Study Report

Basic Info

Reference	Schanze, D.,2011 PMID: 21302348
Citation	Schanze, D., A. B. Ekici, et al. (2011). "Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population." Am J Med Genet B Neuropsychiatr Genet 156(2): 198-203.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	patients with unipolar depression or bipolar disorder (n=633),patients with schizophrenia and related disorders (n=936),volunteer control subjects(n=585)
SNP/Region/Marker Size	6 SNPs
Predominant Ethnicity	Caucasian
Population	German
Age Group	Adults : Mean age at recruitment of the patients was 42.9 years [15.59 SD] and mean age at first hospitalization was 30.2 years[ 12.89 SD].Mean age of control was 28.7 years (9.5 SD).

Detail Info

Sample Diagnosis	ICD10
Sample Status	The 1,569 index cases were assessed at the Psychiatric Department at the University of Wurzburg and met ICD10 criteria for unipolar depression or bipolar disorder (F31 and F33; n=633) or schizophrenia and related disorders (F20.x, F22, and F25; n=936), and were classified into monopolar affective psychoses (n=96), manic-depression (n=287), cycloid psychosis (n=317), unsystematic schizophrenia (n=640) and systematic schizophrenia (n=229) according to Leonhard's nosology [Leonhard, 1999].The 585 volunteer control subjects (57% males) were recruited from the blood donor center at the University of WÃ›urzburg. The preponderance of males in both samples avoided gender distortion in comparison of cases and controls. All subjects were unrelated and of German Caucasian descent.
Technique	PCR and sequencing
Statistical Method	For association statistics we calculated X² tests with corresponding P values and performed permutation tests for correction for multiple testing in the Haploview 4.1 statistical package[Barrett et al., 2005].
Result Summary	In a German population, we found none of the GWA risk alleles associated with psychosis.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 6)

SNP	Related Gene(s)	Risk Allele	Statistical Values	Author Comments	Result Category
rs3016384	OPCML	C	X² tests: allele P-value = 0.67 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs6490121	NOS1	G	X² tests: allele P-value = 0.29 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1344706	ZNF804A	T	X² tests: allele P-value = 0.82 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1602565		C	X² tests: allele P-value = 0.66 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs7192086	SHISA9	T	X² tests: allele P-value = 0.9 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs9922369	RPGRIP1L	A	X² tests: allele P-value = 0.35 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 4)

Gene	Statistical Values/Author Comments	Result Category
ZNF804A	In a German population, we found none of the GWA risk alleles associated with psychosis. In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
NOS1	In a German population, we found none of the GWA risk alleles associated with psychosis. In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
RPGRIP1L	In a German population, we found none of the GWA risk alleles associated with psychosis. In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
OPCML	In a German population, we found none of the GWA risk alleles associated with psychosis. In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs3016384	OPCML	X² tests:allele P-value = 0.85 for SCZ.	No significant association was observed.	Negative
SZ	rs6490121	NOS1	X² tests:allele P-value = 0.67 for SCZ.	No significant association was observed.	Negative
SZ	rs1344706	ZNF804A	X² tests:allele P-value = 0.31 for SCZ.	No significant association was observed.	Negative
SZ	rs1602565		X² tests:allele P-value = 0.87 for SCZ.	No significant association was observed.	Negative
SZ	rs7192086	SHISA9	X² tests:allele P-value = 0.78 for SCZ.	No significant association was observed.	Negative
SZ	rs9922369	RPGRIP1L	X² tests:allele P-value = 0.39 for SCZ.	No significant association was observed.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	ZNF804A	In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
SZ	RPGRIP1L	In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
SZ	NOS1	In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative
SZ	OPCML	In a German population, we found none of the GWA risk alleles associated with psychosis.	Negative