BDgene

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Study Report

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Basic Info

Reference	Wang, L. J., 2015 PMID: 25744938
Citation	Wang, L. J., et al. (2015). "A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder." Sci Rep 5: 8813.
Disease Type	Bipolar II Disorder
Study Design	case-control
Study Type	candidate-gene association study
Sample Size	531 with BP-II and 447 healthy controls
Predominant Ethnicity	Mongloid
Population	Han Chinese
Gender	255 male and 276 female BP-II, 328 male and 119 female controls
Age Group	adults : mean age=31.9, SD=11.5 years of BP-II patients, mean age=35.4, SD=9.7 years of controls

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	BP-II outpatients and inpatients were recruited from Tri-Service General Hospital and National Cheng Kung University Hospital. Patients were initially evaluated in an interview by an attending psychiatrist. Inclusion criteria were a diagnosis of BP-II, either first-onset or with previous episodes. Exclusion criteria were (i) any DSM-IV-TR Axis I diagnosis, including organic mental disorders, substance use disorder, and other major andminor mental illnesses other than BP-II, (ii) any significant medical illness, (iii) any neurological disorders, and (iv) any poorly controlled physical illness that might influence the interview and study results.
Technique	genotyping
Statistical Method	Pearson x2 analysis (two-tailed) was used to analyze the differences in the genotype and allele frequencies of the COMT Val158Met and MTHFR C677T polymorphisms between the BP-II and Control groups. Hardy-Weinberg equilibrium was tested for each study group. To examine the main effects and the interactive effects of gene-to-gene interaction of the COMT and MTHFR genes for the risk of BP-II compared with Controls, we used logistic regression and controlled for the covariates of age and gender. Age, gender, genotypes of COMT and MTHFR, and the interaction of theCOMTand MTHFRgenes were set as independent variables (covariates). The effects of independent variables are expressed as odds ratios (OR) with 95% confidence intervals (CI). Significance was set at P,0.05 (two-tailed). The data were analyzed using SPSS 18.0, the power analysis was done using G-Power 3.
Result Summary	Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II.

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
COMT Val158Met	COMT	point mutation			allelic P-value=0.45, X²=0.56; genotypic P-value=0.075, X²=5.19	For COMT Val158Met, neither the genotypes nor the allelic di...... For COMT Val158Met, neither the genotypes nor the allelic distribution significantly differed between BP-II patients and Controls. More...	Negative
MTHFR C677T	MTHFR	point mutation	G/T		allelic P-value=0.13, X²=2.3; genotypic P-value=0.16, X²=3.61	For MTHFR C677T, neither the genotypes nor the allelic distr...... For MTHFR C677T, neither the genotypes nor the allelic distribution were associated with the risk of BP-II. More...	Negative

Genes reported by this study for BD (count: 2)

Gene	Statistical Values/Author Comments	Result Category
COMT	Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they ...... Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype for the protective effect on the odds of developing BP-II. More...	Positive
MTHFR	Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they ...... Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype for the protective effect on the odds of developing BP-II. More...	Positive

Gene-gene interactions reported by this study for BD (count: 1)

Gene Group	Markers	Statistical Values	Author Comments	Result Category
COMT MTHFR	COMT_Val158Met, MTHFR_C677T	P-value=0.034, OR (95% CI)=0.58 (0.35-0.96);P-value=0.039, OR (95% CI)=0.57 (0.33-0.97)	Logistic regression analysis showed a significant interactio...... Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype for the protective effect on the odds of developing BP-II. More...	Positive