BDgene

Study Report

Basic Info
Reference
Citation Cross-Disorder Group of the Psychiatric Genomics Consortium,(2013). "Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis." Lancet.
Disease Type Bipolar Disorder & Schizophrenia & Major depressive disorder
Study Design case-control
Study Type Genome-wide association study
Sample Size The final dataset consisted of 33 332 cases and 27 888 controls(including pseudocontrols formed from nontransmitted alleles) distributed among the five disorder groups: autism spectrum disorders (4788 trio cases, 4788 trio pseudocontrols, 161 cases, 526 controls), attention defi cit-hyperactivity disorder (1947 trio cases, 1947 trio pseudocontrols, 840 cases, 688 controls), bipolar disorder (6990 cases, 4820 controls), major depressive disorder (9227 cases, 7383 controls), and schizophrenia (9379 cases, 7736 controls).
SNP/Region/Marker Size 1 250 922 SNPs
Predominant Ethnicity Caucasian
Population European

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 10)

Genes reported by this study for BD (count: 9)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs12966547 CCDC68 Association analysis:P-value = 0.00000000026 when BPD,MDD and SZ were combined. Significant association was observed in cross-disorder analysis. Positive
SZ rs4765914 CACNA1C Association analysis:P-value = 0.0000000152 when BPD,MDD and SZ were combined. Significant association was observed in cross-disorder analysis. Positive
SZ rs11191454 AS3MT Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.13(1.08–1.18) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
SZ rs2535629 ITIH3 Association analysis:P-value = 0.00000000000254,OR(95%CI) = 1.1(1.07–1.12) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
SZ rs2799573 CACNB2 Association analysis:P-value = 0.0000000429,OR(95%CI) = 1.08(1.05-1.12) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
SZ rs1024582 CACNA1C CACNA1C-IT3 Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.07(1.05-1.10) when BD and SZ were combined Significant association was observed in cross-disorder analysis. Positive
MDD rs12966547 CCDC68 Association analysis:P-value = 0.00000000026 when BPD,MDD and SZ were combined. Significant association was observed in cross-disorder analysis. Positive
MDD rs4765914 CACNA1C Association analysis:P-value = 0.0000000152 when BPD,MDD and SZ were combined. Significant association was observed in cross-disorder analysis. Positive
MDD rs11191454 AS3MT Association analysis:P-value = 0.0000000139,OR(95%CI) = 1.13(1.08–1.18) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
MDD rs2535629 ITIH3 Association analysis:P-value = 0.00000000000254,OR(95%CI) = 1.1(1.07–1.12) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
MDD rs2799573 CACNB2 Association analysis:P-value = 0.0000000429,OR(95%CI) = 1.08(1.05-1.12) when five disorders were combined Significant association was observed in cross-disorder analysis. Positive
MDD rs1024582 CACNA1C CACNA1C-IT3 Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.07(1.05-1.10) when BD and SZ were combined Significant association was observed in cross-disorder analysis. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ AS3MT Significant association was observed in cross-disorder analysis. Positive
SZ ANK3
SZ SYNE1
SZ CACNB2 Significant association was observed in cross-disorder analysis. Positive
SZ CACNA1C Significant association was observed in cross-disorder analysis. Positive
SZ NT5C2
SZ ITIH3 Significant association was observed in cross-disorder analysis. Positive
SZ CCDC68 Significant association was observed in cross-disorder analysis. Positive
SZ TENM4
MDD AS3MT Significant association was observed in cross-disorder analysis. Positive
MDD ANK3
MDD ITIH3 Significant association was observed in cross-disorder analysis. Positive
MDD SYNE1
MDD CCDC68 Significant association was observed in cross-disorder analysis. Positive
MDD TENM4
MDD CACNB2 Significant association was observed in cross-disorder analysis. Positive
MDD CACNA1C Significant association was observed in cross-disorder analysis. Positive
MDD NT5C2