Search by:Disease = BD-SZ, Source = cross-disorder study, No. of Positive Studies for BD >= 1, No. of Positive Studies for SZ >= 1
Total unique gene count: 104
Note: For BD-SZ shared genes, genes from cross-disorder studies about BD-SZ or BD-SZ-MDD were considered from cross-disorder studies, genes from
intersection analysis of BDgene and SZGene were considered from candidate gene intersection analysis. Some repeated genes may be both
included in cross-disorder studies and the result of candidate gene intersection analysis.
Thus, we conclude that the SERT VNTR polymorphism may be a r.....
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Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Han Chinese.
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Although it will be important to extend the present analysis.....
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Although it will be important to extend the present analysis in a larger sample, our preliminary results suggest that the 5-HTTLPR does not seem to play a major role in the genetics of bipolar and schizophrenic disorders at least in this group of Brazilian psychiatric patients.
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Haplotype analysis of val/met SNP and a dinucleotide repeat .....
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Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P<E-08) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population.
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Our findings suggest that BDNF may be a susceptibility gene .....
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Our findings suggest that BDNF may be a susceptibility gene for MDD and schizophrenia—in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms.
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No association was found between the studied polymorphism an.....
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No association was found between the studied polymorphism and schizophrenia or bipolar affective disorder either for genotype or allele distribution.
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Our results support the view that COMT variation provides a .....
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Our results support the view that COMT variation provides a weak general predisposition to neuropsychiatric disease including psychotic and affective disorders.One SNP also remained significant when only patients with schizophrenia were included.
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Our findings indicate that the 2141C Del variant in the 59 f.....
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Our findings indicate that the 2141C Del variant in the 59 flanking region of the human dopamine D2 receptor gene is unlikely to play a substantial role in genetic predisposition to major psychiatric disorders in Caucasians.
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Our results do not provide evidence for an association betwe.....
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Our results do not provide evidence for an association between this D2 receptor variant and schizophrenia, or delusional disorder, or bipolar affective disorder.
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The allele frequency of the T102C polymorphism established n.....
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The allele frequency of the T102C polymorphism established no significant differences between the patients and controls.Epigenetic dysregulation of HTR2A may contribute to SCZ, BD and earlier age of disease onset.
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In summary, this meta-analysis supports significant associat.....
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In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder.
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The association of variation at G72 with schizophrenia as we.....
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The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.
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DAOA genetic polymorphisms (M15, M18 andM23) were not found .....
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DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.
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M18/rs947267 and M22/rs778293 showed association with SCZ in.....
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M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans. The associations of C allele at M18 and A allele at M22 with SCZ in Asians survived conservative Bonferroni correction for multiple testing for 15 markers and subgroup analysis. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects.
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These findings suggest that the DAOA/G72 gene confers suscep.....
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These findings suggest that the DAOA/G72 gene confers susceptibility to both BD and SZ, but that different polymorphisms may potentially differentiate between these two disorders.
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The risk allele rs1006737 in this gene conferred increased r.....
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The risk allele rs1006737 in this gene conferred increased risk for schizophrenia (P= 0.034) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15).
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This result provides further supporting evidence for DISC1 a.....
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This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family.
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There was an effect of SNP rs1538979 in the pre/postcentral .....
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There was an effect of SNP rs1538979 in the pre/postcentral gyrus with decreased activation in healthy controls and increased activation in patients with schizophrenia.These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia.
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These data support the idea that these apparently distinct d.....
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These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders.
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There was no significant difference in genotype distribution.....
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There was no significant difference in genotype distributions or allele frequencies of the MTHFR 667C>T polymorphism between controls and any of the diagnostic groups.
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The genotype homozygous for the T677 allele was significantl.....
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The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.
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The meta-analysis results suggested that east Asians have a .....
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The meta-analysis results suggested that east Asians have a greater genetic risk from the MTHFR gene in developing schizophrenia and depression, and that the genetic effects in bipolar disorder and depression are different. A further exploration of the involvement of the MTHFR gene in the susceptibility to schizophrenia and affective disorders, with a greater number of studies with larger sample sizes, however, are needed to fully establish the role of the MTHFR gene.
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Our results suggest that homozygosity for the T677 allele of.....
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Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample.
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The results confirm association of schizophrenia with the 1p.....
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The results confirm association of schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folatedependent one-carbon pathway.
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For schizophrenia and MTHFR C677T, the fixed-effects odds ra.....
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For schizophrenia and MTHFR C677T, the fixed-effects odds ratio for TT versus CC was 1.44 (95% CI: 1.21, 1.70), with low heterogeneity (I<sup>2</sup>= 42%)—based on 2, 762 cases and 3, 363 controls. . These results were robust to various sensitively analyses. This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.
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The present findings suggest that the MTHFR C677T polymorphi.....
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The present findings suggest that the MTHFR C677T polymorphism is likely associated with the risk of developing BD and schizophrenia, and influences the age at onset of schizophrenia but not the age at onset of BD.
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A significant increase in homozygosity for the minor allele .....
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A significant increase in homozygosity for the minor allele was found in patients with SZ (genotype distribution chi(2) = 7.32, p = 0.03) but not in BD (genotype distribution chi(2) = 0.52, p = 0.77).The findings suggest that homozygosity for rs725588 could be a risk genotype for SZ.
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This study supports the involvement of NRG1 variants in the .....
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This study supports the involvement of NRG1 variants in the less well studied 3 region in conferring susceptibility to SCZ and BPD in the Scottish population.
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In conclusion, the present findings do not support associati.....
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In conclusion, the present findings do not support association of the NRG1 variants in the CVCR population with schizophrenia or bipolar disorder.
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The initial global haplotype test yielded significant eviden.....
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The initial global haplotype test yielded significant evidence for association (p=.01) with SZ/SA and BP1 (p= .004), although HAPICE was not overtransmitted. The marker showing strongest evidence for association in the deCODE studies, SNP8NRG221533, was associated with SZ/SA (p= .039) and with BP1 (p=.039), with BP1 showing association to the opposite allele as SZ/SA. The pattern of transmission at SNP8NRG221533 was significantly different in SZ/SA than in BP1 (p= .0004). Secondary analyses of markers and phenotypes provided no additional evidence for association to SZ/SA. However, a new marker, rs7014762, was associated with an a priori defined 'typical' bipolar phenotype characterized by excellent recovery between episodes and no mood incongruent features (p=.003)..
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Collectively these findings suggest that regulatory polymorp.....
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Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning.
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Polymorphisms at the promoters of NOS1_1d and NOS1_1f, previ.....
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Polymorphisms at the promoters of NOS1_1d and NOS1_1f, previously shown to be functional in vitro, revealed no significant allelic or genotypic differences among clinical groups and showed no effect on these transcripts' expression.
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GRIN2B expression levels in schizophrenia, bipolar disorder .....
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GRIN2B expression levels in schizophrenia, bipolar disorder and controls were not significantly different. The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
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Gene-based tests:X<sup>2</sup>=6.944, P-value = .....
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Gene-based tests:X<sup>2</sup>=6.944, P-value = 0.068 in recessive model in SZ/SZA, X<sup>2</sup>=4.563, P-value = 0.209 in additive model in SZ/SZA, X<sup>2</sup>=1.671, P-value = 0.769 in dominant model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA.
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Gene-based tests:X<sup>2</sup>=4.723, P-value = .....
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Gene-based tests:X<sup>2</sup>=4.723, P-value = 0.245 in additive model in SZ/SZA, X<sup>2</sup>=4.379, P-value = 0.319 in dominant model in SZ/SZA, X<sup>2</sup>=4.42, P-value = 0.349 in recessive model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA.
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We have demonstrated a significant association of rs12476147.....
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We have demonstrated a significant association of rs12476147 with SZ, and using a powerful within-subject design, an allelic expression imbalance of ZNF804A exonic SNP rs12476147 in the DLPFC.
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These findings suggest that ZNF804A might play an important .....
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These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes.
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In our present study, we found association of MLC1 gene with.....
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In our present study, we found association of MLC1 gene with SCZ and BPAD. This suggests the involvement of MLC1 gene in a common pathway toward the pathogenesis of these two disorders.
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Both intronic and promoter polymorphisms of MLC1 were specif.....
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Both intronic and promoter polymorphisms of MLC1 were specifically and significantly associated with periodic catatonia but not schizophrenia in general.
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Gene-based tests:X<sup>2</sup>=11.321, P-value =.....
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Gene-based tests:X<sup>2</sup>=11.321, P-value = 0.034 in recessive model in SZ/SZA, X<sup>2</sup>=7.892, P-value = 0.205 in dominant model in SZ/SZA, X<sup>2</sup>=5.146, P-value = 0.558 in additive model in SZ/SZA. Nominally significant associations were also noted with the SZ /SZA sample at NPAS2 under a recessive model.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA.
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Therefore, it can be deduced that the nonsynonymous rs769029.....
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Therefore, it can be deduced that the nonsynonymous rs7690296 polymorphism could play an important role in the pathophysiology of both bipolar disorder and schizophrenia.
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Gene-based tests:X<sup>2</sup>=3.815, P-value = .....
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Gene-based tests:X<sup>2</sup>=3.815, P-value = 0.347 in dominant model in SZ/SZA, X<sup>2</sup>=2.768, P-value = 0.564 in recessive model in SZ/SZA, X<sup>2</sup>=1.423, P-value = 0.814 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.
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None of the SNPs showed a significant association with MDD, .....
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None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively.
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There is strong evidence of association of rs2251219 with BP.....
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There is strong evidence of association of rs2251219 with BP. However, our data do not support association of this marker with schizophrenia. Because the region of association has high linkage disequilibrium, forming a large haplotype block across many genes, it is not clear which gene is causally implicated in the disorder.
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In SZ:Smallest P-value per gene=0.00107, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00107, Product of P truncation <=0.01=0.00082, Product of P truncation <=0.001=0.00063 It showed evidence for association with SZ.
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Gene-based tests:X<sup>2</sup>=1.267, P-value = .....
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Gene-based tests:X<sup>2</sup>=1.267, P-value = 0.767 in additive model in SZ/SZA, X<sup>2</sup>=1.576, P-value = 0.788 in recessive model in SZ/SZA, X<sup>2</sup>=0.701, P-value = 0.954 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.
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Gene-based tests:X<sup>2</sup>=1.525, P-value = .....
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Gene-based tests:X<sup>2</sup>=1.525, P-value = 0.481 in recessive model in SZ/SZA, X<sup>2</sup>=0.596, P-value = 0.64 in dominant model in SZ/SZA, X<sup>2</sup>=0.389, P-value = 0.725 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.
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Our larger sample suggests that these findings are not false.....
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Our larger sample suggests that these findings are not false-positive results, and supports the hypothesis that the TNF-a locus plays a role in susceptibility to schizophrenia.
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Gene-based tests:X<sup>2</sup>=9.945, P-value = .....
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Gene-based tests:X<sup>2</sup>=9.945, P-value = 0.056 in dominant model in SZ/SZA, X<sup>2</sup>=5.51, P-value = 0.407 in additive model in SZ/SZA, X<sup>2</sup>=4.505, P-value = 0.699 in recessive model in SZ/SZA.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA.
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AKT1 gene variations appeared to impact the risk for a class.....
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AKT1 gene variations appeared to impact the risk for a class of psychiatric symptoms, comprising SCZ and BPD. Our findings support the view that AKT1 genetic variants are shared by both BPD and SCZ.
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In conclusion, our findings, by showing the involvement of t.....
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In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them.
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These data suggest that a mutation in the SNAP29 gene promot.....
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These data suggest that a mutation in the SNAP29 gene promoter region, or a mutation in linkage disequilibrium with the promoter SNP, may be involved in the pathogenesis of chromosome 22-linked SZ.
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Our results support SYNGR1 as a probable susceptibility gene.....
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Our results support SYNGR1 as a probable susceptibility gene for SCZ and BPAD. Also, the observed association of SYNGR1 with both SCZ and BPAD suggests the likely involvement of a common pathway in the etiology of these disorders.
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Variants in the 15q25 gene cluster are associated with risk .....
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Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells.
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Variants in the 15q25 gene cluster are associated with risk .....
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Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells.
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In SZ:Smallest P-value per gene=0.0005, Product of P truncat.....
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In SZ:Smallest P-value per gene=0.0005, Product of P truncation <=0.01=0.0005, Product of P truncation <=0.001=0.0005 It showed evidence for association with SZ.
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A suggestive association between schizophrenia and rs646558 .....
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A suggestive association between schizophrenia and rs646558 were found. Three of the two marker haplotypes for rs646558 and rs2303377 showed varying frequencies between schizophrenia and controls.
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In SZ:Smallest P-value per gene=0.00812, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00812, Product of P truncation <=0.01=0.00819, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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The application of this approach suggests that it does have .....
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The application of this approach suggests that it does have some merits. The finding for CACNG5, taken together with the earlier implication of CACNA1C and CACNA1B, strongly suggests a key role for voltage-dependent calcium channel genes in the susceptibility to bipolar disorder and/or schizophrenia.
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These findings suggest that variation the ST8SIA2 gene is as.....
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These findings suggest that variation the ST8SIA2 gene is associated with increased risk to mental illness, acting to restrict neuronal plasticity and disrupt early neuronal network formation, rendering the developing and adult brain more vulnerable to secondary genetic or environmental insults.
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Findings of cytogenetic and genetic evidence supported a rol.....
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Findings of cytogenetic and genetic evidence supported a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder
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The frequency of all rare variants combined was greater than.....
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The frequency of all rare variants combined was greater than controls in schizophrenia (OR=1.93, P-value = 0.0057) and bipolar disorder (OR=2.71, P-value = 0.00007).These data identify a candidate gene, highlight the genetic overlap between schizophrenia, bipolar disorder, and depression, and suggest that rare coding variants may contribute significantly to risk of these disorders.
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Variants in the 15q25 gene cluster are associated with risk .....
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Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells.
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In SZ:Smallest P-value per gene=0.00396, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00396, Product of P truncation <=0.01=0.00213, Product of P truncation <=0.001=0.00112 It showed evidence for association with SZ.
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These data add to recent evidence that the combinatorial ana.....
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These data add to recent evidence that the combinatorial analysis of a number of relatively small effect size haplotypes may have significant power to predict an individual's risk of a complex genetic disorder such as psychiatric illness.
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Our results suggest that shared common risk factors for schi.....
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Our results suggest that shared common risk factors for schizophrenia, major depressive disorder and bipolar disorder exist in the CTLA-4 gene in the Chinese Han population.
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In SZ:Smallest P-value per gene=0.00456, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00456, Product of P truncation <=0.01=0.0053, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00028, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00028, Product of P truncation <=0.01=0.00028, Product of P truncation <=0.001=0.00028 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00387, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00387, Product of P truncation <=0.01=0.00387, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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A promoter mutation in a PI regulator affecting the binding .....
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A promoter mutation in a PI regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients.
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These findings indicate that common variations in the BCL9 .....
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These findings indicate that common variations in the BCL9 gene confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder in the Chinese Han population.
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This study strengthens the evidence for association between .....
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This study strengthens the evidence for association between rare variants within NDE1 and SCZ, and may shed light into the molecular mechanisms underlying this severe psychiatric disorder.
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In SZ:Smallest P-value per gene=0.00777, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00777, Product of P truncation <=0.01=0.00777, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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Due to highLD in the region harboring BRD1, we included SNPs.....
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Due to highLD in the region harboring BRD1, we included SNPs located within the ZBED4 gene in this replication analysis. Analysis of genotyped SNPs as well as imputed genotypes showed the strongest association with markers in BRD1. However, due to the high LD we cannot completely rule out ZBED4 as a positional candidate gene for SZ and BPD.
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In SZ:Smallest P-value per gene=0.00135, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00135, Product of P truncation <=0.01=0.00064, Product of P truncation <=0.001=0.00137 It showed evidence for association with SZ.
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Our results suggest that rare noncoding risk variants are as.....
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Our results suggest that rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression.
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In SZ:Smallest P-value per gene=0.00079, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00079, Product of P truncation <=0.01=0.00039, Product of P truncation <=0.001=0.00023 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00038, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00038, Product of P truncation <=0.01=0.00006, Product of P truncation <=0.001=0.00007 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00022, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00022, Product of P truncation <=0.01=0.01111, Product of P truncation <=0.001=0.00129 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00106, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00106, Product of P truncation <=0.01=0.00096, Product of P truncation <=0.001=0.00124 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00583, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00583, Product of P truncation <=0.01=0.00591, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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Our results suggest that rare noncoding risk variants are as.....
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Our results suggest that rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression.
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In SZ:Smallest P-value per gene=0.00132, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00132, Product of P truncation <=0.01=0.00132, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.01216, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.01216, Product of P truncation <=0.01=0.0046, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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The SNP rs11098403 of gene NDST3 is a novel genome-wide sign.....
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The SNP rs11098403 of gene NDST3 is a novel genome-wide significant risk locus at chromosome 4q26 and is significantly associated with schizophrenia and bipolar disorder.
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In SZ:Smallest P-value per gene=0.00608, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00608, Product of P truncation <=0.01=0.00608, Product of P truncation <=0.001=NA It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00199, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00199, Product of P truncation <=0.01=0.00196, Product of P truncation <=0.001=0.00199 It showed evidence for association with SZ.
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In SZ:Smallest P-value per gene=0.00045, Product of P trunca.....
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In SZ:Smallest P-value per gene=0.00045, Product of P truncation <=0.01=0.00045, Product of P truncation <=0.001=0.00045 It showed evidence for association with SZ.
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Thus, we conclude that the SERT VNTR polymorphism may be a r.....
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Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Han Chinese.
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Although it will be important to extend the present analysis.....
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Although it will be important to extend the present analysis in a larger sample, our preliminary results suggest that the 5-HTTLPR does not seem to play a major role in the genetics of bipolar and schizophrenic disorders at least in this group of Brazilian psychiatric patients.
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Haplotype analysis of val/met SNP and a dinucleotide repeat .....
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Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P<E-08) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population.
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Our findings suggest that BDNF may be a susceptibility gene .....
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Our findings suggest that BDNF may be a susceptibility gene for MDD and schizophrenia—in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms.
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No association was found between the studied polymorphism an.....
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No association was found between the studied polymorphism and schizophrenia or bipolar affective disorder either for genotype or allele distribution.
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Our results support the view that COMT variation provides a .....
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Our results support the view that COMT variation provides a weak general predisposition to neuropsychiatric disease including psychotic and affective disorders.One SNP also remained significant when only patients with schizophrenia were included.
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Our findings indicate that the 2141C Del variant in the 59 f.....
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Our findings indicate that the 2141C Del variant in the 59 flanking region of the human dopamine D2 receptor gene is unlikely to play a substantial role in genetic predisposition to major psychiatric disorders in Caucasians.
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Our results do not provide evidence for an association betwe.....
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Our results do not provide evidence for an association between this D2 receptor variant and schizophrenia, or delusional disorder, or bipolar affective disorder.
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The allele frequency of the T102C polymorphism established n.....
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The allele frequency of the T102C polymorphism established no significant differences between the patients and controls.Epigenetic dysregulation of HTR2A may contribute to SCZ, BD and earlier age of disease onset.
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In summary, this meta-analysis supports significant associat.....
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In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder.
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The association of variation at G72 with schizophrenia as we.....
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The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.
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DAOA genetic polymorphisms (M15, M18 andM23) were not found .....
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DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.
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M18/rs947267 and M22/rs778293 showed association with SCZ in.....
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M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans. The associations of C allele at M18 and A allele at M22 with SCZ in Asians survived conservative Bonferroni correction for multiple testing for 15 markers and subgroup analysis. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects.
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These findings suggest that the DAOA/G72 gene confers suscep.....
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These findings suggest that the DAOA/G72 gene confers susceptibility to both BD and SZ, but that different polymorphisms may potentially differentiate between these two disorders.
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The risk allele rs1006737 in this gene conferred increased r.....
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The risk allele rs1006737 in this gene conferred increased risk for schizophrenia (P= 0.034) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15).
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This result provides further supporting evidence for DISC1 a.....
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This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family.
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There was an effect of SNP rs1538979 in the pre/postcentral .....
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There was an effect of SNP rs1538979 in the pre/postcentral gyrus with decreased activation in healthy controls and increased activation in patients with schizophrenia.These findings may provide a better understanding of the neural effects of DISC1 variants and on the pathophysiology of schizophrenia.
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From cross-disorder studies (count: 104)
