BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Gaysina, D.,2010 PMID: 20712760
Citation	Gaysina, D., S. Cohen-Woods, et al. (2010). "Association analysis of DAOA and DAO in bipolar disorder: results from two independent case-control studies." Bipolar Disord 12(5): 579-581.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	The UK sample consisted of 515 BD patients and 1,316 control subjests;the Canadian sample consisted of 385 patients and 312 control subjects.
SNP/Region/Marker Size	10 SNPs
Predominant Ethnicity	Caucasian
Population	British and Canandian
Gender	The UK sample:65% women in BD patients and 58% women in control subjects;the Canadian sample:63% women in BD patients and 54% women in control subjects
Age Group	Adults : Mean age(SD)(year):The UK sample:48.0 (11.4) in BD patients and 41.7 (13.2) in control subjects;the Canadian sample:46.0 (12.5) in BD patients and 43.7 (13.1) in control subjects

Detail Info

SNPs reported by this study for BD (count: 10)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs12584489	DAOA DAOA-AS1	A/T		chi-squared tests: allele P-value = 0.61 for UK sample; allele P-value = 0.43 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1421292	DAOA	A/T		chi-squared tests: allele P-value = 0.66 for UK sample; allele P-value = 0.89 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1935062	DAOA DAOA-AS1	A/C		chi-squared tests: allele P-value = 0.86 for UK sample; allele P-value = 0.67 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2391191	DAOA DAOA-AS1	A/G		chi-squared tests: allele P-value = 0.31 for UK sample; allele P-value = 0.73 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3741775	DAO DAOA	G/T		chi-squared tests: allele P-value = 0.08 for UK sample; allele P-value = 0.92 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs947267	DAOA DAOA-AS1	A/C		chi-squared tests: allele P-value = 0.56 for UK sample; allele P-value = 0.73 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs778292	DAOA	C/T		chi-squared tests: allele P-value = 0.96 for UK sample; allele P-value = 0.29 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3918342	DAOA	C/T		chi-squared tests: allele P-value = 0.52 for UK sample; allele P-value = 0.89 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3916965	DAOA	A/G		chi-squared tests: allele P-value = 0.24 for UK sample; allele P-value = 0.81 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9558562	DAOA DAOA-AS1	A/G		chi-squared tests: allele P-value = 0.05 for UK sample; allele P-value = 0.29 for Canadian sample.	No significant association was observed in BD. No significant association was observed in BD.	Negative

Haplotypes reported by this study for BD (count: 9)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs947267 - rs778292 - rs3918342		DAOA	Haplotype analysis:X<sup>2</sup>=3.44, P-value = 0.75 for UK sample; X<sup>2</sup>=4.21, P-value = 0.76 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs778292 - rs3918342 - rs1421292		DAOA	Haplotype analysis:X<sup>2</sup>=2.87, P-value = 0.41 for UK sample; X<sup>2</sup>=2.87, P-value = 0.41 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs3916965 - rs12584489 - rs2391191		DAOA	Haplotype analysis:X<sup>2</sup>=3.08, P-value = 0.21 for UK sample; X<sup>2</sup>=0.45, P-value = 0.8 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs2391191 - rs9558562 - rs1935062		DAOA	Haplotype analysis:X<sup>2</sup>=2.55, P-value = 0.47 for UK sample; X<sup>2</sup>=1.63, P-value = 0.65 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs1935062 - rs947267 - rs778292		DAOA	Haplotype analysis:X<sup>2</sup>=3.21, P-value = 0.67 for UK sample; X<sup>2</sup>=3.88, P-value = 0.57 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs12584489 - rs2391191 - rs9558562		DAOA	Haplotype analysis:X<sup>2</sup>=1.22, P-value = 0.57 for UK sample; X<sup>2</sup>=0.74, P-value = 0.69 for Canadian sample.	No significant association was found . No significant association was found .	Negative
rs3916965 - rs3741775		DAOA DAO	Interaction analysis:P-value = 0.048(>0.05 after correction) in the UK sample.	No significant association was found . No significant association was found .	Negative
rs1935062 - rs3741775		DAOA DAO	Interaction analysis:P-value = 0.027(>0.05 after correction) in the UK sample.	No significant association was found . No significant association was found .	Negative
rs9558562 - rs1935062 - rs947267		DAOA	Haplotype analysis:X<sup>2</sup>=0.89, P-value = 0.64 for UK sample; X<sup>2</sup>=1.65, P-value = 0.44 for Canadian sample.	No significant association was found . No significant association was found .	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
DAO	In conclusion, our results in two independent Caucasian samples did not provide evidence for associa...... In conclusion, our results in two independent Caucasian samples did not provide evidence for association of DAOA or DAO with BD, nor did we find convincing evidence of statistical epitasis. More...	Negative
DAOA	In conclusion, our results in two independent Caucasian samples did not provide evidence for associa...... In conclusion, our results in two independent Caucasian samples did not provide evidence for association of DAOA or DAO with BD, nor did we find convincing evidence of statistical epitasis. More...	Negative

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
DAOA DAO	rs3916965 - rs3741775; rs1935062 - rs3741775	Interaction analysis: For markers "rs3916965 - rs3741775", P-value = 0.048(>0.05 after correction) in the UK sample. Form markers "rs1935062 - rs3741775", P-value = 0.027(>0.05 after correction) in the UK sample.	No significant association was found . No significant association was found .	Negative