BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Geller, B., 2008 PMID: 18294085
Citation	Geller, B., R. Tillman, et al. (2008). "GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype." J Child Adolesc Psychopharmacol 18(1): 25-29.
Disease Type	Bipolar I Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	50 PEA-BP-I probands in 48 families
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Caucasian
Gender	Female subjects comprised 40.0% of the sample
Age Group	Children : The 50 PEA-BP-I probands in these families were aged 11.2 (SD=2.9) years.

Detail Info

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2241165	GAD1		A	FBAT X²=5.2, df=1, P-value = 0.022. The empirical level of significance for this test using the Monte Carlo method in FBAT was P-value = 0.025.	The FBAT analyses showed preferential transmission of the rs...... The FBAT analyses showed preferential transmission of the rs2241165 A allele. More...	Positive

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2241165 - BDNF_Val66Met		GAD1 BDNF	no P-value given in the original article	No significant interaction was found between the GAD1 and BD...... No significant interaction was found between the GAD1 and BDNF alleles in this sample. More...	Negative

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
GAD1 BDNF	rs2241165 - BDNF_Val66Met	no P-value given in the original article	No significant interaction was found between the GAD1 and BD...... No significant interaction was found between the GAD1 and BDNF alleles in this sample. More...	Negative