Gene Report

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Basic Info

Approved Symbol	GPX3
Approved Name	glutathione peroxidase 3
Previous Name	glutathione peroxidase 3 (plasma)
Location	5q33.1
Position	chr5:151020438-151028993, 1
External Links	HGNC: 4555 Entrez Gene: 2878 Ensembl: ENSG00000211445 UCSC: uc021yga.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fullerton, J. M.,2010	SNP: rs3792797, rs8177435 Haplotype: rs3792797 - rs8177435 - rs5746136 - rs4880(), rs3792797 - rs4880()	We provide evidence that an interaction at both the genotype and haplotype level between SOD2 and GPX3 further increases disease risk.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IDA[1897960]	85
GO:0000302	response to reactive oxygen species	biological process	TAS	5
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0006982	response to lipid hydroperoxide	biological process	TAS[2491950]	1
GO:0004602	glutathione peroxidase activity	molecular function	EXP; IDA[1897960]	4
GO:0042744	hydrogen peroxide catabolic process	biological process	TAS[2491950]	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19199708]	176
GO:0005576	extracellular region	cellular component	TAS	97
GO:0008134	transcription factor binding	molecular function	TAS[8056346]	28
GO:0051289	protein homotetramerization	biological process	IDA[3693360]	3
GO:0008430	selenium binding	molecular function	IDA[2491950]	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00590	Arachidonic acid metabolism	7

ID	Name	No. of Genes in BDgene	Brief Description
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3792797	chr5:151022330 - 151022330(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs8177435	chr5:151024822 - 151024822(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:151020438..151028993 View in gBrowse