BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Study Report

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Basic Info

Reference	Hu, M. C.,2012 PMID: 23044341
Citation	Hu, M. C., S. Y. Lee, et al. (2012). "Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese." Prog Neuropsychopharmacol Biol Psychiatry.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	101 Han Chinese men with comorbid alcoholism and bipolar disorder, and 328 healthy male controls from the community.
SNP/Region/Marker Size	2 variants
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	all male

Detail Info

Sample Diagnosis	DSM
Sample Status	The study was approved by the Institutional Review Board for the Protection of Human Subjects at National Cheng Kung University Hospital. We recruited 101 men with ALC+BP. All participants provided written informed consent after they had been fully informed of the procedures of the study. The healthy control group consisted of 328 volunteers recruited from the community; the SADS-L was used to screen their psychiatric conditions. All volunteers were free of major or minor mental illness, including major depression, bipolar disorder, alcoholism, and so on. Besides, none had a family history of psychiatric disorder among their first-degree relatives.
Technique	PCR-RFLP
Statistical Method	PearsonÃ•s chi-square test
Result Summary	There were no significant differences in the genotypic frequencies of the DRD2TaqIA or the MAOA-uVNTR polymorphisms between the 2 groups. The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018). CONCLUSIONS: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
MAOA promoter VNTR	MAOA	VNTR	3-repeat/4-repeat		Pearsonâ€™s chi-square test:chi square = 0.039,P-value = 0.843	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative
DRD2 TaqI Polymorphism	DRD2	SNP			Pearsonâ€™s chi-square test:chi square = 5.057,P-value = 0.080	No evidence support the association of this variant with BD No evidence support the association of this variant with BD	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
DRD2	The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035...... The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018). CONCLUSIONS: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP. More...	Positive
MAOA	The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035...... The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018). CONCLUSIONS: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
DRD2 MAOA	DRD2_TaqI Polymorphism - MAOA_promoter_3 repeat; DRD2_TaqI Polymorphism - MAOA_promoter_4 repeat	Pearsonâ€™s chi-square test: chi square = 11.268, P-value = 0.004 for DRD2_TaqI Polymorphism-MAOA_promoter_3 repeat; chi square = 0.271,P-value = 0.873 for DRD2_TaqI Polymorphism-MAOA_promoter_4 repeat.	The MAOA-uVNTR 3-repeat had a significant protective effect ...... The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. No evidence support the association of DRD2_TaqI Polymorphism-MAOA_promoter_4 repeat with BD. More...	Positive