SNP Report

Basic Info
Name rs1800497 dbSNP Ensembl
Location chr11:113400106 - 113400106(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.325679
Functional Annotation downstream_gene_variant; missense_variant.
Polyphen Annotation: benign(ENST00000303941)
SIFT Annotation: tolerated(ENST00000303941)
Consequence to Transcript downstream_gene_variant(ENST00000542948); missense_variant(ENST00000303941)
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Wang, T. Y., 2013 A1/A2 P-value=0.39, X2=4.11; P-value=0.39, X2 P-value=0.39, X2=4.11; P-value=0.39, X2=4.13 for male; P-value=0.48, X2=3.51 for female; DRD2 A1/A1: P-value=0.003, OR=4.25 for all BP-I, P-value=0.002, OR=7.33 for male BP-I, P-value=0.34, OR=2.25 for female BP-I, P-value<0.001, OR=5.49 for all BP-II, P-value=0.001, OR=8.56 for male BP-II, P-value=0.15, OR=3.33 for female BP-II; DRD2 A1/A2: P-value=0.93, OR=1.02 for all BP-I, P-value=0.38, OR=1.42 for male BP-I, P-value=0.36, OR=0.66 for female BP-I; P-value=0.10, OR=1.56 for all BP-II, P-value=0.16, OR=1.70 for male BP-II, P-value=0.82, OR=1.11 for female BP-II More... There was no significant difference in the distribution of t...... There was no significant difference in the distribution of the DRD2 Taq-IA polymorphisms between three groups. It showed a significant association between the DRD2/ANKK1 Taq-IA polymorphisms and patients with BP-I and an association between DRD2 and BP-II. A gender-specific association of the DRD2 polymorphisms and the risk for BP-I and BP-II was also found in the regression model. More... Positive
Lee, S. Y.,2010 Genotype distributions: for BP-I, X2=0.639, P-val...... Genotype distributions: for BP-I, X2=0.639, P-value = 0.727; for BP-II, X2=5.482, P-value = 0.065.Logistic regression analysis: DRD2 Taq-I A1/A1, for BP-I, OR=0.635, 95%CI=0.278-1.448, P-value = 0.28; for BP-II, OR=0.471, 95%CI=0.214-1.035, P-value = 0.061; DRD2 Taq-I A1/A2, for BP-I, OR=0.876, 95%CI=0.466-1.644, P-value = 0.679; for BP-II, OR=1.304, 95%CI=0.755-2.252, P-value = 0.341 More... No significant association was observed in BD. No significant association was observed in BD. Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ANKK1 ankyrin repeat and kinase domain containing 1 11q23.2 Mapped by Literature SNP
DRD2 dopamine receptor D2 11q22-q23 28(8/20/0)

SNPs in LD with rs1800497 (count: 45) View in gBrowse (chr11:113379003..113434481 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 45)

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)