Study Report
Basic Info
| Reference |
Lee, S. Y.,2012(a) PMID: 22877924
|
| Citation |
Lee, S. Y., S. L. Chen, et al. (2012). "Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder." Prog Neuropsychopharmacol Biol Psychiatry 39(2): 382-387.
|
| Disease Type |
Bipolar Disorder |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
964 participants: 268 with bipolar-I, 436 with bipolar-II, and 260 healthy controls |
| SNP/Region/Marker Size |
2 variants |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Gender |
130 males and 138 females in BD-I patients,221 males and 215 females in BD-II patients,208 males and 52 females in controls |
| Age Group |
adults
:
Mean age(SD)(year):33.09(11.49) for BD-I patients,31.54(11.32) for BD-II patients and 36.07(9.47) for controls
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Detail Info
| Sample Diagnosis |
DSM |
| Sample Status |
BP-I and BP-II patients were recruited both from outpatient and from inpatient settings.The healthy control group (hereafter Controls) consisted of 236 volunteers recruited from the community. |
| Technique |
PCR-RFLP |
| Statistical Method |
chi-square tests |
| Result Summary |
Logistic regression analysis showed a significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism (P=0.020), which predicted bipolar-II patients. Significant interaction effects for the BDNF Val66Met Val/Val genotype and both DRD3 Ser9Gly Ser/Ser and Ser/Gly genotypes were found only in bipolar-II patients (P=0.027 and 0.006, respectively). CONCLUSION: We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. |
Other variants reported by this study for BD (count: 2)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| DRD3 Ser9Gly |
DRD3 |
point mutation |
Ser9Gly |
|
Chi square test:genotype,P-value = 0.73,chi square = 2.04;allele,P-value = 0.51,chi square = 1.33
|
No evidence support the association of this variant with BD
No evidence support the association of this variant with BD
|
Negative
|
| BDNF Val66Met |
BDNF |
point mutation |
Val/Met |
Val |
Chi square test:genotype,P-value = 0.75,chi square = 1.94;allele,P-value = 0.83,chi square = 0.37
|
No evidence support the association of this variant with BD
No evidence support the association of this variant with BD
|
Negative
|
Genes reported by this study for BD (count: 2)
| Gene |
Statistical Values/Author Comments |
Result Category |
| DRD3 |
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipol......
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct.
More...
|
Positive
|
| BDNF |
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipol......
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct.
More...
|
Positive
|
Gene-gene interactions reported by this study for BD (count: 1)
| Gene Group |
Markers |
Statistical Values |
Author Comments |
Result Category |
|
BDNF
DRD3
|
DRD3_Ser/Gly - BDNF_Val/Met |
DRD3_Ser/Ser-BDNF_Val/Val:OR = 0.10 ,95%CI = 0.01–0.78 ,P-value = 0.027;DRD3_Ser/Gly-BDNF_Val/Val:OR = 0.06 ,95%CI = 0.008–0.45 ,P-value = 0.006
|
Significant association was observed in BP-II , but no signi......
Significant association was observed in BP-II , but no significant association was observed for other three haplotypes.
More...
|
Positive
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