BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Zandi, P. P., 2008 (b) PMID: 18163389
Citation	Zandi, P. P., S. Zollner, et al. (2008). "Family-based SNP association study on 8q24 in bipolar disorder." Am J Med Genet B Neuropsychiatr Genet 147B(5): 612-618.
Disease Type	Bipolar I Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	3512 subjects, 1954 of whom were affected with BP, from 737 multiplex families.
SNP/Region/Marker Size	1458 SNPs
Predominant Ethnicity	Caucasian
Population	European
Gender	The final dataset consisted of 3,512 genotyped subjects, including 1,383 males and 2,129 females.

Detail Info

SNPs reported by this study for BD (count: 6)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs10101440		T/G	G	FBAT allelic P-value = 4.99E-04 ; Geno-PDT genotypic P-value = 1.10E-03	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
rs3750889	ADCY8	A/G	G	FBAT allelic P-value = 3.40E-04 ; Geno-PDT genotypic P-value = 2.63E-02	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
rs6986303	ST3GAL1	G/A	A	FBAT allelic P-value = 2.82E-04 ; Geno-PDT genotypic P-value = 6.60E-03	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
rs1411187	ADCY8	A/G	G	FBAT allelic P-value = 6.70E-04 ; Geno-PDT genotypic P-value = 1.30E-02	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
rs1668875	CASC8	C/G	G	FBAT allelic P-value = 6.75E-03 ; Geno-PDT genotypic P-value = 5.00E-04	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive
rs7462286	ASAP1	T/C	C	FBAT allelic P-value = 1.73E-01 ; Geno-PDT genotypic P-value = 7.00E-04	None of the SNPs were associated with BP in the single-locus...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). More...	Positive

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs1411187 - rs6986303		ADCY8 ST3GAL1	Global X<sup>2</sup>=28.90; global P-value = 3.0E-04	Multi-locus analyses suggested joint effects between ADCY8 a...... Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 , with at least one copy of the ''high risk'' allele required at both genes for association with BP More...	Positive

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
ST3GAL1	None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our thre...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. More...	Positive
ADCY8	None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our thre...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. More...	Positive
FAM84B	None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our thre...... None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
ADCY8 ST3GAL1	rs1411187 - rs6986303	Global X²=28.90; global P-value = 3.0E-04	Multi-locus analyses suggested joint effects between ADCY8 a...... Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 , with at least one copy of the ''high risk'' allele required at both genes for association with BP. More...	Positive