BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Lee, S. Y.,2012(b) PMID: 23026378
Citation	Lee, S. Y., S. L. Chen, et al. (2012). "COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder." Behav Brain Res 237C: 243-248.
Disease Type	Bipolar II Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	314 with bipolar-II without AD, 117 with bipolar-II with AD, and 340 healthy controls.
SNP/Region/Marker Size	2 variants
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	143 males and 171 females in BP-II patients without AD,59 males and 58 females in BP-II patients with AD,250 males and 90 females in controls
Age Group	adults : Mean age(SD)(year):32.2(11.8) in BP-II patients without AD,30.2(10.2) in BP-II patients with AD,34.7(9.2) in controls

Detail Info

Sample Diagnosis	DSM
Sample Status	BP-II patients were recruited from outpatient and inpatient settings. All were initially evaluated in an interview by an attending psychiatrist and followed by a more detailed interview with a clinical psychologist using the Chinese Version of Modified Schedule of Affective Disorder and Schizophrenia-Life Time (SADS-L) [59], which has good inter-rater reliability [60], to determine Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnoses. Inclusion criteria were a diagnosis of BP-II, either first-onset or with previous episodes. Exclusion criteria were (i) any DSM-IV-TR Axis I diagnosis including substance use disorder, organic mental disorders, and major and minor mental illnesses except BP-II and lifetime AD, (ii) any significant medical illness, (iii) any neurological disorders, and(iv) any poorly controlled physical illness that might influence the interview and study results. The diagnosis of AD was based on DSM-IV-TR criteria. Although DSM-IV-TR [3] criteria require a minimum duration of 4 days of hypomania, current epidemiologic data suggest that a 2-day duration is more prevalent in community samples [21,61]; therefore, we used the 2-day minimum for hypomania in the diagnosis of BP-II. The healthy control group (here after Controls) consisted of 340 volunteers recruited from the community. We used the SADS-L [59] to screen their psychiatric conditions. All volunteers were free of major and minor mental illness (affective disorder, schizophrenia, anxiety disorder, personality disorder, substance use disorders, etc.), and none had a family history of psychiatric disorder among their first-degree relatives.
Technique	PCR-RFLP
Statistical Method	chi-square tests
Result Summary	Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
COMT Val158Met	COMT	point mutation	Val158Met		Chi square test:genotype,P-value = 0.34,chi square = 4.52;allele,P-value = 0.61,chi square = 0.98	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
BDNF Val66Met	BDNF	point mutation	Val/Met	Val	Chi square test:genotype,P-value = 0.79,chi square = 1.73;allele,P-value = 0.64,chi square = 0.88	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
COMT	Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD...... Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II. More...	Positive
BDNF	Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD...... Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
BDNF COMT	COMT_Val/Met - BDNF_Val/Met	COMT_Met/Met-BDNF_Val/Val:OR = 0.23,95%CI = 0.05â€“0.99,P-value = 0.048;COMT_Val/Met-BDNF_Val/Val:OR = 0.31,95%CI = 0.13â€“0.73 ,P-value = 0.007	Significant association was observed in BP-II , but no signi...... Significant association was observed in BP-II , but no significant association was observed for other haplotypes. More...	Positive