SNP Report

Basic Info

Name	rs2241165 dbSNP Ensembl
Location	chr2:170821869 - 170821869(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.381789
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000344257, ENST00000358196, ENST00000375272, ENST00000414527, ENST00000429023, ENST00000445006, ENST00000454603, ENST00000455008, ENST00000456864, ENST00000493875, ENST00000625689); NMD_transcript_variant(ENST00000414527, ENST00000493875); non_coding_transcript_exon_variant(ENST00000485013); non_coding_transcript_variant(ENST00000429023, ENST00000485013); upstream_gene_variant(ENST00000418106, ENST00000451730, ENST00000455988, ENST00000486850)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Geller, B., 2008		A	FBAT X²=5.2, df=1, P-value = 0.022. The empirica...... FBAT X²=5.2, df=1, P-value = 0.022. The empirical level of significance for this test using the Monte Carlo method in FBAT was P-value = 0.025. More...	The FBAT analyses showed preferential transmission of the rs...... The FBAT analyses showed preferential transmission of the rs2241165 A allele. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	2q31	2(1/1/0)

SNPs in LD with rs2241165 (count: 3) View in gBrowse (chr2:170805829..170826597 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs3762555	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]
rs6736129		0.841[TSI]
rs1477061	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.879[CEU]; 0.815[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)