BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Huang, C. C.,2012 PMID: 22514151
Citation	Huang, C. C., Y. H. Chang, et al. (2012). "The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder." Am J Med Genet B Neuropsychiatr Genet 159(5): 501-507.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	Seven hundred ninety-two participants were recruited: 208 with BP-I, 329 with BP-II, and 255 healthy controls.
SNP/Region/Marker Size	2 variants
Predominant Ethnicity	Mongloid
Population	Chinese(Taiwan)
Gender	Male/female:111/97 in BPI patients,174/155 in BPII patients and 204/51 in control group
Age Group	Adults : Mean age(SD)(year):34.04(12.03) in BPI patients,32.02(11.58) in BPII patients and 36.09(9.54) in control group

Detail Info

Sample Diagnosis	DSM
Sample Status	BP-I and BP-II patients were recruited from outpatient and inpatient settings. The exclusion criteria were: any DSM-IV-TR Axis I diagnosis other than BP-I or BP-II(either first-onset or with previous episodes), being outside the 18-65-year-old age range, and any other major or minor mental illnesses, neurological disorders, or organic mental disorders.Although theDSM-IV-TRcriterion for hypomania is the minimum duration of 4 days, current epidemiologic data suggest that a 2-day duration is more prevalent in community samples [Akiskal et al.,1977, 1979; Angst, 1998; Benazzi, 2001; Angst et al., 2003; Judd et al.,2003a]; therefore, we used the 2-day minimum for hypomania in the diagnosis of BP-II. The healthy control (HC) group consisted of 255 volunteers recruited fromthe community via advertisement.
Technique	Genotyping
Statistical Method	Logistic regression was then used to examine the main effects and the effects of gene-to-gene interaction of the BDNF and DRD2genes for the risk of BP-I and BP-II in all three groups.
Result Summary	A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP-II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP-II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP-II disorder and that BP-I and BP-II are genetically distinct.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
DRD2/ANKK1 Taq-IA	DRD2	point mutation			allelic P-vaue=0.36, X²=2.03; genotypic P-value=0.15, X²=6.79	The DRD2/ANKK1 Taq1A polymorphism was not associated with ei...... The DRD2/ANKK1 Taq1A polymorphism was not associated with either BP-I or BP-II, in both genotypic and allelic distribution. More...	Negative
BDNF Val66Met	BDNF	point mutation	Val/Met		allelic P-vaue=0.13, X²=4.09; genotypic P-value=0.21, X²=5.91	The BDNF Val66Met polymorphism was not associated with eithe...... The BDNF Val66Met polymorphism was not associated with either BP-I or BP-II, in both genotypic and allelic distribution. More...	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
DRD2	DRD2 Taq-IA A1/A1: logistic Regression P-value=0.18, OR=2.17, 95% CI=0.70-6.77 in BPI, P-value=0.13, OR=2.26, 95% CI=0.79-6.46 in BPII; DRD2 Taq-IA A1/A2: logistic Regression P-value=0.38, OR=0.83, 95% CI=0.34-2.03 in BPI, P-value=0.58, OR=1.24, 95% CI=0.57-2.70 in BPII.	Negative
BDNF	BDNF Val/Va: logistic Regression P-value=0.82, OR=1.10, 95% CI=0.47-2.60 in BPI, P-value=0.04, OR=0.40, 95% CI=0.16-0.97 in BPII, BDNF Val/Met: logistic Regression P-value=0.33, OR=1.18, 95% CI=0.54-2.58 in BPI, P-value=0.36, OR=1.39, 95% CI=0.69-2.80 in BPII. Multiple logistic regression analysis, controlled for age and gender, showed a significant main effe...... Multiple logistic regression analysis, controlled for age and gender, showed a significant main effect of the Val/Val genotype on the BDNF Val66Met gene in the BP-II group. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
BDNF DRD2	BDNF_Val/Val - DRD2_Taq-IA A1/A1; BDNF_Val/Val - DRD2_Taq-IA A1/A2; BDNF_Val/Met - DRD2_Taq-IA A1/A1; BDNF_Val/Met - DRD2_Taq-IA A1/A2	Logistic Regression P-value=0.20, OR=2.16, 95% CI=0.66-7.07 in BPI, P-value=0.015, OR=4.17, 95% CI=1.33-13.08 in BPII for markers "BDNF_Val/Val-DRD2_Taq-IA A1/A2" and negative for all other three groups of markers.	Moreover, in the BP-II group, the interaction between the A1...... Moreover, in the BP-II group, the interaction between the A1/ A2 genotype of the DRD2/ANKK1 Taq1A polymorphism and the Val/Val genotype of the BDNF Val66Met polymorphism were higher than in the Control group. More...	Positive