTT (di)", P-value = 0.4, OR=0.67, 95% CI = 0.27-1.66; For markers "DRD3 (CT) - 5-HTT (dd)", P-value = 0.3, OR = 0.52, 95%CI = 0.15-1.82; For markers "DRD3 (CC) - 5-HTT (di)", P-value = 0.7, OR=0.75, 95% CI=0.19-2.96; For markers "DRD3 (CC) - 5-HTT (dd)", P-value = 0.2, OR = 4.13, 95% CI = 0.5-33.88.	no evidence was found for synergistic interactions between t...... no evidence was found for synergistic interactions between the studied polymorphisms through gene-gene interactions by logistic regression. More...	Negative