BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Lin, C. I.,2010 PMID: 20399505
Citation	Lin, C. I., S. Y. Lee, et al. (2010). "Temperamentsxgenes in bipolar I and bipolar II disorder patients." Psychiatry Res 177(3): 364-366.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	47 BP-I patients, 61 BPII patients and 56 normal controls
SNP/Region/Marker Size	2 variants
Predominant Ethnicity	Mongloid
Population	Chinese(Taiwan)

Detail Info

Sample Diagnosis	DSM
Sample Status	The Chinese version of the Modified Schedule of AffectiveDisorder and Schizophrenia- Lifetime (SADS-L), a semi-structured interview based upon DSM-IV-TR criteria (Endicott and Spitzer, 1978), was used to confirm the diagnosis, except hypomanic duration with a 2-day time period instead of 4 days. The inter-rater reliability of the Chinese version SADSL was good (Huang et al., 2004). This study excluded those with major mental illnesses including illegal substance use disorder except BP-I and BP-II disorders. The control group underwent the same procedure as a study group. TPQ was administered after at least 1 week of inter-episode stage; both Hamilton Depression Rating Scale (HDRS) (Ko et al., 1997) and Young Mania Rating Scale (YMRS) (Yen et al., 2007) scores will be lower than 10 (Young et al., 1995).
Technique	genotyping
Statistical Method	The differences in the genotype frequencies of 5-HTTLPR and DRD3Ser9Gly genes were calculated by Pearson chi-square (X²) analysis (two-tailed).Multiple regression with the following predictors (a) the 5-HTTLPR genotypes, (b) DRD3 Ser9Gly genotypes, (c) NS, (d) HA, (e) the gene_temperament and (f)gene_gene interaction covarying for age and sex was performed to examine the association between the control group and the two bipolar disorders, respectively.
Result Summary	RESULTS: Although no association was found for each individual polymorphism, there is a significant association between DRD1 and BP for haplotype TDT analysis (chi(2) = 16.068, df = 3, p =.0011). CONCLUSIONS: These results indicate that DRD1 may play a role in the etiology of bipolar disorder.

Haplotypes reported by this study for BD (count: 1)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
(DRD3_Ser9Gly) - (5-HTTLPR)		DRD3 SLC6A4	multiple regression:BP-I vs. control group, OR(95%CI)=0.144(0.014-1.479), P-value = 0.103; BP-II vs. control group, OR(95%CI)=1.231(0.173-8.767), P-value = 0.835; BP-I vs. BP-II, OR(95%CI)=0.154(0.023-1.032), P-value = 0.054	No significant association was found . No significant association was found .	Negative

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
5HTTLPR	SLC6A4	microsatellite	short/long		multiple regression:BP-I vs. control group, OR(95%CI)=2.303(0.480-11.052), P-value = 0.297;BP-II vs. control group, OR(95%CI)=0.578(0.128-2.615), P-value = 0.476;BP-I vs. BP-II, OR(95%CI)=2.189(0.695-6.893), P-value = 0.181.For Novelty Seeking:BP-I vs. control group, OR(95%CI)=1.126(0.889-1.427), P-value = 0.324;BP-II vs. control group, OR(95%CI)=1.097(0.913-1.318), P-value = 0.324;BP-I vs. BP-II, OR(95%CI)=0.866(0.742-1.011), P-value = 0.068	No significant association was observed. No significant association was observed.	Negative
DRD3 Ser9Gly	DRD3	point mutation	Ser9Gly		multiple regression:BP-I vs. control group, OR(95%CI)=0.541(0.117-2.514), P-value = 0.434;BP-II vs. control group, OR(95%CI)=0.803(0.208-3.094), P-value = 0.75;BP-I vs. BP-II, OR(95%CI)=0.782(0.251-2.440), P-value = 0.672.For Harm Avoidance, BP-I vs. control group, OR(95%CI)=1.399(1.007-1.943), P-value = 0.045;BP-II vs. control group, OR(95%CI)=1.028(0.833-1.270), P-value = 0.796;BP-I vs. BP-II, OR(95%CI)=1.285(1.048-1.577), P-value = 0.016	Significant associations were found in BP-I. Significant associations were found in BP-I.	Positive

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
SLC6A4	Our study showed no difference between 5-HTTLPR genotypes and BP-I, BP-II and normal controls. Our study showed no difference between 5-HTTLPR genotypes and BP-I, BP-II and normal controls.	Negative
DRD3	We suggested that the distinction between BP-I and BP-II relies on the interaction of DRD3 Ser9Gly g...... We suggested that the distinction between BP-I and BP-II relies on the interaction of DRD3 Ser9Gly genotypes with NS. This result provides initial evidence that the DRD3 Ser9Gly genotypes are moderating the association between NS and bipolar disorders. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
DRD3 SLC6A4	(DRD3_Ser9Gly) - (5-HTTLPR)	multiple regression: BP-I vs. control group, OR(95%CI)=0.144(0.014-1.479), P-value = 0.103; BP-II vs. control group, OR(95%CI) = 1.231(0.173-8.767), P-value = 0.835; BP-I vs. BP-II, OR(95%CI) = 0.154(0.023-1.032), P-value = 0.054.	No significant association was found . No significant association was found .	Negative